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Entry version 164 (07 Oct 2020)
Sequence version 2 (21 Dec 2004)
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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 1850 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (TRP2), Multifunctional tryptophan biosynthesis protein (TRP3)
  2. Anthranilate phosphoribosyltransferase (TRP4)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. Multifunctional tryptophan biosynthesis protein (TRP3)
  5. Tryptophan synthase (TRP5)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00035;UER00042

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRP1
Ordered Locus Names:YDR007W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR007W

Saccharomyces Genome Database

More...
SGDi
S000002414, TRP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001543371 – 224N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST224

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P00912

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00912

PRoteomics IDEntifications database

More...
PRIDEi
P00912

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00912

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32060, 110 interactors

Database of interacting proteins

More...
DIPi
DIP-2671N

Protein interaction database and analysis system

More...
IntActi
P00912, 1 interactor

Molecular INTeraction database

More...
MINTi
P00912

STRING: functional protein association networks

More...
STRINGi
4932.YDR007W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P00912, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00912

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4202, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076364_1_0_1

KEGG Orthology (KO)

More...
KOi
K01817

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYAKSPR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00405, PRAI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00135, PRAI, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR001240, PRAI
IPR011060, RibuloseP-bd_barrel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00697, PRAI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51366, SSF51366, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP
60 70 80 90 100
VIARKISSLV KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH
110 120 130 140 150
GDESWQEYQE FLGLPVIKRL VFPKDCNILL SAASQKPHSF IPLFDSEAGG
160 170 180 190 200
TGELLDWNSI SDWVGRQESP ESLHFMLAGG LTPENVGDAL RLNGVIGVDV
210 220
SGGVETNGVK DSNKIANFVK NAKK
Length:224
Mass (Da):24,144
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03353B85F24FA09D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA80674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA88067 differs from that shown. Reason: Erroneous termination. Truncated C-terminus. This mutation is only found in the substrain S288c / AB972. The S288c reference strain does not contain this mutation.Curated
The sequence CAA88068 differs from that shown. Reason: Erroneous termination. Truncated C-terminus. This mutation is only found in the substrain S288c / AB972. The S288c reference strain does not contain this mutation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti48I → V in strain: CLIB 556 haplotype Ha2 and CLIB 630 haplotype Ha2. 1 Publication1
Natural varianti172S → R in strain: CLIB 556 haplotype Ha1. 1 Publication1
Natural varianti212S → F in strain: CLIB 95, CLIB 382, CLIB 388, CLIB 556 haplotype Ha2, CLIB 630, K1, R12, R13, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01341 Genomic DNA Translation: CAA24634.1
M74015 Genomic DNA Translation: AAA72097.1
U37458 Genomic DNA Translation: AAA80674.1 Different initiation.
AJ585667 Genomic DNA Translation: CAE52187.1
AJ585668 Genomic DNA Translation: CAE52188.1
AJ585669 Genomic DNA Translation: CAE52189.1
AJ585670 Genomic DNA Translation: CAE52190.1
AJ585671 Genomic DNA Translation: CAE52191.1
AJ585672 Genomic DNA Translation: CAE52192.1
AJ585673 Genomic DNA Translation: CAE52193.1
AJ585674 Genomic DNA Translation: CAE52194.1
AJ585675 Genomic DNA Translation: CAE52195.1
AJ585676 Genomic DNA Translation: CAE52196.1
AJ585677 Genomic DNA Translation: CAE52197.1
AJ585678 Genomic DNA Translation: CAE52198.1
AJ585679 Genomic DNA Translation: CAE52199.1
AJ585680 Genomic DNA Translation: CAE52200.1
AJ585681 Genomic DNA Translation: CAE52201.1
AJ585682 Genomic DNA Translation: CAE52202.1
AJ585683 Genomic DNA Translation: CAE52203.1
AJ585684 Genomic DNA Translation: CAE52204.1
AJ585685 Genomic DNA Translation: CAE52205.1
Z48008 Genomic DNA Translation: CAA88067.1 Sequence problems.
Z48008 Genomic DNA Translation: CAA88068.1 Sequence problems.
M30386 Genomic DNA Translation: AAA18406.1
BK006938 Genomic DNA Translation: DAA11855.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A01135, ISBYN

NCBI Reference Sequences

More...
RefSeqi
NP_010290.3, NM_001180315.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR007W_mRNA; YDR007W; YDR007W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR007W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01341 Genomic DNA Translation: CAA24634.1
M74015 Genomic DNA Translation: AAA72097.1
U37458 Genomic DNA Translation: AAA80674.1 Different initiation.
AJ585667 Genomic DNA Translation: CAE52187.1
AJ585668 Genomic DNA Translation: CAE52188.1
AJ585669 Genomic DNA Translation: CAE52189.1
AJ585670 Genomic DNA Translation: CAE52190.1
AJ585671 Genomic DNA Translation: CAE52191.1
AJ585672 Genomic DNA Translation: CAE52192.1
AJ585673 Genomic DNA Translation: CAE52193.1
AJ585674 Genomic DNA Translation: CAE52194.1
AJ585675 Genomic DNA Translation: CAE52195.1
AJ585676 Genomic DNA Translation: CAE52196.1
AJ585677 Genomic DNA Translation: CAE52197.1
AJ585678 Genomic DNA Translation: CAE52198.1
AJ585679 Genomic DNA Translation: CAE52199.1
AJ585680 Genomic DNA Translation: CAE52200.1
AJ585681 Genomic DNA Translation: CAE52201.1
AJ585682 Genomic DNA Translation: CAE52202.1
AJ585683 Genomic DNA Translation: CAE52203.1
AJ585684 Genomic DNA Translation: CAE52204.1
AJ585685 Genomic DNA Translation: CAE52205.1
Z48008 Genomic DNA Translation: CAA88067.1 Sequence problems.
Z48008 Genomic DNA Translation: CAA88068.1 Sequence problems.
M30386 Genomic DNA Translation: AAA18406.1
BK006938 Genomic DNA Translation: DAA11855.1
PIRiA01135, ISBYN
RefSeqiNP_010290.3, NM_001180315.3

3D structure databases

SMRiP00912
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32060, 110 interactors
DIPiDIP-2671N
IntActiP00912, 1 interactor
MINTiP00912
STRINGi4932.YDR007W

PTM databases

iPTMnetiP00912

Proteomic databases

MaxQBiP00912
PaxDbiP00912
PRIDEiP00912

Genome annotation databases

EnsemblFungiiYDR007W_mRNA; YDR007W; YDR007W
GeneIDi851570
KEGGisce:YDR007W

Organism-specific databases

EuPathDBiFungiDB:YDR007W
SGDiS000002414, TRP1

Phylogenomic databases

eggNOGiKOG4202, Eukaryota
HOGENOMiCLU_076364_1_0_1
KOiK01817
OMAiFYAKSPR

Enzyme and pathway databases

UniPathwayiUPA00035;UER00042

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P00912
RNActiP00912, protein

Family and domain databases

CDDicd00405, PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135, PRAI, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR001240, PRAI
IPR011060, RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697, PRAI, 1 hit
SUPFAMiSSF51366, SSF51366, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPF_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00912
Secondary accession number(s): D6VRZ5
, Q03448, Q12131, Q70DA4, Q70DA7, Q70DB2, Q7LHE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 21, 2004
Last modified: October 7, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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