UniProtKB - P00926 (SDHD_ECOLI)
Protein
D-serine dehydratase
Gene
dsdA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:4.3.1.18
Cofactori
pyridoxal 5'-phosphate1 Publication
GO - Molecular functioni
- D-serine ammonia-lyase activity Source: CACAO
- hydro-lyase activity Source: EcoliWiki
- L-serine ammonia-lyase activity Source: GO_Central
- L-threonine ammonia-lyase activity Source: GO_Central
- pyridoxal phosphate binding Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- detoxification of nitrogen compound Source: EcoCyc
- D-serine catabolic process Source: EcoCyc
- D-serine metabolic process Source: EcoliWiki
- L-serine catabolic process Source: GO_Central
- threonine catabolic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | EcoCyc:DSERDEAM-MONOMER MetaCyc:DSERDEAM-MONOMER |
BRENDAi | 4.3.1.18, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: D-serine dehydratase (EC:4.3.1.18)Alternative name(s): D-serine deaminase Short name: DSD |
Gene namesi | Name:dsdA Ordered Locus Names:b2366, JW2363 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185611 | 1 – 442 | D-serine dehydrataseAdd BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 118 | N6-(pyridoxal phosphate)lysineCombined sources1 Publication | 1 |
Proteomic databases
jPOSTi | P00926 |
PaxDbi | P00926 |
PRIDEi | P00926 |
Expressioni
Inductioni
By growth in D-serine.1 Publication
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4260555, 10 interactors 851178, 1 interactor |
IntActi | P00926, 4 interactors |
STRINGi | 511145.b2366 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P00926 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domaini
Crystal structures show a large (N-terminal) and small (C-terminal) domain; the C-terminal domain is mobile and can block access to the active site.1 Publication
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG3048, Bacteria |
HOGENOMi | CLU_035707_0_0_6 |
InParanoidi | P00926 |
PhylomeDBi | P00926 |
Family and domain databases
Gene3Di | 3.40.50.1100, 2 hits |
HAMAPi | MF_01030, D_Ser_dehydrat, 1 hit |
InterProi | View protein in InterPro IPR011780, D_Ser_am_lyase IPR001926, PLP-dep IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS IPR036052, Trypto_synt_PLP_dependent |
PANTHERi | PTHR43419:SF2, PTHR43419:SF2, 1 hit |
Pfami | View protein in Pfam PF00291, PALP, 1 hit |
SUPFAMi | SSF53686, SSF53686, 1 hit |
TIGRFAMsi | TIGR02035, D_Ser_am_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00165, DEHYDRATASE_SER_THR, 1 hit |
i Sequence
Sequence statusi: Complete.
P00926-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENAKMNSLI AQYPLVKDLV ALKETTWFNP GTTSLAEGLP YVGLTEQDVQ
60 70 80 90 100
DAHARLSRFA PYLAKAFPET AATGGIIESE LVAIPAMQKR LEKEYQQPIS
110 120 130 140 150
GQLLLKKDSH LPISGSIKAR GGIYEVLAHA EKLALEAGLL TLDDDYSKLL
160 170 180 190 200
SPEFKQFFSQ YSIAVGSTGN LGLSIGIMSA RIGFKVTVHM SADARAWKKA
210 220 230 240 250
KLRSHGVTVV EYEQDYGVAV EEGRKAAQSD PNCFFIDDEN SRTLFLGYSV
260 270 280 290 300
AGQRLKAQFA QQGRIVDADN PLFVYLPCGV GGGPGGVAFG LKLAFGDHVH
310 320 330 340 350
CFFAEPTHSP CMLLGVHTGL HDQISVQDIG IDNLTAADGL AVGRASGFVG
360 370 380 390 400
RAMERLLDGF YTLSDQTMYD MLGWLAQEEG IRLEPSALAG MAGPQRVCAS
410 420 430 440
VSYQQMHGFS AEQLRNTTHL VWATGGGMVP EEEMNQYLAK GR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | S → T AA sequence (PubMed:9222324).Curated | 1 | |
Sequence conflicti | 85 | P → R in AAA87975 (PubMed:3053699).Curated | 1 | |
Sequence conflicti | 204 | S → T in AAA87975 (PubMed:3053699).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01603 Genomic DNA Translation: AAA87975.1 U00096 Genomic DNA Translation: AAC75425.1 AP009048 Genomic DNA Translation: BAA16229.1 X86379 Genomic DNA Translation: CAA60139.1 |
PIRi | C65010, DWECS |
RefSeqi | NP_416867.1, NC_000913.3 WP_000426427.1, NZ_STEB01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC75425; AAC75425; b2366 BAA16229; BAA16229; BAA16229 |
GeneIDi | 946837 |
KEGGi | ecj:JW2363 eco:b2366 |
PATRICi | fig|1411691.4.peg.4363 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J01603 Genomic DNA Translation: AAA87975.1 U00096 Genomic DNA Translation: AAC75425.1 AP009048 Genomic DNA Translation: BAA16229.1 X86379 Genomic DNA Translation: CAA60139.1 |
PIRi | C65010, DWECS |
RefSeqi | NP_416867.1, NC_000913.3 WP_000426427.1, NZ_STEB01000008.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3SS7 | X-ray | 1.55 | X | 1-442 | [»] | |
3SS9 | X-ray | 1.97 | X | 1-442 | [»] | |
SMRi | P00926 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260555, 10 interactors 851178, 1 interactor |
IntActi | P00926, 4 interactors |
STRINGi | 511145.b2366 |
Proteomic databases
jPOSTi | P00926 |
PaxDbi | P00926 |
PRIDEi | P00926 |
Genome annotation databases
EnsemblBacteriai | AAC75425; AAC75425; b2366 BAA16229; BAA16229; BAA16229 |
GeneIDi | 946837 |
KEGGi | ecj:JW2363 eco:b2366 |
PATRICi | fig|1411691.4.peg.4363 |
Organism-specific databases
EchoBASEi | EB0245 |
Phylogenomic databases
eggNOGi | COG3048, Bacteria |
HOGENOMi | CLU_035707_0_0_6 |
InParanoidi | P00926 |
PhylomeDBi | P00926 |
Enzyme and pathway databases
BioCyci | EcoCyc:DSERDEAM-MONOMER MetaCyc:DSERDEAM-MONOMER |
BRENDAi | 4.3.1.18, 2026 |
Miscellaneous databases
PROi | PR:P00926 |
Family and domain databases
Gene3Di | 3.40.50.1100, 2 hits |
HAMAPi | MF_01030, D_Ser_dehydrat, 1 hit |
InterProi | View protein in InterPro IPR011780, D_Ser_am_lyase IPR001926, PLP-dep IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS IPR036052, Trypto_synt_PLP_dependent |
PANTHERi | PTHR43419:SF2, PTHR43419:SF2, 1 hit |
Pfami | View protein in Pfam PF00291, PALP, 1 hit |
SUPFAMi | SSF53686, SSF53686, 1 hit |
TIGRFAMsi | TIGR02035, D_Ser_am_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00165, DEHYDRATASE_SER_THR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SDHD_ECOLI | |
Accessioni | P00926Primary (citable) accession number: P00926 Secondary accession number(s): P78303 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families