PLG

Functionⁱ

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.1 Publication

Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.1 Publication

Miscellaneous

Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

Catalytic activityⁱ

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.30
  "A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule."
  Kirschbaum N.E., Budzynski A.Z.
  J. Biol. Chem. 265:13669-13676(1990) [PubMed] [Europe PMC] [Abstract]
  Cited for: CATALYTIC ACTIVITY.
EC:3.4.21.7

Activity regulationⁱ

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	134	Fibrin	1
Binding siteⁱ	136	Fibrin	1
Binding siteⁱ	136	Omega-aminocarboxylic acids	1
Binding siteⁱ	158	Omega-aminocarboxylic acids	1
Binding siteⁱ	172	Omega-aminocarboxylic acids	1
Binding siteⁱ	432	Omega-aminocarboxylic acids	1
Binding siteⁱ	445	Omega-aminocarboxylic acids	1
Active siteⁱ	622	Charge relay system	1
Active siteⁱ	665	Charge relay system	1
Active siteⁱ	760	Charge relay system	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease
Biological process	Blood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04553-MONOMER
BRENDAⁱ	3.4.21.7 2681
Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-186797 Signaling by PDGF R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKⁱ	P00747
SIGNORⁱ	P00747

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.233

MEROPSⁱ

S01.233

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasminogen (EC:3.4.21.7) Cleaved into the following 5 chains: Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B
Gene namesⁱ	Name:PLG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9071 PLG
MIMⁱ	173350 gene
neXtProtⁱ	NX_P00747

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Plasminogen deficiency (PLGD)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018657	38	K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.	1
Natural variantⁱVAR_018658	147	L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.	1
Natural variantⁱVAR_018659	235	R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.	1
Natural variantⁱVAR_006627	374	V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.	1
Natural variantⁱVAR_018660	532	R → H in PLGD. 1 Publication	1
Natural variantⁱVAR_006628	591	S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.	1
Natural variantⁱVAR_006629	620	A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.	1
Natural variantⁱVAR_006630	751	G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	741	S → A: Proteolytically cleaved, but abolishes plasmin activity and cell detachment. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Thrombophilia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5340
MalaCards human disease database More...MalaCardsⁱ	PLG
MIMⁱ	217090 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122194
Orphanetⁱ	722 Hypoplasminogenemia 97231 Ligneous conjunctivitis 537072 PLG-related hereditary angioedema with normal C1Inh
PharmGKBⁱ	PA33405

Miscellaneous databases

Pharosⁱ	P00747

Pharosⁱ

P00747

Chemistry databases

ChEMBLⁱ	CHEMBL1801
Drug and drug target database More...DrugBankⁱ	DB00009 Alteplase DB00513 Aminocaproic Acid DB00029 Anistreplase DB06692 Aprotinin DB03709 Bicine DB09130 Copper DB04925 Desmoteplase DB12831 Gabexate DB00015 Reteplase DB00086 Streptokinase DB00031 Tenecteplase DB00302 Tranexamic acid DB00013 Urokinase
DrugCentral More...DrugCentralⁱ	P00747
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2394

Polymorphism and mutation databases

BioMutaⁱ	PLG
DMDMⁱ	130316

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	2 PublicationsAdd BLAST	19
ChainⁱPRO_0000028053	20 – 810	PlasminogenAdd BLAST	791
ChainⁱPRO_0000028054	20 – 580	Plasmin heavy chain AAdd BLAST	561
PeptideⁱPRO_0000028055	20 – 97	Activation peptideAdd BLAST	78
ChainⁱPRO_0000028057	79 – 466	AngiostatinAdd BLAST	388
ChainⁱPRO_0000028056	98 – 580	Plasmin heavy chain A, short formAdd BLAST	483
ChainⁱPRO_0000028058	581 – 810	Plasmin light chain BAdd BLAST	230

