UniProtKB - P00749 (UROK_HUMAN)
Urokinase-type plasminogen activator
PLAU
Functioni
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Catalytic activityi
- Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin. EC:3.4.21.73
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 224 | Charge relay system | 1 | |
Active sitei | 275 | Charge relay system | 1 | |
Active sitei | 376 | Charge relay system | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- chemotaxis Source: ProtInc
- fibrinolysis Source: GO_Central
- negative regulation of fibrinolysis Source: ComplexPortal
- negative regulation of plasminogen activation Source: ComplexPortal
- plasminogen activation Source: AgBase
- positive regulation of cell migration Source: MGI
- proteolysis Source: GO_Central
- regulation of cell adhesion Source: ComplexPortal
- regulation of cell adhesion mediated by integrin Source: BHF-UCL
- regulation of cell population proliferation Source: Ensembl
- regulation of fibrinolysis Source: ComplexPortal
- regulation of plasminogen activation Source: ComplexPortal
- regulation of signaling receptor activity Source: BHF-UCL
- regulation of smooth muscle cell-matrix adhesion Source: BHF-UCL
- regulation of smooth muscle cell migration Source: BHF-UCL
- regulation of wound healing Source: BHF-UCL
- response to hypoxia Source: Ensembl
- signal transduction Source: ProtInc
- smooth muscle cell migration Source: Ensembl
- urokinase plasminogen activator signaling pathway Source: ComplexPortal
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Fibrinolysis, Hemostasis, Plasminogen activation |
Enzyme and pathway databases
BRENDAi | 3.4.21.73, 2681 |
PathwayCommonsi | P00749 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-75205, Dissolution of Fibrin Clot |
SABIO-RKi | P00749 |
SignaLinki | P00749 |
SIGNORi | P00749 |
Protein family/group databases
MEROPSi | S01.231 |
Names & Taxonomyi
Protein namesi | Recommended name: Urokinase-type plasminogen activator (EC:3.4.21.73)Short name: U-plasminogen activator Short name: uPA1 Publication Cleaved into the following 3 chains: |
Gene namesi | Name:PLAUImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9052, PLAU |
MIMi | 191840, gene |
neXtProti | NX_P00749 |
VEuPathDBi | HostDB:ENSG00000122861 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: BHF-UCL
- focal adhesion Source: UniProtKB
- protein complex involved in cell-matrix adhesion Source: ComplexPortal
- serine protease inhibitor complex Source: ComplexPortal
- serine-type endopeptidase complex Source: ComplexPortal
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Quebec platelet disorder (QPD)1 Publication
Pharmaceutical usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 158 | S → E: Abolishes phosphorylation, proadhesive function and ability to induce chemotactic response; when associated with E-323. 1 Publication | 1 | |
Mutagenesisi | 323 | S → E: Abolishes phosphorylation, proadhesive function and ability to induce chemotactic response; when associated with E-158. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5328 |
MalaCardsi | PLAU |
MIMi | 601709, phenotype |
Orphaneti | 220436, Quebec platelet disorder |
PharmGKBi | PA33382 |
Miscellaneous databases
Pharosi | P00749, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3286 |
DrugBanki | DB07129, (2R)-1-(2,6-dimethylphenoxy)propan-2-amine DB07122, 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine DB01905, 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine DB02287, 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine DB03729, 2-Amino-1H-benzimidazol-5-ol DB01725, 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide DB08072, 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE DB07625, 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide DB07626, 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide DB08697, 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide DB03136, 4-Iodobenzo[B]Thiophene-2-Carboxamidine DB01977, 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine DB07076, 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE DB03082, 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide DB02705, 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB02473, 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB02398, 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine DB02551, 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB03865, 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine DB06855, 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine DB06856, 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE DB03046, 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide DB04059, 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide DB04172, [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine DB00594, Amiloride DB03127, Benzamidine DB02526, CRA_10655 DB03159, CRA_8696 DB05254, Fibrinolysin DB03782, N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea DB06857, N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE DB16701, Plasminogen DB03876, Thieno[2,3-B]Pyridine-2-Carboxamidine DB03476, Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine |
DrugCentrali | P00749 |
GuidetoPHARMACOLOGYi | 2393 |
Genetic variation databases
BioMutai | PLAU |
DMDMi | 254763341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 2 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000028318 | 21 – 431 | Urokinase-type plasminogen activatorAdd BLAST | 411 | |
ChainiPRO_0000028319 | 21 – 177 | Urokinase-type plasminogen activator long chain AAdd BLAST | 157 | |
ChainiPRO_0000028320 | 156 – 177 | Urokinase-type plasminogen activator short chain AAdd BLAST | 22 | |
ChainiPRO_0000028321 | 179 – 431 | Urokinase-type plasminogen activator chain BAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 39 | |||
Disulfide bondi | 33 ↔ 51 | |||
Glycosylationi | 38 | O-linked (Fuc) threonine1 Publication | 1 | |
Disulfide bondi | 53 ↔ 62 | |||
Disulfide bondi | 70 ↔ 151 | |||
Disulfide bondi | 91 ↔ 133 | |||
Disulfide bondi | 122 ↔ 146 | |||
Modified residuei | 158 | Phosphoserine1 Publication | 1 | |
Disulfide bondi | 168 ↔ 299 | Interchain (between A and B chains) | ||
Disulfide bondi | 209 ↔ 225 | |||
Disulfide bondi | 217 ↔ 288 | |||
Disulfide bondi | 313 ↔ 382 | |||
GlycosylationiCAR_000026 | 322 | N-linked (GlcNAc...) asparagine | 1 | |
Modified residuei | 323 | Phosphoserine1 Publication | 1 | |
Disulfide bondi | 345 ↔ 361 | |||
Disulfide bondi | 372 ↔ 400 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 177 – 178 | Cleavage; during zymogen activation | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
EPDi | P00749 |
jPOSTi | P00749 |
MassIVEi | P00749 |
MaxQBi | P00749 |
PaxDbi | P00749 |
PeptideAtlasi | P00749 |
PRIDEi | P00749 |
ProteomicsDBi | 51279 [P00749-1] 51280 [P00749-2] |
PTM databases
GlyConnecti | 612, 2 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) 86, 16 N-Linked glycans (1 site) |
GlyGeni | P00749, 3 sites, 13 N-linked glycans (2 sites), 1 O-linked glycan (2 sites) |
iPTMneti | P00749 |
PhosphoSitePlusi | P00749 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000122861, Expressed in epithelium of bronchus and 198 other tissues |
ExpressionAtlasi | P00749, baseline and differential |
Genevisiblei | P00749, HS |
Organism-specific databases
HPAi | ENSG00000122861, Tissue enhanced (urinary) |
Interactioni
Subunit structurei
Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds LRP1B; binding is followed by internalization and degradation.
Interacts with MRC2.
Interacts with PLAUR. In complex with SERPINE1, interacts with PLAUR/uPAR (PubMed:15053742).
Interacts with SORL1 and LRP1, either alone or in complex with SERPINE1; these interactions are abolished in the presence of LRPAP1/RAP (PubMed:15053742). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORLA (PubMed:15053742).
