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Protein

Cationic trypsin

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay system1
Metal bindingi75Calcium1
Metal bindingi77Calcium; via carbonyl oxygen1
Metal bindingi80Calcium; via carbonyl oxygen1
Metal bindingi85Calcium1
Active sitei107Charge relay system1
Active sitei200Charge relay system1
Binding sitei200Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.4 908
SABIO-RKiP00760

Protein family/group databases

MEROPSiS01.151

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin (EC:3.4.21.4)
Alternative name(s):
Beta-trypsin
Cleaved into the following 2 chains:
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000002818518 – 23Activation peptide6
ChainiPRO_000002818624 – 246Cationic trypsinAdd BLAST223
ChainiPRO_000002818724 – 148Alpha-trypsin chain 1Add BLAST125
ChainiPRO_0000028188149 – 246Alpha-trypsin chain 2Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 160
Disulfide bondi48 ↔ 64
Disulfide bondi132 ↔ 233
Disulfide bondi139 ↔ 206
Disulfide bondi171 ↔ 185
Disulfide bondi196 ↔ 220

Post-translational modificationi

Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.
Not sulfated on tyrosine residue(s).

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP00760
PeptideAtlasiP00760
PRIDEiP00760

Miscellaneous databases

PMAP-CutDBiP00760

Expressioni

Tissue specificityi

Synthesized in the acinar cells of the pancreas.

Gene expression databases

BgeeiENSBTAG00000003633 Expressed in 1 organ(s), highest expression level in liver

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi542655, 1 interactor
IntActiP00760, 5 interactors
MINTiP00760
STRINGi9913.ENSBTAP00000033392

Chemistry databases

BindingDBiP00760

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00728
ProteinModelPortaliP00760
SMRiP00760
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00760

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 244Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 195Substrate binding2
Regioni197 – 198Substrate binding2

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP00760
KOiK01312
OMAiTRAGQFC
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG
60 70 80 90 100
SLINSQWVVS AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN
110 120 130 140 150
SNTLNNDIML IKLKSAASLN SRVASISLPT SCASAGTQCL ISGWGNTKSS
160 170 180 190 200
GTSYPDVLKC LKAPILSDSS CKSAYPGQIT SNMFCAGYLE GGKDSCQGDS
210 220 230 240
GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK QTIASN
Length:246
Mass (Da):25,785
Last modified:September 2, 2008 - v3
Checksum:i092E3D8ACCCCC4D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA Translation: AAI34798.1
BC146041 mRNA Translation: AAI46042.1
D38507 mRNA Translation: BAA07516.1
PIRiA90164 TRBOTR
RefSeqiNP_001107199.1, NM_001113727.1
XP_002687054.3, XM_002687008.5
XP_871686.4, XM_866593.7
UniGeneiBt.91423

Genome annotation databases

EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245
GeneIDi615026
780933
KEGGibta:615026
bta:780933

Similar proteinsi

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA Translation: AAI34798.1
BC146041 mRNA Translation: AAI46042.1
D38507 mRNA Translation: BAA07516.1
PIRiA90164 TRBOTR
RefSeqiNP_001107199.1, NM_001113727.1
XP_002687054.3, XM_002687008.5
XP_871686.4, XM_866593.7
UniGeneiBt.91423

