UniProtKB - P00747 (PLMN_HUMAN)
Plasminogen
PLG
Functioni
Miscellaneous
Catalytic activityi
- Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.1 Publication EC:3.4.21.7
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 134 | Fibrin | 1 | |
Binding sitei | 136 | Fibrin | 1 | |
Binding sitei | 136 | Omega-aminocarboxylic acids | 1 | |
Binding sitei | 158 | Omega-aminocarboxylic acids | 1 | |
Binding sitei | 172 | Omega-aminocarboxylic acids | 1 | |
Binding sitei | 432 | Omega-aminocarboxylic acids | 1 | |
Binding sitei | 445 | Omega-aminocarboxylic acids | 1 | |
Active sitei | 622 | Charge relay system | 1 | |
Active sitei | 665 | Charge relay system | 1 | |
Active sitei | 760 | Charge relay system | 1 |
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- chaperone binding Source: CAFA
- endopeptidase activity Source: CAFA
- enzyme binding Source: CAFA
- kinase binding Source: CAFA
- protein antigen binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- serine-type endopeptidase activity Source: CAFA
- serine-type peptidase activity Source: AgBase
- signaling receptor binding Source: AgBase
GO - Biological processi
- blood coagulation Source: HGNC-UCL
- cellular protein metabolic process Source: Reactome
- extracellular matrix disassembly Source: BHF-UCL
- fibrinolysis Source: CAFA
- interaction with symbiont Source: CAFA
- labyrinthine layer blood vessel development Source: Ensembl
- mononuclear cell migration Source: Ensembl
- muscle cell cellular homeostasis Source: Ensembl
- myoblast differentiation Source: Ensembl
- negative regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of cell-substrate adhesion Source: BHF-UCL
- negative regulation of fibrinolysis Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of blood vessel endothelial cell migration Source: CAFA
- positive regulation of fibrinolysis Source: AgBase
- proteolysis Source: CAFA
- proteolysis involved in cellular protein catabolic process Source: Ensembl
- tissue regeneration Source: Ensembl
- tissue remodeling Source: UniProtKB-KW
- trophoblast giant cell differentiation Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04553-MONOMER |
BRENDAi | 3.4.21.7, 2681 |
PathwayCommonsi | P00747 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-186797, Signaling by PDGF R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205, Dissolution of Fibrin Clot |
SABIO-RKi | P00747 |
SIGNORi | P00747 |
Protein family/group databases
MEROPSi | S01.233 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000122194.18 |
HGNCi | HGNC:9071, PLG |
MIMi | 173350, gene |
neXtProti | NX_P00747 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: CAFA
Plasma Membrane
- extrinsic component of external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- cell surface Source: BHF-UCL
- intracellular membrane-bounded organelle Source: Ensembl
- platelet alpha granule lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Plasminogen deficiency (PLGD)8 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018657 | 38 | K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar. | 1 | |
Natural variantiVAR_018658 | 147 | L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl. | 1 | |
Natural variantiVAR_018659 | 235 | R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar. | 1 | |
Natural variantiVAR_006627 | 374 | V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar. | 1 | |
Natural variantiVAR_018660 | 532 | R → H in PLGD. 1 Publication | 1 | |
Natural variantiVAR_006628 | 591 | S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar. | 1 | |
Natural variantiVAR_006629 | 620 | A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar. | 1 | |
Natural variantiVAR_006630 | 751 | G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 741 | S → A: Proteolytically cleaved, but abolishes plasmin activity and cell detachment. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, ThrombophiliaOrganism-specific databases
