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Protein

Renin

Gene

REN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. EC:3.4.23.15

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 µM for angiotensinogen (in absence of ATP6AP2)
  2. KM=0.15 µM for angiotensinogen (in presence of membrane-bound ATP6AP2)

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1041
    Active sitei2921

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • aspartic-type endopeptidase activity Source: HGNC
    • insulin-like growth factor receptor binding Source: Ensembl
    • peptidase activity Source: HGNC
    • signaling receptor binding Source: HGNC

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.23.15 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P00797

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    A01.007

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Renin (EC:3.4.23.15)
    Alternative name(s):
    Angiotensinogenase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:REN
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000143839.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9958 REN

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    179820 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P00797

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Renal tubular dysgenesis (RTD)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    See also OMIM:267430
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035088104D → N in RTD. 1 PublicationCorresponds to variant dbSNP:rs868694193Ensembl.1
    Natural variantiVAR_035087230R → K in RTD. 1 PublicationCorresponds to variant dbSNP:rs121917742EnsemblClinVar.1
    Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
    See also OMIM:613092
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06377016L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 PublicationCorresponds to variant dbSNP:rs121917743EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5972

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    REN

    MalaCards human disease database

    More...
    MalaCardsi
    REN
    MIMi267430 phenotype
    613092 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143839

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    217330 REN-related autosomal dominant tubulointerstitial kidney disease
    97369 Renal tubular dysgenesis of genetic origin

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA297

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL286

    Drug and drug target database

    More...
    DrugBanki
    DB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
    DB02296 1-Hydroxy-3-Methylbutane
    DB03736 2-Cyclopropylmethylenepropanal
    DB03024 2-Methyl-3-(2-Aminothiazolo)Propanal
    DB09026 Aliskiren
    DB01844 Dimethylformamide
    DB03395 Enalkiren
    DB04379 N-Methyl-N-(Methylbenzyl)Formamide
    DB00212 Remikiren
    DB05203 SPP1148

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2413

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    REN

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    132326

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002608124 – 66Activation peptide1 PublicationAdd BLAST43
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002608267 – 406ReninAdd BLAST340

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagine1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 1241 Publication
    Glycosylationi141N-linked (GlcNAc...) asparagine1
    Disulfide bondi283 ↔ 2871 Publication
    Disulfide bondi325 ↔ 3621 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P00797

    PeptideAtlas

    More...
    PeptideAtlasi
    P00797

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00797

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    51287
    51288 [P00797-2]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    513

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P00797

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P00797

    UniCarbKB; an annotated and curated database of glycan structures

    More...
    UniCarbKBi
    P00797

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    P00797

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143839 Expressed in 69 organ(s), highest expression level in kidney

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_REN

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P00797 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P00797 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB025903
    HPA005131

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with ATP6AP2.2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGTP010192EBI-715794,EBI-751728

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111904, 8 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-59219N

    The Eukaryotic Linear Motif resource for Functional Sites in Proteins

    More...
    ELMi
    P00797

    Protein interaction database and analysis system

    More...
    IntActi
    P00797, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000272190

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P00797

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1406
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P00797

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00797

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P00797

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 403Peptidase A1PROSITE-ProRule annotationAdd BLAST318

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1339 Eukaryota
    ENOG410XNV7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157898

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000197681

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG000482

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00797

    KEGG Orthology (KO)

    More...
    KOi
    K01380

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LGKYYTE

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0JP7

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P00797

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314990

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd05487 renin_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.70.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    IPR034135 Renin-like_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR13683 PTHR13683, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00792 PEPSIN

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50630 SSF50630, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P00797-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG
    60 70 80 90 100
    VDMARLGPEW SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK
    110 120 130 140 150
    VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS
    160 170 180 190 200
    TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE
    210 220 230 240 250
    QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ
    260 270 280 290 300
    HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
    310 320 330 340 350
    STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY
    360 370 380 390 400
    VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI

    GFALAR
    Length:406
    Mass (Da):45,057
    Last modified:January 1, 1988 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AFDF8E973B21EDA
    GO
    Isoform 2 (identifier: P00797-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-233: Missing.

