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Protein

Plasminogen

Gene

PLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.1 Publication
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.1 Publication

Miscellaneous

Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

Catalytic activityi

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.1 Publication

Activity regulationi

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134Fibrin1
Binding sitei136Fibrin1
Binding sitei136Omega-aminocarboxylic acids1
Binding sitei158Omega-aminocarboxylic acids1
Binding sitei172Omega-aminocarboxylic acids1
Binding sitei432Omega-aminocarboxylic acids1
Binding sitei445Omega-aminocarboxylic acids1
Active sitei622Charge relay system1
Active sitei665Charge relay system1
Active sitei760Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processBlood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling

Enzyme and pathway databases

BioCyciMetaCyc:HS04553-MONOMER
BRENDAi3.4.21.7 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-186797 Signaling by PDGF
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKiP00747
SIGNORiP00747

Protein family/group databases

MEROPSiS01.233

Names & Taxonomyi

Protein namesi
Gene namesi
Name:PLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000122194.18
HGNCiHGNC:9071 PLG
MIMi173350 gene
neXtProtiNX_P00747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Plasminogen deficiency (PLGD)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.
See also OMIM:217090
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01865738K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.1
Natural variantiVAR_018658147L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.1
Natural variantiVAR_018659235R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.1
Natural variantiVAR_006627374V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.1
Natural variantiVAR_018660532R → H in PLGD. 1 Publication1
Natural variantiVAR_006628591S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.1
Natural variantiVAR_006629620A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.1
Natural variantiVAR_006630751G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi741S → A: Proteolytically cleaved, but abolishes plasmin activity and cell detachment. 1 Publication1

Keywords - Diseasei

Disease mutation, Thrombophilia

Organism-specific databases

DisGeNETi5340
MalaCardsiPLG
MIMi217090 phenotype
OpenTargetsiENSG00000122194
Orphaneti722 Hypoplasminogenemia
97231 Ligneous conjunctivitis
PharmGKBiPA33405

Chemistry databases

ChEMBLiCHEMBL1801
DrugBankiDB00009 Alteplase
DB00513 Aminocaproic Acid
DB00029 Anistreplase
DB06692 Aprotinin
DB03709 Bicine
DB04925 Desmoteplase
DB00015 Reteplase
DB00086 Streptokinase
DB00031 Tenecteplase
DB00302 Tranexamic Acid
DB00013 Urokinase
GuidetoPHARMACOLOGYi2394

Polymorphism and mutation databases

BioMutaiPLG
DMDMi130316

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000002805320 – 810PlasminogenAdd BLAST791
ChainiPRO_000002805420 – 580Plasmin heavy chain AAdd BLAST561
PeptideiPRO_000002805520 – 97Activation peptideAdd BLAST78
ChainiPRO_000002805779 – 466AngiostatinAdd BLAST388
ChainiPRO_000002805698 – 580Plasmin heavy chain A, short formAdd BLAST483
ChainiPRO_0000028058581 – 810Plasmin light chain BAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 73
Disulfide bondi53 ↔ 61
Disulfide bondi103 ↔ 181
Disulfide bondi124 ↔ 164
Disulfide bondi152 ↔ 176
Disulfide bondi185 ↔ 262
Disulfide bondi188 ↔ 316
Disulfide bondi206 ↔ 245
Disulfide bondi234 ↔ 257
GlycosylationiCAR_000016268O-linked (GalNAc...) serine2 Publications1
Disulfide bondi275 ↔ 352
Disulfide bondi296 ↔ 335
GlycosylationiCAR_000017308N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi324 ↔ 347
GlycosylationiCAR_000018365O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi377 ↔ 454
Disulfide bondi398 ↔ 437
Disulfide bondi426 ↔ 449
Disulfide bondi481 ↔ 560
Disulfide bondi502 ↔ 543
Disulfide bondi531 ↔ 555
Disulfide bondi567 ↔ 685Interchain (between A and B chains)
Disulfide bondi577 ↔ 585Interchain (between A and B chains)
Modified residuei597Phosphoserine1 Publication1
Disulfide bondi607 ↔ 623
Modified residuei688PhosphoserineCombined sources1
Disulfide bondi699 ↔ 766
Disulfide bondi729 ↔ 745
Disulfide bondi756 ↔ 784

