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Entry version 161 (26 Feb 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Anthranilate synthase component 1

Gene

trpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Cooperatively feedback inhibited by tryptophan.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.2 µM for chorismate (at pH 7.5)3 Publications
  2. KM=15 mM for ammonia (at 37 degrees Celsius and at pH 7.6)3 Publications

    pH dependencei

    Optimum pH is between 7.2 and 7.8.3 Publications

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.
    Proteins known to be involved in the 5 steps of the subpathway in this organism are:
    1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 1 (trpE), Bifunctional protein TrpGD (trpGD)
    2. Anthranilate phosphoribosyltransferase (trpD), Bifunctional protein TrpGD (trpGD)
    3. Tryptophan biosynthesis protein TrpCF (trpC)
    4. Tryptophan biosynthesis protein TrpCF (trpC)
    5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase alpha chain (trpA), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
    This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40TryptophanBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi361MagnesiumBy similarity1
    Binding sitei449ChorismateBy similarity1
    Binding sitei469ChorismateBy similarity1
    Binding sitei485Chorismate; via amide nitrogenBy similarity1
    Metal bindingi498MagnesiumBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • anthranilate synthase activity Source: EcoCyc
    • metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    • tryptophan biosynthetic process Source: EcoCyc

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAllosteric enzyme, Lyase
    Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:ANTHRANSYNCOMPI-MONOMER
    ECOL316407:JW1256-MONOMER
    MetaCyc:ANTHRANSYNCOMPI-MONOMER

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P00895

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00035;UER00040

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Anthranilate synthase component 1 (EC:4.1.3.27)
    Short name:
    AS
    Short name:
    ASI
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:trpE
    Ordered Locus Names:b1264, JW1256
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001540921 – 520Anthranilate synthase component 1Add BLAST520

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P00895

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P00895

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00895

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large lpha subunit (TrpE).

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4260124, 12 interactors
    850213, 4 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-4783 Anthranilate synthase complex

    Protein interaction database and analysis system

    More...
    IntActi
    P00895, 25 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b1264

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00895

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 293Tryptophan bindingBy similarity3
    Regioni328 – 329Chorismate bindingBy similarity2
    Regioni483 – 485Chorismate bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CRQ Bacteria
    COG0147 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_006493_9_4_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00895

    KEGG Orthology (KO)

    More...
    KOi
    K01657

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P00895

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.60.120.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005801 ADC_synthase
    IPR019999 Anth_synth_I-like
    IPR006805 Anth_synth_I_N
    IPR005257 Anth_synth_I_TrpE
    IPR015890 Chorismate_C

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11236:SF22 PTHR11236:SF22, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04715 Anth_synt_I_N, 1 hit
    PF00425 Chorismate_bind, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF001373 TrpE, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00095 ANTSNTHASEI