    Show »
    Length:403
    Mass (Da):44,726
    Checksum:i4DEF0016D9EF5854
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1B0GUZ2A0A1B0GUZ2_HUMAN
    Renin
    REN
    368Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55R → S in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti189E → Q in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti304S → C in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti351V → I (PubMed:6138751).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06377016L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 PublicationCorresponds to variant dbSNP:rs121917743EnsemblClinVar.1
    Natural variantiVAR_02037533R → W. Corresponds to variant dbSNP:rs11571098Ensembl.1
    Natural variantiVAR_035088104D → N in RTD. 1 PublicationCorresponds to variant dbSNP:rs868694193Ensembl.1
    Natural variantiVAR_029171160Q → K. Corresponds to variant dbSNP:rs11571083Ensembl.1
    Natural variantiVAR_020376217G → R. Corresponds to variant dbSNP:rs11571117EnsemblClinVar.1
    Natural variantiVAR_035087230R → K in RTD. 1 PublicationCorresponds to variant dbSNP:rs121917742EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012899231 – 233Missing in isoform 2. Curated3

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L00073
    , L00064, L00065, L00066, L00067, L00068, L00069, L00070, L00071, L00072 Genomic DNA Translation: AAA60363.1
    M26901, M26899, M26900 Genomic DNA Translation: AAA60364.1
    M10152
    , M10030, M10128, M10150, M10151 Genomic DNA Translation: AAD03461.1
    AY436324 Genomic DNA Translation: AAR03502.1
    CR536498 mRNA Translation: CAG38737.1
    EU332871 Genomic DNA Translation: ABY87560.1
    AL592114 Genomic DNA No translation available.
    AL592146 Genomic DNA No translation available.
    BC033474 mRNA Translation: AAH33474.1
    BC047752 mRNA Translation: AAH47752.1
    M15410 Genomic DNA Translation: AAA60263.1
    M26440 Genomic DNA Translation: AAA60365.1
    M13253 Genomic DNA Translation: AAA60262.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS30981.1 [P00797-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A21454 REHUK

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000528.1, NM_000537.3 [P00797-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.3210

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000272190; ENSP00000272190; ENSG00000143839 [P00797-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5972

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5972

    UCSC genome browser

    More...
    UCSCi
    uc001haq.3 human [P00797-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Wikipedia

    Renin entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L00073
    , L00064, L00065, L00066, L00067, L00068, L00069, L00070, L00071, L00072 Genomic DNA Translation: AAA60363.1
    M26901, M26899, M26900 Genomic DNA Translation: AAA60364.1
    M10152
    , M10030, M10128, M10150, M10151 Genomic DNA Translation: AAD03461.1
    AY436324 Genomic DNA Translation: AAR03502.1
    CR536498 mRNA Translation: CAG38737.1
    EU332871 Genomic DNA Translation: ABY87560.1
    AL592114 Genomic DNA No translation available.
    AL592146 Genomic DNA No translation available.
    BC033474 mRNA Translation: AAH33474.1
    BC047752 mRNA Translation: AAH47752.1
    M15410 Genomic DNA Translation: AAA60263.1
    M26440 Genomic DNA Translation: AAA60365.1
    M13253 Genomic DNA Translation: AAA60262.1
    CCDSiCCDS30981.1 [P00797-1]
    PIRiA21454 REHUK
    RefSeqiNP_000528.1, NM_000537.3 [P00797-1]
    UniGeneiHs.3210