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQ7X-ray2.20A24-246[»]
1AUJX-ray2.10A24-246[»]
1AZ8X-ray1.80A24-246[»]
1BJUX-ray1.80A24-246[»]
1BJVX-ray1.80A24-246[»]
1BTPX-ray2.20A18-246[»]
1BTWX-ray1.70A18-246[»]
1BTXX-ray1.70A18-246[»]
1BTYX-ray1.50A18-246[»]
1BTZX-ray2.00A18-246[»]
1C1NX-ray1.40A24-246[»]
1C1OX-ray1.40A24-246[»]
1C1PX-ray1.37A24-246[»]
1C1QX-ray1.37A24-246[»]
1C1RX-ray1.37A24-246[»]
1C1SX-ray1.63A24-246[»]
1C1TX-ray1.37A24-246[»]
1C2DX-ray1.65A24-246[»]
1C2EX-ray1.65A24-246[»]
1C2FX-ray1.70A24-246[»]
1C2GX-ray1.65A24-246[»]
1C2HX-ray1.40A24-246[»]
1C2IX-ray1.47A24-246[»]
1C2JX-ray1.40A24-246[»]
1C2KX-ray1.65A24-246[»]
1C2LX-ray1.50A24-246[»]
1C2MX-ray1.40A24-246[»]
1C5PX-ray1.43A24-246[»]
1C5QX-ray1.43A24-246[»]
1C5RX-ray1.47A24-246[»]
1C5SX-ray1.36A24-246[»]
1C5TX-ray1.37A24-246[»]
1C5UX-ray1.37A24-246[»]
1C5VX-ray1.48A24-246[»]
1C9TX-ray3.30A/B/C/D/E/F24-246[»]
1CE5X-ray1.90A24-246[»]
1CU7model-A24-246[»]
1CU8model-A24-246[»]
1CU9model-A24-246[»]
1D6RX-ray2.30A24-246[»]
1EB2X-ray2.00A24-246[»]
1EJMX-ray1.85A/C/E24-246[»]
1EZXX-ray2.60C4-246[»]
1F0TX-ray1.80A4-246[»]
1F0UX-ray1.90A4-246[»]
1F2SX-ray1.79E24-246[»]
1G36X-ray1.90A24-246[»]
1G3BX-ray1.80A19-246[»]
1G3CX-ray1.80A19-246[»]
1G3DX-ray1.80A19-246[»]
1G3EX-ray1.80A19-246[»]
1G9IX-ray2.20E24-246[»]
1GBTX-ray2.00A24-246[»]
1GHZX-ray1.39A24-246[»]
1GI0X-ray1.42A24-246[»]
1GI1X-ray1.42A24-246[»]
1GI2X-ray1.38A24-246[»]
1GI3X-ray1.44A24-246[»]
1GI4X-ray1.37A24-246[»]
1GI5X-ray1.60A24-246[»]
1GI6X-ray1.49A24-246[»]
1GJ6X-ray1.50A24-246[»]
1HJ9X-ray0.95A24-246[»]
1J8AX-ray1.21A24-246[»]
1JIRX-ray2.00A24-246[»]
1JRSX-ray1.80A24-246[»]
1JRTX-ray1.70A24-246[»]
1K1IX-ray2.20A24-246[»]
1K1JX-ray2.20A24-246[»]
1K1LX-ray2.50A24-246[»]
1K1MX-ray2.20A24-246[»]
1K1NX-ray2.00A24-246[»]
1K1OX-ray2.00A24-246[»]
1K1PX-ray1.90A24-246[»]
1LQEX-ray2.20A4-246[»]
1MAXX-ray1.80A24-246[»]
1MAYX-ray1.80A24-246[»]
1MTSX-ray1.90A24-246[»]
1MTUX-ray1.90A24-246[»]
1MTVX-ray1.90A24-246[»]
1MTWX-ray1.90A24-246[»]
1N6XX-ray1.40A24-246[»]
1N6YX-ray1.40A24-246[»]
1NC6X-ray1.90A24-246[»]
1NTPneutron diffraction1.80A24-246[»]
1O2HX-ray1.77A24-246[»]