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 73
Disulfide bondⁱ	53 ↔ 61
Disulfide bondⁱ	103 ↔ 181
Disulfide bondⁱ	124 ↔ 164
Disulfide bondⁱ	152 ↔ 176
Disulfide bondⁱ	185 ↔ 262
Disulfide bondⁱ	188 ↔ 316
Disulfide bondⁱ	206 ↔ 245
Disulfide bondⁱ	234 ↔ 257
GlycosylationⁱCAR_000016	268	O-linked (GalNAc...) serine2 Publications	1
Disulfide bondⁱ	275 ↔ 352
Disulfide bondⁱ	296 ↔ 335
GlycosylationⁱCAR_000017	308	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	324 ↔ 347
GlycosylationⁱCAR_000018	365	O-linked (GalNAc...) threonine1 Publication	1
Disulfide bondⁱ	377 ↔ 454
Disulfide bondⁱ	398 ↔ 437
Disulfide bondⁱ	426 ↔ 449
Disulfide bondⁱ	481 ↔ 560
Disulfide bondⁱ	502 ↔ 543
Disulfide bondⁱ	531 ↔ 555
Disulfide bondⁱ	567 ↔ 685	Interchain (between A and B chains)
Disulfide bondⁱ	577 ↔ 585	Interchain (between A and B chains)
Modified residueⁱ	597	Phosphoserine1 Publication	1
Disulfide bondⁱ	607 ↔ 623
Modified residueⁱ	688	PhosphoserineCombined sources	1
Disulfide bondⁱ	699 ↔ 766
Disulfide bondⁱ	729 ↔ 745
Disulfide bondⁱ	756 ↔ 784

Post-translational modificationⁱ

N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).3 Publications

In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	78 – 79	Cleavage; by stromelysin-1	2
Siteⁱ	466 – 467	Cleavage; by stromelysin-19	2
Siteⁱ	580 – 581	Cleavage; by plasminogen activator	2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	non-CPTAC-1151
jPOSTⁱ	P00747
MassIVEⁱ	P00747
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00747
PaxDbⁱ	P00747
PeptideAtlas More...PeptideAtlasⁱ	P00747
PRIDEⁱ	P00747
ProteomicsDBⁱ	51277

2D gel databases

SWISS-2DPAGEⁱ	P00747

SWISS-2DPAGEⁱ

P00747

PTM databases

GlyConnectⁱ	502
iPTMnetⁱ	P00747
PhosphoSitePlusⁱ	P00747
UniCarbKBⁱ	P00747

Miscellaneous databases

PMAP-CutDBⁱ	P00747

PMAP-CutDBⁱ

P00747

Expressionⁱ

Tissue specificityⁱ

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Gene expression databases

Bgeeⁱ	ENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P00747 baseline and differential
Genevisibleⁱ	P00747 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000668 CAB016678 HPA021602 HPA048823 HPA053770

HPAⁱ

CAB000668
CAB016678
HPA021602
HPA048823
HPA053770

Interactionⁱ

Subunit structureⁱ

Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488).

Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047).

Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin:

Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).

6 Publications

(Microbial infection) Interacts with Staphylococcus aureus protein FnbB; this interaction provides active plasmin on the surface of bacteria cells.

1 Publication

Binary interactionsⁱ

Entry	#Exp.	IntAct	Notes
Q6V4L1	2	EBI-999394,EBI-984250	From Streptococcus pyogenes.
Q6V4L4	2	EBI-999394,EBI-984286	From Streptococcus pyogenes.
Q6V4L5	2	EBI-999394,EBI-984118	From Streptococcus pyogenes.
Q6V4L9	2	EBI-999394,EBI-984197	From Streptococcus pyogenes.
P02749	2	EBI-999394,EBI-2114682
P28300	2	EBI-999394,EBI-20724846
Q8N4S9	2	EBI-999394,EBI-6875061
P75390	5	EBI-999394,EBI-2259629	From Mycoplasma pneumoniae (strain ATCC 29342 / M129).
P75391	11	EBI-999394,EBI-2259621	From Mycoplasma pneumoniae (strain ATCC 29342 / M129).
P75392	5	EBI-999394,EBI-2259593	From Mycoplasma pneumoniae (strain ATCC 29342 / M129).
P75393	3	EBI-999394,EBI-2259617	From Mycoplasma pneumoniae (strain ATCC 29342 / M129).
Q99SU7	7	EBI-999394,EBI-7689378	From Staphylococcus aureus (strain N315).
P00779	2	EBI-999394,EBI-1035089	From Streptococcus dysgalactiae subsp. equisimilis.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111356, 40 interactors
CORUMⁱ	P00747
IntActⁱ	P00747, 48 interactors
Molecular INTeraction database More...MINTⁱ	P00747
STRINGⁱ	9606.ENSP00000308938

