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Protein

Carbonic anhydrase 2

Gene

Ca2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.1 Publication

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Activity regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorBy similarity1
Active sitei67By similarity1
Metal bindingi94Zinc; catalyticBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1
Metal bindingi119Zinc; catalyticBy similarity1
Active sitei127By similarity1

GO - Molecular functioni

  • arylesterase activity Source: MGI
  • carbonate dehydratase activity Source: MGI
  • zinc ion binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 2 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase II
Carbonic anhydrase II
Short name:
CA-II
Gene namesi
Name:Ca2
Synonyms:Car2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88269 Car2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3689

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000774192 – 260Carbonic anhydrase 2Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei165PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP00920
MaxQBiP00920
PaxDbiP00920
PeptideAtlasiP00920
PRIDEiP00920

PTM databases

iPTMnetiP00920
PhosphoSitePlusiP00920
SwissPalmiP00920

Expressioni

Gene expression databases

BgeeiENSMUSG00000027562 Expressed in 334 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_CAR2
ExpressionAtlasiP00920 baseline and differential
GenevisibleiP00920 MM

Interactioni

Subunit structurei

Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198483, 2 interactors
IntActiP00920, 6 interactors
MINTiP00920
STRINGi10090.ENSMUSP00000029078

Structurei

3D structure databases

ProteinModelPortaliP00920
SMRiP00920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 259Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 199Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP00920
KOiK18245
OMAiHKEFPIA
OrthoDBiEOG091G0XFM
PhylomeDBiP00920
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P00920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHHWGYSKH NGPENWHKDF PIANGDRQSP VDIDTATAQH DPALQPLLIS
60 70 80 90 100
YDKAASKSIV NNGHSFNVEF DDSQDNAVLK GGPLSDSYRL IQFHFHWGSS
110 120 130 140 150
DGQGSEHTVN KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKIG
160 170 180 190 200
PASQGLQKVL EALHSIKTKG KRAAFANFDP CSLLPGNLDY WTYPGSLTTP
210 220 230 240 250
PLLECVTWIV LREPITVSSE QMSHFRTLNF NEEGDAEEAM VDNWRPAQPL
260
KNRKIKASFK
Length:260
Mass (Da):29,033
Last modified:May 1, 2007 - v4
Checksum:i095760368D446AA6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX78A0A0A6YX78_MOUSE
Carbonic anhydrase 2
Car2
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Q → H in AAA37356 (PubMed:6420240).Curated1
Sequence conflicti39Q → H in AAH55291 (PubMed:15489334).Curated1
Sequence conflicti145I → Y in AAA37356 (PubMed:6420240).Curated1
Sequence conflicti145I → Y in AAA37357 (PubMed:2995362).Curated1
Sequence conflicti213E → D in AAA37357 (PubMed:2995362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00811 mRNA Translation: AAA37356.1
M81022
, M81016, M81017, M81018, M81019, M81020, M81021 Genomic DNA Translation: AAA37357.1
AK002333 mRNA Translation: BAB22019.1
AK002498 mRNA Translation: BAB22146.2
BC055291 mRNA Translation: AAH55291.1
M25944 mRNA Translation: AAA39505.1
CCDSiCCDS17251.1
PIRiA23900 CRMS2
RefSeqiNP_033931.4, NM_009801.4
XP_006530113.1, XM_006530050.1
UniGeneiMm.1186

Genome annotation databases

EnsembliENSMUST00000029078; ENSMUSP00000029078; ENSMUSG00000027562
GeneIDi12349
KEGGimmu:12349
UCSCiuc008oqt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00811 mRNA Translation: AAA37356.1
M81022
, M81016, M81017, M81018, M81019, M81020, M81021 Genomic DNA Translation: AAA37357.1
AK002333 mRNA Translation: BAB22019.1
AK002498 mRNA Translation: BAB22146.2
BC055291 mRNA Translation: AAH55291.1
M25944 mRNA Translation: AAA39505.1
CCDSiCCDS17251.1
PIRiA23900 CRMS2
RefSeqiNP_033931.4, NM_009801.4
XP_006530113.1, XM_006530050.1
UniGeneiMm.1186

3D structure databases

ProteinModelPortaliP00920
SMRiP00920
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198483, 2 interactors
IntActiP00920, 6 interactors
MINTiP00920
STRINGi10090.ENSMUSP00000029078

Chemistry databases

ChEMBLiCHEMBL3689

PTM databases

iPTMnetiP00920
PhosphoSitePlusiP00920
SwissPalmiP00920

Proteomic databases

EPDiP00920
MaxQBiP00920
PaxDbiP00920
PeptideAtlasiP00920
PRIDEiP00920

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029078; ENSMUSP00000029078; ENSMUSG00000027562
GeneIDi12349
KEGGimmu:12349
UCSCiuc008oqt.2 mouse

Organism-specific databases

CTDi12349
MGIiMGI:88269 Car2

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP00920
KOiK18245
OMAiHKEFPIA
OrthoDBiEOG091G0XFM
PhylomeDBiP00920
TreeFamiTF316425

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-1475029 Reversible hydration of carbon dioxide

Miscellaneous databases

ChiTaRSiCar2 mouse
PROiPR:P00920
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027562 Expressed in 334 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_CAR2
ExpressionAtlasiP00920 baseline and differential
GenevisibleiP00920 MM

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAH2_MOUSE
AccessioniPrimary (citable) accession number: P00920
Secondary accession number(s): Q6LDQ7
, Q7TPE1, Q9DCT3, Q9DCY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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