DisGeNETi | 5340 |
MalaCardsi | PLG |
MIMi | 217090, phenotype |
OpenTargetsi | ENSG00000122194 |
Orphaneti | 722, Hypoplasminogenemia 537072, PLG-related hereditary angioedema with normal C1Inh |
PharmGKBi | PA33405 |
Miscellaneous databases
Pharosi | P00747, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1801 |
DrugBanki | DB00009, Alteplase DB00513, Aminocaproic acid DB00029, Anistreplase DB06692, Aprotinin DB03709, Bicine DB09130, Copper DB04925, Desmoteplase DB12831, Gabexate DB00015, Reteplase DB00086, Streptokinase DB00031, Tenecteplase DB00302, Tranexamic acid DB00013, Urokinase |
DrugCentrali | P00747 |
GuidetoPHARMACOLOGYi | 2394 |
Polymorphism and mutation databases
BioMutai | PLG |
DMDMi | 130316 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 2 PublicationsAdd BLAST | 19 | |
ChainiPRO_0000028053 | 20 – 810 | PlasminogenAdd BLAST | 791 | |
ChainiPRO_0000028054 | 20 – 580 | Plasmin heavy chain AAdd BLAST | 561 | |
PeptideiPRO_0000028055 | 20 – 97 | Activation peptideAdd BLAST | 78 | |
ChainiPRO_0000028057 | 79 – 466 | AngiostatinAdd BLAST | 388 | |
ChainiPRO_0000028056 | 98 – 580 | Plasmin heavy chain A, short formAdd BLAST | 483 | |
ChainiPRO_0000028058 | 581 – 810 | Plasmin light chain BAdd BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 73 | |||
Disulfide bondi | 53 ↔ 61 | |||
Disulfide bondi | 103 ↔ 181 | |||
Disulfide bondi | 124 ↔ 164 | |||
Disulfide bondi | 152 ↔ 176 | |||
Disulfide bondi | 185 ↔ 262 | |||
Disulfide bondi | 188 ↔ 316 | |||
Disulfide bondi | 206 ↔ 245 | |||
Disulfide bondi | 234 ↔ 257 | |||
GlycosylationiCAR_000016 | 268 | O-linked (GalNAc...) serine2 Publications | 1 | |
Disulfide bondi | 275 ↔ 352 | |||
Disulfide bondi | 296 ↔ 335 | |||
GlycosylationiCAR_000017 | 308 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 324 ↔ 347 | |||
GlycosylationiCAR_000018 | 365 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 377 ↔ 454 | |||
Disulfide bondi | 398 ↔ 437 | |||
Disulfide bondi | 426 ↔ 449 | |||
Disulfide bondi | 481 ↔ 560 | |||
Disulfide bondi | 502 ↔ 543 | |||
Disulfide bondi | 531 ↔ 555 | |||
Disulfide bondi | 567 ↔ 685 | Interchain (between A and B chains) | ||
Disulfide bondi | 577 ↔ 585 | Interchain (between A and B chains) | ||
Modified residuei | 597 | Phosphoserine1 Publication | 1 | |
Disulfide bondi | 607 ↔ 623 | |||
Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 699 ↔ 766 | |||
Disulfide bondi | 729 ↔ 745 | |||
Disulfide bondi | 756 ↔ 784 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 78 – 79 | Cleavage; by stromelysin-1 | 2 | |
Sitei | 466 – 467 | Cleavage; by stromelysin-19 | 2 | |
Sitei | 580 – 581 | Cleavage; by plasminogen activator | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
CPTACi | non-CPTAC-1151 |
jPOSTi | P00747 |
MassIVEi | P00747 |
MaxQBi | P00747 |
PaxDbi | P00747 |
PeptideAtlasi | P00747 |
PRIDEi | P00747 |
ProteomicsDBi | 51277 |
2D gel databases
SWISS-2DPAGEi | P00747 |
PTM databases
GlyConnecti | 502, 11 N-Linked glycans (3 sites), 2 O-Linked glycans (2 sites) |
GlyGeni | P00747, 15 sites, 8 N-linked glycans (1 site), 10 O-linked glycans (12 sites) |
iPTMneti | P00747 |
PhosphoSitePlusi | P00747 |
UniCarbKBi | P00747 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000122194, Expressed in right lobe of liver and 125 other tissues |
ExpressionAtlasi | P00747, baseline and differential |
Genevisiblei | P00747, HS |
Organism-specific databases
HPAi | ENSG00000122194, Tissue enriched (liver) |
Interactioni
Subunit structurei
Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488).
Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047).
Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin:
Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).
6 Publications(Microbial infection) Interacts with Staphylococcus aureus protein FnbB; this interaction provides active plasmin on the surface of bacteria cells.