Chemistry databases

BindingDBⁱ

P00747

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	25 – 33	Combined sources	9
Beta strandⁱ	36 – 42	Combined sources	7
Helixⁱ	46 – 55	Combined sources	10
Beta strandⁱ	57 – 59	Combined sources	3
Beta strandⁱ	63 – 67	Combined sources	5
Turnⁱ	68 – 71	Combined sources	4
Beta strandⁱ	72 – 77	Combined sources	6
Turnⁱ	80 – 82	Combined sources	3
Beta strandⁱ	85 – 96	Combined sources	12
Helixⁱ	97 – 99	Combined sources	3
Beta strandⁱ	102 – 104	Combined sources	3
Beta strandⁱ	105 – 110	Combined sources	6
Helixⁱ	113 – 115	Combined sources	3
Turnⁱ	119 – 121	Combined sources	3
Beta strandⁱ	131 – 133	Combined sources	3
Turnⁱ	139 – 141	Combined sources	3
Turnⁱ	143 – 146	Combined sources	4
Beta strandⁱ	148 – 150	Combined sources	3
Beta strandⁱ	155 – 157	Combined sources	3
Beta strandⁱ	163 – 167	Combined sources	5
Beta strandⁱ	172 – 175	Combined sources	4
Beta strandⁱ	180 – 182	Combined sources	3
Beta strandⁱ	184 – 190	Combined sources	7
Beta strandⁱ	205 – 207	Combined sources	3
Beta strandⁱ	209 – 211	Combined sources	3
Beta strandⁱ	213 – 215	Combined sources	3
Helixⁱ	221 – 223	Combined sources	3
Helixⁱ	225 – 227	Combined sources	3
Beta strandⁱ	237 – 239	Combined sources	3
Beta strandⁱ	244 – 248	Combined sources	5
Beta strandⁱ	254 – 256	Combined sources	3
Beta strandⁱ	273 – 276	Combined sources	4
Beta strandⁱ	281 – 283	Combined sources	3
Beta strandⁱ	291 – 293	Combined sources	3
Beta strandⁱ	295 – 297	Combined sources	3
Beta strandⁱ	303 – 305	Combined sources	3
Turnⁱ	311 – 313	Combined sources	3
Helixⁱ	315 – 317	Combined sources	3
Beta strandⁱ	334 – 339	Combined sources	6
Beta strandⁱ	343 – 346	Combined sources	4
Beta strandⁱ	377 – 379	Combined sources	3
Beta strandⁱ	382 – 384	Combined sources	3
Beta strandⁱ	405 – 407	Combined sources	3
Turnⁱ	413 – 415	Combined sources	3
Turnⁱ	417 – 419	Combined sources	3
Beta strandⁱ	429 – 431	Combined sources	3
Beta strandⁱ	436 – 441	Combined sources	6
Beta strandⁱ	446 – 450	Combined sources	5
Beta strandⁱ	460 – 462	Combined sources	3
Beta strandⁱ	481 – 483	Combined sources	3
Beta strandⁱ	487 – 489	Combined sources	3
Beta strandⁱ	509 – 511	Combined sources	3
Beta strandⁱ	514 – 516	Combined sources	3
Turnⁱ	518 – 520	Combined sources	3
Turnⁱ	522 – 525	Combined sources	4
Beta strandⁱ	542 – 546	Combined sources	5
Beta strandⁱ	552 – 554	Combined sources	3
Beta strandⁱ	582 – 586	Combined sources	5
Beta strandⁱ	595 – 600	Combined sources	6
Beta strandⁱ	605 – 613	Combined sources	9
Beta strandⁱ	616 – 619	Combined sources	4
Helixⁱ	621 – 623	Combined sources	3
Turnⁱ	624 – 626	Combined sources	3
Helixⁱ	630 – 632	Combined sources	3
Beta strandⁱ	633 – 638	Combined sources	6
Beta strandⁱ	640 – 644	Combined sources	5
Beta strandⁱ	650 – 659	Combined sources	10
Turnⁱ	661 – 663	Combined sources	3
Beta strandⁱ	667 – 673	Combined sources	7
Beta strandⁱ	698 – 704	Combined sources	7
Beta strandⁱ	708 – 710	Combined sources	3
Turnⁱ	711 – 714	Combined sources	4
Beta strandⁱ	717 – 724	Combined sources	8
Helixⁱ	726 – 729	Combined sources	4
Turnⁱ	732 – 737	Combined sources	6
Beta strandⁱ	743 – 746	Combined sources	4
Beta strandⁱ	749 – 751	Combined sources	3
Beta strandⁱ	752 – 754	Combined sources	3
Beta strandⁱ	763 – 768	Combined sources	6
Beta strandⁱ	771 – 780	Combined sources	10
Beta strandⁱ	782 – 785	Combined sources	4
Beta strandⁱ	791 – 795	Combined sources	5
Helixⁱ	796 – 799	Combined sources	4
Helixⁱ	800 – 809	Combined sources	10