4 PublicationsBinary interactionsi
P00749
With | #Exp. | IntAct |
---|---|---|
ADAM28 [Q9UKQ2] | 3 | EBI-3905042,EBI-1384181 |
APP [P05067] | 3 | EBI-3905042,EBI-77613 |
PLAUR - isoform 1 [Q03405-1] | 2 | EBI-3905042,EBI-15695188 |
Protein-protein interaction databases
BioGRIDi | 111344, 81 interactors |
ComplexPortali | CPX-483, uPA-PAI-1 complex CPX-487, uPA-uPAR complex CPX-501, uPA-uPAR-vitronectin complex |
CORUMi | P00749 |
DIPi | DIP-46387N |
ELMi | P00749 |
IntActi | P00749, 15 interactors |
MINTi | P00749 |
STRINGi | 9606.ENSP00000361850 |
Chemistry databases
BindingDBi | P00749 |
Miscellaneous databases
RNActi | P00749, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P00749 |
BMRBi | P00749 |
SASBDBi | P00749 |
SMRi | P00749 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00749 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 63 | EGF-likePROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 70 – 151 | KringlePROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 179 – 424 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 246 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 57 | Binds urokinase plasminogen activator surface receptorBy similarityAdd BLAST | 24 | |
Regioni | 152 – 177 | Connecting peptideAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Kringle, SignalPhylogenomic databases
eggNOGi | ENOG502QRMI, Eukaryota |
InParanoidi | P00749 |
PhylomeDBi | P00749 |
TreeFami | TF329901 |
Family and domain databases
CDDi | cd00108, KR, 1 hit cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER IPR034814, Urokinase |
PANTHERi | PTHR24264:SF38, PTHR24264:SF38, 1 hit |
Pfami | View protein in Pfam PF00051, Kringle, 1 hit PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRALLARLLL CVLVVSDSKG SNELHQVPSN CDCLNGGTCV SNKYFSNIHW
60 70 80 90 100
CNCPKKFGGQ HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL
110 120 130 140 150
QQTYHAHRSD ALQLGLGKHN YCRNPDNRRR PWCYVQVGLK LLVQECMVHD
160 170 180 190 200
CADGKKPSSP PEELKFQCGQ KTLRPRFKII GGEFTTIENQ PWFAAIYRRH
210 220 230 240 250
RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG RSRLNSNTQG
260 270 280 290 300
EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL
310 320 330 340 350
PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY
360 370 380 390 400
YGSEVTTKML CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC
410 420 430
ALKDKPGVYT RVSHFLPWIR SHTKEENGLA L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R3G7 | S4R3G7_HUMAN | Urokinase-type plasminogen activato... | PLAU | 106 | Annotation score: | ||
E7ET40 | E7ET40_HUMAN | Urokinase-type plasminogen activato... | PLAU | 414 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | D → G in BAG60754 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 151 | C → W in CAA26535 (PubMed:3888571).Curated | 1 | |
Sequence conflicti | 386 | G → C in CAA26535 (PubMed:3888571).Curated | 1 | |
Sequence conflicti | 430 | A → V in CAA26535 (PubMed:3888571).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038730 | 15 | V → L1 PublicationCorresponds to variant dbSNP:rs2227580EnsemblClinVar. | 1 | |
Natural variantiVAR_006722 | 141 | L → P14 PublicationsCorresponds to variant dbSNP:rs2227564Ensembl. | 1 | |
Natural variantiVAR_013102 | 214 | I → M2 PublicationsCorresponds to variant dbSNP:rs1050120Ensembl. | 1 | |
