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Protein

Renin

Gene

REN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Activity regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.

Kineticsi

  1. KM=1 µM for angiotensinogen (in absence of ATP6AP2)
  2. KM=0.15 µM for angiotensinogen (in presence of membrane-bound ATP6AP2)

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei1041
    Active sitei2921

    GO - Molecular functioni

    • aspartic-type endopeptidase activity Source: HGNC
    • insulin-like growth factor receptor binding Source: Ensembl
    • peptidase activity Source: HGNC
    • signaling receptor binding Source: HGNC

    GO - Biological processi

    Keywordsi

    Molecular functionAspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BRENDAi3.4.23.15 2681
    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    SIGNORiP00797

    Protein family/group databases

    MEROPSiA01.007

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renin (EC:3.4.23.15)
    Alternative name(s):
    Angiotensinogenase
    Gene namesi
    Name:REN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000143839.13
    HGNCiHGNC:9958 REN
    MIMi179820 gene
    neXtProtiNX_P00797

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Renal tubular dysgenesis (RTD)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    See also OMIM:267430
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_035088104D → N in RTD. 1 PublicationCorresponds to variant dbSNP:rs868694193Ensembl.1
    Natural variantiVAR_035087230R → K in RTD. 1 PublicationCorresponds to variant dbSNP:rs121917742EnsemblClinVar.1
    Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
    See also OMIM:613092
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06377016L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 PublicationCorresponds to variant dbSNP:rs121917743EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi5972
    GeneReviewsiREN
    MalaCardsiREN
    MIMi267430 phenotype
    613092 phenotype
    OpenTargetsiENSG00000143839
    Orphaneti217330 REN-related autosomal dominant tubulointerstitial kidney disease
    97369 Renal tubular dysgenesis of genetic origin
    PharmGKBiPA297

    Chemistry databases

    ChEMBLiCHEMBL286
    DrugBankiDB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
    DB02296 1-Hydroxy-3-Methylbutane
    DB03736 2-Cyclopropylmethylenepropanal
    DB03024 2-Methyl-3-(2-Aminothiazolo)Propanal
    DB09026 Aliskiren
    DB01844 Dimethylformamide
    DB03395 Enalkiren
    DB04379 N-Methyl-N-(Methylbenzyl)Formamide
    DB00212 Remikiren
    DB05203 SPP1148
    GuidetoPHARMACOLOGYi2413

    Polymorphism and mutation databases

    BioMutaiREN
    DMDMi132326

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Signal peptidei1 – 231 PublicationAdd BLAST23
    PropeptideiPRO_000002608124 – 66Activation peptide1 PublicationAdd BLAST43
    ChainiPRO_000002608267 – 406ReninAdd BLAST340

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi71N-linked (GlcNAc...) asparagine1
    Disulfide bondi117 ↔ 1241 Publication
    Glycosylationi141N-linked (GlcNAc...) asparagine1
    Disulfide bondi283 ↔ 2871 Publication
    Disulfide bondi325 ↔ 3621 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP00797
    PeptideAtlasiP00797
    PRIDEiP00797
    ProteomicsDBi51287
    51288 [P00797-2]

    PTM databases

    GlyConnecti513
    iPTMnetiP00797
    PhosphoSitePlusiP00797
    UniCarbKBiP00797

    Miscellaneous databases

    PMAP-CutDBiP00797

    Expressioni

    Gene expression databases

    BgeeiENSG00000143839 Expressed in 69 organ(s), highest expression level in kidney
    CleanExiHS_REN
    ExpressionAtlasiP00797 baseline and differential
    GenevisibleiP00797 HS

    Organism-specific databases

    HPAiCAB025903
    HPA005131

    Interactioni

    Subunit structurei

    Interacts with ATP6AP2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGTP010192EBI-715794,EBI-751728

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi111904, 8 interactors
    DIPiDIP-59219N
    ELMiP00797
    IntActiP00797, 3 interactors
    STRINGi9606.ENSP00000272190

    Chemistry databases

    BindingDBiP00797

    Structurei

    Secondary structure

    1406
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP00797
    SMRiP00797
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00797

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini86 – 403Peptidase A1PROSITE-ProRule annotationAdd BLAST318

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiKOG1339 Eukaryota
    ENOG410XNV7 LUCA
    GeneTreeiENSGT00760000118929
    HOGENOMiHOG000197681
    HOVERGENiHBG000482
    InParanoidiP00797
    KOiK01380
    OMAiLGKYYTE
    OrthoDBiEOG091G0JP7
    PhylomeDBiP00797
    TreeFamiTF314990

