UniProtKB - P00747 (PLMN_HUMAN)
Protein
Plasminogen
Gene
PLG
Organism
Homo sapiens (Human)
Status
Functioni
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.1 Publication
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.1 Publication
Miscellaneous
Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
Catalytic activityi
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.1 Publication
Activity regulationi
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.1 Publication
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Binding sitei | 134 | Fibrin | 1 | |
| Binding sitei | 136 | Fibrin | 1 | |
| Binding sitei | 136 | Omega-aminocarboxylic acids | 1 | |
| Binding sitei | 158 | Omega-aminocarboxylic acids | 1 | |
| Binding sitei | 172 | Omega-aminocarboxylic acids | 1 | |
| Binding sitei | 432 | Omega-aminocarboxylic acids | 1 | |
| Binding sitei | 445 | Omega-aminocarboxylic acids | 1 | |
| Active sitei | 622 | Charge relay system | 1 | |
| Active sitei | 665 | Charge relay system | 1 | |
| Active sitei | 760 | Charge relay system | 1 |
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- chaperone binding Source: CAFA
- endopeptidase activity Source: CAFA
- enzyme binding Source: CAFA
- kinase binding Source: CAFA
- proteasome core complex binding Source: CAFA
- protein antigen binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- serine-type endopeptidase activity Source: CAFA
- serine-type peptidase activity Source: AgBase
- signaling receptor binding Source: AgBase
GO - Biological processi
- blood coagulation Source: HGNC
- cellular protein metabolic process Source: Reactome
- extracellular matrix disassembly Source: BHF-UCL
- fibrinolysis Source: CAFA
- interaction with symbiont Source: CAFA
- interaction with symbiont via secreted substance involved in symbiotic interaction Source: CAFA
- modification by host of symbiont morphology or physiology via secreted substance Source: CAFA
- negative regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
- negative regulation of cell proliferation Source: ProtInc
- negative regulation of cell-substrate adhesion Source: BHF-UCL
- negative regulation of fibrinolysis Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of blood vessel endothelial cell migration Source: CAFA
- positive regulation of fibrinolysis Source: AgBase
- proteolysis Source: CAFA
- tissue remodeling Source: UniProtKB-KW
Keywordsi
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Blood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling |
Enzyme and pathway databases
| BioCyci | MetaCyc:HS04553-MONOMER |
| BRENDAi | 3.4.21.7 2681 |
| Reactomei | R-HSA-114608 Platelet degranulation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-186797 Signaling by PDGF R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205 Dissolution of Fibrin Clot |
| SABIO-RKi | P00747 |
| SIGNORi | P00747 |
Protein family/group databases
| MEROPSi | S01.233 |
Names & Taxonomyi
| Protein namesi | |
| Gene namesi | Name:PLG |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000122194.18 |
| HGNCi | HGNC:9071 PLG |
| MIMi | 173350 gene |
| neXtProti | NX_P00747 |
Pathology & Biotechi
Involvement in diseasei
Plasminogen deficiency (PLGD)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.