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BBSX-ray2.80A/B67-406[»]
    1BILX-ray2.40A/B70-406[»]
    1BIMX-ray2.80A/B70-406[»]
    1HRNX-ray1.80A/B70-406[»]
    1RNEX-ray2.40A67-406[»]
    2BKSX-ray2.20A/B67-406[»]
    2BKTX-ray2.30A/B67-406[»]
    2FS4X-ray2.20A/B74-406[»]
    2G1NX-ray2.90A/B74-406[»]
    2G1OX-ray2.70A/B74-406[»]
    2G1RX-ray2.42A/B74-406[»]
    2G1SX-ray2.50A/B74-406[»]
    2G1YX-ray2.50A/B74-406[»]
    2G20X-ray2.40A/B74-406[»]
    2G21X-ray2.20A/B74-406[»]
    2G22X-ray2.50A/B74-406[»]
    2G24X-ray1.90A/B74-406[»]
    2G26X-ray2.10A/B74-406[»]
    2G27X-ray2.90A/B74-406[»]
    2I4QX-ray2.30A/B73-406[»]
    2IKOX-ray1.90A/B67-406[»]
    2IKUX-ray2.60A/B67-406[»]
    2IL2X-ray2.24A/B67-406[»]
    2RENX-ray2.50A67-406[»]
    2V0ZX-ray2.20C/O67-406[»]
    2V10X-ray3.10C/O67-406[»]
    2V11X-ray3.10C/O67-406[»]
    2V12X-ray3.20C/O67-406[»]
    2V13X-ray2.80A67-406[»]
    2V16X-ray2.80C/O67-406[»]
    2X0BX-ray4.33A/C/E/G24-406[»]
    3D91X-ray2.20A/B67-406[»]
    3G6ZX-ray2.00A/B67-406[»]
    3G70X-ray2.00A/B67-406[»]
    3G72X-ray1.90A/B67-406[»]
    3GW5X-ray2.00A/B70-406[»]
    3K1WX-ray1.50A/B67-406[»]
    3KM4X-ray1.90A/B70-406[»]
    3O9LX-ray2.40A/C67-232[»]
    B/D237-406[»]
    3OADX-ray2.17A/C67-232[»]
    B/D237-406[»]
    3OAGX-ray2.30A/C67-232[»]
    B/D237-406[»]
    3OOTX-ray2.55A/B67-406[»]
    3OQFX-ray2.78A/B67-406[»]
    3OQKX-ray2.90A/B67-406[»]
    3OWNX-ray2.00A/B67-406[»]
    3Q3TX-ray2.60A/B67-406[»]
    3Q4BX-ray2.19A/B67-406[»]
    3Q5HX-ray2.16A/B67-406[»]
    3SFCX-ray2.10A/B67-406[»]
    3VCMX-ray2.93A/B67-406[»]
    P/Q24-66[»]
    3VSWX-ray3.00A/B67-406[»]
    3VSXX-ray2.80A/B67-406[»]
    3VUCX-ray2.60A/B67-406[»]
    3VYDX-ray2.81A/B67-406[»]
    3VYEX-ray2.70A/B67-406[»]
    3VYFX-ray2.80A/B67-406[»]
    4AMTX-ray2.60A24-406[»]
    4GJ5X-ray2.40A/B67-406[»]
    4GJ6X-ray2.58A/B67-406[»]
    4GJ7X-ray2.80A/B67-406[»]
    4GJ8X-ray2.50A/B67-406[»]
    4GJ9X-ray2.60A/B67-406[»]
    4GJAX-ray2.60A/B67-406[»]
    4GJBX-ray2.75A/B67-406[»]
    4GJCX-ray2.40A/B67-406[»]
    4GJDX-ray2.65A/B67-406[»]
    4PYVX-ray2.65A/B67-406[»]
    4Q1NX-ray2.09A/B67-406[»]
    4RYCX-ray2.45A/B67-406[»]
    4RYGX-ray2.65A/B67-406[»]
    4RZ1X-ray2.60A/B67-406[»]
    4S1GX-ray2.10A/B67-406[»]
    4XX3X-ray2.40A/B67-406[»]
    4XX4X-ray2.40A/B67-406[»]
    5KOQX-ray2.70A/B70-406[»]
    5KOSX-ray2.41A/B70-406[»]
    5KOTX-ray2.10A/B70-406[»]
    5SXNX-ray2.10A/B68-406[»]
    5SY2X-ray2.25A/B67-406[»]
    5SY3X-ray2.30A/B68-406[»]
    5SZ9X-ray2.85A/B68-406[»]
    5T4SX-ray2.64A/B68-406[»]
    5TMGX-ray2.20A/B70-406[»]
    5TMKX-ray2.65A/B70-406[»]
    5V8VX-ray2.60A/B70-406[»]
    5VPMX-ray2.90A/B70-406[»]
    5VRPX-ray3.22A/B70-406[»]
    ProteinModelPortaliP00797
    SMRiP00797
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111904, 8 interactors
    DIPiDIP-59219N
    ELMiP00797
    IntActiP00797, 3 interactors
    STRINGi9606.ENSP00000272190

