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Entry version 246 (13 Nov 2019)
Sequence version 2 (01 Jul 1989)
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Protein

Plasminogen

Gene

PLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.1 Publication
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.1 Publication

Miscellaneous

Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.1 Publication EC:3.4.21.7

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei134Fibrin1
Binding sitei136Fibrin1
Binding sitei136Omega-aminocarboxylic acids1
Binding sitei158Omega-aminocarboxylic acids1
Binding sitei172Omega-aminocarboxylic acids1
Binding sitei432Omega-aminocarboxylic acids1
Binding sitei445Omega-aminocarboxylic acids1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei622Charge relay system1
Active sitei665Charge relay system1
Active sitei760Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processBlood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04553-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.7 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-186797 Signaling by PDGF
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-75205 Dissolution of Fibrin Clot

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00747

SIGNOR Signaling Network Open Resource

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SIGNORi
P00747

Protein family/group databases

MEROPS protease database

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MEROPSi
S01.233

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasminogen (EC:3.4.21.7)
Cleaved into the following 5 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9071 PLG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173350 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00747

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Plasminogen deficiency (PLGD)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01865738K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.1
Natural variantiVAR_018658147L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.1
Natural variantiVAR_018659235R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.1
Natural variantiVAR_006627374V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.1
Natural variantiVAR_018660532R → H in PLGD. 1 Publication1
Natural variantiVAR_006628591S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.1
Natural variantiVAR_006629620A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.1
Natural variantiVAR_006630751G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi741S → A: Proteolytically cleaved, but abolishes plasmin activity and cell detachment. 1 Publication1

Keywords - Diseasei

Disease mutation, Thrombophilia

Organism-specific databases

DisGeNET

More...
DisGeNETi
5340

MalaCards human disease database

More...
MalaCardsi
PLG
MIMi217090 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000122194

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
722 Hypoplasminogenemia
97231 Ligneous conjunctivitis
537072 PLG-related hereditary angioedema with normal C1Inh

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33405

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P00747

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1801

Drug and drug target database

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DrugBanki
DB00009 Alteplase
DB00513 Aminocaproic Acid
DB00029 Anistreplase
DB06692 Aprotinin
DB03709 Bicine
DB09130 Copper
DB04925 Desmoteplase
DB12831 Gabexate
DB00015 Reteplase
DB00086 Streptokinase
DB00031 Tenecteplase
DB00302 Tranexamic acid
DB00013 Urokinase

DrugCentral

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DrugCentrali
P00747

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2394

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
130316

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 192 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002805320 – 810PlasminogenAdd BLAST791
ChainiPRO_000002805420 – 580Plasmin heavy chain AAdd BLAST561
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002805520 – 97Activation peptideAdd BLAST78
ChainiPRO_000002805779 – 466AngiostatinAdd BLAST388
ChainiPRO_000002805698 – 580Plasmin heavy chain A, short formAdd BLAST483
ChainiPRO_0000028058581 – 810Plasmin light chain BAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 73
Disulfide bondi53 ↔ 61
Disulfide bondi103 ↔ 181
Disulfide bondi124 ↔ 164
Disulfide bondi152 ↔ 176
Disulfide bondi185 ↔ 262
Disulfide bondi188 ↔ 316
Disulfide bondi206 ↔ 245
Disulfide bondi234 ↔ 257
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000016268O-linked (GalNAc...) serine2 Publications1
Disulfide bondi275 ↔ 352
Disulfide bondi296 ↔ 335
GlycosylationiCAR_000017308N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi324 ↔ 347
GlycosylationiCAR_000018365O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi377 ↔ 454
Disulfide bondi398 ↔ 437
Disulfide bondi426 ↔ 449
Disulfide bondi481 ↔ 560
Disulfide bondi502 ↔ 543
Disulfide bondi531 ↔ 555
Disulfide bondi567 ↔ 685Interchain (between A and B chains)
Disulfide bondi577 ↔ 585Interchain (between A and B chains)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei597Phosphoserine1 Publication1
Disulfide bondi607 ↔ 623
Modified residuei688PhosphoserineCombined sources1
Disulfide bondi699 ↔ 766
Disulfide bondi729 ↔ 745
Disulfide bondi756 ↔ 784

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).3 Publications
In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei78 – 79Cleavage; by stromelysin-12
Sitei466 – 467Cleavage; by stromelysin-192
Sitei580 – 581Cleavage; by plasminogen activator2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1151

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P00747

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P00747

MaxQB - The MaxQuant DataBase

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MaxQBi
P00747

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00747

PeptideAtlas

More...
PeptideAtlasi
P00747

PRoteomics IDEntifications database

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PRIDEi
P00747

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51277

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P00747

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
502

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00747

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P00747

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P00747

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P00747

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00747 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P00747 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000668
CAB016678
HPA021602
HPA048823
HPA053770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488).

Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047).

Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin:

Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).

6 Publications

(Microbial infection) Interacts with Staphylococcus aureus protein FnbB; this interaction provides active plasmin on the surface of bacteria cells.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111356, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P00747

Protein interaction database and analysis system

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IntActi
P00747, 48 interactors

Molecular INTeraction database

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MINTi
P00747

STRING: functional protein association networks

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STRINGi
9606.ENSP00000308938

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P00747

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1810
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00747

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00747

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 98PANPROSITE-ProRule annotationAdd BLAST79
Domaini103 – 181Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini184 – 262Kringle 2PROSITE-ProRule annotationAdd BLAST79
Domaini275 – 352Kringle 3PROSITE-ProRule annotationAdd BLAST78
Domaini377 – 454Kringle 4PROSITE-ProRule annotationAdd BLAST78
Domaini481 – 560Kringle 5PROSITE-ProRule annotationAdd BLAST80
Domaini581 – 808Peptidase S1PROSITE-ProRule annotationAdd BLAST228

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Kringle domains mediate interaction with CSPG4.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDXR Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112892

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00747

KEGG Orthology (KO)

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KOi
K01315

Identification of Orthologs from Complete Genome Data

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OMAi
TELCAGN

Database of Orthologous Groups

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OrthoDBi
1058295at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P00747

TreeFam database of animal gene trees

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TreeFami
TF329901

Family and domain databases

Conserved Domains Database

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CDDi
cd00108 KR, 5 hits
cd00190 Tryp_SPc, 1 hit

