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Protein

Complement factor B

Gene

CFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b. EC:3.4.21.47

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei526Charge relay system1
Active sitei576Charge relay system1
Active sitei699Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • complement binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.47 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-173736 Alternative complement activation
R-HSA-174577 Activation of C3 and C5
R-HSA-977606 Regulation of Complement cascade

SIGNOR Signaling Network Open Resource

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SIGNORi
P00751

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.196

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement factor B (EC:3.4.21.47)
Alternative name(s):
C3/C5 convertase
Glycine-rich beta glycoprotein
Short name:
GBG
PBF2
Properdin factor B
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFB
Synonyms:BF, BFD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000243649.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1037 CFB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138470 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00751

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hemolytic uremic syndrome atypical 4 (AHUS4)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Disease descriptionAn atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
See also OMIM:612924
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063659166S → P in AHUS4. 1 Publication1
Natural variantiVAR_063660203R → Q in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs745794224Ensembl.1
Natural variantiVAR_063661242I → L in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs144812066EnsemblClinVar.1
Natural variantiVAR_063221286F → L in AHUS4; gain-of-function mutation that results in enhanced formation of the C3bBb. 1 PublicationCorresponds to variant dbSNP:rs117905900EnsemblClinVar.1
Natural variantiVAR_063222323K → E in AHUS4; gain-of-function mutation that results in enhanced formation of the C3bBb. 1 PublicationCorresponds to variant dbSNP:rs121909748EnsemblClinVar.1
Natural variantiVAR_063662323K → Q in AHUS4. 1 Publication1
Natural variantiVAR_063663458M → I in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs200837114Ensembl.1
Natural variantiVAR_063664533K → R in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs149101394EnsemblClinVar.1
Complement factor B deficiency (CFBD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
See also OMIM:615561

Keywords - Diseasei

Disease mutation, Hemolytic uremic syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
629

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CFB

MalaCards human disease database

More...
MalaCardsi
CFB
MIMi603075 phenotype
612924 phenotype
615561 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000243649

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93578 Atypical hemolytic-uremic syndrome with B factor anomaly
279 NON RARE IN EUROPE: Age-related macular degeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25341

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5731

Drug and drug target database

More...
DrugBanki
DB02459 4-Guanidinobenzoic Acid
DB04491 Diisopropylphosphono Group

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2339

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CFB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
584908

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002754526 – 764Complement factor BAdd BLAST739
ChainiPRO_000002754626 – 259Complement factor B Ba fragmentAdd BLAST234
ChainiPRO_0000027547260 – 764Complement factor B Bb fragmentAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 761 Publication
Disulfide bondi62 ↔ 981 Publication
Disulfide bondi103 ↔ 1451 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi122N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi131 ↔ 1581 Publication
Glycosylationi142N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi165 ↔ 2051 Publication
Disulfide bondi191 ↔ 2181 Publication
Glycosylationi285N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi291N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi378N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi478 ↔ 5961 Publication
Disulfide bondi511 ↔ 5271 Publication
Disulfide bondi599 ↔ 6151 Publication
Disulfide bondi656 ↔ 6821 Publication
Disulfide bondi695 ↔ 7251 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycation, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P00751

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P00751

MaxQB - The MaxQuant DataBase

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MaxQBi
P00751

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00751

PeptideAtlas

More...
PeptideAtlasi
P00751

PRoteomics IDEntifications database

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PRIDEi
P00751

ProteomicsDB human proteome resource

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ProteomicsDBi
51285
51286 [P00751-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P00751

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
P00751

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P00751

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P00751

GlyConnect protein glycosylation platform

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GlyConnecti
753

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00751

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00751

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243649 Expressed in 199 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CFB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P00751 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P00751 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016381
HPA000951
HPA001817
HPA001832

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
C3P010243EBI-1223668,EBI-905851

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107098, 16 interactors

Database of interacting proteins

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DIPi
DIP-38319N

Protein interaction database and analysis system

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IntActi
P00751, 6 interactors

Molecular INTeraction database

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MINTi
P00751

STRING: functional protein association networks

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STRINGi
9606.ENSP00000416561

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P00751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DLEX-ray2.10A/B470-764[»]
1Q0PX-ray1.80A254-476[»]
1RRKX-ray2.00A268-764[»]
1RS0X-ray2.60A268-764[»]
1RTKX-ray2.30A268-764[»]
2OK5X-ray2.30A26-764[»]
2WINX-ray3.90I/J/K/L260-764[»]
2XWBX-ray3.49F/H35-764[»]
2XWJX-ray4.00I/J/K/L26-764[»]
3HRZX-ray2.20D26-764[»]
3HS0X-ray3.00D/I26-764[»]
5M6WX-ray6.00J/L260-764[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P00751