1O2IX-ray1.50A24-246[»]
1O2JX-ray1.65A24-246[»]
1O2KX-ray1.63A24-246[»]
1O2LX-ray1.68A24-246[»]
1O2MX-ray1.69A24-246[»]
1O2NX-ray1.50A24-246[»]
1O2OX-ray1.63A24-246[»]
1O2PX-ray1.47A24-246[»]
1O2QX-ray1.50A24-246[»]
1O2RX-ray1.45A24-246[»]
1O2SX-ray1.65A24-246[»]
1O2TX-ray1.62A24-246[»]
1O2UX-ray1.41A24-246[»]
1O2VX-ray1.50A24-246[»]
1O2WX-ray1.38A24-246[»]
1O2XX-ray1.46A24-246[»]
1O2YX-ray1.45A24-246[»]
1O2ZX-ray1.65A24-246[»]
1O30X-ray1.55A24-246[»]
1O31X-ray1.66A24-246[»]
1O32X-ray1.78A24-246[»]
1O33X-ray1.46A24-246[»]
1O34X-ray1.50A24-246[»]
1O35X-ray1.41A24-246[»]
1O36X-ray1.70A24-246[»]
1O37X-ray1.45A24-246[»]
1O38X-ray1.38A24-246[»]
1O39X-ray1.59A24-246[»]
1O3AX-ray2.00A24-246[»]
1O3BX-ray1.75A24-246[»]
1O3CX-ray1.64A24-246[»]
1O3DX-ray1.33A24-246[»]
1O3EX-ray1.64A24-246[»]
1O3FX-ray1.55A24-246[»]
1O3GX-ray1.55A24-246[»]
1O3HX-ray1.53A24-246[»]
1O3IX-ray1.51A24-246[»]
1O3JX-ray1.40A24-246[»]
1O3KX-ray1.43A24-246[»]
1O3LX-ray1.40A24-246[»]
1O3MX-ray1.55A24-246[»]
1O3NX-ray1.55A24-246[»]
1O3OX-ray1.55A24-246[»]
1OPHX-ray2.30B4-246[»]
1OX1X-ray2.00A24-246[»]
1OYQX-ray1.90A24-246[»]
1P2IX-ray1.65A24-246[»]
1P2JX-ray1.35A24-246[»]
1P2KX-ray1.60A24-246[»]
1PPCX-ray1.80E24-246[»]
1PPEX-ray2.00E24-246[»]
1PPHX-ray1.90E24-246[»]
1QA0X-ray1.80A24-246[»]
1QB1X-ray1.80A24-246[»]
1QB6X-ray1.80A24-246[»]
1QB9X-ray1.80A24-246[»]
1QBNX-ray1.80A24-246[»]
1QBOX-ray1.80A24-246[»]
1QCPX-ray1.80A24-246[»]
1QL7X-ray2.10A24-246[»]
1QL8X-ray3.00A24-246[»]
1RXPX-ray1.70A24-246[»]
1S0QX-ray1.02A24-246[»]
1S0RX-ray1.02A24-246[»]
1SBWX-ray1.80A24-246[»]
1SFIX-ray1.65A24-246[»]
1SMFX-ray2.10E24-246[»]
1TABX-ray2.30E24-246[»]
1TAWX-ray1.80A24-246[»]
1TGBX-ray1.80A18-246[»]
1TGCX-ray1.80A18-246[»]
1TGNX-ray1.65A18-246[»]
1TGSX-ray1.80Z18-246[»]
1TGTX-ray1.70A18-246[»]
1TIOX-ray1.93A24-246[»]
1TLDX-ray1.50A24-246[»]
1TNGX-ray1.80A18-246[»]
1TNHX-ray1.80A18-246[»]
1TNIX-ray1.90A18-246[»]
1TNJX-ray1.80A18-246[»]
1TNKX-ray1.80A18-246[»]
1TNLX-ray1.90A18-246[»]
1TPAX-ray1.90E24-246[»]
1TPOX-ray1.70A24-246[»]
1TPPX-ray1.40A24-246[»]
1TPSX-ray1.90A24-246[»]
1TX7X-ray1.75A24-246[»]
1TX8X-ray1.70A24-246[»]