See also OMIM:217090| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_018657 | 38 | K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar. | 1 | |
| Natural variantiVAR_018658 | 147 | L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl. | 1 | |
| Natural variantiVAR_018659 | 235 | R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar. | 1 | |
| Natural variantiVAR_006627 | 374 | V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar. | 1 | |
| Natural variantiVAR_018660 | 532 | R → H in PLGD. 1 Publication | 1 | |
| Natural variantiVAR_006628 | 591 | S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar. | 1 | |
| Natural variantiVAR_006629 | 620 | A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar. | 1 | |
| Natural variantiVAR_006630 | 751 | G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar. | 1 |
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 741 | S → A: Proteolytically cleaved, but abolishes plasmin activity and cell detachment. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, ThrombophiliaOrganism-specific databases
| DisGeNETi | 5340 |
| MalaCardsi | PLG |
| MIMi | 217090 phenotype |
| OpenTargetsi | ENSG00000122194 |
| Orphaneti | 722 Hypoplasminogenemia 97231 Ligneous conjunctivitis |
| PharmGKBi | PA33405 |
Chemistry databases
| ChEMBLi | CHEMBL1801 |
| DrugBanki | DB00009 Alteplase DB00513 Aminocaproic Acid DB00029 Anistreplase DB06692 Aprotinin DB03709 Bicine DB04925 Desmoteplase DB00015 Reteplase DB00086 Streptokinase DB00031 Tenecteplase DB00302 Tranexamic Acid DB00013 Urokinase |
| GuidetoPHARMACOLOGYi | 2394 |
Polymorphism and mutation databases
| BioMutai | PLG |
| DMDMi | 130316 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | 1 – 19 | 2 PublicationsAdd BLAST | 19 | |
| ChainiPRO_0000028053 | 20 – 810 | PlasminogenAdd BLAST | 791 | |
| ChainiPRO_0000028054 | 20 – 580 | Plasmin heavy chain AAdd BLAST | 561 | |
| PeptideiPRO_0000028055 | 20 – 97 | Activation peptideAdd BLAST | 78 | |
| ChainiPRO_0000028057 | 79 – 466 | AngiostatinAdd BLAST | 388 | |
| ChainiPRO_0000028056 | 98 – 580 | Plasmin heavy chain A, short formAdd BLAST | 483 | |
| ChainiPRO_0000028058 | 581 – 810 | Plasmin light chain BAdd BLAST | 230 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 49 ↔ 73 | |||
| Disulfide bondi | 53 ↔ 61 | |||
| Disulfide bondi | 103 ↔ 181 | |||
| Disulfide bondi | 124 ↔ 164 | |||
| Disulfide bondi | 152 ↔ 176 | |||
| Disulfide bondi | 185 ↔ 262 | |||
| Disulfide bondi | 188 ↔ 316 | |||
| Disulfide bondi | 206 ↔ 245 | |||
| Disulfide bondi | 234 ↔ 257 | |||
| GlycosylationiCAR_000016 | 268 | O-linked (GalNAc...) serine2 Publications | 1 | |
| Disulfide bondi | 275 ↔ 352 | |||
| Disulfide bondi | 296 ↔ 335 | |||
| GlycosylationiCAR_000017 | 308 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
| Disulfide bondi | 324 ↔ 347 | |||
| GlycosylationiCAR_000018 | 365 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Disulfide bondi | 377 ↔ 454 | |||
| Disulfide bondi | 398 ↔ 437 | |||
| Disulfide bondi | 426 ↔ 449 | |||
| Disulfide bondi | 481 ↔ 560 | |||
| Disulfide bondi | 502 ↔ 543 | |||
| Disulfide bondi | 531 ↔ 555 | |||
| Disulfide bondi | 567 ↔ 685 | Interchain (between A and B chains) | ||
| Disulfide bondi | 577 ↔ 585 | Interchain (between A and B chains) | ||
| Modified residuei | 597 | Phosphoserine1 Publication | 1 | |
| Disulfide bondi | 607 ↔ 623 | |||
| Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
| Disulfide bondi | 699 ↔ 766 | |||
| Disulfide bondi | 729 ↔ 745 | |||
| Disulfide bondi | 756 ↔ 784 |
Post-translational modificationi
N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).3 Publications
In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.2 Publications
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 78 – 79 | Cleavage; by stromelysin-1 | 2 | |
| Sitei | 466 – 467 | Cleavage; by stromelysin-19 | 2 | |
| Sitei | 580 – 581 | Cleavage; by plasminogen activator | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
| MaxQBi | P00747 |
| PaxDbi | P00747 |
| PeptideAtlasi | P00747 |
| PRIDEi | P00747 |
| ProteomicsDBi | 51277 |
2D gel databases
| SWISS-2DPAGEi | P00747 |
PTM databases
| GlyConnecti | 502 |
| iPTMneti | P00747 |
| PhosphoSitePlusi | P00747 |
| UniCarbKBi | P00747 |
Miscellaneous databases
| PMAP-CutDBi | P00747 |
Expressioni
Tissue specificityi
Present in plasma and many other extracellular fluids. It is synthesized in the liver.