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00751

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P00751

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 100Sushi 1PROSITE-ProRule annotationAdd BLAST66
Domaini101 – 160Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini163 – 220Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini270 – 469VWFAPROSITE-ProRule annotationAdd BLAST200
Domaini477 – 757Peptidase S1PROSITE-ProRule annotationAdd BLAST281

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The unliganded VWA domain has an inactive 'locked' conformation whereby the scissile Arg-259|Lys-260 bond is protected from proteolytic activation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158605

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002567

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P00751

KEGG Orthology (KO)

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KOi
K01335

Database of Orthologous Groups

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OrthoDBi
172139at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P00751

TreeFam database of animal gene trees

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TreeFami
TF330194

Family and domain databases

Conserved Domains Database

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CDDi
cd00033 CCP, 3 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011360 Compl_C2_B
IPR028341 Complement_B
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR19325:SF394 PTHR19325:SF394, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 3 hits
PF00089 Trypsin, 1 hit
PF00092 VWA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001154 Compl_C2_B, 1 hit
PIRSF500181 Complement_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 3 hits
SM00020 Tryp_SPc, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF53300 SSF53300, 1 hit
SSF57535 SSF57535, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 3 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P00751-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR
60 70 80 90 100
LLQEGQALEY VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA
110 120 130 140 150
IHCPRPHDFE NGEYWPRSPY YNVSDEISFH CYDGYTLRGS ANRTCQVNGR
160 170 180 190 200
WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ YRLEDSVTYH CSRGLTLRGS
210 220 230 240 250
QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE TIEGVDAEDG
260 270 280 290 300
HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV
310 320 330 340 350
ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK
360 370 380 390 400
SGTNTKKALQ AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT
410 420 430 440 450
VIDEIRDLLY IGKDRKNPRE DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ
460 470 480 490 500
HVFKVKDMEN LEDVFYQMID ESQSLSLCGM VWEHRKGTDY HKQPWQAKIS
510 520 530 540 550
VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS VGGEKRDLEI
560 570 580 590 600
EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT
610 620 630 640 650
EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG
660 670 680 690 700
DKKGSCERDA QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG
710 720 730 740 750
GPLIVHKRSR FIQVGVISWG VVDVCKNQKR QKQVPAHARD FHINLFQVLP
760
WLKEKLQDED LGFL
Length:764
Mass (Da):85,533
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BB6C101CC6AC200
GO
Isoform 2 (identifier: P00751-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-621: GEKRDLEIEV...TTTCQQQKEE → KDATEGPGLH...LQEGRSGTWR
     622-764: Missing.