1TYNX-ray2.00A24-246[»]
1UTNX-ray1.15A4-246[»]
1UTOX-ray1.15A4-246[»]
1UTPX-ray1.30A4-246[»]
1UTQX-ray1.15A4-246[»]
1V2JX-ray1.90T24-246[»]
1V2KX-ray2.00T24-246[»]
1V2LX-ray1.60T24-246[»]
1V2MX-ray1.65T24-246[»]
1V2NX-ray1.80T24-246[»]
1V2OX-ray1.62T24-246[»]
1V2PX-ray1.92T24-246[»]
1V2QX-ray2.30T24-246[»]
1V2RX-ray1.70T24-246[»]
1V2SX-ray1.72T24-246[»]
1V2TX-ray1.90T24-246[»]
1V2UX-ray1.80T24-246[»]
1V2VX-ray1.80T24-246[»]
1V2WX-ray1.75T24-246[»]
1XUFX-ray1.90A24-246[»]
1XUGX-ray1.50A24-246[»]
1XUHX-ray2.20A24-246[»]
1XUIX-ray1.50A24-246[»]
1XUJX-ray1.92A24-246[»]
1XUKX-ray1.80A24-246[»]
1Y3UX-ray1.80A24-246[»]
1Y3VX-ray1.60A24-246[»]
1Y3WX-ray1.80A24-246[»]
1Y3XX-ray1.70A24-246[»]
1Y3YX-ray1.75A24-246[»]
1Y59X-ray1.20T24-246[»]
1Y5AX-ray1.40T24-246[»]
1Y5BX-ray1.65T24-246[»]
1Y5UX-ray1.60T24-246[»]
1YP9X-ray2.10A24-246[»]
1YYYX-ray2.10124-246[»]
1ZR0X-ray1.80A/C24-246[»]
1ZZZX-ray1.90A10-246[»]
2A7HX-ray2.10A24-246[»]
2AGEX-ray1.15X24-246[»]
2AGGX-ray1.28X24-246[»]
2AGIX-ray1.14X24-246[»]
2AH4X-ray1.13X24-246[»]
2AYWX-ray0.97A24-246[»]
2BLVX-ray1.20A24-246[»]
2BLWX-ray1.20A24-246[»]
2BTCX-ray1.50E24-246[»]
2BY5X-ray1.30X4-246[»]
2BY6X-ray1.30X4-246[»]
2BY7X-ray1.30X4-246[»]
2BY8X-ray1.30X4-246[»]
2BY9X-ray1.30X4-246[»]
2BYAX-ray1.30X4-246[»]
2BZAX-ray1.90A24-246[»]
2CMYX-ray2.25A24-246[»]
2D8WX-ray2.00A24-246[»]
2F3CX-ray2.50E24-246[»]
2FI3X-ray1.58E24-246[»]
2FI4X-ray1.58E24-246[»]
2FI5X-ray1.58E24-246[»]
2FTLX-ray1.62E24-246[»]
2FTMX-ray1.65A24-246[»]
2FX4X-ray1.65A24-246[»]
2FX6X-ray1.57A24-246[»]
2G55X-ray1.82A24-246[»]
2G5NX-ray1.51A24-246[»]
2G5VX-ray1.45A24-246[»]
2G81X-ray1.55E24-246[»]
2G8TX-ray1.41A24-246[»]
2ILNX-ray2.00A/B24-246[»]
2J9NX-ray1.50A24-246[»]
2O9QX-ray1.70A24-246[»]
2OTVX-ray1.56A24-246[»]
2OXSX-ray1.32A24-246[»]
2PLXX-ray1.56A24-246[»]
2PTCX-ray1.90E24-246[»]
2PTNX-ray1.55A24-246[»]
2QN5X-ray3.00T24-246[»]
2QYIX-ray2.60A/C24-246[»]
2TGAX-ray1.80A18-246[»]
2TGDX-ray2.10A18-246[»]
2TGPX-ray1.90Z18-246[»]
2TGTX-ray1.70A18-246[»]
2TIOX-ray1.93A24-246[»]
2TLDX-ray2.60E24-246[»]
2TPIX-ray2.10Z18-246[»]
2UUYX-ray1.15A24-246[»]
2XTTX-ray0.93B24-246[»]
2ZDKX-ray1.67A24-246[»]