Gene expression databases
| Bgeei | ENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver |
| CleanExi | HS_PLG |
| ExpressionAtlasi | P00747 baseline and differential |
| Genevisiblei | P00747 HS |
Organism-specific databases
| HPAi | CAB000668 CAB016678 HPA021602 HPA048823 HPA053770 |
Interactioni
Subunit structurei
Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488). Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047). Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).6 Publications
Binary interactionsi
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- chaperone binding Source: CAFA
- enzyme binding Source: CAFA
- kinase binding Source: CAFA
- protein antigen binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- signaling receptor binding Source: AgBase
Protein-protein interaction databases
| BioGridi | 111356, 38 interactors |
| IntActi | P00747, 44 interactors |
| MINTi | P00747 |
| STRINGi | 9606.ENSP00000308938 |
Chemistry databases
| BindingDBi | P00747 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| DisProti | DP00191 |
| ProteinModelPortali | P00747 |
| SMRi | P00747 |
| ModBasei | Search... |
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P00747 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 20 – 98 | PANPROSITE-ProRule annotationAdd BLAST | 79 | |
| Domaini | 103 – 181 | Kringle 1PROSITE-ProRule annotationAdd BLAST | 79 | |
| Domaini | 184 – 262 | Kringle 2PROSITE-ProRule annotationAdd BLAST | 79 | |
| Domaini | 275 – 352 | Kringle 3PROSITE-ProRule annotationAdd BLAST | 78 | |
| Domaini | 377 – 454 | Kringle 4PROSITE-ProRule annotationAdd BLAST | 78 | |
| Domaini | 481 – 560 | Kringle 5PROSITE-ProRule annotationAdd BLAST | 80 | |
| Domaini | 581 – 808 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 228 |
Domaini
Kringle domains mediate interaction with CSPG4.1 Publication
Sequence similaritiesi
Keywords - Domaini
Kringle, Repeat, SignalPhylogenomic databases
| eggNOGi | ENOG410IDXR Eukaryota COG5640 LUCA |
| GeneTreei | ENSGT00760000119133 |
| HOGENOMi | HOG000112892 |
| HOVERGENi | HBG004381 |
| InParanoidi | P00747 |
| KOi | K01315 |
| OMAi | SGHTCQR |
| OrthoDBi | EOG091G0AH5 |
| PhylomeDBi | P00747 |
| TreeFami | TF329901 |
Family and domain databases
| CDDi | cd00108 KR, 5 hits cd00190 Tryp_SPc, 1 hit |
| Gene3Di | 2.40.20.10, 4 hits |
| InterProi | View protein in InterPro IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR023317 Pept_S1A_plasmin IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER |
| Pfami | View protein in Pfam PF00051 Kringle, 5 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit |
| PIRSFi | PIRSF001150 Plasmin, 1 hit |
| PRINTSi | PR00722 CHYMOTRYPSIN |
| SMARTi | View protein in SMART SM00130 KR, 5 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit |
| SUPFAMi | SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 5 hits |
| PROSITEi | View protein in PROSITE PS00021 KRINGLE_1, 5 hits PS50070 KRINGLE_2, 5 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit |
Sequence (1+)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P00747-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA
60 70 80 90 100
AKCEEDEEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL
110 120 130 140 150
SECKTGNGKN YRGTMSKTKN GITCQKWSST SPHRPRFSPA THPSEGLEEN
