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Protein

Deoxycytidylate deaminase

Gene

CD

Organism
Enterobacteria phage T2 (Bacteriophage T2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19Zinc 1; structuralBy similarity1
Metal bindingi49Zinc 1; structuralBy similarity1
Metal bindingi94Zinc 1; structuralBy similarity1
Metal bindingi102Zinc 2; catalyticBy similarity1
Metal bindingi104Zinc 2; catalyticBy similarity1
Active sitei106Proton donorBy similarity1
Metal bindingi132Zinc 2; catalyticBy similarity1
Metal bindingi135Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
Biological processNucleotide biosynthesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:CD
OrganismiEnterobacteria phage T2 (Bacteriophage T2)
Taxonomic identifieri10664 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717001 – 188Deoxycytidylate deaminaseAdd BLAST188

Interactioni

Subunit structurei

Homohexamer.

Structurei

3D structure databases

ProteinModelPortaliP00814
SMRiP00814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 171CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Family and domain databases

CDDicd01286 deoxycytidylate_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR016473 dCMP_deaminase
IPR015517 dCMP_deaminase-rel
IPR035105 Deoxycytidylate_deaminase_dom
PANTHERiPTHR11086 PTHR11086, 1 hit
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PIRSFiPIRSF006019 dCMP_deaminase, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P00814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASTVLQIA YLVSQESKCC SWKVGAVIEK NGRIISTGYN GSPAGGVNCD
60 70 80 90 100
NYAAIEGWLL NKPKHTIIQG HKPECVSFGT SDRFVLAKEH RSAHSEWSSK
110 120 130 140 150
NEIHAELNAI LFAARNGSSI EGATMYVTLS PCPDCAKAIA QSGIKKLVYC
160 170 180
ETYDKNKPGW DDILRNAGIE VFNVPKLNWE NISEFCGE
Length:188
Mass (Da):20,599
Last modified:July 21, 1986 - v1
Checksum:iA13EAF89D5CEB14A
GO

Sequence databases

PIRiA01011 DUBPC2

Similar proteinsi

Entry informationi

Entry nameiDCTD_BPT2
AccessioniPrimary (citable) accession number: P00814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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