Natural variantiVAR_038731 | 231 | K → Q1 PublicationCorresponds to variant dbSNP:rs2227567EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038368 | 1 – 29 | MRALL…HQVPS → MVFHLRTRYEQA in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15476 mRNA Translation: AAA61253.1 X02760 mRNA Translation: CAA26535.1 D00244 mRNA Translation: BAA00175.1 K03226 mRNA Translation: AAC97138.1 X02419 Genomic DNA Translation: CAA26268.1 AF377330 Genomic DNA Translation: AAK53822.1 BT007391 mRNA Translation: AAP36055.1 AK298560 mRNA Translation: BAG60754.1 AL596247 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54544.1 BC013575 mRNA Translation: AAH13575.1 D11143 mRNA Translation: BAA01919.1 K02286 Genomic DNA Translation: AAA61252.1 |
CCDSi | CCDS44442.1 [P00749-2] CCDS7339.1 [P00749-1] |
PIRi | A00931, UKHU |
RefSeqi | NP_001138503.1, NM_001145031.2 NP_001306120.1, NM_001319191.1 NP_002649.1, NM_002658.4 |
Genome annotation databases
Ensembli | ENST00000372764.4; ENSP00000361850.3; ENSG00000122861.16 ENST00000446342.5; ENSP00000388474.1; ENSG00000122861.16 [P00749-2] |
GeneIDi | 5328 |
KEGGi | hsa:5328 |
MANE-Selecti | ENST00000372764.4; ENSP00000361850.3; NM_002658.6; NP_002649.2 |
UCSCi | uc001jwa.4, human [P00749-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Urokinase entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15476 mRNA Translation: AAA61253.1 X02760 mRNA Translation: CAA26535.1 D00244 mRNA Translation: BAA00175.1 K03226 mRNA Translation: AAC97138.1 X02419 Genomic DNA Translation: CAA26268.1 AF377330 Genomic DNA Translation: AAK53822.1 BT007391 mRNA Translation: AAP36055.1 AK298560 mRNA Translation: BAG60754.1 AL596247 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54544.1 BC013575 mRNA Translation: AAH13575.1 D11143 mRNA Translation: BAA01919.1 K02286 Genomic DNA Translation: AAA61252.1 |
CCDSi | CCDS44442.1 [P00749-2] CCDS7339.1 [P00749-1] |
PIRi | A00931, UKHU |
RefSeqi | NP_001138503.1, NM_001145031.2 NP_001306120.1, NM_001319191.1 NP_002649.1, NM_002658.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C5W | X-ray | 1.94 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1C5X | X-ray | 1.75 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1C5Y | X-ray | 1.65 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1C5Z | X-ray | 1.85 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1EJN | X-ray | 1.80 | A | 179-431 | [»] | |
1F5K | X-ray | 1.80 | U | 179-431 | [»] | |
1F5L | X-ray | 2.10 | A | 179-431 | [»] | |
1F92 | X-ray | 2.60 | A | 179-431 | [»] | |
1FV9 | X-ray | 3.00 | A | 179-423 | [»] | |
1GI7 | X-ray | 1.79 | A | 156-178 | [»] | |
B | 179-423 | [»] | ||||
1GI8 | X-ray | 1.75 | A | 156-178 | [»] | |
B | 179-423 | [»] | ||||
1GI9 | X-ray | 1.80 | A | 156-178 | [»] | |
B | 179-423 | [»] | ||||
1GJ7 | X-ray | 1.50 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJ8 | X-ray | 1.64 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJ9 | X-ray | 1.80 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJA | X-ray | 1.56 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJB | X-ray | 1.90 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJC | X-ray | 1.73 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1GJD | X-ray | 1.75 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1KDU | NMR | - | A | 69-153 | [»] | |
1LMW | X-ray | 2.50 | A/C | 156-178 | [»] | |
B/D | 179-431 | [»] | ||||
1O3P | X-ray | 1.81 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1O5A | X-ray | 1.68 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1O5B | X-ray | 1.85 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1O5C | X-ray | 1.63 | A | 156-178 | [»] | |
B | 179-431 | [»] | ||||
1OWD | X-ray | 2.32 | A | 179-423 | [»] | |