Database of protein disorder

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DisProti
DP00191

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR023317 Pept_S1A_plasmin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051 Kringle, 5 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001150 Plasmin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00130 KR, 5 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00021 KRINGLE_1, 5 hits
PS50070 KRINGLE_2, 5 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P00747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA
60 70 80 90 100
AKCEEDEEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL
110 120 130 140 150
SECKTGNGKN YRGTMSKTKN GITCQKWSST SPHRPRFSPA THPSEGLEEN
160 170 180 190 200
YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE CEEECMHCSG ENYDGKISKT
210 220 230 240 250
MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE LRPWCFTTDP
260 270 280 290 300
NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS
310 320 330 340 350
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP
360 370 380 390 400
SCDSSPVSTE QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS
410 420 430 440 450
WSSMTPHRHQ KTPENYPNAG LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN
460 470 480 490 500
LKKCSGTEAS VVAPPPVVLL PDVETPSEED CMFGNGKGYR GKRATTVTGT
510 520 530 540 550
PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG PWCYTTNPRK
560 570 580 590 600
LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT
610 620 630 640 650
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ
660 670 680 690 700
EIEVSRLFLE PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF
710 720 730 740 750
ITGWGETQGT FGAGLLKEAQ LPVIENKVCN RYEFLNGRVQ STELCAGHLA
760 770 780 790 800
GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV
810
TWIEGVMRNN
Length:810
Mass (Da):90,569
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B31CB877CCB3AB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVI2A6PVI2_HUMAN
Plasminogen
PLG
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TEH5Q5TEH5_HUMAN
HCG2029799, isoform CRA_b
PLG hCG_2029799
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50A → AQ AA sequence (PubMed:122932).Curated1
Sequence conflicti72Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti72Q → E AA sequence (PubMed:122932).Curated1
Sequence conflicti86Missing AA sequence (Ref. 7) Curated1
Sequence conflicti86Missing AA sequence (PubMed:122932).Curated1
Sequence conflicti361Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti361Q → E AA sequence (Ref. 9) Curated1
Sequence conflicti701I → V in AAA36451 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01865738K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.1
Natural variantiVAR_01177946I → R. Corresponds to variant dbSNP:rs1049573Ensembl.1
Natural variantiVAR_01628757E → K1 PublicationCorresponds to variant dbSNP:rs4252070Ensembl.1
Natural variantiVAR_016288133H → Q1 PublicationCorresponds to variant dbSNP:rs4252186Ensembl.1
Natural variantiVAR_018658147L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.1
Natural variantiVAR_018659235R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.1
Natural variantiVAR_016289261R → H1 PublicationCorresponds to variant dbSNP:rs4252187Ensembl.1
Natural variantiVAR_006627374V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.1
Natural variantiVAR_016290408R → W1 PublicationCorresponds to variant dbSNP:rs4252119Ensembl.1
Natural variantiVAR_011780453K → I. Corresponds to variant dbSNP:rs1804181Ensembl.1
Natural variantiVAR_016291472D → N4 PublicationsCorresponds to variant dbSNP:rs4252125Ensembl.1
Natural variantiVAR_016292494A → V1 PublicationCorresponds to variant dbSNP:rs4252128Ensembl.1
Natural variantiVAR_016293523R → W1 PublicationCorresponds to variant dbSNP:rs4252129Ensembl.1
Natural variantiVAR_018660532R → H in PLGD. 1 Publication1
Natural variantiVAR_006628591S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.1
Natural variantiVAR_006629620A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.1
Natural variantiVAR_031213676V → D1 PublicationCorresponds to variant dbSNP:rs17857492Ensembl.1
Natural variantiVAR_006630751G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M34276
, M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1
X05199 mRNA Translation: CAA28831.1
M74220 mRNA Translation: AAA36451.1
AY192161 Genomic DNA Translation: AAN85555.1
AL109933 Genomic DNA No translation available.
BC060513 mRNA Translation: AAH60513.1
K02922 mRNA Translation: AAA60124.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5279.1

Protein sequence database of the Protein Information Resource

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PIRi
A35229 PLHU

NCBI Reference Sequences

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RefSeqi
NP_000292.1, NM_000301.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000308192; ENSP00000308938; ENSG00000122194

Database of genes from NCBI RefSeq genomes

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GeneIDi
5340

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5340

UCSC genome browser

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UCSCi
uc003qtm.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Plasmin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34276
, M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1
X05199 mRNA Translation: CAA28831.1
M74220 mRNA Translation: AAA36451.1
AY192161 Genomic DNA Translation: AAN85555.1
AL109933 Genomic DNA No translation available.
BC060513 mRNA Translation: AAH60513.1
K02922 mRNA Translation: AAA60124.1
CCDSiCCDS5279.1
PIRiA35229 PLHU
RefSeqiNP_000292.1, NM_000301.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B2INMR-A181-263[»]
1BMLX-ray2.90A/B561-810[»]
1BUIX-ray2.65A/B561-810[»]
1CEAX-ray2.06A/B100-187[»]
1CEBX-ray2.07A/B100-187[»]
1DDJX-ray2.00A/B/C/D564-810[»]
1HPJNMR-A103-181[»]
1HPKNMR-A103-181[»]
1I5KX-ray2.70A/B184-262[»]
1KI0X-ray1.75A100-352[»]
1KRNX-ray1.67A374-461[»]
1L4DX-ray2.30A562-810[»]
1L4ZX-ray2.80A563-810[»]
1PK4X-ray1.90A376-454[»]
1PKRX-ray2.48A101-181[»]
1PMKX-ray2.25A/B374-461[»]
1QRZX-ray2.00A/B/C/D565-810[»]
1RJXX-ray2.30B564-810[»]
2DOHX-ray2.30X100-333[»]
2DOIX-ray3.10A/X100-333[»]
2KNFNMR-A480-562[»]
2L0SNMR-A272-354[»]
2PK4X-ray2.25A375-454[»]
3UIRX-ray2.78A/B564-810[»]
4A5TX-ray3.49S20-810[»]
4CIKX-ray1.78A101-181[»]
4DCBX-ray2.03F576-585[»]
4DURX-ray2.45A/B20-810[»]
4DUUX-ray5.20A20-810[»]
5HPGX-ray1.66A/B480-563[»]
5UGDX-ray1.38A562-810[»]
5UGGX-ray1.20A562-810[»]
6D3XX-ray1.80A/B565-810[»]
6D3YX-ray1.32A564-810[»]
6D3ZX-ray2.00A565-810[»]
6D40X-ray1.43A563-810[»]
6OG4X-ray1.70A/B183-264[»]
SMRiP00747
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111356, 40 interactors
CORUMiP00747
IntActiP00747, 48 interactors
MINTiP00747
STRINGi9606.ENSP00000308938