160 170 180 190 200
YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE CEEECMHCSG ENYDGKISKT
210 220 230 240 250
MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE LRPWCFTTDP
260 270 280 290 300
NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS
310 320 330 340 350
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP
360 370 380 390 400
SCDSSPVSTE QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS
410 420 430 440 450
WSSMTPHRHQ KTPENYPNAG LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN
460 470 480 490 500
LKKCSGTEAS VVAPPPVVLL PDVETPSEED CMFGNGKGYR GKRATTVTGT
510 520 530 540 550
PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG PWCYTTNPRK
560 570 580 590 600
LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT
610 620 630 640 650
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ
660 670 680 690 700
EIEVSRLFLE PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF
710 720 730 740 750
ITGWGETQGT FGAGLLKEAQ LPVIENKVCN RYEFLNGRVQ STELCAGHLA
760 770 780 790 800
GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV
810
TWIEGVMRNN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| Q5TEH5 | Q5TEH5_HUMAN | HCG2029799, isoform CRA_b | PLG hCG_2029799 | 136 | Annotation score: | ||
| A6PVI2 | A6PVI2_HUMAN | Plasminogen | PLG | 166 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 50 | A → AQ AA sequence (PubMed:122932).Curated | 1 | |
| Sequence conflicti | 72 | Q → E AA sequence (Ref. 7) Curated | 1 | |
| Sequence conflicti | 72 | Q → E AA sequence (PubMed:122932).Curated | 1 | |
| Sequence conflicti | 86 | Missing AA sequence (Ref. 7) Curated | 1 | |
| Sequence conflicti | 86 | Missing AA sequence (PubMed:122932).Curated | 1 | |
| Sequence conflicti | 361 | Q → E AA sequence (Ref. 7) Curated | 1 | |
| Sequence conflicti | 361 | Q → E AA sequence (Ref. 9) Curated | 1 | |
| Sequence conflicti | 701 | I → V in AAA36451 (Ref. 3) Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_018657 | 38 | K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar. | 1 | |
| Natural variantiVAR_011779 | 46 | I → R. Corresponds to variant dbSNP:rs1049573Ensembl. | 1 | |
| Natural variantiVAR_016287 | 57 | E → K1 PublicationCorresponds to variant dbSNP:rs4252070Ensembl. | 1 | |
| Natural variantiVAR_016288 | 133 | H → Q1 PublicationCorresponds to variant dbSNP:rs4252186Ensembl. | 1 | |
| Natural variantiVAR_018658 | 147 | L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl. | 1 | |
| Natural variantiVAR_018659 | 235 | R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar. | 1 | |
| Natural variantiVAR_016289 | 261 | R → H1 PublicationCorresponds to variant dbSNP:rs4252187Ensembl. | 1 | |
| Natural variantiVAR_006627 | 374 | V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar. | 1 | |
| Natural variantiVAR_016290 | 408 | R → W1 PublicationCorresponds to variant dbSNP:rs4252119Ensembl. | 1 | |
| Natural variantiVAR_011780 | 453 | K → I. Corresponds to variant dbSNP:rs1804181Ensembl. | 1 | |
| Natural variantiVAR_016291 | 472 | D → N4 PublicationsCorresponds to variant dbSNP:rs4252125Ensembl. | 1 | |
| Natural variantiVAR_016292 | 494 | A → V1 PublicationCorresponds to variant dbSNP:rs4252128Ensembl. | 1 | |
| Natural variantiVAR_016293 | 523 | R → W1 PublicationCorresponds to variant dbSNP:rs4252129Ensembl. | 1 | |
