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Entry version 197 (07 Apr 2021)
Sequence version 3 (29 Mar 2004)
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Protein

Histidine biosynthesis trifunctional protein

Gene

HIS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-histidine biosynthesis

This protein is involved in step 2, 3 and 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate. This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi618ZincBy similarity1
Metal bindingi621ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei687By similarity1
Active sitei688By similarity1
Metal bindingi721ZincBy similarity1
Metal bindingi780ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • histidine biosynthetic process Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Oxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Metal-binding, NAD, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00031;UER00007
UPA00031;UER00008
UPA00031;UER00014

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine biosynthesis trifunctional proteinCurated
Including the following 3 domains:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19By similarity)
Phosphoribosyl-ATP pyrophosphohydrolase (EC:3.6.1.31By similarity)
Histidinol dehydrogenase (EC:1.1.1.23By similarity)
Short name:
HDH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIS41 PublicationImported
Ordered Locus Names:YCL030C
ORF Names:YCL183, YCL30C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000535, HIS4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YCL030C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001359141 – 799Histidine biosynthesis trifunctional proteinAdd BLAST799

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P00815

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00815

PRoteomics IDEntifications database

More...
PRIDEi
P00815

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00815

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by amino acid and purine starvation in a GCN4 dependent manner.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
30953, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-6402N

Protein interaction database and analysis system

More...
IntActi
P00815, 14 interactors

Molecular INTeraction database

More...
MINTi
P00815

STRING: functional protein association networks

More...
STRINGi
4932.YCL030C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P00815, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00815

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 229Phosphoribosyl-AMP cyclohydrolaseBy similarityAdd BLAST229
Regioni230 – 312Phosphoribosyl-ATP pyrophosphohydrolaseBy similarityAdd BLAST83
Regioni313 – 799Histidinol dehydrogenaseBy similarityAdd BLAST487

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2697, Eukaryota
KOG4311, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006732_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00815

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAVKIRM

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06572, Histidinol_dh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.400, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01024, HisD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR008179, HisE
IPR016298, Histidine_synth_trifunct
IPR001692, Histidinol_DH_CS
IPR012131, Hstdl_DH
IPR021130, PRib-ATP_PPHydrolase-like
IPR002496, PRib_AMP_CycHydrolase_dom
IPR038019, PRib_AMP_CycHydrolase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21256, PTHR21256, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00815, Histidinol_dh, 1 hit
PF01502, PRA-CH, 1 hit
PF01503, PRA-PH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001257, His_trifunctional, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00083, HOLDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141734, SSF141734, 1 hit
SSF53720, SSF53720, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00069, hisD, 1 hit
TIGR03188, histidine_hisI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00611, HISOL_DEHYDROGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00815-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLPILPLID DLASWNSKKE YVSLVGQVLL DGSSLSNEEI LQFSKEEEVP
60 70 80 90 100
LVALSLPSGK FSDDEIIAFL NNGVSSLFIA SQDAKTAEHL VEQLNVPKER
110 120 130 140 150
VVVEENGVFS NQFMVKQKFS QDKIVSIKKL SKDMLTKEVL GEVRTDRPDG
160 170 180 190 200
LYTTLVVDQY ERCLGLVYSS KKSIAKAIDL GRGVYYSRSR NEIWIKGETS
210 220 230 240 250
GNGQKLLQIS TDCDSDALKF IVEQENVGFC HLETMSCFGE FKHGLVGLES
260 270 280 290 300
LLKQRLQDAP EESYTRRLFN DSALLDAKIK EEAEELTEAK GKKELSWEAA
310 320 330 340 350
DLFYFALAKL VANDVSLKDV ENNLNMKHLK VTRRKGDAKP KFVGQPKAEE
360 370 380 390 400
EKLTGPIHLD VVKASDKVGV QKALSRPIQK TSEIMHLVNP IIENVRDKGN
410 420 430 440 450
SALLEYTEKF DGVKLSNPVL NAPFPEEYFE GLTEEMKEAL DLSIENVRKF
460 470 480 490 500
HAAQLPTETL EVETQPGVLC SRFPRPIEKV GLYIPGGTAI LPSTALMLGV
510 520 530 540 550
PAQVAQCKEI VFASPPRKSD GKVSPEVVYV AEKVGASKIV LAGGAQAVAA
560 570 580 590 600
MAYGTETIPK VDKILGPGNQ FVTAAKMYVQ NDTQALCSID MPAGPSEVLV
610 620 630 640 650
IADEDADVDF VASDLLSQAE HGIDSQVILV GVNLSEKKIQ EIQDAVHNQA
660 670 680 690 700
LQLPRVDIVR KCIAHSTIVL CDGYEEALEM SNQYAPEHLI LQIANANDYV
710 720 730 740 750
KLVDNAGSVF VGAYTPESCG DYSSGTNHTL PTYGYARQYS GANTATFQKF
760 770 780 790
ITAQNITPEG LENIGRAVMC VAKKEGLDGH RNAVKIRMSK LGLIPKDFQ
Length:799
Mass (Da):87,721
Last modified:March 29, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B82D289BEAB754D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53A → R in CAA24617 (PubMed:7049842).Curated1
Sequence conflicti386H → Y in CAA24617 (PubMed:7049842).Curated1
Sequence conflicti402 – 403AL → VF in CAA24617 (PubMed:7049842).Curated2
Sequence conflicti441D → N in CAA24617 (PubMed:7049842).Curated1
Sequence conflicti794I → F in CAA24617 (PubMed:7049842).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01310 Genomic DNA Translation: CAA24617.1
X59720 Genomic DNA Translation: CAA42355.2
V01309 Genomic DNA Translation: CAA24616.1
M11491 Genomic DNA Translation: AAA67504.1
M11492 Genomic DNA Translation: AAA67505.1
M11694 Unassigned DNA Translation: AAA18400.1
M11695 Unassigned DNA Translation: AAA18401.1
M11696 Unassigned DNA Translation: AAA18402.1
BK006937 Genomic DNA Translation: DAA07454.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S17473, SHBY