1OWE | X-ray | 1.60 | A | 179-423 | [»] | |
1OWH | X-ray | 1.61 | A | 179-423 | [»] | |
1OWI | X-ray | 2.93 | A | 179-423 | [»] | |
1OWJ | X-ray | 3.10 | A | 179-423 | [»] | |
1OWK | X-ray | 2.80 | A | 179-423 | [»] | |
1SC8 | X-ray | 2.40 | U | 164-425 | [»] | |
1SQA | X-ray | 2.00 | A | 179-423 | [»] | |
1SQO | X-ray | 1.84 | A | 179-423 | [»] | |
1SQT | X-ray | 1.90 | A | 179-423 | [»] | |
1U6Q | X-ray | 2.02 | A | 179-423 | [»] | |
1URK | NMR | - | A | 26-155 | [»] | |
1VJ9 | X-ray | 2.40 | U | 164-425 | [»] | |
1VJA | X-ray | 2.00 | U | 164-425 | [»] | |
1W0Z | X-ray | 1.90 | U | 179-425 | [»] | |
1W10 | X-ray | 2.00 | U | 179-425 | [»] | |
1W11 | X-ray | 2.00 | U | 179-425 | [»] | |
1W12 | X-ray | 2.40 | U | 179-425 | [»] | |
1W13 | X-ray | 2.00 | U | 179-425 | [»] | |
1W14 | X-ray | 2.20 | U | 179-425 | [»] | |
2FD6 | X-ray | 1.90 | A | 31-152 | [»] | |
2I9A | X-ray | 1.90 | A/B/C/D | 21-163 | [»] | |
2I9B | X-ray | 2.80 | A/B/C/D | 21-163 | [»] | |
2NWN | X-ray | 2.15 | A | 179-431 | [»] | |
2O8T | X-ray | 1.45 | A | 179-431 | [»] | |
2O8U | X-ray | 1.70 | A | 179-431 | [»] | |
2O8W | X-ray | 1.86 | A | 179-431 | [»] | |
2R2W | X-ray | 2.01 | U | 179-431 | [»] | |
2VIN | X-ray | 1.90 | A | 179-431 | [»] | |
2VIO | X-ray | 1.80 | A | 179-431 | [»] | |
2VIP | X-ray | 1.72 | A | 179-431 | [»] | |
2VIQ | X-ray | 2.00 | A | 179-431 | [»] | |
2VIV | X-ray | 1.72 | A | 179-431 | [»] | |
2VIW | X-ray | 2.05 | A | 179-431 | [»] | |
2VNT | X-ray | 2.20 | A/B/C/D/E/F | 156-431 | [»] | |
3BT1 | X-ray | 2.80 | A | 21-153 | [»] | |
3BT2 | X-ray | 2.50 | A | 21-153 | [»] | |
3IG6 | X-ray | 1.83 | A/C | 156-178 | [»] | |
B/D | 179-431 | [»] | ||||
3KGP | X-ray | 2.35 | A | 179-431 | [»] | |
3KHV | X-ray | 2.35 | A | 179-431 | [»] | |
3KID | X-ray | 2.71 | U | 179-431 | [»] | |
3M61 | X-ray | 1.68 | U | 179-431 | [»] | |
3MHW | X-ray | 1.45 | U | 179-425 | [»] | |
3MWI | X-ray | 2.03 | U | 179-424 | [»] | |
3OX7 | X-ray | 1.58 | U | 179-431 | [»] | |
3OY5 | X-ray | 2.31 | U | 179-431 | [»] | |
3OY6 | X-ray | 2.31 | U | 179-431 | [»] | |
3PB1 | X-ray | 2.30 | E | 179-431 | [»] | |
3QN7 | X-ray | 1.90 | A | 179-431 | [»] | |
3U73 | X-ray | 3.19 | A | 21-152 | [»] | |
4DVA | X-ray | 1.94 | U | 179-424 | [»] | |
4DW2 | X-ray | 2.97 | U | 179-424 | [»] | |
4FU7 | X-ray | 2.00 | A | 179-424 | [»] | |
4FU8 | X-ray | 2.20 | A | 179-424 | [»] | |
4FU9 | X-ray | 1.60 | A | 179-424 | [»] | |
4FUB | X-ray | 1.90 | A | 179-424 | [»] | |
4FUC | X-ray | 1.72 | A | 179-424 | [»] | |
4FUD | X-ray | 2.00 | A | 179-424 | [»] | |
4FUE | X-ray | 2.00 | A | 179-424 | [»] | |
4FUF | X-ray | 2.00 | A | 179-424 | [»] | |
4FUG | X-ray | 1.80 | A | 179-424 | [»] | |
4FUH | X-ray | 1.60 | A | 179-424 | [»] | |
4FUI | X-ray | 2.00 | A | 179-424 | [»] | |
4FUJ | X-ray | 2.05 | A | 179-424 | [»] | |
4GLY | X-ray | 1.52 | A | 179-423 | [»] | |
4H42 | X-ray | 2.01 | U | 179-426 | [»] | |
4JK5 | X-ray | 1.55 | A | 179-423 | [»] | |
4JK6 | X-ray | 2.20 | A | 179-423 | [»] | |
4K24 | X-ray | 4.50 | A | 21-153 | [»] | |
4MNV | X-ray | 1.80 | A | 179-423 | [»] | |
4MNW | X-ray | 1.49 | A | 179-423 | [»] | |
4MNX | X-ray | 1.85 | A | 179-423 | [»] | |
4MNY | X-ray | 1.70 | A/B | 179-423 | [»] | |
4OS1 | X-ray | 2.20 | A | 179-423 | [»] | |
4OS2 | X-ray | 1.79 | A | 179-423 | [»] | |
4OS4 | X-ray | 2.00 | A | 179-423 | [»] | |
4OS5 | X-ray | 2.26 | A | 179-423 | [»] | |
4OS6 | X-ray | 1.75 | A | 179-423 | [»] | |
4OS7 | X-ray | 2.00 | A | 179-423 | [»] | |
4X0W | X-ray | 2.10 | U | 179-425 | [»] | |
4X1N | X-ray | 1.80 | U | 179-425 | [»] | |