    Family and domain databases

    CDDicd05487 renin_like, 1 hit
    Gene3Di2.40.70.10, 2 hits
    InterProiView protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    IPR034135 Renin-like_dom
    PANTHERiPTHR13683 PTHR13683, 1 hit
    PfamiView protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit
    PRINTSiPR00792 PEPSIN
    SUPFAMiSSF50630 SSF50630, 1 hit
    PROSITEiView protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P00797-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG
    60 70 80 90 100
    VDMARLGPEW SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK
    110 120 130 140 150
    VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS
    160 170 180 190 200
    TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE
    210 220 230 240 250
    QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ
    260 270 280 290 300
    HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
    310 320 330 340 350
    STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY
    360 370 380 390 400
    VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI

    GFALAR
    Length:406
    Mass (Da):45,057
    Last modified:January 1, 1988 - v1
    Checksum:i5AFDF8E973B21EDA
    GO
    Isoform 2 (identifier: P00797-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-233: Missing.

    Show »
    Length:403
    Mass (Da):44,726
    Checksum:i4DEF0016D9EF5854
    GO

    Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1B0GUZ2A0A1B0GUZ2_HUMAN
    Renin
    REN
    368Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti55R → S in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti189E → Q in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti304S → C in AAA60364 (PubMed:3530608).Curated1
    Sequence conflicti351V → I (PubMed:6138751).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06377016L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 PublicationCorresponds to variant dbSNP:rs121917743EnsemblClinVar.1
    Natural variantiVAR_02037533R → W. Corresponds to variant dbSNP:rs11571098Ensembl.1
    Natural variantiVAR_035088104D → N in RTD. 1 PublicationCorresponds to variant dbSNP:rs868694193Ensembl.1
    Natural variantiVAR_029171160Q → K. Corresponds to variant dbSNP:rs11571083Ensembl.1
    Natural variantiVAR_020376217G → R. Corresponds to variant dbSNP:rs11571117EnsemblClinVar.1
    Natural variantiVAR_035087230R → K in RTD. 1 PublicationCorresponds to variant dbSNP:rs121917742EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_012899231 – 233Missing in isoform 2. Curated3

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L00073
    , L00064, L00065, L00066, L00067, L00068, L00069, L00070, L00071, L00072 Genomic DNA Translation: AAA60363.1
    M26901, M26899, M26900 Genomic DNA Translation: AAA60364.1
    M10152
    , M10030, M10128, M10150, M10151 Genomic DNA Translation: AAD03461.1
    AY436324 Genomic DNA Translation: AAR03502.1
    CR536498 mRNA Translation: CAG38737.1
    EU332871 Genomic DNA Translation: ABY87560.1
    AL592114 Genomic DNA No translation available.
    AL592146 Genomic DNA No translation available.
    BC033474 mRNA Translation: AAH33474.1
    BC047752 mRNA Translation: AAH47752.1
    M15410 Genomic DNA Translation: AAA60263.1
    M26440 Genomic DNA Translation: AAA60365.1
    M13253 Genomic DNA Translation: AAA60262.1
    CCDSiCCDS30981.1 [P00797-1]
    PIRiA21454 REHUK
    RefSeqiNP_000528.1, NM_000537.3 [P00797-1]
    UniGeneiHs.3210

    Genome annotation databases

    EnsembliENST00000272190; ENSP00000272190; ENSG00000143839 [P00797-1]
    GeneIDi5972
    KEGGihsa:5972
    UCSCiuc001haq.3 human [P00797-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Renin entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L00073
    , L00064, L00065, L00066, L00067, L00068, L00069, L00070, L00071, L00072 Genomic DNA Translation: AAA60363.1
    M26901, M26899, M26900 Genomic DNA Translation: AAA60364.1
    M10152
    , M10030, M10128, M10150, M10151 Genomic DNA Translation: AAD03461.1
    AY436324 Genomic DNA Translation: AAR03502.1
    CR536498 mRNA Translation: CAG38737.1
    EU332871 Genomic DNA Translation: ABY87560.1
    AL592114 Genomic DNA No translation available.
    AL592146 Genomic DNA No translation available.
    BC033474 mRNA Translation: AAH33474.1
    BC047752 mRNA Translation: AAH47752.1
    M15410 Genomic DNA Translation: AAA60263.1
    M26440 Genomic DNA Translation: AAA60365.1
    M13253 Genomic DNA Translation: AAA60262.1
    CCDSiCCDS30981.1 [P00797-1]
    PIRiA21454 REHUK
    RefSeqiNP_000528.1, NM_000537.3 [P00797-1]
    UniGeneiHs.3210