NCBI Reference Sequences

More...
RefSeqi
NP_009900.2, NM_001178675.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YCL030C_mRNA; YCL030C; YCL030C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YCL030C

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01310 Genomic DNA Translation: CAA24617.1
X59720 Genomic DNA Translation: CAA42355.2
V01309 Genomic DNA Translation: CAA24616.1
M11491 Genomic DNA Translation: AAA67504.1
M11492 Genomic DNA Translation: AAA67505.1
M11694 Unassigned DNA Translation: AAA18400.1
M11695 Unassigned DNA Translation: AAA18401.1
M11696 Unassigned DNA Translation: AAA18402.1
BK006937 Genomic DNA Translation: DAA07454.1
PIRiS17473, SHBY
RefSeqiNP_009900.2, NM_001178675.1

3D structure databases

SMRiP00815
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi30953, 33 interactors
DIPiDIP-6402N
IntActiP00815, 14 interactors
MINTiP00815
STRINGi4932.YCL030C

PTM databases

iPTMnetiP00815

Proteomic databases

MaxQBiP00815
PaxDbiP00815
PRIDEiP00815

Genome annotation databases

EnsemblFungiiYCL030C_mRNA; YCL030C; YCL030C
GeneIDi850327
KEGGisce:YCL030C

Organism-specific databases

SGDiS000000535, HIS4
VEuPathDBiFungiDB:YCL030C

Phylogenomic databases

eggNOGiKOG2697, Eukaryota
KOG4311, Eukaryota
HOGENOMiCLU_006732_0_1_1
InParanoidiP00815
OMAiNAVKIRM

Enzyme and pathway databases

UniPathwayiUPA00031;UER00007
UPA00031;UER00008
UPA00031;UER00014

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P00815
RNActiP00815, protein

Family and domain databases

CDDicd06572, Histidinol_dh, 1 hit
Gene3Di3.10.20.400, 1 hit
HAMAPiMF_01024, HisD, 1 hit
InterProiView protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR008179, HisE
IPR016298, Histidine_synth_trifunct
IPR001692, Histidinol_DH_CS
IPR012131, Hstdl_DH
IPR021130, PRib-ATP_PPHydrolase-like
IPR002496, PRib_AMP_CycHydrolase_dom
IPR038019, PRib_AMP_CycHydrolase_sf
PANTHERiPTHR21256, PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815, Histidinol_dh, 1 hit
PF01502, PRA-CH, 1 hit
PF01503, PRA-PH, 1 hit
PIRSFiPIRSF001257, His_trifunctional, 1 hit
PRINTSiPR00083, HOLDHDRGNASE
SUPFAMiSSF141734, SSF141734, 1 hit
SSF53720, SSF53720, 1 hit
TIGRFAMsiTIGR00069, hisD, 1 hit
TIGR03188, histidine_hisI, 1 hit
PROSITEiView protein in PROSITE
PS00611, HISOL_DEHYDROGENASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIS2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00815
Secondary accession number(s): D6VQY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 29, 2004
Last modified: April 7, 2021
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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