2ZDLX-ray1.80A24-246[»]
2ZDMX-ray1.93A24-246[»]
2ZDNX-ray1.98A24-246[»]
2ZFSX-ray1.51A24-246[»]
2ZFTX-ray1.76A24-246[»]
2ZHDX-ray1.94A24-246[»]
2ZQ1X-ray1.68A24-246[»]
2ZQ2X-ray1.40A24-246[»]
3A7TX-ray1.75A24-246[»]
3A7VX-ray1.75A24-246[»]
3A7WX-ray1.75A24-246[»]
3A7XX-ray1.75A24-246[»]
3A7YX-ray1.81A24-246[»]
3A7ZX-ray1.80A24-246[»]
3A80X-ray1.75A24-246[»]
3A81X-ray1.78A24-246[»]
3A82X-ray1.75A24-246[»]
3A83X-ray1.78A24-246[»]
3A84X-ray1.75A24-246[»]
3A85X-ray1.75A24-246[»]
3A86X-ray1.75A24-246[»]
3A87X-ray1.75A24-246[»]
3A88X-ray1.75A24-246[»]
3A89X-ray1.80A24-246[»]
3A8AX-ray1.40A24-246[»]
3A8BX-ray1.75A24-246[»]
3A8CX-ray1.85A24-246[»]
3A8DX-ray1.75A24-246[»]
3AASX-ray1.75A24-246[»]
3AAUX-ray1.80A24-246[»]
3AAVX-ray1.70A/B24-246[»]
3ATIX-ray1.71A24-246[»]
3ATKX-ray1.74A24-246[»]
3ATLX-ray1.74A24-246[»]
3ATMX-ray1.72A24-246[»]
3BTDX-ray1.90E24-246[»]
3BTEX-ray1.85E24-246[»]
3BTFX-ray1.80E24-246[»]
3BTGX-ray1.90E24-246[»]
3BTHX-ray1.75E24-246[»]
3BTKX-ray1.85E24-246[»]
3BTMX-ray1.80E24-246[»]
3BTQX-ray1.90E24-246[»]
3BTTX-ray1.90E24-246[»]
3BTWX-ray2.05E24-246[»]
3D65X-ray1.64E24-246[»]
3E8LX-ray2.48A/B24-246[»]
3GY2X-ray1.57A24-246[»]
3GY3X-ray1.70A24-246[»]
3GY4X-ray1.55A24-246[»]
3GY5X-ray1.57A24-246[»]
3GY6X-ray1.70A24-246[»]
3GY7X-ray1.55A24-246[»]
3GY8X-ray1.75A24-246[»]
3I29X-ray2.40A24-246[»]
3ITIX-ray1.55A24-246[»]
3LJJX-ray1.55A24-246[»]
3LJOX-ray1.50A24-246[»]
3M35X-ray2.20A24-246[»]
3M7QX-ray1.70A24-246[»]
3MFJX-ray0.80A24-246[»]
3MI4X-ray0.80A24-246[»]
3NK8X-ray1.15A24-246[»]
3NKKX-ray1.12A24-246[»]
3OTJOther2.15E24-246[»]
3PLBX-ray1.18A24-246[»]
3PLKX-ray1.53A24-246[»]
3PLPX-ray1.63A24-246[»]
3PM3X-ray1.53A24-246[»]
3PMJX-ray1.45A24-246[»]
3PTBX-ray1.70A24-246[»]
3PTNX-ray1.70A24-246[»]
3PWBX-ray1.63A24-246[»]
3PWCX-ray1.60A24-246[»]
3PYHX-ray2.00A24-246[»]
3Q00X-ray1.70A24-246[»]
3QK1X-ray2.08A24-246[»]
3RDZX-ray2.26A/B24-246[»]
3RU4X-ray1.68T24-246[»]
3RXAX-ray1.70A24-246[»]
3RXBX-ray1.70A24-246[»]
3RXCX-ray1.70A24-246[»]
3RXDX-ray1.70A24-246[»]
3RXEX-ray1.70A24-246[»]
3RXFX-ray1.70A24-246[»]
3RXGX-ray1.70A24-246[»]
3RXHX-ray1.70A24-246[»]
3RXIX-ray1.60A24-246[»]
3RXJX-ray1.70A24-246[»]
