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Protein

Ornithine decarboxylase

Gene

Odc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.2 Publications

Catalytic activityi

L-ornithine = putrescine + CO2.By similarity

Cofactori

pyridoxal 5'-phosphate2 Publications

Activity regulationi

Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (Odc1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei197Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates1 Publication1
Binding sitei200Pyridoxal phosphateBy similarity1
Binding sitei237Pyridoxal phosphate; via amino nitrogen1 Publication1
Active sitei360Proton donor; shared with dimeric partner3 Publications1
Binding sitei361Substrate; shared with dimeric partnerBy similarity1
Binding sitei389Pyridoxal phosphate1 Publication1

GO - Molecular functioni

  • ornithine decarboxylase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.17 3474
ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-351202 Metabolism of polyamines
UniPathwayi
UPA00535;UER00288

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:Odc1
Synonyms:Odc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97402 Odc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi387G → A: Partial loss of activity. 1 Publication1
Mutagenesisi387G → C, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W or Y: Loss of activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001498921 – 461Ornithine decarboxylaseAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-(pyridoxal phosphate)lysineCombined sources2 Publications1
Modified residuei303Phosphoserine; by CK21 Publication1
Modified residuei360S-nitrosocysteineBy similarity1

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP00860
MaxQBiP00860
PaxDbiP00860
PRIDEiP00860

PTM databases

iPTMnetiP00860
PhosphoSitePlusiP00860

Expressioni

Tissue specificityi

Expressed during testis development in the outer part of the seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSMUSG00000011179 Expressed in 103 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_ODC1
ExpressionAtlasiP00860 baseline and differential
GenevisibleiP00860 MM

Interactioni

Subunit structurei

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (PubMed:8106349, PubMed:10378276). Does not form a heterodimer with AZIN2 (PubMed:24967154).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP00860, 1 interactor
STRINGi10090.ENSMUSP00000128661

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00860
SMRiP00860
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00860

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni274 – 277Pyridoxal phosphate binding1 Publication4
Regioni331 – 332Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiP00860
KOiK01581
OMAiVVGYICE
OrthoDBiEOG091G0AJV
TreeFamiTF300760

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P00860-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFTKDEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG
110 120 130 140 150
LGVPAERVIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AVSDARCVFD MATEVGFSMH LLDIGGGFPG SEDTKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ
310 320 330 340 350
PGSDDEDESN EQTFMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC NLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPNIYYVMS RPMWQLMKQI QSHGFPPEVE EQDDGTLPMS CAQESGMDRH
460
PAACASARIN V
Length:461
Mass (Da):51,177
Last modified:July 27, 2011 - v2
Checksum:iB581753F57AC0A30
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJC5A0A1Y7VJC5_MOUSE
Ornithine decarboxylase
Odc1
197Annotation score:
A0A1Y7VMF9A0A1Y7VMF9_MOUSE
Ornithine decarboxylase
Odc1
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178R → W in AAA39846 (PubMed:3456155).Curated1
Sequence conflicti206E → D in AAA51638 (PubMed:2982844).Curated1
Sequence conflicti206E → D in AAA39845 (PubMed:3856848).Curated1
Sequence conflicti206E → D in CAA30301 (PubMed:3362685).Curated1
Sequence conflicti206E → D in AAA39849 (PubMed:3372502).Curated1
Sequence conflicti206E → D in AAB27809 (PubMed:8350350).Curated1
Sequence conflicti350Y → H in AAA39848 (PubMed:3456155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20617 mRNA Translation: AAA51638.1
M10624 mRNA Translation: AAA39845.1
X07392 Genomic DNA Translation: CAA30301.1
J03733 Genomic DNA Translation: AAA39849.1
S64539 mRNA Translation: AAB27809.1
EU684749 mRNA Translation: ACD81645.1
AK139610 mRNA Translation: BAE24082.1
CH466582 Genomic DNA Translation: EDK98494.1
BC059826 mRNA Translation: AAH59826.1
BC083122 mRNA Translation: AAH83122.1
M12330 mRNA Translation: AAA39846.1
M12331 mRNA Translation: AAA39848.1
CCDSiCCDS25829.1
PIRiA01077 DCMSO
I56477
RefSeqiNP_038642.2, NM_013614.2
XP_017170479.1, XM_017314990.1
UniGeneiMm.34102
Mm.472891

Genome annotation databases

EnsembliENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179
GeneIDi18263
KEGGimmu:18263
UCSCiuc007ncv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20617 mRNA Translation: AAA51638.1
M10624 mRNA Translation: AAA39845.1
X07392 Genomic DNA Translation: CAA30301.1
J03733 Genomic DNA Translation: AAA39849.1
S64539 mRNA Translation: AAB27809.1
EU684749 mRNA Translation: ACD81645.1
AK139610 mRNA Translation: BAE24082.1
CH466582 Genomic DNA Translation: EDK98494.1
BC059826 mRNA Translation: AAH59826.1
BC083122 mRNA Translation: AAH83122.1
M12330 mRNA Translation: AAA39846.1
M12331 mRNA Translation: AAA39848.1
CCDSiCCDS25829.1
PIRiA01077 DCMSO
I56477
RefSeqiNP_038642.2, NM_013614.2
XP_017170479.1, XM_017314990.1
UniGeneiMm.34102
Mm.472891

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7ODCX-ray1.60A1-424[»]
ProteinModelPortaliP00860
SMRiP00860
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00860, 1 interactor
STRINGi10090.ENSMUSP00000128661

Chemistry databases

ChEMBLiCHEMBL2840

PTM databases

iPTMnetiP00860
PhosphoSitePlusiP00860

Proteomic databases

EPDiP00860
MaxQBiP00860
PaxDbiP00860
PRIDEiP00860

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171737; ENSMUSP00000128661; ENSMUSG00000011179
GeneIDi18263
KEGGimmu:18263
UCSCiuc007ncv.1 mouse

Organism-specific databases

CTDi4953
MGIiMGI:97402 Odc1

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiP00860
KOiK01581
OMAiVVGYICE
OrthoDBiEOG091G0AJV
TreeFamiTF300760

Enzyme and pathway databases

UniPathwayi
UPA00535;UER00288

BRENDAi4.1.1.17 3474
ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-351202 Metabolism of polyamines

Miscellaneous databases

EvolutionaryTraceiP00860
PROiPR:P00860
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011179 Expressed in 103 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_ODC1
ExpressionAtlasiP00860 baseline and differential
GenevisibleiP00860 MM

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCOR_MOUSE
AccessioniPrimary (citable) accession number: P00860
Secondary accession number(s): Q61997, Q61998, Q6PB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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