4X1P | X-ray | 1.60 | U | 179-425 | [»] | |
4X1Q | X-ray | 2.28 | U | 179-425 | [»] | |
4X1R | X-ray | 2.10 | U | 179-425 | [»] | |
4X1S | X-ray | 1.90 | U | 179-425 | [»] | |
4XSK | X-ray | 1.50 | U | 179-424 | [»] | |
4ZHL | X-ray | 2.06 | U | 179-425 | [»] | |
4ZHM | X-ray | 1.90 | U | 179-425 | [»] | |
4ZKN | X-ray | 1.36 | U | 179-425 | [»] | |
4ZKO | X-ray | 1.29 | U | 179-425 | [»] | |
4ZKR | X-ray | 1.36 | U | 179-425 | [»] | |
4ZKS | X-ray | 1.85 | U | 179-425 | [»] | |
5HGG | X-ray | 1.97 | A/B | 179-424 | [»] | |
5WXF | X-ray | 1.46 | U | 179-431 | [»] | |
5WXO | X-ray | 1.64 | U | 179-431 | [»] | |
5WXP | X-ray | 1.75 | U | 179-431 | [»] | |
5WXQ | X-ray | 1.79 | U | 179-431 | [»] | |
5WXR | X-ray | 1.75 | U | 179-431 | [»] | |
5WXS | X-ray | 2.30 | U | 179-431 | [»] | |
5WXT | X-ray | 2.10 | U | 179-431 | [»] | |
5XG4 | X-ray | 3.00 | U | 179-424 | [»] | |
5YC6 | X-ray | 1.18 | U | 179-424 | [»] | |
5YC7 | X-ray | 2.00 | U | 179-424 | [»] | |
5Z1C | X-ray | 1.45 | U | 179-423 | [»] | |
5ZA7 | X-ray | 1.70 | U | 179-431 | [»] | |
5ZA8 | X-ray | 1.90 | U | 179-431 | [»] | |
5ZA9 | X-ray | 1.62 | U | 179-431 | [»] | |
5ZAE | X-ray | 1.73 | U | 179-431 | [»] | |
5ZAF | X-ray | 1.65 | U | 179-431 | [»] | |
5ZAG | X-ray | 1.95 | U | 179-431 | [»] | |
5ZAH | X-ray | 2.98 | U | 179-431 | [»] | |
5ZAJ | X-ray | 1.65 | U | 179-431 | [»] | |
5ZC5 | X-ray | 1.90 | U | 179-431 | [»] | |
6AG2 | X-ray | 1.77 | U | 179-431 | [»] | |
6AG3 | X-ray | 2.48 | U | 179-431 | [»] | |
6AG7 | X-ray | 1.90 | U | 179-423 | [»] | |
6AG9 | X-ray | 1.63 | U | 179-431 | [»] | |
6JYP | X-ray | 2.25 | U | 179-424 | [»] | |
6JYQ | X-ray | 1.75 | U | 179-424 | [»] | |
6L04 | X-ray | 2.21 | U | 179-423 | [»] | |
6L05 | X-ray | 2.49 | U | 179-423 | [»] | |
6NMB | X-ray | 2.30 | A/B/C/D | 162-431 | [»] | |
6XVD | X-ray | 1.40 | U | 179-431 | [»] | |
7DZD | X-ray | 2.00 | U | 179-423 | [»] | |
AlphaFoldDBi | P00749 | |||||
BMRBi | P00749 | |||||
SASBDBi | P00749 | |||||
SMRi | P00749 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111344, 81 interactors |
ComplexPortali | CPX-483, uPA-PAI-1 complex CPX-487, uPA-uPAR complex CPX-501, uPA-uPAR-vitronectin complex |
CORUMi | P00749 |
DIPi | DIP-46387N |
ELMi | P00749 |
IntActi | P00749, 15 interactors |
MINTi | P00749 |
STRINGi | 9606.ENSP00000361850 |
Chemistry databases
BindingDBi | P00749 |
ChEMBLi | CHEMBL3286 |
DrugBanki | DB07129, (2R)-1-(2,6-dimethylphenoxy)propan-2-amine DB07122, 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine DB01905, 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine DB02287, 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine DB03729, 2-Amino-1H-benzimidazol-5-ol DB01725, 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide DB08072, 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE DB07625, 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide DB07626, 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide DB08697, 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide DB03136, 4-Iodobenzo[B]Thiophene-2-Carboxamidine DB01977, 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine DB07076, 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE DB03082, 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide DB02705, 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB02473, 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB02398, 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine DB02551, 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine DB03865, 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine DB06855, 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine DB06856, 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE DB03046, 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide DB04059, 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide DB04172, [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine DB00594, Amiloride DB03127, Benzamidine DB02526, CRA_10655 DB03159, CRA_8696 DB05254, Fibrinolysin DB03782, N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea DB06857, N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE DB16701, Plasminogen DB03876, Thieno[2,3-B]Pyridine-2-Carboxamidine DB03476, Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine |
DrugCentrali | P00749 |
GuidetoPHARMACOLOGYi | 2393 |
Protein family/group databases
MEROPSi | S01.231 |
PTM databases
GlyConnecti | 612, 2 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) 86, 16 N-Linked glycans (1 site) |
GlyGeni | P00749, 3 sites, 13 N-linked glycans (2 sites), 1 O-linked glycan (2 sites) |
iPTMneti | P00749 |
PhosphoSitePlusi | P00749 |
Genetic variation databases
BioMutai | PLAU |
DMDMi | 254763341 |
Proteomic databases
EPDi | P00749 |
jPOSTi | P00749 |
MassIVEi | P00749 |
MaxQBi | P00749 |
PaxDbi | P00749 |
PeptideAtlasi | P00749 |
PRIDEi | P00749 |
ProteomicsDBi | 51279 [P00749-1] 51280 [P00749-2] |
Protocols and materials databases
ABCDi | P00749, 2 sequenced antibodies |
Antibodypediai | 1899, 1066 antibodies from 44 providers |
DNASUi | 5328 |
Genome annotation databases
Ensembli | ENST00000372764.4; ENSP00000361850.3; ENSG00000122861.16 ENST00000446342.5; ENSP00000388474.1; ENSG00000122861.16 [P00749-2] |
GeneIDi | 5328 |
KEGGi | hsa:5328 |
MANE-Selecti | ENST00000372764.4; ENSP00000361850.3; NM_002658.6; NP_002649.2 |
UCSCi | uc001jwa.4, human [P00749-1] |
Organism-specific databases
CTDi | 5328 |
DisGeNETi | 5328 |
GeneCardsi | PLAU |
HGNCi | HGNC:9052, PLAU |
HPAi | ENSG00000122861, Tissue enhanced (urinary) |
MalaCardsi | PLAU |
MIMi | 191840, gene 601709, phenotype |
neXtProti | NX_P00749 |
Orphaneti | 220436, Quebec platelet disorder |
PharmGKBi | PA33382 |
VEuPathDBi | HostDB:ENSG00000122861 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRMI, Eukaryota |
InParanoidi | P00749 |
PhylomeDBi | P00749 |
TreeFami | TF329901 |
Enzyme and pathway databases
BRENDAi | 3.4.21.73, 2681 |
PathwayCommonsi | P00749 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-75205, Dissolution of Fibrin Clot |
SABIO-RKi | P00749 |
SignaLinki | P00749 |
SIGNORi | P00749 |
Miscellaneous databases
BioGRID-ORCSi | 5328, 14 hits in 1086 CRISPR screens |
ChiTaRSi | PLAU, human |
EvolutionaryTracei | P00749 |
GeneWikii | PLAU |
GenomeRNAii | 5328 |
Pharosi | P00749, Tchem |
PROi | PR:P00749 |
RNActi | P00749, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122861, Expressed in epithelium of bronchus and 198 other tissues |
ExpressionAtlasi | P00749, baseline and differential |
Genevisiblei | P00749, HS |
Family and domain databases
CDDi | cd00108, KR, 1 hit cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER IPR034814, Urokinase |
PANTHERi | PTHR24264:SF38, PTHR24264:SF38, 1 hit |
Pfami | View protein in Pfam PF00051, Kringle, 1 hit PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UROK_HUMAN | |
Accessioni | P00749Primary (citable) accession number: P00749 Secondary accession number(s): B4DPZ2 Q969W6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 258 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families