Show more details

3D structure databases

SMRⁱ	P00747
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P00747

EvolutionaryTraceⁱ

P00747

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	20 – 98	PANPROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	103 – 181	Kringle 1PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	184 – 262	Kringle 2PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	275 – 352	Kringle 3PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	377 – 454	Kringle 4PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	481 – 560	Kringle 5PROSITE-ProRule annotationAdd BLAST	80
Domainⁱ	581 – 808	Peptidase S1PROSITE-ProRule annotationAdd BLAST	228

Domainⁱ

Kringle domains mediate interaction with CSPG4.1 Publication

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IDXR Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155208
HOGENOMⁱ	HOG000112892
InParanoidⁱ	P00747
KEGG Orthology (KO) More...KOⁱ	K01315
OMAⁱ	TELCAGN
Database of Orthologous Groups More...OrthoDBⁱ	1058295at2759
PhylomeDBⁱ	P00747
TreeFamⁱ	TF329901

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00108 KR, 5 hits cd00190 Tryp_SPc, 1 hit
Database of protein disorder More...DisProtⁱ	DP00191
Gene3Dⁱ	2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR023317 Pept_S1A_plasmin IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00051 Kringle, 5 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001150 Plasmin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130 KR, 5 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 5 hits
PROSITEⁱ	View protein in PROSITE PS00021 KRINGLE_1, 5 hits PS50070 KRINGLE_2, 5 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P00747-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA 
        60         70         80         90        100
AKCEEDEEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL 
       110        120        130        140        150
SECKTGNGKN YRGTMSKTKN GITCQKWSST SPHRPRFSPA THPSEGLEEN 
       160        170        180        190        200
YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE CEEECMHCSG ENYDGKISKT 
       210        220        230        240        250
MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE LRPWCFTTDP 
       260        270        280        290        300
NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS 
       310        320        330        340        350
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP 
       360        370        380        390        400
SCDSSPVSTE QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS 
       410        420        430        440        450
WSSMTPHRHQ KTPENYPNAG LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN 
       460        470        480        490        500
LKKCSGTEAS VVAPPPVVLL PDVETPSEED CMFGNGKGYR GKRATTVTGT 
       510        520        530        540        550
PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG PWCYTTNPRK 
       560        570        580        590        600
LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT 
       610        620        630        640        650
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ 
       660        670        680        690        700
EIEVSRLFLE PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF 
       710        720        730        740        750
ITGWGETQGT FGAGLLKEAQ LPVIENKVCN RYEFLNGRVQ STELCAGHLA 
       760        770        780        790        800
GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV 
       810
TWIEGVMRNN

