UniProtKB - P00860 (DCOR_MOUSE)

BLAST

>sp|P00860|DCOR_MOUSE Ornithine decarboxylase OS=Mus musculus OX=10090 GN=Odc1 PE=1 SV=2
MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQI
KYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLL
LERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPG
SEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQ
PGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQI
QSHGFPPEVEEQDDGTLPMSCAQESGMDRHPAACASARINV

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History
Entry version 165 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Ornithine decarboxylase

Gene

Odc1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.2 Publications

Catalytic activityⁱ

L-ornithine = putrescine + CO₂.By similarity

Cofactorⁱ

pyridoxal 5'-phosphate2 Publications

Activity regulationⁱ

Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.By similarity

Pathwayⁱ: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:

Ornithine decarboxylase (Odc1)

This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	197	Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates1 Publication	1
Binding siteⁱ	200	Pyridoxal phosphateBy similarity	1
Binding siteⁱ	237	Pyridoxal phosphate; via amino nitrogen1 Publication	1
Active siteⁱ	360	Proton donor; shared with dimeric partner3 Publications	1
Binding siteⁱ	361	Substrate; shared with dimeric partnerBy similarity	1
Binding siteⁱ	389	Pyridoxal phosphate1 Publication	1

GO - Molecular functionⁱ

ornithine decarboxylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24967154
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24967154

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

kidney development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16138831
polyamine metabolic process Source: MGI
positive regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16138831
putrescine biosynthetic process Source: MGI
putrescine biosynthetic process from ornithine
Source: UniProtKB
Inferred from direct assayⁱ
- 24967154
regulation of protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24967154
response to virus Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BRENDAⁱ	4.1.1.17 3474
Reactomeⁱ	R-MMU-350562 Regulation of ornithine decarboxylase (ODC) R-MMU-351202 Metabolism of polyamines
UniPathwayⁱ	UPA00535;UER00288

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ornithine decarboxylase (EC:4.1.1.17) Short name: ODC
Gene namesⁱ	Name:Odc1 Synonyms:Odc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:97402 Odc1

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	387	G → A: Partial loss of activity. 1 Publication		1
Mutagenesisⁱ	387	G → C, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W or Y: Loss of activity. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL2840

ChEMBLⁱ

CHEMBL2840

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000149892	1 – 461	Ornithine decarboxylaseAdd BLAST		461

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	69	N6-(pyridoxal phosphate)lysineCombined sources2 Publications	1
Modified residueⁱ	303	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	360	S-nitrosocysteineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein, S-nitrosylation

Proteomic databases

EPDⁱ	P00860
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00860
PaxDbⁱ	P00860
PRIDEⁱ	P00860

PTM databases

iPTMnetⁱ	P00860
PhosphoSitePlusⁱ	P00860

Expressionⁱ

Tissue specificityⁱ

Expressed during testis development in the outer part of the seminiferous tubules.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000011179 Expressed in 103 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	MM_ODC1
ExpressionAtlasⁱ	P00860 baseline and differential
Genevisibleⁱ	P00860 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (PubMed:8106349, PubMed:10378276). Does not form a heterodimer with AZIN2 (PubMed:24967154).3 Publications

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24967154

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P00860, 1 interactor
STRINGⁱ	10090.ENSMUSP00000128661

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 6	Combined sources	4
Beta strandⁱ	9 – 14	Combined sources	6
Helixⁱ	20 – 28	Combined sources	9
Beta strandⁱ	40 – 44	Combined sources	5
Helixⁱ	45 – 58	Combined sources	14
Beta strandⁱ	62 – 67	Combined sources	6
Helixⁱ	68 – 70	Combined sources	3
Helixⁱ	74 – 83	Combined sources	10
Beta strandⁱ	86 – 89	Combined sources	4
Helixⁱ	92 – 100	Combined sources	9
Helixⁱ	105 – 107	Combined sources	3
Beta strandⁱ	108 – 110	Combined sources	3
Helixⁱ	117 – 125	Combined sources	9
Beta strandⁱ	130 – 133	Combined sources	4
Helixⁱ	136 – 145	Combined sources	10
Beta strandⁱ	150 – 155	Combined sources	6
Helixⁱ	174 – 186	Combined sources	13
Beta strandⁱ	190 – 195	Combined sources	6
Helixⁱ	206 – 225	Combined sources	20
Beta strandⁱ	231 – 233	Combined sources	3
Beta strandⁱ	241 – 246	Combined sources	6
Helixⁱ	248 – 262	Combined sources	15
Helixⁱ	265 – 267	Combined sources	3
Beta strandⁱ	270 – 273	Combined sources	4
Helixⁱ	277 – 280	Combined sources	4
Helixⁱ	281 – 283	Combined sources	3
Beta strandⁱ	284 – 296	Combined sources	13
Beta strandⁱ	313 – 319	Combined sources	7
Turnⁱ	322 – 326	Combined sources	5
Helixⁱ	327 – 331	Combined sources	5
Beta strandⁱ	339 – 342	Combined sources	4
Beta strandⁱ	350 – 356	Combined sources	7
Beta strandⁱ	358 – 360	Combined sources	3
Beta strandⁱ	365 – 373	Combined sources	9
Beta strandⁱ	380 – 383	Combined sources	4
Beta strandⁱ	388 – 390	Combined sources	3
Helixⁱ	391 – 393	Combined sources	3
Helixⁱ	397 – 399	Combined sources	3
Beta strandⁱ	404 – 410	Combined sources	7
Helixⁱ	411 – 417	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P00860
SMRⁱ	P00860
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P00860