Show »
Length:621
Mass (Da):68,872
Checksum:i181713F2D4D9EC1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JH38A0A0G2JH38_HUMAN
Complement factor B
CFB
589Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRT3C9JRT3_HUMAN
Complement factor B
CFB
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5H1H7C5H1_HUMAN
Complement factor B
CFB
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C526H7C526_HUMAN
Complement factor B
CFB
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBL9F8WBL9_HUMAN
Complement factor B
CFB
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti297I → T AA sequence (PubMed:6342610).Curated1
Sequence conflicti300V → L in AAA36225 (PubMed:6546754).Curated1
Sequence conflicti328D → V in AAA36225 (PubMed:6546754).Curated1
Sequence conflicti356 – 357KK → EE in AAA36225 (PubMed:6546754).Curated2
Sequence conflicti537I → T in AAA36219 (PubMed:6957884).Curated1
Sequence conflicti764L → H in AAA36220 (PubMed:6957884).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two major variants, F and S, and 2 minor variants, as well as at least 14 very rare variants, have been identified. The variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD) [MIMi:603075]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0162749L → H2 PublicationsCorresponds to variant dbSNP:rs4151667EnsemblClinVar.1
Natural variantiVAR_00649328W → Q in allele FA; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_00649228W → R in allele S. 4 Publications1
Natural variantiVAR_00649432R → Q in allele S. 6 PublicationsCorresponds to variant dbSNP:rs641153EnsemblClinVar.1
Natural variantiVAR_01627532R → W4 PublicationsCorresponds to variant dbSNP:rs12614EnsemblClinVar.1
Natural variantiVAR_063659166S → P in AHUS4. 1 Publication1
Natural variantiVAR_063660203R → Q in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs745794224Ensembl.1
Natural variantiVAR_063661242I → L in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs144812066EnsemblClinVar.1
Natural variantiVAR_016276252G → S1 PublicationCorresponds to variant dbSNP:rs4151651EnsemblClinVar.1
Natural variantiVAR_063221286F → L in AHUS4; gain-of-function mutation that results in enhanced formation of the C3bBb. 1 PublicationCorresponds to variant dbSNP:rs117905900EnsemblClinVar.1
Natural variantiVAR_063222323K → E in AHUS4; gain-of-function mutation that results in enhanced formation of the C3bBb. 1 PublicationCorresponds to variant dbSNP:rs121909748EnsemblClinVar.1
Natural variantiVAR_063662323K → Q in AHUS4. 1 Publication1
Natural variantiVAR_063663458M → I in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs200837114Ensembl.1
Natural variantiVAR_063664533K → R in AHUS4. 1 PublicationCorresponds to variant dbSNP:rs149101394EnsemblClinVar.1
Natural variantiVAR_016277565K → E2 PublicationsCorresponds to variant dbSNP:rs4151659EnsemblClinVar.1
Natural variantiVAR_016278651D → E1 PublicationCorresponds to variant dbSNP:rs4151660Ensembl.1
Natural variantiVAR_006495736A → S in allele FA. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005380543 – 621GEKRD…QQKEE → KDATEGPGLHLCSPGNTSHF LQILHSTHPQCSPIPCTPDQ SGMGEDVKLGMTRGQRQEAA HKEVVPTLLLQEGRSGTWR in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_005381622 – 764Missing in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X72875 mRNA Translation: CAA51389.1
S67310 mRNA Translation: AAD13989.1
L15702 mRNA Translation: AAA16820.1
X00284 mRNA Translation: CAA25077.1
AF349679 mRNA Translation: AAK30167.1
AF019413 Genomic DNA Translation: AAB67977.1
AF551848 Genomic DNA Translation: AAN71991.1
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX005143 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AK223400 mRNA Translation: BAD97120.1
AL645922 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03550.1
BC004143 mRNA Translation: AAH04143.1
BC007990 mRNA Translation: AAH07990.1
K01566 mRNA Translation: AAA36225.2
J00125 Genomic DNA No translation available.
J00126 mRNA Translation: AAA36226.1
J00185 mRNA Translation: AAA36219.1 Sequence problems.
J00186 mRNA Translation: AAA36220.1
M15082 Genomic DNA Translation: AAA59625.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4729.1 [P00751-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S34075 BBHU

NCBI Reference Sequences

More...
RefSeqi
NP_001701.2, NM_001710.5 [P00751-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.69771

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399981; ENSP00000382862; ENSG00000241253
ENST00000417261; ENSP00000414889; ENSG00000239754 [P00751-1]
ENST00000419411; ENSP00000391902; ENSG00000242335 [P00751-1]
ENST00000419920; ENSP00000411474; ENSG00000241253
ENST00000424727; ENSP00000401719; ENSG00000243570 [P00751-1]
ENST00000425368; ENSP00000416561; ENSG00000243649 [P00751-1]
ENST00000426239; ENSP00000413351; ENSG00000242335 [P00751-1]
ENST00000427888; ENSP00000411515; ENSG00000239754 [P00751-1]
ENST00000433503; ENSP00000388352; ENSG00000241534 [P00751-1]
ENST00000436692; ENSP00000389604; ENSG00000243570 [P00751-1]
ENST00000455591; ENSP00000414341; ENSG00000241534 [P00751-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:629

UCSC genome browser

More...
UCSCi
uc003nyj.5 human [P00751-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72875 mRNA Translation: CAA51389.1
S67310 mRNA Translation: AAD13989.1
L15702 mRNA Translation: AAA16820.1
X00284 mRNA Translation: CAA25077.1
AF349679 mRNA Translation: AAK30167.1
AF019413 Genomic DNA Translation: AAB67977.1
AF551848 Genomic DNA Translation: AAN71991.1
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX005143 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AK223400 mRNA Translation: BAD97120.1
AL645922 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03550.1
BC004143 mRNA Translation: AAH04143.1
BC007990 mRNA Translation: AAH07990.1
K01566 mRNA Translation: AAA36225.2
J00125 Genomic DNA No translation available.
J00126 mRNA Translation: AAA36226.1
J00185 mRNA Translation: AAA36219.1 Sequence problems.
J00186 mRNA Translation: AAA36220.1
M15082 Genomic DNA Translation: AAA59625.1
CCDSiCCDS4729.1 [P00751-1]
PIRiS34075 BBHU
RefSeqiNP_001701.2, NM_001710.5 [P00751-1]
UniGeneiHs.69771

