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UniProtKB - P00773 (CELA1_RAT)
Protein
Chymotrypsin-like elastase family member 1
Gene
Cela1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Acts upon elastin.
Catalytic activityi
- Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. EC:3.4.21.36
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 71 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 85 | CalciumBy similarity | 1 | |
Metal bindingi | 90 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 95 | CalciumBy similarity | 1 | |
Active sitei | 119 | Charge relay systemBy similarity | 1 | |
Active sitei | 214 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- digestive system development Source: RGD
- elastin catabolic process Source: RGD
- exocrine pancreas development Source: RGD
- inflammatory response Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- pancreas morphogenesis Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- post-embryonic development Source: RGD
- proteolysis Source: GO_Central
- regulation of cell differentiation Source: RGD
- regulation of cell population proliferation Source: RGD
- tissue remodeling Source: RGD
- Wnt signaling pathway Source: RGD
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Ligand | Calcium, Metal-binding |
Protein family/group databases
MEROPSi | S01.153 |
Names & Taxonomyi
Protein namesi | Recommended name: Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)Alternative name(s): Elastase-1 |
Gene namesi | Name:Cela1 Synonyms:Ela1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2547, Cela1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | 1 PublicationAdd BLAST | 16 | |
PropeptideiPRO_0000027683 | 17 – 26 | Activation peptide | 10 | |
ChainiPRO_0000027684 | 27 – 266 | Chymotrypsin-like elastase family member 1Add BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 72 | PROSITE-ProRule annotation | ||
Disulfide bondi | 153 ↔ 220 | PROSITE-ProRule annotation | ||
Disulfide bondi | 184 ↔ 200 | PROSITE-ProRule annotation | ||
Disulfide bondi | 210 ↔ 240 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
PaxDbi | P00773 |
PRIDEi | P00773 |
Expressioni
Tissue specificityi
Pancreas.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 264 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 238 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
InParanoidi | P00773 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P00773 |
TreeFami | TF330455 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P00773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRFLVFASL VLYGHSTQDF PETNARVVGG AEARRNSWPS QISLQYLSGG
60 70 80 90 100
SWYHTCGGTL IRRNWVMTAA HCVSSQMTFR VVVGDHNLSQ NDGTEQYVSV
110 120 130 140 150
QKIMVHPTWN SNNVAAGYDI ALLRLAQSVT LNNYVQLAVL PQEGTILANN
160 170 180 190 200
NPCYITGWGR TRTNGQLSQT LQQAYLPSVD YSICSSSSYW GSTVKTTMVC
210 220 230 240 250
AGGDGVRSGC QGDSGGPLHC LVNGQYSVHG VTSFVSSMGC NVSKKPTVFT
260
RVSAYISWMN NVIAYT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSI5 | A0A0G2JSI5_RAT | Chymotrypsin-like elastase family m... | Cela1 Ela1, rCG_50853 | 266 | Annotation score: | ||
A0A8I5ZM51 | A0A8I5ZM51_RAT | Chymotrypsin-like elastase family m... | Cela1 | 511 | Annotation score: | ||
A0A8I5ZY98 | A0A8I5ZY98_RAT | Chymotrypsin-like elastase family m... | Cela1 | 544 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | M → V in AAA98811 (PubMed:6094548).Curated | 1 | |
Sequence conflicti | 108 | T → N in AAA98811 (PubMed:6094548).Curated | 1 | |
Sequence conflicti | 244 | K → R in AAA98811 (PubMed:6094548).Curated | 1 | |
Sequence conflicti | 266 | T → N in AAA98811 (PubMed:6094548).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01234 mRNA Translation: CAA24544.1 L00117 , L00112, L00113, L00114, L00115, L00116 Genomic DNA Translation: AAA98811.1 |
PIRi | A00960, ELRT1 |
RefSeqi | NP_036684.1, NM_012552.4 |
Genome annotation databases
GeneIDi | 24331 |
KEGGi | rno:24331 |
UCSCi | RGD:2547, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01234 mRNA Translation: CAA24544.1 L00117 , L00112, L00113, L00114, L00115, L00116 Genomic DNA Translation: AAA98811.1 |
PIRi | A00960, ELRT1 |
RefSeqi | NP_036684.1, NM_012552.4 |
3D structure databases
AlphaFoldDBi | P00773 |
SMRi | P00773 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006351 |
Protein family/group databases
MEROPSi | S01.153 |
Proteomic databases
PaxDbi | P00773 |
PRIDEi | P00773 |
Genome annotation databases
GeneIDi | 24331 |
KEGGi | rno:24331 |
UCSCi | RGD:2547, rat |
Organism-specific databases
CTDi | 1990 |
RGDi | 2547, Cela1 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
InParanoidi | P00773 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P00773 |
TreeFami | TF330455 |
Miscellaneous databases
PROi | PR:P00773 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CELA1_RAT | |
Accessioni | P00773Primary (citable) accession number: P00773 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families