| Natural variantiVAR_018660 | 532 | R → H in PLGD. 1 Publication | 1 | |
| Natural variantiVAR_006628 | 591 | S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar. | 1 | |
| Natural variantiVAR_006629 | 620 | A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar. | 1 | |
| Natural variantiVAR_031213 | 676 | V → D1 PublicationCorresponds to variant dbSNP:rs17857492Ensembl. | 1 | |
| Natural variantiVAR_006630 | 751 | G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar. | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34276 M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1 |
| CCDSi | CCDS5279.1 |
| PIRi | A35229 PLHU |
| RefSeqi | NP_000292.1, NM_000301.3 |
| UniGenei | Hs.143436 |
Genome annotation databases
| Ensembli | ENST00000308192; ENSP00000308938; ENSG00000122194 |
| GeneIDi | 5340 |
| KEGGi | hsa:5340 |
| UCSCi | uc003qtm.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
| Wikipedia Plasmin entry |
| SeattleSNPs |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34276 M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1 |
| CCDSi | CCDS5279.1 |
| PIRi | A35229 PLHU |
| RefSeqi | NP_000292.1, NM_000301.3 |
| UniGenei | Hs.143436 |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1B2I | NMR | - | A | 181-263 | [»] | |
| 1BML | X-ray | 2.90 | A/B | 561-810 | [»] | |
| 1BUI | X-ray | 2.65 | A/B | 561-810 | [»] | |
| 1CEA | X-ray | 2.06 | A/B | 100-187 | [»] | |
| 1CEB | X-ray | 2.07 | A/B | 100-187 | [»] | |
| 1DDJ | X-ray | 2.00 | A/B/C/D | 564-810 | [»] | |
| 1HPJ | NMR | - | A | 103-181 | [»] | |
| 1HPK | NMR | - | A | 103-181 | [»] | |
| 1I5K | X-ray | 2.70 | A/B | 184-262 | [»] | |
| 1KI0 | X-ray | 1.75 | A | 100-352 | [»] | |
| 1KRN | X-ray | 1.67 | A | 374-461 | [»] | |
| 1L4D | X-ray | 2.30 | A | 562-810 | [»] | |
| 1L4Z | X-ray | 2.80 | A | 563-810 | [»] | |
| 1PK4 | X-ray | 1.90 | A | 376-454 | [»] | |
| 1PKR | X-ray | 2.48 | A | 101-181 | [»] | |
| 1PMK | X-ray | 2.25 | A/B | 374-461 | [»] | |
| 1QRZ | X-ray | 2.00 | A/B/C/D | 565-810 | [»] | |
| 1RJX | X-ray | 2.30 | B | 564-810 | [»] | |
| 2DOH | X-ray | 2.30 | X | 100-333 | [»] | |
| 2DOI | X-ray | 3.10 | A/X | 100-333 | [»] | |
| 2KNF | NMR | - | A | 480-562 | [»] | |
| 2L0S | NMR | - | A | 272-354 | [»] | |
| 2PK4 | X-ray | 2.25 | A | 375-454 | [»] | |
| 3UIR | X-ray | 2.78 | A/B | 564-810 | [»] | |
| 4A5T | X-ray | 3.49 | S | 20-810 | [»] | |
| 4CIK | X-ray | 1.78 | A | 101-181 | [»] | |
| 4DCB | X-ray | 2.03 | F | 576-585 | [»] | |
| 4DUR | X-ray | 2.45 | A/B | 20-810 | [»] | |
| 4DUU | X-ray | 5.20 | A | 20-810 | [»] | |
| 5HPG | X-ray | 1.66 | A/B | 480-563 | [»] | |
| 5UGD | X-ray | 1.38 | A | 562-810 | [»] | |
| 5UGG | X-ray | 1.20 | A | 562-810 | [»] | |
| DisProti | DP00191 | |||||
| ProteinModelPortali | P00747 | |||||
| SMRi | P00747 | |||||
| ModBasei | Search... | |||||
| MobiDBi | Search... | |||||
Protein-protein interaction databases
| BioGridi | 111356, 38 interactors |
| IntActi | P00747, 44 interactors |
| MINTi | P00747 |
| STRINGi | 9606.ENSP00000308938 |
Chemistry databases
| BindingDBi | P00747 |
| ChEMBLi | CHEMBL1801 |
| DrugBanki | DB00009 Alteplase DB00513 Aminocaproic Acid DB00029 Anistreplase DB06692 Aprotinin DB03709 Bicine DB04925 Desmoteplase DB00015 Reteplase DB00086 Streptokinase DB00031 Tenecteplase DB00302 Tranexamic Acid DB00013 Urokinase |