3RXKX-ray1.60A24-246[»]
3RXLX-ray1.70A24-246[»]
3RXMX-ray1.70A24-246[»]
3RXOX-ray1.60A24-246[»]
3RXPX-ray1.60A24-246[»]
3RXQX-ray1.68A24-246[»]
3RXRX-ray1.72A24-246[»]
3RXSX-ray1.74A24-246[»]
3RXTX-ray1.70A24-246[»]
3RXUX-ray1.68A24-246[»]
3RXVX-ray1.70A24-246[»]
3T25X-ray1.70A24-246[»]
3T26X-ray1.70A24-246[»]
3T27X-ray1.95A24-246[»]
3T28X-ray2.80A24-246[»]
3T29X-ray1.75A24-246[»]
3TPIX-ray1.90Z18-246[»]
3UNQX-ray1.62A24-246[»]
3UNRX-ray1.20A24-246[»]
3UNSX-ray1.80A24-246[»]
3UOPX-ray1.69A24-246[»]
3UPEX-ray1.54A24-246[»]
3UQOX-ray1.80A24-246[»]
3UQVX-ray2.40A24-246[»]
3UUZX-ray2.10A/B24-246[»]
3UWIX-ray1.43A24-246[»]
3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
3V0XX-ray1.90A24-246[»]
3V12X-ray1.80A24-246[»]
3V13X-ray1.63A24-246[»]
3VEQX-ray2.25B24-246[»]
3VPKX-ray1.94A24-246[»]
4AB8X-ray1.60A24-246[»]
4AB9X-ray1.20A24-246[»]
4ABAX-ray1.25A24-246[»]
4ABBX-ray1.25A24-246[»]
4ABDX-ray1.25A24-246[»]
4ABEX-ray1.30A24-246[»]
4ABFX-ray1.30A24-246[»]
4ABGX-ray1.52A24-246[»]
4ABHX-ray1.25A24-246[»]
4ABIX-ray1.55A24-246[»]
4ABJX-ray1.45A24-246[»]
4AOQX-ray2.00A/B/C24-246[»]
4AORX-ray1.70A/B/C24-246[»]
4B1TX-ray1.78A/C24-246[»]
4B2AX-ray1.89A/C24-246[»]
4B2BX-ray1.36A/C24-246[»]
4B2CX-ray1.43A/C24-246[»]
4GUXX-ray1.80A/B/C1-246[»]
4HGCX-ray1.29A24-246[»]
4I8GX-ray0.80A24-246[»]
4I8HX-ray0.75A24-246[»]
4I8JX-ray0.87A24-246[»]
4I8KX-ray0.85A24-246[»]
4I8LX-ray0.87A24-246[»]
4J2YX-ray2.00B24-246[»]
4KTSX-ray1.30A24-246[»]
4KTUX-ray1.35A24-246[»]
4MTBX-ray1.22A24-246[»]
4NCYX-ray1.42A24-246[»]
4NIVX-ray1.00A24-246[»]
4NIWX-ray1.31A24-246[»]
4NIXX-ray1.30A24-246[»]
4NIYX-ray2.84A/B/C/D24-246[»]
4TPIX-ray2.20Z18-246[»]
4TPYX-ray1.30A24-246[»]
4U2WX-ray1.00A24-246[»]
4XOJX-ray0.91A1-246[»]
4Y0YX-ray1.25E24-246[»]
4Y0ZX-ray1.37E24-246[»]
4Y10X-ray1.37E24-246[»]
4Y11X-ray1.30E24-246[»]
4YTAX-ray1.20A24-246[»]
5EG4X-ray1.32A24-246[»]
5F6MX-ray1.10A24-246[»]
5FXLX-ray1.78A1-246[»]
5GIBX-ray2.70A/B24-246[»]
5GXPX-ray2.80A/B24-246[»]
5JYIX-ray1.91A1-246[»]
5K7Relectron microscopy1.70A24-246[»]
5LGOX-ray1.12A24-246[»]
5LH4X-ray1.37A24-246[»]
5LH8X-ray1.54A24-246[»]
5MN1X-ray0.79A24-246[»]