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	274 – 277	Pyridoxal phosphate binding1 Publication		4
Regionⁱ	331 – 332	Substrate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the Orn/Lys/Arg decarboxylase class-II family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0622 Eukaryota COG0019 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011560
HOGENOMⁱ	HOG000274133
HOVERGENⁱ	HBG005456
InParanoidⁱ	P00860
KEGG Orthology (KO) More...KOⁱ	K01581
OMAⁱ	VVGYICE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AJV
TreeFamⁱ	TF300760

Family and domain databases

Gene3Dⁱ	2.40.37.10, 1 hit 3.20.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009006 Ala_racemase/Decarboxylase_C IPR022643 De-COase2_C IPR022657 De-COase2_CS IPR022644 De-COase2_N IPR022653 De-COase2_pyr-phos_BS IPR000183 Orn/DAP/Arg_de-COase IPR002433 Orn_de-COase IPR029066 PLP-binding_barrel
PANTHERⁱ	PTHR11482 PTHR11482, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02784 Orn_Arg_deC_N, 1 hit PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSⁱ	PR01179 ODADCRBXLASE PR01182 ORNDCRBXLASE
SUPFAMⁱ	SSF50621 SSF50621, 1 hit SSF51419 SSF51419, 1 hit
PROSITEⁱ	View protein in PROSITE PS00878 ODR_DC_2_1, 1 hit PS00879 ODR_DC_2_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P00860-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSFTKDEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK 
        60         70         80         90        100
KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG 
       110        120        130        140        150
LGVPAERVIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK 
       160        170        180        190        200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS 
       210        220        230        240        250
GCTDPETFVQ AVSDARCVFD MATEVGFSMH LLDIGGGFPG SEDTKLKFEE 
       260        270        280        290        300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ 
       310        320        330        340        350
PGSDDEDESN EQTFMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY 
       360        370        380        390        400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF 
       410        420        430        440        450
QRPNIYYVMS RPMWQLMKQI QSHGFPPEVE EQDDGTLPMS CAQESGMDRH 
       460 
PAACASARIN V

Length:461

Mass (Da):51,177

Last modified:July 27, 2011 - v2

Checksum:ⁱB581753F57AC0A30

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1Y7VJC5	A0A1Y7VJC5_MOUSE	Ornithine decarboxylase Ornithine decarboxylase	Odc1	197	Annotation score:
A0A1Y7VMF9	A0A1Y7VMF9_MOUSE	Ornithine decarboxylase Ornithine decarboxylase	Odc1	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	178	R → W in AAA39846 (PubMed:3456155).Curated	1
Sequence conflictⁱ	206	E → D in AAA51638 (PubMed:2982844).Curated	1
Sequence conflictⁱ	206	E → D in AAA39845 (PubMed:3856848).Curated	1
Sequence conflictⁱ	206	E → D in CAA30301 (PubMed:3362685).Curated	1
Sequence conflictⁱ	206	E → D in AAA39849 (PubMed:3372502).Curated	1
Sequence conflictⁱ	206	E → D in AAB27809 (PubMed:8350350).Curated	1
Sequence conflictⁱ	350	Y → H in AAA39848 (PubMed:3456155).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20617 mRNA Translation: AAA51638.1 M10624 mRNA Translation: AAA39845.1 X07392 Genomic DNA Translation: CAA30301.1 J03733 Genomic DNA Translation: AAA39849.1 S64539 mRNA Translation: AAB27809.1 EU684749 mRNA Translation: ACD81645.1 AK139610 mRNA Translation: BAE24082.1 CH466582 Genomic DNA Translation: EDK98494.1 BC059826 mRNA Translation: AAH59826.1 BC083122 mRNA Translation: AAH83122.1 M12330 mRNA Translation: AAA39846.1 M12331 mRNA Translation: AAA39848.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25829.1
PIRⁱ	A01077 DCMSO I56477
NCBI Reference Sequences More...RefSeqⁱ	NP_038642.2, NM_013614.2 XP_017170479.1, XM_017314990.1
UniGeneⁱ	Mm.34102 Mm.472891

Genome annotation databases

Ensemblⁱ	ENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179
GeneIDⁱ	18263
KEGGⁱ	mmu:18263
UCSC genome browser More...UCSCⁱ	uc007ncv.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
P00860	Ornithine decarboxylase-like protein (Fragment)		Daphnia magna		136	UniRef100_P00860
Ornithine decarboxylase-like protein (Fragment)		Daphnia magna		135