Length:810

Mass (Da):90,569

Last modified:July 1, 1989 - v2

Checksum:ⁱ8B31CB877CCB3AB6

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6PVI2	A6PVI2_HUMAN	Plasminogen Plasminogen	PLG	166	Annotation score:
Q5TEH5	Q5TEH5_HUMAN	HCG2029799, isoform CRA_b HCG2029799, isoform CRA_b (Plasminogen)	PLG hCG_2029799	136	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	50	A → AQ AA sequence (PubMed:122932).Curated	1
Sequence conflictⁱ	72	Q → E AA sequence (Ref. 7) Curated	1
Sequence conflictⁱ	72	Q → E AA sequence (PubMed:122932).Curated	1
Sequence conflictⁱ	86	Missing AA sequence (Ref. 7) Curated	1
Sequence conflictⁱ	86	Missing AA sequence (PubMed:122932).Curated	1
Sequence conflictⁱ	361	Q → E AA sequence (Ref. 7) Curated	1
Sequence conflictⁱ	361	Q → E AA sequence (Ref. 9) Curated	1
Sequence conflictⁱ	701	I → V in AAA36451 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018657	38	K → E in PLGD; common mutation. 1 PublicationCorresponds to variant dbSNP:rs73015965EnsemblClinVar.	1
Natural variantⁱVAR_011779	46	I → R. Corresponds to variant dbSNP:rs1049573Ensembl.	1
Natural variantⁱVAR_016287	57	E → K1 PublicationCorresponds to variant dbSNP:rs4252070Ensembl.	1
Natural variantⁱVAR_016288	133	H → Q1 PublicationCorresponds to variant dbSNP:rs4252186Ensembl.	1
Natural variantⁱVAR_018658	147	L → P in PLGD. 1 PublicationCorresponds to variant dbSNP:rs770198253Ensembl.	1
Natural variantⁱVAR_018659	235	R → H in PLGD; severe type 1 deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918030EnsemblClinVar.	1
Natural variantⁱVAR_016289	261	R → H1 PublicationCorresponds to variant dbSNP:rs4252187Ensembl.	1
Natural variantⁱVAR_006627	374	V → F in PLGD; Nagoya-1. 1 PublicationCorresponds to variant dbSNP:rs121918028EnsemblClinVar.	1
Natural variantⁱVAR_016290	408	R → W1 PublicationCorresponds to variant dbSNP:rs4252119Ensembl.	1
Natural variantⁱVAR_011780	453	K → I. Corresponds to variant dbSNP:rs1804181Ensembl.	1
Natural variantⁱVAR_016291	472	D → N4 PublicationsCorresponds to variant dbSNP:rs4252125Ensembl.	1
Natural variantⁱVAR_016292	494	A → V1 PublicationCorresponds to variant dbSNP:rs4252128Ensembl.	1
Natural variantⁱVAR_016293	523	R → W1 PublicationCorresponds to variant dbSNP:rs4252129Ensembl.	1
Natural variantⁱVAR_018660	532	R → H in PLGD. 1 Publication	1
Natural variantⁱVAR_006628	591	S → P in PLGD; may be associated with susceptibility to thrombosis. 1 PublicationCorresponds to variant dbSNP:rs121918029EnsemblClinVar.	1
Natural variantⁱVAR_006629	620	A → T in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/Tochigi/Kagoshima; may be associated with susceptibility to thrombosis. 4 PublicationsCorresponds to variant dbSNP:rs121918027EnsemblClinVar.	1
Natural variantⁱVAR_031213	676	V → D1 PublicationCorresponds to variant dbSNP:rs17857492Ensembl.	1
Natural variantⁱVAR_006630	751	G → R in PLGD; Kanagawa-1; 50% activity. 1 PublicationCorresponds to variant dbSNP:rs121918033EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34276 M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5279.1
PIRⁱ	A35229 PLHU
NCBI Reference Sequences More...RefSeqⁱ	NP_000292.1, NM_000301.3