1 PublicationBinary interactionsi
Hide detailsP00747
GO - Molecular functioni
- apolipoprotein binding Source: BHF-UCL
- chaperone binding Source: CAFA
- enzyme binding Source: CAFA
- kinase binding Source: CAFA
- protein antigen binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- signaling receptor binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 111356, 41 interactors |
CORUMi | P00747 |
IntActi | P00747, 52 interactors |
MINTi | P00747 |
STRINGi | 9606.ENSP00000308938 |
Chemistry databases
BindingDBi | P00747 |
Miscellaneous databases
RNActi | P00747, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P00747 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00747 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 98 | PANPROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 103 – 181 | Kringle 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 184 – 262 | Kringle 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 275 – 352 | Kringle 3PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 377 – 454 | Kringle 4PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 481 – 560 | Kringle 5PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 581 – 808 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 228 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Kringle, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QVNP, Eukaryota |
GeneTreei | ENSGT00940000155208 |
HOGENOMi | CLU_017565_0_0_1 |
InParanoidi | P00747 |
OMAi | TELCAGN |
OrthoDBi | 164039at2759 |
PhylomeDBi | P00747 |
TreeFami | TF329901 |
Family and domain databases
CDDi | cd00108, KR, 5 hits cd00190, Tryp_SPc, 1 hit |
DisProti | DP00191 |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR023317, Pept_S1A_plasmin IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00051, Kringle, 5 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001150, Plasmin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 5 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 5 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 5 hits PS50070, KRINGLE_2, 5 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA
60 70 80 90 100
AKCEEDEEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL
110 120 130 140 150
SECKTGNGKN YRGTMSKTKN GITCQKWSST SPHRPRFSPA THPSEGLEEN
160 170 180 190 200
YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE CEEECMHCSG ENYDGKISKT
210 220 230 240 250
MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE LRPWCFTTDP
260 270 280 290 300
NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS
310 320 330 340 350
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP
360 370 380 390 400
SCDSSPVSTE QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS
410 420 430 440 450
WSSMTPHRHQ KTPENYPNAG LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN
460 470 480 490 500
LKKCSGTEAS VVAPPPVVLL PDVETPSEED CMFGNGKGYR GKRATTVTGT
510 520 530 540 550
PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG PWCYTTNPRK
560 570 580 590 600
LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT
610 620 630 640 650
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ
660 670 680 690 700
EIEVSRLFLE PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF
710 720 730 740 750
ITGWGETQGT FGAGLLKEAQ LPVIENKVCN RYEFLNGRVQ STELCAGHLA
760 770 780 790 800
GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV
810
TWIEGVMRNN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6PVI2 | A6PVI2_HUMAN | Plasminogen | PLG | 166 | Annotation score: | ||
Q5TEH5 | Q5TEH5_HUMAN | HCG2029799, isoform CRA_b | PLG hCG_2029799 | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | A → AQ AA sequence (PubMed:122932).Curated | 1 | |
Sequence conflicti | 72 | Q → E AA sequence (Ref. 7) Curated | 1 | |
Sequence conflicti | 72 | Q → E AA sequence (PubMed:122932).Curated | 1 | |
Sequence conflicti | 86 | Missing AA sequence (Ref. 7) Curated | 1 | |
Sequence conflicti | 86 | Missing AA sequence (PubMed:122932).Curated | 1 | |
Sequence conflicti | 361 | Q → E AA sequence (Ref. 7) Curated | 1 | |
Sequence conflicti | 361 | Q → E AA sequence (Ref. 9) Curated | 1 | |