Post-translational modificationi

N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).3 Publications
In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei78 – 79Cleavage; by stromelysin-12
Sitei466 – 467Cleavage; by stromelysin-192
Sitei580 – 581Cleavage; by plasminogen activator2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

MaxQBiP00747
PaxDbiP00747
PeptideAtlasiP00747
PRIDEiP00747
ProteomicsDBi51277

2D gel databases

SWISS-2DPAGEiP00747

PTM databases

GlyConnecti502
iPTMnetiP00747
PhosphoSitePlusiP00747
UniCarbKBiP00747

Miscellaneous databases

PMAP-CutDBiP00747

Expressioni

Tissue specificityi

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Gene expression databases

BgeeiENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver
CleanExiHS_PLG
ExpressionAtlasiP00747 baseline and differential
GenevisibleiP00747 HS

Organism-specific databases

HPAiCAB000668
CAB016678
HPA021602
HPA048823
HPA053770

Interactioni

Subunit structurei

Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488). Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047). Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111356, 38 interactors
IntActiP00747, 44 interactors
MINTiP00747
STRINGi9606.ENSP00000308938

Chemistry databases

BindingDBiP00747

Structurei

Secondary structure

1810
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00191
ProteinModelPortaliP00747
SMRiP00747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00747

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 98PANPROSITE-ProRule annotationAdd BLAST79
Domaini103 – 181Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini184 – 262Kringle 2PROSITE-ProRule annotationAdd BLAST79
Domaini275 – 352Kringle 3PROSITE-ProRule annotationAdd BLAST78
Domaini377 – 454Kringle 4PROSITE-ProRule annotationAdd BLAST78
Domaini481 – 560Kringle 5PROSITE-ProRule annotationAdd BLAST80
Domaini581 – 808Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Domaini

Kringle domains mediate interaction with CSPG4.1 Publication

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOGENOMiHOG000112892
HOVERGENiHBG004381
InParanoidiP00747
KOiK01315
OMAiSGHTCQR
OrthoDBiEOG091G0AH5
PhylomeDBiP00747
TreeFamiTF329901

