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UniProtKB - P00860 (DCOR_MOUSE)
Protein
Ornithine decarboxylase
Gene
Odc1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
2 PublicationsCatalytic activityi
- EC:4.1.1.17By similarity
Cofactori
pyridoxal 5'-phosphate2 Publications
Activity regulationi
Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.By similarity
: putrescine biosynthesis via L-ornithine pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine. This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 197 | Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates1 Publication | 1 | |
Binding sitei | 200 | Pyridoxal phosphateBy similarity | 1 | |
Binding sitei | 237 | Pyridoxal phosphate; via amino nitrogen1 Publication | 1 | |
Active sitei | 360 | Proton donor; shared with dimeric partner3 Publications | 1 | |
Binding sitei | 361 | Substrate; shared with dimeric partnerBy similarity | 1 | |
Binding sitei | 389 | Pyridoxal phosphate1 Publication | 1 |
GO - Molecular functioni
- ornithine decarboxylase activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- kidney development Source: MGI
- polyamine metabolic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- putrescine biosynthetic process Source: MGI
- putrescine biosynthetic process from ornithine Source: UniProtKB
- regulation of protein catabolic process Source: UniProtKB
- response to virus Source: Ensembl
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Polyamine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 4.1.1.17, 3474 |
Reactomei | R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-351202, Metabolism of polyamines |
SABIO-RKi | P00860 |
UniPathwayi | UPA00535;UER00288 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Odc1 Synonyms:Odc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97402, Odc1 |
VEuPathDBi | HostDB:ENSMUSG00000011179 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: MGI
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 387 | G → A: Partial loss of activity. 1 Publication | 1 | |
Mutagenesisi | 387 | G → C, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W or Y: Loss of activity. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL2840 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149892 | 1 – 461 | Ornithine decarboxylaseAdd BLAST | 461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 69 | N6-(pyridoxal phosphate)lysineCombined sources2 Publications | 1 | |
Modified residuei | 303 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 360 | S-nitrosocysteineBy similarity | 1 |
Keywords - PTMi
Phosphoprotein, S-nitrosylationProteomic databases
EPDi | P00860 |
MaxQBi | P00860 |
PaxDbi | P00860 |
PRIDEi | P00860 |
ProteomicsDBi | 279314 |
PTM databases
iPTMneti | P00860 |
PhosphoSitePlusi | P00860 |
Expressioni
Tissue specificityi
Expressed during testis development in the outer part of the seminiferous tubules.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000011179, Expressed in spermatid and 139 other tissues |
ExpressionAtlasi | P00860, baseline and differential |
Genevisiblei | P00860, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 201896, 1 interactor |
IntActi | P00860, 1 interactor |
STRINGi | 10090.ENSMUSP00000128661 |
Miscellaneous databases
RNActi | P00860, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P00860 |
SMRi | P00860 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00860 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 274 – 277 | Pyridoxal phosphate binding1 Publication | 4 | |
Regioni | 331 – 332 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the Orn/Lys/Arg decarboxylase class-II family.Curated
Phylogenomic databases
eggNOGi | KOG0622, Eukaryota |
GeneTreei | ENSGT00950000182995 |
HOGENOMi | CLU_026444_1_1_1 |
InParanoidi | P00860 |
OMAi | YCRSMAS |
OrthoDBi | 725914at2759 |
PhylomeDBi | P00860 |
TreeFami | TF300760 |
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR022643, De-COase2_C IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR002433, Orn_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR11482, PTHR11482, 1 hit |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit PF00278, Orn_DAP_Arg_deC, 1 hit |
PRINTSi | PR01179, ODADCRBXLASE PR01182, ORNDCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P00860-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSFTKDEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG
110 120 130 140 150
LGVPAERVIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AVSDARCVFD MATEVGFSMH LLDIGGGFPG SEDTKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ
310 320 330 340 350