| GuidetoPHARMACOLOGYi | 2394 |
Protein family/group databases
| MEROPSi | S01.233 |
PTM databases
| GlyConnecti | 502 |
| iPTMneti | P00747 |
| PhosphoSitePlusi | P00747 |
| UniCarbKBi | P00747 |
Polymorphism and mutation databases
| BioMutai | PLG |
| DMDMi | 130316 |
2D gel databases
| SWISS-2DPAGEi | P00747 |
Proteomic databases
| MaxQBi | P00747 |
| PaxDbi | P00747 |
| PeptideAtlasi | P00747 |
| PRIDEi | P00747 |
| ProteomicsDBi | 51277 |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000308192; ENSP00000308938; ENSG00000122194 |
| GeneIDi | 5340 |
| KEGGi | hsa:5340 |
| UCSCi | uc003qtm.5 human |
Organism-specific databases
| CTDi | 5340 |
| DisGeNETi | 5340 |
| EuPathDBi | HostDB:ENSG00000122194.18 |
| GeneCardsi | PLG |
| HGNCi | HGNC:9071 PLG |
| HPAi | CAB000668 CAB016678 HPA021602 HPA048823 HPA053770 |
| MalaCardsi | PLG |
| MIMi | 173350 gene 217090 phenotype |
| neXtProti | NX_P00747 |
| OpenTargetsi | ENSG00000122194 |
| Orphaneti | 722 Hypoplasminogenemia 97231 Ligneous conjunctivitis |
| PharmGKBi | PA33405 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG410IDXR Eukaryota COG5640 LUCA |
| GeneTreei | ENSGT00760000119133 |
| HOGENOMi | HOG000112892 |
| HOVERGENi | HBG004381 |
| InParanoidi | P00747 |
| KOi | K01315 |
| OMAi | SGHTCQR |
| OrthoDBi | EOG091G0AH5 |
| PhylomeDBi | P00747 |
| TreeFami | TF329901 |
Enzyme and pathway databases
| BioCyci | MetaCyc:HS04553-MONOMER |
| BRENDAi | 3.4.21.7 2681 |
| Reactomei | R-HSA-114608 Platelet degranulation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-186797 Signaling by PDGF R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205 Dissolution of Fibrin Clot |
| SABIO-RKi | P00747 |
| SIGNORi | P00747 |
Miscellaneous databases
| ChiTaRSi | PLG human |
| EvolutionaryTracei | P00747 |
| GeneWikii | Plasmin Plasminogen_activator |
| GenomeRNAii | 5340 |
| PMAP-CutDBi | P00747 |
| PROi | PR:P00747 |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver |
| CleanExi | HS_PLG |
| ExpressionAtlasi | P00747 baseline and differential |
| Genevisiblei | P00747 HS |
Family and domain databases
| CDDi | cd00108 KR, 5 hits cd00190 Tryp_SPc, 1 hit |
| Gene3Di | 2.40.20.10, 4 hits |
| InterProi | View protein in InterPro IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR023317 Pept_S1A_plasmin IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER |
| Pfami | View protein in Pfam PF00051 Kringle, 5 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit |
| PIRSFi | PIRSF001150 Plasmin, 1 hit |
| PRINTSi | PR00722 CHYMOTRYPSIN |
| SMARTi | View protein in SMART SM00130 KR, 5 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit |
| SUPFAMi | SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 5 hits |
| PROSITEi | View protein in PROSITE PS00021 KRINGLE_1, 5 hits PS50070 KRINGLE_2, 5 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | PLMN_HUMAN | |
| Accessioni | P00747Primary (citable) accession number: P00747 Secondary accession number(s): Q15146, Q5TEH4, Q6PA00 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
| Last sequence update: | July 1, 1989 | |
| Last modified: | November 7, 2018 | |
| This is version 235 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