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DLEX-ray2.10A/B470-764[»]
1Q0PX-ray1.80A254-476[»]
1RRKX-ray2.00A268-764[»]
1RS0X-ray2.60A268-764[»]
1RTKX-ray2.30A268-764[»]
2OK5X-ray2.30A26-764[»]
2WINX-ray3.90I/J/K/L260-764[»]
2XWBX-ray3.49F/H35-764[»]
2XWJX-ray4.00I/J/K/L26-764[»]
3HRZX-ray2.20D26-764[»]
3HS0X-ray3.00D/I26-764[»]
5M6WX-ray6.00J/L260-764[»]
ProteinModelPortaliP00751
SMRiP00751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107098, 16 interactors
DIPiDIP-38319N
IntActiP00751, 6 interactors
MINTiP00751
STRINGi9606.ENSP00000416561

Chemistry databases

BindingDBiP00751
ChEMBLiCHEMBL5731
DrugBankiDB02459 4-Guanidinobenzoic Acid
DB04491 Diisopropylphosphono Group
GuidetoPHARMACOLOGYi2339

Protein family/group databases

MEROPSiS01.196

PTM databases

CarbonylDBiP00751
GlyConnecti753
iPTMnetiP00751
PhosphoSitePlusiP00751

Polymorphism and mutation databases

BioMutaiCFB
DMDMi584908

2D gel databases

DOSAC-COBS-2DPAGEiP00751
REPRODUCTION-2DPAGEiP00751
SWISS-2DPAGEiP00751

Proteomic databases

EPDiP00751
jPOSTiP00751
MaxQBiP00751
PaxDbiP00751
PeptideAtlasiP00751
PRIDEiP00751
ProteomicsDBi51285
51286 [P00751-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399981; ENSP00000382862; ENSG00000241253
ENST00000417261; ENSP00000414889; ENSG00000239754 [P00751-1]
ENST00000419411; ENSP00000391902; ENSG00000242335 [P00751-1]
ENST00000419920; ENSP00000411474; ENSG00000241253
ENST00000424727; ENSP00000401719; ENSG00000243570 [P00751-1]
ENST00000425368; ENSP00000416561; ENSG00000243649 [P00751-1]
ENST00000426239; ENSP00000413351; ENSG00000242335 [P00751-1]
ENST00000427888; ENSP00000411515; ENSG00000239754 [P00751-1]
ENST00000433503; ENSP00000388352; ENSG00000241534 [P00751-1]
ENST00000436692; ENSP00000389604; ENSG00000243570 [P00751-1]
ENST00000455591; ENSP00000414341; ENSG00000241534 [P00751-1]
GeneIDi629
KEGGihsa:629
UCSCiuc003nyj.5 human [P00751-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
629
DisGeNETi629
EuPathDBiHostDB:ENSG00000243649.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CFB
GeneReviewsiCFB

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0038706
HGNCiHGNC:1037 CFB
HPAiCAB016381
HPA000951
HPA001817
HPA001832
MalaCardsiCFB
MIMi138470 gene
603075 phenotype
612924 phenotype
615561 phenotype
neXtProtiNX_P00751
OpenTargetsiENSG00000243649
Orphaneti93578 Atypical hemolytic-uremic syndrome with B factor anomaly
279 NON RARE IN EUROPE: Age-related macular degeneration
PharmGKBiPA25341

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000158605
HOVERGENiHBG002567
InParanoidiP00751
KOiK01335
OrthoDBi172139at2759
PhylomeDBiP00751
TreeFamiTF330194

Enzyme and pathway databases

BRENDAi3.4.21.47 2681
ReactomeiR-HSA-173736 Alternative complement activation
R-HSA-174577 Activation of C3 and C5
R-HSA-977606 Regulation of Complement cascade
SIGNORiP00751

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CFB human
EvolutionaryTraceiP00751

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Complement_factor_B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
629

Protein Ontology

More...
PROi
PR:P00751

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000243649 Expressed in 199 organ(s), highest expression level in right lobe of liver
CleanExiHS_CFB
ExpressionAtlasiP00751 baseline and differential
GenevisibleiP00751 HS

Family and domain databases

CDDicd00033 CCP, 3 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR011360 Compl_C2_B
IPR028341 Complement_B
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR19325:SF394 PTHR19325:SF394, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 3 hits
PF00089 Trypsin, 1 hit
PF00092 VWA, 1 hit
PIRSFiPIRSF001154 Compl_C2_B, 1 hit
PIRSF500181 Complement_B, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 3 hits
SM00020 Tryp_SPc, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF53300 SSF53300, 1 hit
SSF57535 SSF57535, 3 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFAB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00751
Secondary accession number(s): B0QZQ6
, O15006, Q29944, Q53F89, Q5JP67, Q5ST50, Q96HX6, Q9BTF5, Q9BX92
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: January 16, 2019
This is version 234 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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