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BBSX-ray2.80A/B67-406[»]
    1BILX-ray2.40A/B70-406[»]
    1BIMX-ray2.80A/B70-406[»]
    1HRNX-ray1.80A/B70-406[»]
    1RNEX-ray2.40A67-406[»]
    2BKSX-ray2.20A/B67-406[»]
    2BKTX-ray2.30A/B67-406[»]
    2FS4X-ray2.20A/B74-406[»]
    2G1NX-ray2.90A/B74-406[»]
    2G1OX-ray2.70A/B74-406[»]
    2G1RX-ray2.42A/B74-406[»]
    2G1SX-ray2.50A/B74-406[»]
    2G1YX-ray2.50A/B74-406[»]
    2G20X-ray2.40A/B74-406[»]
    2G21X-ray2.20A/B74-406[»]
    2G22X-ray2.50A/B74-406[»]
    2G24X-ray1.90A/B74-406[»]
    2G26X-ray2.10A/B74-406[»]
    2G27X-ray2.90A/B74-406[»]
    2I4QX-ray2.30A/B73-406[»]
    2IKOX-ray1.90A/B67-406[»]
    2IKUX-ray2.60A/B67-406[»]
    2IL2X-ray2.24A/B67-406[»]
    2RENX-ray2.50A67-406[»]
    2V0ZX-ray2.20C/O67-406[»]
    2V10X-ray3.10C/O67-406[»]
    2V11X-ray3.10C/O67-406[»]
    2V12X-ray3.20C/O67-406[»]
    2V13X-ray2.80A67-406[»]
    2V16X-ray2.80C/O67-406[»]
    2X0BX-ray4.33A/C/E/G24-406[»]
    3D91X-ray2.20A/B67-406[»]
    3G6ZX-ray2.00A/B67-406[»]
    3G70X-ray2.00A/B67-406[»]
    3G72X-ray1.90A/B67-406[»]
    3GW5X-ray2.00A/B70-406[»]
    3K1WX-ray1.50A/B67-406[»]
    3KM4X-ray1.90A/B70-406[»]
    3O9LX-ray2.40A/C67-232[»]
    B/D237-406[»]
    3OADX-ray2.17A/C67-232[»]
    B/D237-406[»]
    3OAGX-ray2.30A/C67-232[»]
    B/D237-406[»]
    3OOTX-ray2.55A/B67-406[»]
    3OQFX-ray2.78A/B67-406[»]
    3OQKX-ray2.90A/B67-406[»]
    3OWNX-ray2.00A/B67-406[»]
    3Q3TX-ray2.60A/B67-406[»]
    3Q4BX-ray2.19A/B67-406[»]
    3Q5HX-ray2.16A/B67-406[»]
    3SFCX-ray2.10A/B67-406[»]
    3VCMX-ray2.93A/B67-406[»]
    P/Q24-66[»]
    3VSWX-ray3.00A/B67-406[»]
    3VSXX-ray2.80A/B67-406[»]
    3VUCX-ray2.60A/B67-406[»]
    3VYDX-ray2.81A/B67-406[»]
    3VYEX-ray2.70A/B67-406[»]
    3VYFX-ray2.80A/B67-406[»]
    4AMTX-ray2.60A24-406[»]
    4GJ5X-ray2.40A/B67-406[»]
    4GJ6X-ray2.58A/B67-406[»]
    4GJ7X-ray2.80A/B67-406[»]
    4GJ8X-ray2.50A/B67-406[»]
    4GJ9X-ray2.60A/B67-406[»]
    4GJAX-ray2.60A/B67-406[»]
    4GJBX-ray2.75A/B67-406[»]
    4GJCX-ray2.40A/B67-406[»]
    4GJDX-ray2.65A/B67-406[»]
    4PYVX-ray2.65A/B67-406[»]
    4Q1NX-ray2.09A/B67-406[»]
    4RYCX-ray2.45A/B67-406[»]
    4RYGX-ray2.65A/B67-406[»]
    4RZ1X-ray2.60A/B67-406[»]
    4S1GX-ray2.10A/B67-406[»]
    4XX3X-ray2.40A/B67-406[»]
    4XX4X-ray2.40A/B67-406[»]
    5KOQX-ray2.70A/B70-406[»]
    5KOSX-ray2.41A/B70-406[»]
    5KOTX-ray2.10A/B70-406[»]
    5SXNX-ray2.10A/B68-406[»]
    5SY2X-ray2.25A/B67-406[»]
    5SY3X-ray2.30A/B68-406[»]
    5SZ9X-ray2.85A/B68-406[»]
    5T4SX-ray2.64A/B68-406[»]
    5TMGX-ray2.20A/B70-406[»]
    5TMKX-ray2.65A/B70-406[»]
    5V8VX-ray2.60A/B70-406[»]
    5VPMX-ray2.90A/B70-406[»]
    5VRPX-ray3.22A/B70-406[»]
    ProteinModelPortaliP00797
    SMRiP00797
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111904, 8 interactors
    DIPiDIP-59219N
    ELMiP00797
    IntActiP00797, 3 interactors
    STRINGi9606.ENSP00000272190