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56322 SSF56322, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00565 trpE_proteo, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P00895-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MQTQKPTLEL LTCEGAYRDN PTALFHQLCG DRPATLLLES ADIDSKDDLK
    60 70 80 90 100
    SLLLVDSALR ITALGDTVTI QALSGNGEAL LALLDNALPA GVESEQSPNC
    110 120 130 140 150
    RVLRFPPVSP LLDEDARLCS LSVFDAFRLL QNLLNVPKEE REAMFFGGLF
    160 170 180 190 200
    SYDLVAGFED LPQLSAENNC PDFCFYLAET LMVIDHQKKS TRIQASLFAP
    210 220 230 240 250
    NEEEKQRLTA RLNELRQQLT EAAPPLPVVS VPHMRCECNQ SDEEFGGVVR
    260 270 280 290 300
    LLQKAIRAGE IFQVVPSRRF SLPCPSPLAA YYVLKKSNPS PYMFFMQDND
    310 320 330 340 350
    FTLFGASPES SLKYDATSRQ IEIYPIAGTR PRGRRADGSL DRDLDSRIEL
    360 370 380 390 400
    EMRTDHKELS EHLMLVDLAR NDLARICTPG SRYVADLTKV DRYSYVMHLV
    410 420 430 440 450
    SRVVGELRHD LDALHAYRAC MNMGTLSGAP KVRAMQLIAE AEGRRRGSYG
    460 470 480 490 500
    GAVGYFTAHG DLDTCIVIRS ALVENGIATV QAGAGVVLDS VPQSEADETR
    510 520
    NKARAVLRAI ATAHHAQETF
    Length:520
    Mass (Da):57,494
    Last modified:November 1, 1997 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87696C0538CF66EA
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147G → S in CAA23666 (PubMed:7038627).Curated1
    Sequence conflicti147G → S in CAA23671 (PubMed:7021857).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti13C → S in strain: TRPA2/COLVB. 1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    V00368 Genomic DNA Translation: CAA23666.1
    V00372 Genomic DNA Translation: CAA23671.1
    J01714 Genomic DNA Translation: AAA57297.1
    U00096 Genomic DNA Translation: AAC74346.1
    AP009048 Genomic DNA Translation: BAA14799.1
    M24959 Genomic DNA Translation: AAA24692.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    C64874 NNEC1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_415780.1, NC_000913.3
    WP_001194582.1, NZ_SSZK01000031.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC74346; AAC74346; b1264
    BAA14799; BAA14799; BAA14799

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    945846

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW1256
    eco:b1264

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.1019

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    V00368 Genomic DNA Translation: CAA23666.1
    V00372 Genomic DNA Translation: CAA23671.1
    J01714 Genomic DNA Translation: AAA57297.1
    U00096 Genomic DNA Translation: AAC74346.1
    AP009048 Genomic DNA Translation: BAA14799.1
    M24959 Genomic DNA Translation: AAA24692.1
    PIRiC64874 NNEC1
    RefSeqiNP_415780.1, NC_000913.3
    WP_001194582.1, NZ_SSZK01000031.1

    3D structure databases

    SMRiP00895
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi4260124, 12 interactors
    850213, 4 interactors
    ComplexPortaliCPX-4783 Anthranilate synthase complex
    IntActiP00895, 25 interactors
    STRINGi511145.b1264

    Proteomic databases

    jPOSTiP00895
    PaxDbiP00895
    PRIDEiP00895

    Genome annotation databases

    EnsemblBacteriaiAAC74346; AAC74346; b1264
    BAA14799; BAA14799; BAA14799
    GeneIDi945846
    KEGGiecj:JW1256
    eco:b1264
    PATRICifig|1411691.4.peg.1019

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1021

    Phylogenomic databases

    eggNOGiENOG4105CRQ Bacteria
    COG0147 LUCA
    HOGENOMiCLU_006493_9_4_6
    InParanoidiP00895
    KOiK01657
    PhylomeDBiP00895

    Enzyme and pathway databases

    UniPathwayiUPA00035;UER00040
    BioCyciEcoCyc:ANTHRANSYNCOMPI-MONOMER
    ECOL316407:JW1256-MONOMER
    MetaCyc:ANTHRANSYNCOMPI-MONOMER
    SABIO-RKiP00895

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P00895

    Family and domain databases

    Gene3Di3.60.120.10, 1 hit
    InterProiView protein in InterPro
    IPR005801 ADC_synthase
    IPR019999 Anth_synth_I-like
    IPR006805 Anth_synth_I_N
    IPR005257 Anth_synth_I_TrpE
    IPR015890 Chorismate_C
    PANTHERiPTHR11236:SF22 PTHR11236:SF22, 1 hit
    PfamiView protein in Pfam
    PF04715 Anth_synt_I_N, 1 hit
    PF00425 Chorismate_bind, 1 hit
    PIRSFiPIRSF001373 TrpE, 1 hit
    PRINTSiPR00095 ANTSNTHASEI
    SUPFAMiSSF56322 SSF56322, 1 hit
    TIGRFAMsiTIGR00565 trpE_proteo, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPE_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00895
    Secondary accession number(s): P78249
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1997
    Last modified: February 26, 2020
    This is version 161 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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