Sequence conflicti | 701 | I → V in AAA36451 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018657 | 38 | K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar. | 1 | |
Natural variantiVAR_011779 | 46 | I → R. Corresponds to variant dbSNP:rs1049573Ensembl. | 1 | |
Natural variantiVAR_016287 | 57 | E → K1 PublicationCorresponds to variant dbSNP:rs4252070EnsemblClinVar. | 1 | |
Natural variantiVAR_016288 | 133 | H → Q1 PublicationCorresponds to variant dbSNP:rs4252186Ensembl. | 1 | |
Natural variantiVAR_018658 | 147 | L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl. | 1 | |
Natural variantiVAR_018659 | 235 | R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar. | 1 | |
Natural variantiVAR_016289 | 261 | R → H1 PublicationCorresponds to variant dbSNP:rs4252187EnsemblClinVar. | 1 | |
Natural variantiVAR_006627 | 374 | V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar. | 1 | |
Natural variantiVAR_016290 | 408 | R → W1 PublicationCorresponds to variant dbSNP:rs4252119EnsemblClinVar. | 1 | |
Natural variantiVAR_011780 | 453 | K → I. Corresponds to variant dbSNP:rs1804181Ensembl. | 1 | |
Natural variantiVAR_016291 | 472 | D → N4 PublicationsCorresponds to variant dbSNP:rs4252125EnsemblClinVar. | 1 | |
Natural variantiVAR_016292 | 494 | A → V1 PublicationCorresponds to variant dbSNP:rs4252128EnsemblClinVar. | 1 | |
Natural variantiVAR_016293 | 523 | R → W1 PublicationCorresponds to variant dbSNP:rs4252129EnsemblClinVar. | 1 | |
Natural variantiVAR_018660 | 532 | R → H in PLGD. 1 Publication | 1 | |
Natural variantiVAR_006628 | 591 | S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar. | 1 | |
Natural variantiVAR_006629 | 620 | A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar. | 1 | |
Natural variantiVAR_031213 | 676 | V → D1 PublicationCorresponds to variant dbSNP:rs17857492Ensembl. | 1 | |
Natural variantiVAR_006630 | 751 | G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34276 , M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1 |
CCDSi | CCDS5279.1 |
PIRi | A35229, PLHU |
RefSeqi | NP_000292.1, NM_000301.3 |
Genome annotation databases
Ensembli | ENST00000308192; ENSP00000308938; ENSG00000122194 |
GeneIDi | 5340 |
KEGGi | hsa:5340 |
UCSCi | uc003qtm.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Plasmin entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34276 , M33272, M33274, M33275, M33278, M33279, M33280, M33282, M33283, M33284, M33285, M33286, M33287, M33288, M33289, M33290, M34272, M34273, M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1 |
CCDSi | CCDS5279.1 |
PIRi | A35229, PLHU |
RefSeqi | NP_000292.1, NM_000301.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B2I | NMR | - | A | 181-263 | [»] | |
1BML | X-ray | 2.90 | A/B | 561-810 | [»] | |
1BUI | X-ray | 2.65 | A/B | 561-810 | [»] | |
1CEA | X-ray | 2.06 | A/B | 100-187 | [»] | |
1CEB | X-ray | 2.07 | A/B | 100-187 | [»] | |
1DDJ | X-ray | 2.00 | A/B/C/D | 564-810 | [»] | |
1HPJ | NMR | - | A | 103-181 | [»] | |
1HPK | NMR | - | A | 103-181 | [»] | |
1I5K | X-ray | 2.70 | A/B | 184-262 | [»] | |
1KI0 | X-ray | 1.75 | A | 100-352 | [»] | |
1KRN | X-ray | 1.67 | A | 374-461 | [»] | |
1L4D | X-ray | 2.30 | A | 562-810 | [»] | |
1L4Z | X-ray | 2.80 | A | 563-810 | [»] | |
1PK4 | X-ray | 1.90 | A | 376-454 | [»] | |
1PKR | X-ray | 2.48 | A | 101-181 | [»] | |
1PMK | X-ray | 2.25 | A/B | 374-461 | [»] | |
1QRZ | X-ray | 2.00 | A/B/C/D | 565-810 | [»] | |
1RJX | X-ray | 2.30 | B | 564-810 | [»] | |
2DOH | X-ray | 2.30 | X | 100-333 | [»] | |
2DOI | X-ray | 3.10 | A/X | 100-333 | [»] | |
2KNF | NMR | - | A | 480-562 | [»] | |
2L0S | NMR | - | A | 272-354 | [»] | |
2PK4 | X-ray | 2.25 | A | 375-454 | [»] | |
3UIR | X-ray | 2.78 | A/B | 564-810 | [»] | |
4A5T | X-ray | 3.49 | S | 20-810 | [»] | |
4CIK | X-ray | 1.78 | A | 101-181 | [»] | |
4DCB | X-ray | 2.03 | F | 576-585 | [»] | |
4DUR | X-ray | 2.45 | A/B | 20-810 | [»] | |
4DUU | X-ray | 5.20 | A | 20-810 | [»] | |
5HPG | X-ray | 1.66 | A/B | 480-563 | [»] | |
5UGD | X-ray | 1.38 | A | 562-810 | [»] | |