Chemistry databases

BindingDBiP00747
ChEMBLiCHEMBL1801
DrugBankiDB00009 Alteplase
DB00513 Aminocaproic Acid
DB00029 Anistreplase
DB06692 Aprotinin
DB03709 Bicine
DB09130 Copper
DB04925 Desmoteplase
DB12831 Gabexate
DB00015 Reteplase
DB00086 Streptokinase
DB00031 Tenecteplase
DB00302 Tranexamic acid
DB00013 Urokinase
DrugCentraliP00747
GuidetoPHARMACOLOGYi2394

Protein family/group databases

MEROPSiS01.233

PTM databases

GlyConnecti502
iPTMnetiP00747
PhosphoSitePlusiP00747
UniCarbKBiP00747

Polymorphism and mutation databases

BioMutaiPLG
DMDMi130316

2D gel databases

SWISS-2DPAGEiP00747

Proteomic databases

CPTACinon-CPTAC-1151
jPOSTiP00747
MassIVEiP00747
MaxQBiP00747
PaxDbiP00747
PeptideAtlasiP00747
PRIDEiP00747
ProteomicsDBi51277

Genome annotation databases

EnsembliENST00000308192; ENSP00000308938; ENSG00000122194
GeneIDi5340
KEGGihsa:5340
UCSCiuc003qtm.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5340
DisGeNETi5340

GeneCards: human genes, protein and diseases

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GeneCardsi
PLG
HGNCiHGNC:9071 PLG
HPAiCAB000668
CAB016678
HPA021602
HPA048823
HPA053770
MalaCardsiPLG
MIMi173350 gene
217090 phenotype
neXtProtiNX_P00747
OpenTargetsiENSG00000122194
Orphaneti722 Hypoplasminogenemia
97231 Ligneous conjunctivitis
537072 PLG-related hereditary angioedema with normal C1Inh
PharmGKBiPA33405

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000155208
HOGENOMiHOG000112892
InParanoidiP00747
KOiK01315
OMAiTELCAGN
OrthoDBi1058295at2759
PhylomeDBiP00747
TreeFamiTF329901

Enzyme and pathway databases

BioCyciMetaCyc:HS04553-MONOMER
BRENDAi3.4.21.7 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-186797 Signaling by PDGF
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKiP00747
SIGNORiP00747

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLG human
EvolutionaryTraceiP00747

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Plasmin
Plasminogen_activator

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5340
PharosiP00747
PMAP-CutDBiP00747

Protein Ontology

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PROi
PR:P00747

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP00747 baseline and differential
GenevisibleiP00747 HS

Family and domain databases

CDDicd00108 KR, 5 hits
cd00190 Tryp_SPc, 1 hit
DisProtiDP00191
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR023317 Pept_S1A_plasmin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 5 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001150 Plasmin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 5 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 5 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 5 hits
PS50070 KRINGLE_2, 5 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLMN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00747
Secondary accession number(s): Q15146, Q5TEH4, Q6PA00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 13, 2019
This is version 246 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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