Genome annotation databases

Ensemblⁱ	ENST00000308192; ENSP00000308938; ENSG00000122194
GeneIDⁱ	5340
KEGGⁱ	hsa:5340
UCSC genome browser More...UCSCⁱ	uc003qtm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00747	cDNA FLJ58778, highly similar to Plasminogen		HUMAN		407	UniRef100_P00747
HCG2029799, isoform CRA_b		HUMAN		136
Uncharacterized protein DKFZp779M0222 (Fragment)		HUMAN		210
UPI000004C08E		HUMAN		791
UPI000FF8751E				246
+3

Protein	Similar proteins		Species	Score	Length	Source
P00747	Plasminogen		PONAB		810	UniRef90_P00747
Plasminogen		MACMU		810
cDNA FLJ58778, highly similar to Plasminogen		HUMAN		407
Uncharacterized protein		PANPA		822
PLG isoform 1		PANTR		136
+35

Protein	Similar proteins		Species	Score	Length	Source
P00747	Plasminogen		PONAB		810	UniRef50_P00747
Plasminogen		MACMU		810
Plasminogen		BOVIN		812
Plasminogen		ERIEU		810
Plasminogen (Fragment)		SHEEP		343
+358

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Plasmin entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34276 M34275 Genomic DNA Translation: AAA60113.1 X05199 mRNA Translation: CAA28831.1 M74220 mRNA Translation: AAA36451.1 AY192161 Genomic DNA Translation: AAN85555.1 AL109933 Genomic DNA No translation available. BC060513 mRNA Translation: AAH60513.1 K02922 mRNA Translation: AAA60124.1
CCDSⁱ	CCDS5279.1
PIRⁱ	A35229 PLHU
RefSeqⁱ	NP_000292.1, NM_000301.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B2I	NMR	-	A	181-263	[»]
	1BML	X-ray	2.90	A/B	561-810	[»]
	1BUI	X-ray	2.65	A/B	561-810	[»]
	1CEA	X-ray	2.06	A/B	100-187	[»]
	1CEB	X-ray	2.07	A/B	100-187	[»]
	1DDJ	X-ray	2.00	A/B/C/D	564-810	[»]
	1HPJ	NMR	-	A	103-181	[»]
	1HPK	NMR	-	A	103-181	[»]
	1I5K	X-ray	2.70	A/B	184-262	[»]
	1KI0	X-ray	1.75	A	100-352	[»]
	1KRN	X-ray	1.67	A	374-461	[»]
	1L4D	X-ray	2.30	A	562-810	[»]
	1L4Z	X-ray	2.80	A	563-810	[»]
	1PK4	X-ray	1.90	A	376-454	[»]
	1PKR	X-ray	2.48	A	101-181	[»]
	1PMK	X-ray	2.25	A/B	374-461	[»]
	1QRZ	X-ray	2.00	A/B/C/D	565-810	[»]
	1RJX	X-ray	2.30	B	564-810	[»]
	2DOH	X-ray	2.30	X	100-333	[»]
	2DOI	X-ray	3.10	A/X	100-333	[»]
	2KNF	NMR	-	A	480-562	[»]
	2L0S	NMR	-	A	272-354	[»]
	2PK4	X-ray	2.25	A	375-454	[»]
	3UIR	X-ray	2.78	A/B	564-810	[»]
	4A5T	X-ray	3.49	S	20-810	[»]
	4CIK	X-ray	1.78	A	101-181	[»]
	4DCB	X-ray	2.03	F	576-585	[»]
	4DUR	X-ray	2.45	A/B	20-810	[»]
	4DUU	X-ray	5.20	A	20-810	[»]
	5HPG	X-ray	1.66	A/B	480-563	[»]
	5UGD	X-ray	1.38	A	562-810	[»]
	5UGG	X-ray	1.20	A	562-810	[»]
	6D3X	X-ray	1.80	A/B	565-810	[»]
	6D3Y	X-ray	1.32	A	564-810	[»]
	6D3Z	X-ray	2.00	A	565-810	[»]
	6D40	X-ray	1.43	A	563-810	[»]
	6OG4	X-ray	1.70	A/B	183-264	[»]
SMRⁱ	P00747
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111356, 40 interactors
CORUMⁱ	P00747
IntActⁱ	P00747, 48 interactors
MINTⁱ	P00747
STRINGⁱ	9606.ENSP00000308938