Family and domain databases

CDDicd00108 KR, 5 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR023317 Pept_S1A_plasmin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 5 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001150 Plasmin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 5 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 5 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 5 hits
PS50070 KRINGLE_2, 5 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P00747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA
60 70 80 90 100
AKCEEDEEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL
110 120 130 140 150
SECKTGNGKN YRGTMSKTKN GITCQKWSST SPHRPRFSPA THPSEGLEEN
160 170 180 190 200
YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE CEEECMHCSG ENYDGKISKT
210 220 230 240 250
MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE LRPWCFTTDP
260 270 280 290 300
NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS
310 320 330 340 350
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP
360 370 380 390 400
SCDSSPVSTE QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS
410 420 430 440 450
WSSMTPHRHQ KTPENYPNAG LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN
460 470 480 490 500
LKKCSGTEAS VVAPPPVVLL PDVETPSEED CMFGNGKGYR GKRATTVTGT
510 520 530 540 550
PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG PWCYTTNPRK
560 570 580 590 600
LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT
610 620 630 640 650
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ
660 670 680 690 700
EIEVSRLFLE PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF
710 720 730 740 750
ITGWGETQGT FGAGLLKEAQ LPVIENKVCN RYEFLNGRVQ STELCAGHLA
760 770 780 790 800
GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV
810
TWIEGVMRNN
Length:810
Mass (Da):90,569
Last modified:July 1, 1989 - v2
Checksum:i8B31CB877CCB3AB6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TEH5Q5TEH5_HUMAN
HCG2029799, isoform CRA_b
PLG hCG_2029799
136Annotation score:
A6PVI2A6PVI2_HUMAN
Plasminogen
PLG
166Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → AQ AA sequence (PubMed:122932).Curated1
Sequence conflicti72Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti72Q → E AA sequence (PubMed:122932).Curated1
Sequence conflicti86Missing AA sequence (Ref. 7) Curated1
Sequence conflicti86Missing AA sequence (PubMed:122932).Curated1
Sequence conflicti361Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti361Q → E AA sequence (Ref. 9) Curated1
Sequence conflicti701I → V in AAA36451 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01865738K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.1
Natural variantiVAR_01177946I → R. Corresponds to variant dbSNP:rs1049573Ensembl.1
Natural variantiVAR_01628757E → K1 PublicationCorresponds to variant dbSNP:rs4252070Ensembl.1
Natural variantiVAR_016288133H → Q1 PublicationCorresponds to variant dbSNP:rs4252186Ensembl.1
Natural variantiVAR_018658147L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.1
Natural variantiVAR_018659235R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.1
Natural variantiVAR_016289261R → H1 PublicationCorresponds to variant dbSNP:rs4252187Ensembl.1
Natural variantiVAR_006627374V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.1
Natural variantiVAR_016290408R → W1 PublicationCorresponds to variant dbSNP:rs4252119Ensembl.1
Natural variantiVAR_011780453K → I. Corresponds to variant dbSNP:rs1804181Ensembl.1
Natural variantiVAR_016291472D → N4 PublicationsCorresponds to variant dbSNP:rs4252125Ensembl.1
Natural variantiVAR_016292494A → V1 PublicationCorresponds to variant dbSNP:rs4252128Ensembl.1
Natural variantiVAR_016293523R → W1 PublicationCorresponds to variant dbSNP:rs4252129Ensembl.1
Natural variantiVAR_018660532R → H in PLGD. 1 Publication1
Natural variantiVAR_006628591S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.1
Natural variantiVAR_006629620A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.1
Natural variantiVAR_031213676V → D1 PublicationCorresponds to variant dbSNP:rs17857492Ensembl.1
Natural variantiVAR_006630751G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34276
, M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1
X05199 mRNA Translation: CAA28831.1
M74220 mRNA Translation: AAA36451.1
AY192161 Genomic DNA Translation: AAN85555.1
AL109933 Genomic DNA No translation available.
BC060513 mRNA Translation: AAH60513.1
K02922 mRNA Translation: AAA60124.1
CCDSiCCDS5279.1
PIRiA35229 PLHU
RefSeqiNP_000292.1, NM_000301.3
UniGeneiHs.143436

Genome annotation databases

EnsembliENST00000308192; ENSP00000308938; ENSG00000122194
GeneIDi5340
KEGGihsa:5340
UCSCiuc003qtm.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Plasmin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34276
, M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1
X05199 mRNA Translation: CAA28831.1
M74220 mRNA Translation: AAA36451.1
AY192161 Genomic DNA Translation: AAN85555.1
AL109933 Genomic DNA No translation available.
BC060513 mRNA Translation: AAH60513.1
K02922 mRNA Translation: AAA60124.1
CCDSiCCDS5279.1
PIRiA35229 PLHU
RefSeqiNP_000292.1, NM_000301.3
UniGeneiHs.143436

