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Protein

Streptogrisin-A

Gene

sprA

Organism
Streptomyces griseus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a primary specificity for large aliphatic or aromatic amino acids.

Catalytic activityi

Hydrolysis of proteins with specificity similar to chymotrypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Charge relay systemBy similarity1
Active sitei171Charge relay systemBy similarity1
Active sitei253Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.261

Names & Taxonomyi

Protein namesi
Recommended name:
Streptogrisin-A (EC:3.4.21.80)
Alternative name(s):
Pronase enzyme A
SGPA
Serine protease A
Gene namesi
Name:sprA
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Protein family/group databases

Allergomei3640 Str g Pronase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Add BLAST38
PropeptideiPRO_000002690939 – 1151 PublicationAdd BLAST77
ChainiPRO_0000026910116 – 297Streptogrisin-AAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi130 ↔ 1501 Publication
Disulfide bondi247 ↔ 2741 Publication

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00776
SMRiP00776
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00776

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004236 Pept_S1_alpha_lytic
IPR001316 Pept_S1A_streptogrisin
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF02983 Pro_Al_protease, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001134 Streptogrisin, 1 hit
PRINTSiPR00861 ALYTICPTASE
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00776-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFKRFSPLS STSRYARLLA VASGLVAAAA LATPSAVAAP EAESKATVSQ
60 70 80 90 100
LADASSAILA ADVAGTAWYT EASTGKIVLT ADSTVSKAEL AKVSNALAGS
110 120 130 140 150
KAKLTVKRAE GKFTPLIAGG EAITTGGSRC SLGFNVSVNG VAHALTAGHC
160 170 180 190 200
TNISASWSIG TRTGTSFPNN DYGIIRHSNP AAADGRVYLY NGSYQDITTA
210 220 230 240 250
GNAFVGQAVQ RSGSTTGLRS GSVTGLNATV NYGSSGIVYG MIQTNVCAEP
260 270 280 290
GDSGGSLFAG STALGLTSGG SGNCRTGGTT FYQPVTEALS AYGATVL
Length:297
Mass (Da):29,663
Last modified:February 1, 1991 - v2
Checksum:i7F6CF04A81B4B3C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → TS AA sequence (PubMed:4214713).Curated1
Sequence conflicti184D → N AA sequence (PubMed:4214713).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17103 Genomic DNA Translation: AAA26818.1
PIRiA26974 PRSMAG
RefSeqiWP_003964236.1, NZ_MDDK01000013.1

Genome annotation databases

GeneIDi6210956

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17103 Genomic DNA Translation: AAA26818.1
PIRiA26974 PRSMAG
RefSeqiWP_003964236.1, NZ_MDDK01000013.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SGCX-ray1.80A117-297[»]
2SGAX-ray1.50A117-297[»]
3SGAX-ray1.80E117-297[»]
4SGAX-ray1.80E117-297[»]
5SGAX-ray1.80E117-297[»]
ProteinModelPortaliP00776
SMRiP00776
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3640 Str g Pronase
MEROPSiS01.261

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6210956

Miscellaneous databases

EvolutionaryTraceiP00776

Family and domain databases

InterProiView protein in InterPro
IPR004236 Pept_S1_alpha_lytic
IPR001316 Pept_S1A_streptogrisin
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF02983 Pro_Al_protease, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001134 Streptogrisin, 1 hit
PRINTSiPR00861 ALYTICPTASE
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRTA_STRGR
AccessioniPrimary (citable) accession number: P00776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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