PGSDDEDESN EQTFMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPNIYYVMS RPMWQLMKQI QSHGFPPEVE EQDDGTLPMS CAQESGMDRH
460
PAACASARIN V
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VJC5 | A0A1Y7VJC5_MOUSE | Ornithine decarboxylase | Odc1 | 197 | Annotation score: | ||
A0A1Y7VMF9 | A0A1Y7VMF9_MOUSE | Ornithine decarboxylase | Odc1 | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | R → W in AAA39846 (PubMed:3456155).Curated | 1 | |
Sequence conflicti | 206 | E → D in AAA51638 (PubMed:2982844).Curated | 1 | |
Sequence conflicti | 206 | E → D in AAA39845 (PubMed:3856848).Curated | 1 | |
Sequence conflicti | 206 | E → D in CAA30301 (PubMed:3362685).Curated | 1 | |
Sequence conflicti | 206 | E → D in AAA39849 (PubMed:3372502).Curated | 1 | |
Sequence conflicti | 206 | E → D in AAB27809 (PubMed:8350350).Curated | 1 | |
Sequence conflicti | 350 | Y → H in AAA39848 (PubMed:3456155).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20617 mRNA Translation: AAA51638.1 M10624 mRNA Translation: AAA39845.1 X07392 Genomic DNA Translation: CAA30301.1 J03733 Genomic DNA Translation: AAA39849.1 S64539 mRNA Translation: AAB27809.1 EU684749 mRNA Translation: ACD81645.1 AK139610 mRNA Translation: BAE24082.1 CH466582 Genomic DNA Translation: EDK98494.1 BC059826 mRNA Translation: AAH59826.1 BC083122 mRNA Translation: AAH83122.1 M12330 mRNA Translation: AAA39846.1 M12331 mRNA Translation: AAA39848.1 |
CCDSi | CCDS25829.1 |
PIRi | A01077, DCMSO I56477 |
RefSeqi | NP_038642.2, NM_013614.2 XP_017170479.1, XM_017314990.1 |
Genome annotation databases
Ensembli | ENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179 |
GeneIDi | 18263 |
KEGGi | mmu:18263 |
UCSCi | uc007ncv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20617 mRNA Translation: AAA51638.1 M10624 mRNA Translation: AAA39845.1 X07392 Genomic DNA Translation: CAA30301.1 J03733 Genomic DNA Translation: AAA39849.1 S64539 mRNA Translation: AAB27809.1 EU684749 mRNA Translation: ACD81645.1 AK139610 mRNA Translation: BAE24082.1 CH466582 Genomic DNA Translation: EDK98494.1 BC059826 mRNA Translation: AAH59826.1 BC083122 mRNA Translation: AAH83122.1 M12330 mRNA Translation: AAA39846.1 M12331 mRNA Translation: AAA39848.1 |
CCDSi | CCDS25829.1 |
PIRi | A01077, DCMSO I56477 |
RefSeqi | NP_038642.2, NM_013614.2 XP_017170479.1, XM_017314990.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7ODC | X-ray | 1.60 | A | 1-424 | [»] | |
AlphaFoldDBi | P00860 | |||||
SMRi | P00860 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201896, 1 interactor |
IntActi | P00860, 1 interactor |
STRINGi | 10090.ENSMUSP00000128661 |
Chemistry databases
ChEMBLi | CHEMBL2840 |
PTM databases
iPTMneti | P00860 |
PhosphoSitePlusi | P00860 |
Proteomic databases
EPDi | P00860 |
MaxQBi | P00860 |
PaxDbi | P00860 |
PRIDEi | P00860 |
ProteomicsDBi | 279314 |
Protocols and materials databases
Antibodypediai | 781, 886 antibodies from 34 providers |
DNASUi | 18263 |
Genome annotation databases
Ensembli | ENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179 |
GeneIDi | 18263 |
KEGGi | mmu:18263 |
UCSCi | uc007ncv.1, mouse |
Organism-specific databases
CTDi | 4953 |
MGIi | MGI:97402, Odc1 |
VEuPathDBi | HostDB:ENSMUSG00000011179 |
Phylogenomic databases
eggNOGi | KOG0622, Eukaryota |
GeneTreei | ENSGT00950000182995 |
HOGENOMi | CLU_026444_1_1_1 |
InParanoidi | P00860 |
OMAi | YCRSMAS |
OrthoDBi | 725914at2759 |
PhylomeDBi | P00860 |
TreeFami | TF300760 |
Enzyme and pathway databases
UniPathwayi | UPA00535;UER00288 |
BRENDAi | 4.1.1.17, 3474 |
Reactomei | R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-351202, Metabolism of polyamines |
SABIO-RKi | P00860 |
Miscellaneous databases
BioGRID-ORCSi | 18263, 4 hits in 75 CRISPR screens |
ChiTaRSi | Odc1, mouse |
EvolutionaryTracei | P00860 |
PROi | PR:P00860 |
RNActi | P00860, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000011179, Expressed in spermatid and 139 other tissues |
ExpressionAtlasi | P00860, baseline and differential |
Genevisiblei | P00860, MM |
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR022643, De-COase2_C IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR002433, Orn_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR11482, PTHR11482, 1 hit |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit PF00278, Orn_DAP_Arg_deC, 1 hit |
PRINTSi | PR01179, ODADCRBXLASE PR01182, ORNDCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCOR_MOUSE | |
Accessioni | P00860Primary (citable) accession number: P00860 Secondary accession number(s): Q61997, Q61998, Q6PB87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families