5MNAX-ray1.44A24-246[»]
5MNBX-ray0.94A24-246[»]
5MNCX-ray0.92A24-246[»]
5MNEX-ray1.01A24-246[»]
5MNFX-ray0.99A24-246[»]
5MNGX-ray0.86A24-246[»]
5MNHX-ray0.93A24-246[»]
5MNKX-ray0.80A24-246[»]
5MNLX-ray1.04A24-246[»]
5MNMX-ray0.98A24-246[»]
5MNNX-ray0.86A24-246[»]
5MNOX-ray0.96A24-246[»]
5MNPX-ray1.01A24-246[»]
5MNQX-ray1.34A24-246[»]
5MNXneutron diffraction1.42A24-246[»]
5MNYneutron diffraction1.43A24-246[»]
5MNZneutron diffraction1.45A24-246[»]
5MO0neutron diffraction1.50A24-246[»]
5MO1neutron diffraction1.49A24-246[»]
5MO2neutron diffraction1.50A24-246[»]
5MONOther0.94A24-246[»]
5MOOOther1.44A24-246[»]
5MOPOther0.99A24-246[»]
5MOQOther0.93A24-246[»]
5MOROther0.98A24-246[»]
5MOSOther0.96A24-246[»]
5PTPX-ray1.34A24-246[»]
5T3HX-ray1.55A24-246[»]
6AVLX-ray2.00A24-246[»]
6B6NX-ray2.00A24-246[»]
6B6OX-ray2.40A24-246[»]
6B6PX-ray2.00A24-246[»]
6B6QX-ray2.00A24-246[»]
6B6RX-ray2.00A24-246[»]
6B6SX-ray2.00A24-246[»]
6B6TX-ray2.00A24-246[»]
6FIDX-ray2.20A24-246[»]
DisProtiDP00728
ProteinModelPortaliP00760
SMRiP00760
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi542655, 1 interactor
IntActiP00760, 5 interactors
MINTiP00760
STRINGi9913.ENSBTAP00000033392

Chemistry databases

BindingDBiP00760
ChEMBLiCHEMBL3769

Protein family/group databases

MEROPSiS01.151

Proteomic databases

PaxDbiP00760
PeptideAtlasiP00760
PRIDEiP00760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245
GeneIDi615026
780933
KEGGibta:615026
bta:780933

Organism-specific databases

CTDi5644

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP00760
KOiK01312
OMAiTRAGQFC
OrthoDBiEOG091G0DF7
TreeFamiTF331065

Enzyme and pathway databases

BRENDAi3.4.21.4 908
SABIO-RKiP00760

Miscellaneous databases

EvolutionaryTraceiP00760
PMAP-CutDBiP00760
PROiPR:P00760

Gene expression databases

BgeeiENSBTAG00000003633 Expressed in 1 organ(s), highest expression level in liver

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRY1_BOVIN
AccessioniPrimary (citable) accession number: P00760
Secondary accession number(s): A6H6Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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