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Entry version 129 (08 May 2019)
Sequence version 2 (16 Jan 2019)
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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.1 Publication
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The kcat is 900 sec(-1) for the isomerization of dihydroxyacetone phosphate (PubMed:2021650). The kcat is 0.011 sec(-1) for the production of methylglyoxal via the elimination reaction (PubMed:2021650). Produces methylglyoxal with a calculated cellular velocity of 0.4 mM per day (PubMed:2021650).1 Publication
  1. KM=0.62 mM for dihydroxyacetone phosphate (at pH 7.9)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

    This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.PROSITE-ProRule annotation
    Proteins known to be involved in this subpathway in this organism are:
    1. Triosephosphate isomerase (TPI1)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

    Pathwayi: gluconeogenesis

    This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.PROSITE-ProRule annotation
    View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51SubstratePROSITE-ProRule annotation1
    Binding sitei53SubstratePROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei135ElectrophilePROSITE-ProRule annotation1
    Active sitei205Proton acceptor1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • methylglyoxal synthase activity Source: UniProtKB
    • protein homodimerization activity Source: UniProtKB
    • triose-phosphate isomerase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase, Lyase
    Biological processGluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    5.3.1.1 1749

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P00939

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00189
    UPA00138

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Triosephosphate isomerase1 Publication (EC:5.3.1.11 Publication)
    Short name:
    TIM
    Alternative name(s):
    Methylglyoxal synthase1 Publication (EC:4.2.3.31 Publication)
    Triose-phosphate isomerase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TPI1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3930

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000901191 – 288Triosephosphate isomeraseAdd BLAST288

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53N6-acetyllysineBy similarity1
    Modified residuei55Deamidated asparagine1 Publication1
    Modified residuei107Nitrated tyrosineBy similarity1
    Modified residuei111Deamidated asparagine1 Publication1
    Modified residuei119PhosphoserineBy similarity1
    Modified residuei145PhosphoserineBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
    Modified residuei188N6-succinyllysineBy similarity1
    Modified residuei195N6-acetyllysine; alternateBy similarity1
    Modified residuei195N6-succinyllysine; alternateBy similarity1
    Modified residuei198PhosphoserineBy similarity1
    Modified residuei212PhosphothreonineBy similarity1
    Modified residuei233N6-acetyllysine; alternateBy similarity1
    Modified residuei233N6-methyllysine; alternateBy similarity1
    Modified residuei233N6-succinyllysine; alternateBy similarity1
    Modified residuei237PhosphoserineBy similarity1
    Modified residuei248Nitrated tyrosineBy similarity1
    Modified residuei251PhosphoserineBy similarity1
    Modified residuei253PhosphothreonineBy similarity1
    Modified residuei262PhosphoserineBy similarity1
    Modified residuei277N6-acetyllysineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Asn-55 and Asn-111 undergo deamidation which gives rise to four extra negative charges. These are expected to decrease subunit-subunit interactions and so expose the hydrophobic interface to the aqueous environment.1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Methylation, Nitration, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00939

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSOCUG00000025649 Expressed in 3 organ(s), highest expression level in prefrontal cortex

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    PROSITE-ProRule annotation1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9986.ENSOCUP00000019840

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P00939

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1288
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00939

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P00939

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1643 Eukaryota
    COG0149 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000013354

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000226413

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00939

    KEGG Orthology (KO)

    More...
    KOi
    K01803

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LCVGEGL

    Database of Orthologous Groups

    More...
    OrthoDBi
    1272577at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300829

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00311 TIM, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00147_B TIM_B, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785 Aldolase_TIM
    IPR035990 TIM_sf
    IPR022896 TrioseP_Isoase_bac/euk
    IPR000652 Triosephosphate_isomerase
    IPR020861 Triosephosphate_isomerase_AS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR21139 PTHR21139, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00121 TIM, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51351 SSF51351, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00419 tim, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00171 TIM_1, 1 hit
    PS51440 TIM_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P00939-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAGTGQEAEF RFSAFYISRQ RPQPRPHGGT DLQCAGPSAM APSRKFFVGG
    60 70 80 90 100
    NWKMNGRKKN LGELITTLNA AKVPADTEVV CAPPTAYIDF ARQKLDPKIA
    110 120 130 140 150
    VAAQNCYKVT NGAFTGEISP GMIKDCGATW VVLGHSERRH VFGESDELIG
    160 170 180 190 200
    QKVAHALSEG LGVIACIGEK LDEREAGITE KVVFEQTKVI ADNVKDWSKV
    210 220 230 240 250
    VLAYEPVWAI GTGKTATPQQ AQEVHEKLRG WLKSNVSDAV AQSTRIIYGG
    260 270 280
    SVTGATCKEL ASQPDVDGFL VGGASLKPEF VDIINAKQ
    Length:288
    Mass (Da):30,962
    Last modified:January 16, 2019 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB43FE0FF01AA8C42
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AAGW02051581 Genomic DNA No translation available.
    V00902 mRNA Translation: CAA24267.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A01165 ISRBT

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_002712957.1, XM_002712911.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSOCUT00000025399; ENSOCUP00000019840; ENSOCUG00000025649

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    100348316

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ocu:100348316

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AAGW02051581 Genomic DNA No translation available.
    V00902 mRNA Translation: CAA24267.1
    PIRiA01165 ISRBT
    RefSeqiXP_002712957.1, XM_002712911.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1R2RX-ray1.50A/B/C/D41-288[»]
    1R2SX-ray2.85A/B/C/D41-288[»]
    1R2TX-ray2.25A/B41-288[»]
    4OWGX-ray1.55A/B41-288[»]
    SMRiP00939
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000019840

    Chemistry databases

    BindingDBiP00939
    ChEMBLiCHEMBL3930

    Proteomic databases

    PRIDEiP00939

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSOCUT00000025399; ENSOCUP00000019840; ENSOCUG00000025649
    GeneIDi100348316
    KEGGiocu:100348316

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    7167

    Phylogenomic databases

    eggNOGiKOG1643 Eukaryota
    COG0149 LUCA
    GeneTreeiENSGT00390000013354
    HOGENOMiHOG000226413
    InParanoidiP00939
    KOiK01803
    OMAiLCVGEGL
    OrthoDBi1272577at2759
    TreeFamiTF300829

    Enzyme and pathway databases

    UniPathwayiUPA00109;UER00189
    UPA00138
    BRENDAi5.3.1.1 1749
    SABIO-RKiP00939

    Miscellaneous databases

    EvolutionaryTraceiP00939

    Gene expression databases

    BgeeiENSOCUG00000025649 Expressed in 3 organ(s), highest expression level in prefrontal cortex

    Family and domain databases

    CDDicd00311 TIM, 1 hit
    Gene3Di3.20.20.70, 1 hit
    HAMAPiMF_00147_B TIM_B, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR035990 TIM_sf
    IPR022896 TrioseP_Isoase_bac/euk
    IPR000652 Triosephosphate_isomerase
    IPR020861 Triosephosphate_isomerase_AS
    PANTHERiPTHR21139 PTHR21139, 1 hit
    PfamiView protein in Pfam
    PF00121 TIM, 1 hit
    SUPFAMiSSF51351 SSF51351, 1 hit
    TIGRFAMsiTIGR00419 tim, 1 hit
    PROSITEiView protein in PROSITE
    PS00171 TIM_1, 1 hit
    PS51440 TIM_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPIS_RABIT
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00939
    Secondary accession number(s): G1TS29
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 16, 2019
    Last modified: May 8, 2019
    This is version 129 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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    Main funding by: National Institutes of Health

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