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B2INMR-A181-263[»]
1BMLX-ray2.90A/B561-810[»]
1BUIX-ray2.65A/B561-810[»]
1CEAX-ray2.06A/B100-187[»]
1CEBX-ray2.07A/B100-187[»]
1DDJX-ray2.00A/B/C/D564-810[»]
1HPJNMR-A103-181[»]
1HPKNMR-A103-181[»]
1I5KX-ray2.70A/B184-262[»]
1KI0X-ray1.75A100-352[»]
1KRNX-ray1.67A374-461[»]
1L4DX-ray2.30A562-810[»]
1L4ZX-ray2.80A563-810[»]
1PK4X-ray1.90A376-454[»]
1PKRX-ray2.48A101-181[»]
1PMKX-ray2.25A/B374-461[»]
1QRZX-ray2.00A/B/C/D565-810[»]
1RJXX-ray2.30B564-810[»]
2DOHX-ray2.30X100-333[»]
2DOIX-ray3.10A/X100-333[»]
2KNFNMR-A480-562[»]
2L0SNMR-A272-354[»]
2PK4X-ray2.25A375-454[»]
3UIRX-ray2.78A/B564-810[»]
4A5TX-ray3.49S20-810[»]
4CIKX-ray1.78A101-181[»]
4DCBX-ray2.03F576-585[»]
4DURX-ray2.45A/B20-810[»]
4DUUX-ray5.20A20-810[»]
5HPGX-ray1.66A/B480-563[»]
5UGDX-ray1.38A562-810[»]
5UGGX-ray1.20A562-810[»]
DisProtiDP00191
ProteinModelPortaliP00747
SMRiP00747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111356, 38 interactors
IntActiP00747, 44 interactors
MINTiP00747
STRINGi9606.ENSP00000308938

Chemistry databases

BindingDBiP00747
ChEMBLiCHEMBL1801
DrugBankiDB00009 Alteplase
DB00513 Aminocaproic Acid
DB00029 Anistreplase
DB06692 Aprotinin
DB03709 Bicine
DB04925 Desmoteplase
DB00015 Reteplase
DB00086 Streptokinase
DB00031 Tenecteplase
DB00302 Tranexamic Acid
DB00013 Urokinase
GuidetoPHARMACOLOGYi2394

Protein family/group databases

MEROPSiS01.233

PTM databases

GlyConnecti502
iPTMnetiP00747
PhosphoSitePlusiP00747
UniCarbKBiP00747

Polymorphism and mutation databases

BioMutaiPLG
DMDMi130316

2D gel databases

SWISS-2DPAGEiP00747

Proteomic databases

MaxQBiP00747
PaxDbiP00747
PeptideAtlasiP00747
PRIDEiP00747
ProteomicsDBi51277

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308192; ENSP00000308938; ENSG00000122194
GeneIDi5340
KEGGihsa:5340
UCSCiuc003qtm.5 human

Organism-specific databases

CTDi5340
DisGeNETi5340
EuPathDBiHostDB:ENSG00000122194.18
GeneCardsiPLG
HGNCiHGNC:9071 PLG
HPAiCAB000668
CAB016678
HPA021602
HPA048823
HPA053770
MalaCardsiPLG
MIMi173350 gene
217090 phenotype
neXtProtiNX_P00747
OpenTargetsiENSG00000122194
Orphaneti722 Hypoplasminogenemia
97231 Ligneous conjunctivitis
PharmGKBiPA33405
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOGENOMiHOG000112892
HOVERGENiHBG004381
InParanoidiP00747
KOiK01315
OMAiSGHTCQR
OrthoDBiEOG091G0AH5
PhylomeDBiP00747
TreeFamiTF329901

Enzyme and pathway databases

BioCyciMetaCyc:HS04553-MONOMER
BRENDAi3.4.21.7 2681
ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-186797 Signaling by PDGF
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKiP00747
SIGNORiP00747

Miscellaneous databases

ChiTaRSiPLG human
EvolutionaryTraceiP00747
GeneWikiiPlasmin
Plasminogen_activator
GenomeRNAii5340
PMAP-CutDBiP00747
PROiPR:P00747
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver
CleanExiHS_PLG
ExpressionAtlasiP00747 baseline and differential
GenevisibleiP00747 HS

Family and domain databases

CDDicd00108 KR, 5 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR023317 Pept_S1A_plasmin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 5 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001150 Plasmin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 5 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 5 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 5 hits
PS50070 KRINGLE_2, 5 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLMN_HUMAN
AccessioniPrimary (citable) accession number: P00747
Secondary accession number(s): Q15146, Q5TEH4, Q6PA00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 235 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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