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Protein

Chymotrypsin-2

Gene
N/A
Organism
Vespa orientalis (Oriental hornet)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39Charge relay system1 Publication1
Active sitei82Charge relay system1 Publication1
Active sitei173Charge relay system1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin II
OrganismiVespa orientalis (Oriental hornet)
Taxonomic identifieri7447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000886771 – 216Chymotrypsin-2Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 40PROSITE-ProRule annotation1 Publication
Disulfide bondi146 ↔ 159PROSITE-ProRule annotation1 Publication
Disulfide bondi169 ↔ 193PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP00768

Structurei

3D structure databases

ProteinModelPortaliP00768
SMRiP00768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 216Peptidase S1PROSITE-ProRule annotationAdd BLAST216

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P00768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IVGGTNAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSEHQVT
60 70 80 90 100
VGSVLLNKEE AVYNAKELIV NKNYNSIRLI NDIGLIRVSK DISFTQLVQP
110 120 130 140 150
VKLPVSNTIK AGDPVVLTGW GRIYVNGPIP NNLQQITLSI VNQQTCKSKH
160 170 180 190 200
WGLTDSQICT FTKRGEGACH GDSGGPLVAN GVQIGIVSYG HPCAIGSPNV
210
FTRVYSFLDW IQKNQL
Length:216
Mass (Da):23,471
Last modified:July 21, 1986 - v1
Checksum:iF235BF992AEFEDE1
GO

Sequence databases

PIRiA00954 KYVH2O

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA00954 KYVH2O

3D structure databases

ProteinModelPortaliP00768
SMRiP00768
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.438

Proteomic databases

PRIDEiP00768

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTR2_VESOR
AccessioniPrimary (citable) accession number: P00768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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