5UGG | X-ray | 1.20 | A | 562-810 | [»] | |
6D3X | X-ray | 1.80 | A/B | 565-810 | [»] | |
6D3Y | X-ray | 1.32 | A | 564-810 | [»] | |
6D3Z | X-ray | 2.00 | A | 565-810 | [»] | |
6D40 | X-ray | 1.43 | A | 563-810 | [»] | |
6OG4 | X-ray | 1.70 | A/B | 183-264 | [»] | |
6OQJ | NMR | - | A | 179-262 | [»] | |
6OQK | NMR | - | A | 179-262 | [»] | |
6Q1U | X-ray | 2.35 | A/B | 562-810 | [»] | |
SMRi | P00747 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111356, 41 interactors |
CORUMi | P00747 |
IntActi | P00747, 52 interactors |
MINTi | P00747 |
STRINGi | 9606.ENSP00000308938 |
Chemistry databases
BindingDBi | P00747 |
ChEMBLi | CHEMBL1801 |
DrugBanki | DB00009, Alteplase DB00513, Aminocaproic acid DB00029, Anistreplase DB06692, Aprotinin DB03709, Bicine DB09130, Copper DB04925, Desmoteplase DB12831, Gabexate DB00015, Reteplase DB00086, Streptokinase DB00031, Tenecteplase DB00302, Tranexamic acid DB00013, Urokinase |
DrugCentrali | P00747 |
GuidetoPHARMACOLOGYi | 2394 |
Protein family/group databases
MEROPSi | S01.233 |
PTM databases
GlyConnecti | 502, 11 N-Linked glycans (3 sites), 2 O-Linked glycans (2 sites) |
GlyGeni | P00747, 15 sites, 8 N-linked glycans (1 site), 10 O-linked glycans (12 sites) |
iPTMneti | P00747 |
PhosphoSitePlusi | P00747 |
UniCarbKBi | P00747 |
Polymorphism and mutation databases
BioMutai | PLG |
DMDMi | 130316 |
2D gel databases
SWISS-2DPAGEi | P00747 |
Proteomic databases
CPTACi | non-CPTAC-1151 |
jPOSTi | P00747 |
MassIVEi | P00747 |
MaxQBi | P00747 |
PaxDbi | P00747 |
PeptideAtlasi | P00747 |
PRIDEi | P00747 |
ProteomicsDBi | 51277 |
Protocols and materials databases
Antibodypediai | 3285, 1274 antibodies |
Genome annotation databases
Ensembli | ENST00000308192; ENSP00000308938; ENSG00000122194 |
GeneIDi | 5340 |
KEGGi | hsa:5340 |
UCSCi | uc003qtm.5, human |
Organism-specific databases
CTDi | 5340 |
DisGeNETi | 5340 |
EuPathDBi | HostDB:ENSG00000122194.18 |
GeneCardsi | PLG |
HGNCi | HGNC:9071, PLG |
HPAi | ENSG00000122194, Tissue enriched (liver) |
MalaCardsi | PLG |
MIMi | 173350, gene 217090, phenotype |
neXtProti | NX_P00747 |
OpenTargetsi | ENSG00000122194 |
Orphaneti | 722, Hypoplasminogenemia 537072, PLG-related hereditary angioedema with normal C1Inh |
PharmGKBi | PA33405 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVNP, Eukaryota |
GeneTreei | ENSGT00940000155208 |
HOGENOMi | CLU_017565_0_0_1 |
InParanoidi | P00747 |
OMAi | TELCAGN |
OrthoDBi | 164039at2759 |
PhylomeDBi | P00747 |
TreeFami | TF329901 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04553-MONOMER |
BRENDAi | 3.4.21.7, 2681 |
PathwayCommonsi | P00747 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-186797, Signaling by PDGF R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205, Dissolution of Fibrin Clot |
SABIO-RKi | P00747 |
SIGNORi | P00747 |
Miscellaneous databases
BioGRID-ORCSi | 5340, 33 hits in 846 CRISPR screens |
ChiTaRSi | PLG, human |
EvolutionaryTracei | P00747 |
GeneWikii | Plasmin Plasminogen_activator |
GenomeRNAii | 5340 |
Pharosi | P00747, Tclin |
PROi | PR:P00747 |
RNActi | P00747, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122194, Expressed in right lobe of liver and 125 other tissues |
ExpressionAtlasi | P00747, baseline and differential |
Genevisiblei | P00747, HS |
Family and domain databases
CDDi | cd00108, KR, 5 hits cd00190, Tryp_SPc, 1 hit |
DisProti | DP00191 |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR023317, Pept_S1A_plasmin IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00051, Kringle, 5 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001150, Plasmin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 5 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 5 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 5 hits PS50070, KRINGLE_2, 5 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLMN_HUMAN | |
Accessioni | P00747Primary (citable) accession number: P00747 Secondary accession number(s): Q15146, Q5TEH4, Q6PA00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 253 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries