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UniProtKB - P00772 (CELA1_PIG)
Protein
Chymotrypsin-like elastase family member 1
Gene
CELA1
Organism
Sus scrofa (Pig)
Status
Functioni
Acts upon elastin.
Catalytic activityi
- Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. EC:3.4.21.36
Cofactori
Ca2+Note: Binds 1 Ca2+ ion per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 71 | Charge relay system2 Publications | 1 | |
Metal bindingi | 85 | Calcium | 1 | |
Metal bindingi | 90 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 95 | Calcium | 1 | |
Active sitei | 119 | Charge relay system1 Publication | 1 | |
Active sitei | 214 | Charge relay system1 Publication | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.4.21.36, 6170 |
Protein family/group databases
MEROPSi | S01.153 |
Names & Taxonomyi
Protein namesi | Recommended name: Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)Alternative name(s): Elastase-1 |
Gene namesi | Name:CELA1 Synonyms:ELA1 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Add BLAST | 16 | |
PropeptideiPRO_0000027681 | 17 – 26 | Activation peptide2 Publications | 10 | |
ChainiPRO_0000027682 | 27 – 266 | Chymotrypsin-like elastase family member 1Add BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 72 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 153 ↔ 220 | |||
Disulfide bondi | 184 ↔ 200 | |||
Disulfide bondi | 210 ↔ 240 |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
PaxDbi | P00772 |
Expressioni
Tissue specificityi
Pancreas. Basal layers of the epidermis, hair follicle and sebaceous gland epithelia (at protein level).1 Publication
Gene expression databases
Bgeei | ENSSSCG00000029782, Expressed in oocyte and 13 other tissues |
Genevisiblei | P00772, SS |
Interactioni
Binary interactionsi
P00772
With | #Exp. | IntAct |
---|---|---|
SERPINA1 [P01009] from Homo sapiens. | 2 | EBI-986248,EBI-986224 |
Protein-protein interaction databases
BioGRIDi | 1148920, 1 interactor |
DIPi | DIP-378N |
IntActi | P00772, 1 interactor |
MINTi | P00772 |
STRINGi | 9823.ENSSSCP00000026330 |
Chemistry databases
BindingDBi | P00772 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P00772 |
PCDDBi | P00772 |
SMRi | P00772 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00772 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 264 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 238 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
HOGENOMi | CLU_006842_0_4_1 |
InParanoidi | P00772 |
OrthoDBi | 1314811at2759 |
TreeFami | TF330455 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P00772-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLLVVASL VLYGHSTQDF PETNARVVGG TEAQRNSWPS QISLQYRSGS
60 70 80 90 100
SWAHTCGGTL IRQNWVMTAA HCVDRELTFR VVVGEHNLNQ NDGTEQYVGV
110 120 130 140 150
QKIVVHPYWN TDDVAAGYDI ALLRLAQSVT LNSYVQLGVL PRAGTILANN
160 170 180 190 200
SPCYITGWGL TRTNGQLAQT LQQAYLPTVD YAICSSSSYW GSTVKNSMVC
210 220 230 240 250
AGGDGVRSGC QGDSGGPLHC LVNGQYAVHG VTSFVSRLGC NVTRKPTVFT
260
RVSAYISWIN NVIASN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | D → N AA sequence (PubMed:4578945).Curated | 1 | |
Sequence conflicti | 126 | A → G in BAA00118 (PubMed:3648024).Curated | 1 | |
Sequence conflicti | 184 | C → L in BAA00118 (PubMed:3648024).Curated | 1 | |
Sequence conflicti | 204 | D → N AA sequence (PubMed:4578945).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04036 Transcribed RNA Translation: CAA27670.1 D00160 mRNA Translation: BAA00118.1 |
PIRi | JS0013, ELPG |
RefSeqi | NP_998988.1, NM_213823.1 XP_005655631.1, XM_005655574.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Worthington enzyme manual |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04036 Transcribed RNA Translation: CAA27670.1 D00160 mRNA Translation: BAA00118.1 |
PIRi | JS0013, ELPG |
RefSeqi | NP_998988.1, NM_213823.1 XP_005655631.1, XM_005655574.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B0E | X-ray | 1.80 | A | 27-266 | [»] | |
1BMA | X-ray | 1.80 | A | 27-266 | [»] | |
1BTU | X-ray | 1.60 | A | 27-266 | [»] | |
1C1M | X-ray | 2.20 | A | 27-266 | [»] | |
1E34 | X-ray | 1.80 | B | 27-266 | [»] | |
1E35 | X-ray | 1.90 | B | 27-266 | [»] | |
1E36 | X-ray | 1.70 | B | 27-266 | [»] | |
1E37 | X-ray | 1.75 | B | 27-266 | [»] | |
1E38 | X-ray | 1.70 | B | 27-266 | [»] | |
1EAI | X-ray | 2.40 | A/B | 27-266 | [»] | |
1EAS | X-ray | 1.80 | A | 27-266 | [»] | |
1EAT | X-ray | 2.00 | A | 27-266 | [»] | |
1EAU | X-ray | 2.00 | A | 27-266 | [»] | |
1ELA | X-ray | 2.00 | A | 27-266 | [»] | |
1ELB | X-ray | 2.10 | A | 27-266 | [»] | |
1ELC | X-ray | 1.75 | A | 27-266 | [»] | |
1ELD | X-ray | 2.00 | E | 27-266 | [»] | |
1ELE | X-ray | 2.00 | E | 27-266 | [»] | |
1ELF | X-ray | 1.70 | A | 27-266 | [»] | |
1ELG | X-ray | 1.65 | A | 27-266 | [»] | |
1ESA | X-ray | 1.65 | A | 27-266 | [»] | |
1ESB | X-ray | 2.30 | A | 27-266 | [»] | |
1EST | X-ray | 2.50 | A | 27-266 | [»] | |
1FLE | X-ray | 1.90 | E | 27-266 | [»] | |
1FZZ | X-ray | 1.86 | A | 27-266 | [»] | |
1GVK | X-ray | 0.94 | B | 27-266 | [»] | |
1GWA | X-ray | 1.85 | A | 27-266 | [»] | |
1H9L | X-ray | 1.67 | B | 27-266 | [»] | |
1HAX | X-ray | 1.60 | B | 27-266 | [»] | |
1HAY | X-ray | 1.70 | B | 27-266 | [»] | |
1HAZ | X-ray | 1.40 | B | 27-266 | [»] | |
1HB0 | X-ray | 2.05 | B | 27-266 | [»] | |
1HV7 | X-ray | 1.70 | A | 27-266 | [»] | |
1INC | X-ray | 1.94 | A | 27-266 | [»] | |
1JIM | X-ray | 2.31 | A | 27-266 | [»] | |
1L0Z | X-ray | 1.50 | A | 27-266 | [»] | |
1L1G | X-ray | 1.50 | A | 27-266 | [»] | |
1LKA | X-ray | 1.70 | A | 27-266 | [»] | |
1LKB | X-ray | 1.70 | A | 27-266 | [»] | |
1LVY | X-ray | 1.87 | A | 27-266 | [»] | |
1MCV | X-ray | 1.80 | A | 27-266 | [»] | |
1MMJ | X-ray | 2.20 | N | 27-266 | [»] | |
1NES | X-ray | 1.65 | E | 27-266 | [»] | |
1OKX | X-ray | 2.80 | A/B | 27-266 | [»] | |
1QGF | X-ray | 1.70 | A | 27-266 | [»] | |
1QIX | X-ray | 1.90 | B | 27-266 | [»] | |
1QNJ | X-ray | 1.10 | A | 27-266 | [»] | |
1QR3 | X-ray | 1.60 | E | 27-266 | [»] | |
1UO6 | X-ray | 1.65 | A | 27-266 | [»] | |
1UVO | X-ray | 1.85 | A | 27-266 | [»] | |
1UVP | X-ray | 1.85 | A | 27-266 | [»] | |
2A7C | X-ray | 1.65 | A | 27-266 | [»] | |
2A7J | X-ray | 1.65 | A | 27-266 | [»] | |
2BB4 | X-ray | 1.60 | A | 27-266 | [»] | |
2BD2 | X-ray | 1.70 | A | 27-266 | [»] | |
2BD3 | X-ray | 1.60 | A | 27-266 | [»] | |
2BD4 | X-ray | 1.70 | A | 27-266 | [»] | |
2BD5 | X-ray | 1.80 | A | 27-266 | [»] | |
2BD7 | X-ray | 1.60 | A | 27-266 | [»] | |
2BD8 | X-ray | 1.70 | A | 27-266 | [»] | |
2BD9 | X-ray | 1.90 | A | 27-266 | [»] | |
2BDA | X-ray | 1.80 | A | 27-266 | [»] | |
2BDB | X-ray | 1.70 | A | 27-266 | [»] | |
2BDC | X-ray | 1.80 | A | 27-266 | [»] | |
2BLO | X-ray | 1.33 | A | 27-266 | [»] | |
2BLQ | X-ray | 1.33 | A | 27-266 | [»] | |
2CV3 | X-ray | 1.90 | A | 27-266 | [»] | |
2D26 | X-ray | 3.30 | C | 27-266 | [»] | |
2DE8 | X-ray | 1.50 | A | 27-266 | [»] | |
2DE9 | X-ray | 1.30 | A | 27-266 | [»] | |
2EST | X-ray | 2.50 | E | 27-266 | [»] | |
2FO9 | X-ray | 2.00 | A | 27-266 | [»] | |
2FOA | X-ray | 1.90 | A | 27-266 | [»] | |
2FOB | X-ray | 1.90 | A | 27-266 | [»] | |
2FOC | X-ray | 2.00 | A | 27-266 | [»] | |
2FOD | X-ray | 2.00 | A | 27-266 | [»] | |
2FOE | X-ray | 2.20 | A | 27-266 | [»] | |
2FOF | X-ray | 2.20 | A | 27-266 | [»] | |
2FOG | X-ray | 1.90 | A | 27-266 | [»] | |
2FOH | X-ray | 1.80 | A | 27-266 | [»] | |
2G4T | X-ray | 2.15 | A | 27-266 | [»] | |
2G4U | X-ray | 1.84 | A | 27-266 | [»] | |
2H1U | X-ray | 1.60 | A | 27-266 | [»] | |
2IOT | X-ray | 1.60 | A | 27-266 | [»] | |
2OQU | X-ray | 1.80 | A | 27-266 | [»] | |
2V0B | X-ray | 1.65 | A | 27-266 | [»] | |
2V35 | X-ray | 1.67 | A | 27-266 | [»] | |
3E3T | X-ray | 1.60 | A | 27-266 | [»] | |
3EST | X-ray | 1.65 | A | 27-266 | [»] | |
3HGN | Other | 1.65 | A | 27-266 | [»] | |
3HGP | X-ray | 0.94 | A | 27-266 | [»] | |
3MNB | X-ray | 1.20 | A | 27-266 | [»] | |
3MNC | X-ray | 1.12 | A | 27-266 | [»] | |
3MNS | X-ray | 1.50 | A | 27-266 | [»] | |
3MNX | X-ray | 1.39 | A | 27-266 | [»] | |
3MO3 | X-ray | 1.80 | A | 27-266 | [»] | |
3MO6 | X-ray | 1.66 | A | 27-266 | [»] | |
3MO9 | X-ray | 2.00 | A | 27-266 | [»] | |
3MOC | X-ray | 1.82 | A | 27-266 | [»] | |
3MTY | X-ray | 1.10 | A | 27-266 | [»] | |
3MU0 | X-ray | 1.40 | A | 27-266 | [»] | |
3MU1 | X-ray | 1.74 | A | 27-266 | [»] | |
3MU4 | X-ray | 1.10 | A | 27-266 | [»] | |
3MU5 | X-ray | 1.40 | A | 27-266 | [»] | |
3MU8 | X-ray | 1.55 | A | 27-266 | [»] | |
3ODD | X-ray | 1.10 | A | 27-266 | [»] | |
3ODF | X-ray | 1.10 | A | 27-266 | [»] | |
3UOU | X-ray | 2.00 | A | 27-266 | [»] | |
4EST | X-ray | 1.78 | E | 27-266 | [»] | |
4GVU | X-ray | 1.55 | A | 27-266 | [»] | |
4YM9 | X-ray | 1.80 | A | 27-266 | [»] | |
5AVD | X-ray | 0.86 | A | 27-266 | [»] | |
5EST | X-ray | 2.09 | E | 27-266 | [»] | |
6EST | X-ray | 1.80 | A | 27-266 | [»] | |
6Q8S | X-ray | 1.80 | A | 27-266 | [»] | |
6QBU | X-ray | 1.38 | A | 27-266 | [»] | |
6QEN | X-ray | 1.20 | A | 27-266 | [»] | |
6QEO | X-ray | 1.30 | A | 27-266 | [»] | |
6TH7 | X-ray | 2.20 | A/B | 27-266 | [»] | |
7EST | X-ray | 1.80 | E | 27-266 | [»] | |
8EST | X-ray | 1.78 | E | 27-266 | [»] | |
9EST | X-ray | 1.90 | A | 27-266 | [»] | |
AlphaFoldDBi | P00772 | |||||
PCDDBi | P00772 | |||||
SMRi | P00772 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 1148920, 1 interactor |
DIPi | DIP-378N |
IntActi | P00772, 1 interactor |
MINTi | P00772 |
STRINGi | 9823.ENSSSCP00000026330 |
Chemistry databases
BindingDBi | P00772 |
ChEMBLi | CHEMBL3517 |
Protein family/group databases
MEROPSi | S01.153 |
Proteomic databases
PaxDbi | P00772 |
Genome annotation databases
Organism-specific databases
CTDi | 1990 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
HOGENOMi | CLU_006842_0_4_1 |
InParanoidi | P00772 |
OrthoDBi | 1314811at2759 |
TreeFami | TF330455 |
Enzyme and pathway databases
BRENDAi | 3.4.21.36, 6170 |
Miscellaneous databases
EvolutionaryTracei | P00772 |
PROi | PR:P00772 |
Gene expression databases
Bgeei | ENSSSCG00000029782, Expressed in oocyte and 13 other tissues |
Genevisiblei | P00772, SS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CELA1_PIG | |
Accessioni | P00772Primary (citable) accession number: P00772 Secondary accession number(s): Q29625 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families