    Chemistry databases

    BindingDBiP00797
    ChEMBLiCHEMBL286
    DrugBankiDB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
    DB02296 1-Hydroxy-3-Methylbutane
    DB03736 2-Cyclopropylmethylenepropanal
    DB03024 2-Methyl-3-(2-Aminothiazolo)Propanal
    DB09026 Aliskiren
    DB01844 Dimethylformamide
    DB03395 Enalkiren
    DB04379 N-Methyl-N-(Methylbenzyl)Formamide
    DB00212 Remikiren
    DB05203 SPP1148
    GuidetoPHARMACOLOGYi2413

    Protein family/group databases

    MEROPSiA01.007

    PTM databases

    GlyConnecti513
    iPTMnetiP00797
    PhosphoSitePlusiP00797
    UniCarbKBiP00797

    Polymorphism and mutation databases

    BioMutaiREN
    DMDMi132326

    Proteomic databases

    PaxDbiP00797
    PeptideAtlasiP00797
    PRIDEiP00797
    ProteomicsDBi51287
    51288 [P00797-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    5972
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000272190; ENSP00000272190; ENSG00000143839 [P00797-1]
    GeneIDi5972
    KEGGihsa:5972
    UCSCiuc001haq.3 human [P00797-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5972
    DisGeNETi5972
    EuPathDBiHostDB:ENSG00000143839.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    REN
    GeneReviewsiREN
    HGNCiHGNC:9958 REN
    HPAiCAB025903
    HPA005131
    MalaCardsiREN
    MIMi179820 gene
    267430 phenotype
    613092 phenotype
    neXtProtiNX_P00797
    OpenTargetsiENSG00000143839
    Orphaneti217330 REN-related autosomal dominant tubulointerstitial kidney disease
    97369 Renal tubular dysgenesis of genetic origin
    PharmGKBiPA297

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1339 Eukaryota
    ENOG410XNV7 LUCA
    GeneTreeiENSGT00940000157898
    HOGENOMiHOG000197681
    HOVERGENiHBG000482
    InParanoidiP00797
    KOiK01380
    OMAiLGKYYTE
    OrthoDBiEOG091G0JP7
    PhylomeDBiP00797
    TreeFamiTF314990

    Enzyme and pathway databases

    BRENDAi3.4.23.15 2681
    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    SIGNORiP00797

    Miscellaneous databases

    EvolutionaryTraceiP00797

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Renin

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5972
    PMAP-CutDBiP00797

    Protein Ontology

    More...
    PROi
    PR:P00797

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143839 Expressed in 69 organ(s), highest expression level in kidney
    CleanExiHS_REN
    ExpressionAtlasiP00797 baseline and differential
    GenevisibleiP00797 HS

    Family and domain databases

    CDDicd05487 renin_like, 1 hit
    Gene3Di2.40.70.10, 2 hits
    InterProiView protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    IPR034135 Renin-like_dom
    PANTHERiPTHR13683 PTHR13683, 1 hit
    PfamiView protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit
    PRINTSiPR00792 PEPSIN
    SUPFAMiSSF50630 SSF50630, 1 hit
    PROSITEiView protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRENI_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00797
    Secondary accession number(s): Q6FI38, Q6T5C2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 1, 1988
    Last modified: December 5, 2018
    This is version 218 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    7. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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