    Chemistry databases

    BindingDBiP00797
    ChEMBLiCHEMBL286
    DrugBankiDB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
    DB02296 1-Hydroxy-3-Methylbutane
    DB03736 2-Cyclopropylmethylenepropanal
    DB03024 2-Methyl-3-(2-Aminothiazolo)Propanal
    DB09026 Aliskiren
    DB01844 Dimethylformamide
    DB03395 Enalkiren
    DB04379 N-Methyl-N-(Methylbenzyl)Formamide
    DB00212 Remikiren
    DB05203 SPP1148
    GuidetoPHARMACOLOGYi2413

    Protein family/group databases

    MEROPSiA01.007

    PTM databases

    GlyConnecti513
    iPTMnetiP00797
    PhosphoSitePlusiP00797
    UniCarbKBiP00797

    Polymorphism and mutation databases

    BioMutaiREN
    DMDMi132326

    Proteomic databases

    PaxDbiP00797
    PeptideAtlasiP00797
    PRIDEiP00797
    ProteomicsDBi51287
    51288 [P00797-2]

    Protocols and materials databases

    DNASUi5972
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000272190; ENSP00000272190; ENSG00000143839 [P00797-1]
    GeneIDi5972
    KEGGihsa:5972
    UCSCiuc001haq.3 human [P00797-1]

    Organism-specific databases

    CTDi5972
    DisGeNETi5972
    EuPathDBiHostDB:ENSG00000143839.13
    GeneCardsiREN
    GeneReviewsiREN
    HGNCiHGNC:9958 REN
    HPAiCAB025903
    HPA005131
    MalaCardsiREN
    MIMi179820 gene
    267430 phenotype
    613092 phenotype
    neXtProtiNX_P00797
    OpenTargetsiENSG00000143839
    Orphaneti217330 REN-related autosomal dominant tubulointerstitial kidney disease
    97369 Renal tubular dysgenesis of genetic origin
    PharmGKBiPA297
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1339 Eukaryota
    ENOG410XNV7 LUCA
    GeneTreeiENSGT00760000118929
    HOGENOMiHOG000197681
    HOVERGENiHBG000482
    InParanoidiP00797
    KOiK01380
    OMAiLGKYYTE
    OrthoDBiEOG091G0JP7
    PhylomeDBiP00797
    TreeFamiTF314990

    Enzyme and pathway databases

    BRENDAi3.4.23.15 2681
    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    SIGNORiP00797

    Miscellaneous databases

    EvolutionaryTraceiP00797
    GeneWikiiRenin
    GenomeRNAii5972
    PMAP-CutDBiP00797
    PROiPR:P00797
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000143839 Expressed in 69 organ(s), highest expression level in kidney
    CleanExiHS_REN
    ExpressionAtlasiP00797 baseline and differential
    GenevisibleiP00797 HS

    Family and domain databases

    CDDicd05487 renin_like, 1 hit
    Gene3Di2.40.70.10, 2 hits
    InterProiView protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR012848 Aspartic_peptidase_N
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    IPR034135 Renin-like_dom
    PANTHERiPTHR13683 PTHR13683, 1 hit
    PfamiView protein in Pfam
    PF07966 A1_Propeptide, 1 hit
    PF00026 Asp, 1 hit
    PRINTSiPR00792 PEPSIN
    SUPFAMiSSF50630 SSF50630, 1 hit
    PROSITEiView protein in PROSITE
    PS00141 ASP_PROTEASE, 2 hits
    PS51767 PEPTIDASE_A1, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiRENI_HUMAN
    AccessioniPrimary (citable) accession number: P00797
    Secondary accession number(s): Q6FI38, Q6T5C2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 1, 1988
    Last modified: November 7, 2018
    This is version 217 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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