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Protein

Streptokinase C

Gene

skc

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

GO - Biological processi

Keywordsi

Biological processPlasminogen activation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Streptokinase C
Gene namesi
Name:skc
OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Taxonomic identifieri119602 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000002242827 – 440Streptokinase CAdd BLAST414

Proteomic databases

PRIDEiP00779

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLGP007472EBI-1035089,EBI-999394From Homo sapiens.

Protein-protein interaction databases

IntActiP00779, 1 interactor

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00779
SMRiP00779
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00779

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004093 SAK/SK
IPR036120 SAK/SK_sf
IPR008124 SK
PfamiView protein in Pfam
PF02821 Staphylokinase, 3 hits
PRINTSiPR01753 STREPKINASE
SUPFAMiSSF54328 SSF54328, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00779-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS
160 170 180 190 200
VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ AKSVDVEYTV QFTPLNPDDD
210 220 230 240 250
FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK
Length:440
Mass (Da):50,140
Last modified:April 1, 1988 - v1
Checksum:i8FC1F22648ACC77A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298 – 300EKY → LEYK AA sequence (PubMed:6760891).Curated3
Sequence conflicti438N → D AA sequence (PubMed:6760891).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti195L → D. 1
Natural varianti207D → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA Translation: AAA26974.1
X72832 Genomic DNA Translation: CAA51351.1
PIRiA00967 BZSO
A22801

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA Translation: AAA26974.1
X72832 Genomic DNA Translation: CAA51351.1
PIRiA00967 BZSO
A22801

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779
SMRiP00779
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00779, 1 interactor

Proteomic databases

PRIDEiP00779

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP00779

Family and domain databases

InterProiView protein in InterPro
IPR004093 SAK/SK
IPR036120 SAK/SK_sf
IPR008124 SK
PfamiView protein in Pfam
PF02821 Staphylokinase, 3 hits
PRINTSiPR01753 STREPKINASE
SUPFAMiSSF54328 SSF54328, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSTRP_STREQ
AccessioniPrimary (citable) accession number: P00779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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