Protein	Similar proteins		Species	Score	Length	Source
P00860	Ornithine decarboxylase		MUSPA		461	UniRef90_P00860
Ornithine decarboxylase		RAT		461
Ornithine decarboxylase	)	HUMAN		461
Ornithine decarboxylase-like protein (Fragment)		Daphnia magna		136
Ornithine decarboxylase (Fragment)		ESCRO		479
+85

Protein	Similar proteins		Species	Score	Length	Source
P00860	Ornithine decarboxylase		MUSPA		461	UniRef50_P00860
Ornithine decarboxylase	)	HUMAN		461
Ornithine decarboxylase		RAT		461
Ornithine decarboxylase (Fragment)		CHICK		450
Ornithine decarboxylase		BOVIN		461
+923

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20617 mRNA Translation: AAA51638.1 M10624 mRNA Translation: AAA39845.1 X07392 Genomic DNA Translation: CAA30301.1 J03733 Genomic DNA Translation: AAA39849.1 S64539 mRNA Translation: AAB27809.1 EU684749 mRNA Translation: ACD81645.1 AK139610 mRNA Translation: BAE24082.1 CH466582 Genomic DNA Translation: EDK98494.1 BC059826 mRNA Translation: AAH59826.1 BC083122 mRNA Translation: AAH83122.1 M12330 mRNA Translation: AAA39846.1 M12331 mRNA Translation: AAA39848.1
CCDSⁱ	CCDS25829.1
PIRⁱ	A01077 DCMSO I56477
RefSeqⁱ	NP_038642.2, NM_013614.2 XP_017170479.1, XM_017314990.1
UniGeneⁱ	Mm.34102 Mm.472891

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	7ODC	X-ray	1.60	A	1-424	[»]
ProteinModelPortalⁱ	P00860
SMRⁱ	P00860
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P00860, 1 interactor
STRINGⁱ	10090.ENSMUSP00000128661

Chemistry databases

ChEMBLⁱ	CHEMBL2840

ChEMBLⁱ

CHEMBL2840

PTM databases

iPTMnetⁱ	P00860
PhosphoSitePlusⁱ	P00860

Proteomic databases

EPDⁱ	P00860
MaxQBⁱ	P00860
PaxDbⁱ	P00860
PRIDEⁱ	P00860

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179
GeneIDⁱ	18263
KEGGⁱ	mmu:18263
UCSCⁱ	uc007ncv.1 mouse

Organism-specific databases

CTDⁱ	4953
MGIⁱ	MGI:97402 Odc1

Phylogenomic databases

eggNOGⁱ	KOG0622 Eukaryota COG0019 LUCA
GeneTreeⁱ	ENSGT00390000011560
HOGENOMⁱ	HOG000274133
HOVERGENⁱ	HBG005456
InParanoidⁱ	P00860
KOⁱ	K01581
OMAⁱ	VVGYICE
OrthoDBⁱ	EOG091G0AJV
TreeFamⁱ	TF300760

Enzyme and pathway databases

UniPathwayⁱ	UPA00535;UER00288
BRENDAⁱ	4.1.1.17 3474
Reactomeⁱ	R-MMU-350562 Regulation of ornithine decarboxylase (ODC) R-MMU-351202 Metabolism of polyamines

Miscellaneous databases

EvolutionaryTraceⁱ	P00860
Protein Ontology More...PROⁱ	PR:P00860
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000011179 Expressed in 103 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	MM_ODC1
ExpressionAtlasⁱ	P00860 baseline and differential
Genevisibleⁱ	P00860 MM

Family and domain databases

Gene3Dⁱ	2.40.37.10, 1 hit 3.20.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009006 Ala_racemase/Decarboxylase_C IPR022643 De-COase2_C IPR022657 De-COase2_CS IPR022644 De-COase2_N IPR022653 De-COase2_pyr-phos_BS IPR000183 Orn/DAP/Arg_de-COase IPR002433 Orn_de-COase IPR029066 PLP-binding_barrel
PANTHERⁱ	PTHR11482 PTHR11482, 1 hit
Pfamⁱ	View protein in Pfam PF02784 Orn_Arg_deC_N, 1 hit PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSⁱ	PR01179 ODADCRBXLASE PR01182 ORNDCRBXLASE
SUPFAMⁱ	SSF50621 SSF50621, 1 hit SSF51419 SSF51419, 1 hit
PROSITEⁱ	View protein in PROSITE PS00878 ODR_DC_2_1, 1 hit PS00879 ODR_DC_2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCOR_MOUSE
Accessionⁱ	P00860Primary (citable) accession number: P00860 Secondary accession number(s): Q61997, Q61998, Q6PB87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P00860 (DCOR_MOUSE)

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Ornithine decarboxylase

Odc1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine biosynthesis via L-ornithine pathway

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: putrescine biosynthesis via L-ornithine pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