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UniProtKB - P00807 (BLAC_STAAU)
Protein
Beta-lactamase
Gene
blaZ
Organism
Staphylococcus aureus
Status
Functioni
Catalytic activityi
- EC:3.5.2.6PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | Acyl-ester intermediate | 1 |
GO - Molecular functioni
- beta-lactamase activity Source: UniProtKB-EC
GO - Biological processi
- beta-lactam antibiotic catabolic process Source: InterPro
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Antibiotic resistance |
Enzyme and pathway databases
SABIO-RKi | P00807 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:blaZ |
Encoded oni | Plasmid pI2582 Publications |
Organismi | Staphylococcus aureus |
Taxonomic identifieri | 1280 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus |
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4114 |
DrugBanki | DB02642, [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate DB11367, Cefroxadine DB04133, Degraded Cephaloridine DB09324, Sulbactam |
DrugCentrali | P00807 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | PROSITE-ProRule annotation1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000017020 | 25 – 281 | Beta-lactamaseAdd BLAST | 257 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P00807 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00807 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 227 | Substrate binding | 3 |
Sequence similaritiesi
Belongs to the class-A beta-lactamase family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR045155, Beta-lactam_cat IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS IPR012640, Membr_lipoprot_lipid_attach_CS |
PANTHERi | PTHR35333, PTHR35333, 1 hit |
Pfami | View protein in Pfam PF13354, Beta-lactamase2, 1 hit PF08139, LPAM_1, 1 hit |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P00807-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKLIFLIVI ALVLSACNSN SSHAKELNDL EKKYNAHIGV YALDTKSGKE
60 70 80 90 100
VKFNSDKRFA YASTSKAINS AILLEQVPYN KLNKKVHINK DDIVAYSPIL
110 120 130 140 150
EKYVGKDITL KALIEASMTY SDNTANNKII KEIGGIKKVK QRLKELGDKV
160 170 180 190 200
TNPVRYEIEL NYYSPKSKKD TSTPAAFGKT LNKLIANGKL SKENKKFLLD
210 220 230 240 250
LMLNNKSGDT LIKDGVPKDY KVADKSGQAI TYASRNDVAF VYPKGQSEPI
260 270 280
VLVIFTNKDN KSDKPNDKLI SETAKSVMKE F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04121 Genomic DNA Translation: CAA27733.1 X16471 Genomic DNA Translation: CAA34491.1 M15526 Genomic DNA Translation: AAA98239.1 X52734 Genomic DNA Translation: CAA36953.1 |
PIRi | A01002, PNSAP |
RefSeqi | NP_878023.1, NC_005054.1 WP_000733283.1, NZ_WWCF01000102.1 YP_003329488.1, NC_013550.1 YP_006937602.1, NC_013319.1 YP_006937751.1, NC_013323.1 YP_006938263.1, NC_013337.1 YP_006938770.1, NC_013352.1 YP_008709799.1, NC_022598.1 |
Genome annotation databases
GeneIDi | 58063709 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04121 Genomic DNA Translation: CAA27733.1 X16471 Genomic DNA Translation: CAA34491.1 M15526 Genomic DNA Translation: AAA98239.1 X52734 Genomic DNA Translation: CAA36953.1 |
PIRi | A01002, PNSAP |
RefSeqi | NP_878023.1, NC_005054.1 WP_000733283.1, NZ_WWCF01000102.1 YP_003329488.1, NC_013550.1 YP_006937602.1, NC_013319.1 YP_006937751.1, NC_013323.1 YP_006938263.1, NC_013337.1 YP_006938770.1, NC_013352.1 YP_008709799.1, NC_022598.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ALQ | X-ray | 1.80 | A | 24-244 | [»] | |
1BLC | X-ray | 2.20 | A | 25-281 | [»] | |
1BLH | X-ray | 2.30 | A | 25-281 | [»] | |
1BLP | X-ray | 2.30 | A | 25-281 | [»] | |
1DJA | X-ray | 1.90 | A | 25-281 | [»] | |
1DJB | X-ray | 2.10 | A | 25-281 | [»] | |
1DJC | X-ray | 2.00 | A | 25-281 | [»] | |
1GHI | X-ray | 2.30 | A | 25-281 | [»] | |
1GHM | X-ray | 1.86 | A | 25-281 | [»] | |
1GHP | X-ray | 1.76 | A | 25-281 | [»] | |
1KGE | X-ray | 2.00 | A | 25-281 | [»] | |
1KGF | X-ray | 2.20 | A | 25-281 | [»] | |
1KGG | X-ray | 2.30 | A | 24-281 | [»] | |
1OME | X-ray | 2.30 | A/B | 25-281 | [»] | |
1PIO | X-ray | 2.80 | A/B | 25-281 | [»] | |
3BLM | X-ray | 2.00 | A | 25-281 | [»] | |
6WGR | X-ray | 1.88 | A/B/C | 25-281 | [»] | |
SMRi | P00807 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | P00807 |
ChEMBLi | CHEMBL4114 |
DrugBanki | DB02642, [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate DB11367, Cefroxadine DB04133, Degraded Cephaloridine DB09324, Sulbactam |
DrugCentrali | P00807 |
Genome annotation databases
GeneIDi | 58063709 |
Enzyme and pathway databases
SABIO-RKi | P00807 |
Miscellaneous databases
EvolutionaryTracei | P00807 |
PROi | PR:P00807 |
Family and domain databases
Gene3Di | 3.40.710.10, 1 hit |
InterProi | View protein in InterPro IPR012338, Beta-lactam/transpept-like IPR045155, Beta-lactam_cat IPR000871, Beta-lactam_class-A IPR023650, Beta-lactam_class-A_AS IPR012640, Membr_lipoprot_lipid_attach_CS |
PANTHERi | PTHR35333, PTHR35333, 1 hit |
Pfami | View protein in Pfam PF13354, Beta-lactamase2, 1 hit PF08139, LPAM_1, 1 hit |
PRINTSi | PR00118, BLACTAMASEA |
SUPFAMi | SSF56601, SSF56601, 1 hit |
PROSITEi | View protein in PROSITE PS00146, BETA_LACTAMASE_A, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BLAC_STAAU | |
Accessioni | P00807Primary (citable) accession number: P00807 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Plasmid, Transposable elementDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families