Chemistry databases

BindingDBⁱ	P00747
ChEMBLⁱ	CHEMBL1801
DrugBankⁱ	DB00009 Alteplase DB00513 Aminocaproic Acid DB00029 Anistreplase DB06692 Aprotinin DB03709 Bicine DB09130 Copper DB04925 Desmoteplase DB12831 Gabexate DB00015 Reteplase DB00086 Streptokinase DB00031 Tenecteplase DB00302 Tranexamic acid DB00013 Urokinase
DrugCentralⁱ	P00747
GuidetoPHARMACOLOGYⁱ	2394

Protein family/group databases

MEROPSⁱ	S01.233

MEROPSⁱ

S01.233

PTM databases

GlyConnectⁱ	502
iPTMnetⁱ	P00747
PhosphoSitePlusⁱ	P00747
UniCarbKBⁱ	P00747

Polymorphism and mutation databases

BioMutaⁱ	PLG
DMDMⁱ	130316

2D gel databases

SWISS-2DPAGEⁱ	P00747

SWISS-2DPAGEⁱ

P00747

Proteomic databases

CPTACⁱ	non-CPTAC-1151
jPOSTⁱ	P00747
MassIVEⁱ	P00747
MaxQBⁱ	P00747
PaxDbⁱ	P00747
PeptideAtlasⁱ	P00747
PRIDEⁱ	P00747
ProteomicsDBⁱ	51277

Genome annotation databases

Ensemblⁱ	ENST00000308192; ENSP00000308938; ENSG00000122194
GeneIDⁱ	5340
KEGGⁱ	hsa:5340
UCSCⁱ	uc003qtm.5 human

Organism-specific databases

CTDⁱ	5340
DisGeNETⁱ	5340
GeneCardsⁱ	PLG
HGNCⁱ	HGNC:9071 PLG
HPAⁱ	CAB000668 CAB016678 HPA021602 HPA048823 HPA053770
MalaCardsⁱ	PLG
MIMⁱ	173350 gene 217090 phenotype
neXtProtⁱ	NX_P00747
OpenTargetsⁱ	ENSG00000122194
Orphanetⁱ	722 Hypoplasminogenemia 97231 Ligneous conjunctivitis 537072 PLG-related hereditary angioedema with normal C1Inh
PharmGKBⁱ	PA33405
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDXR Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00940000155208
HOGENOMⁱ	HOG000112892
InParanoidⁱ	P00747
KOⁱ	K01315
OMAⁱ	TELCAGN
OrthoDBⁱ	1058295at2759
PhylomeDBⁱ	P00747
TreeFamⁱ	TF329901

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04553-MONOMER
BRENDAⁱ	3.4.21.7 2681
Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-186797 Signaling by PDGF R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-75205 Dissolution of Fibrin Clot
SABIO-RKⁱ	P00747
SIGNORⁱ	P00747

Miscellaneous databases

ChiTaRSⁱ	PLG human
EvolutionaryTraceⁱ	P00747
GeneWikiⁱ	Plasmin Plasminogen_activator
GenomeRNAiⁱ	5340
Pharosⁱ	P00747
PMAP-CutDBⁱ	P00747
Protein Ontology More...PROⁱ	PR:P00747
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122194 Expressed in 101 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	P00747 baseline and differential
Genevisibleⁱ	P00747 HS

Family and domain databases

CDDⁱ	cd00108 KR, 5 hits cd00190 Tryp_SPc, 1 hit
DisProtⁱ	DP00191
Gene3Dⁱ	2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR023317 Pept_S1A_plasmin IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfamⁱ	View protein in Pfam PF00051 Kringle, 5 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001150 Plasmin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130 KR, 5 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 5 hits
PROSITEⁱ	View protein in PROSITE PS00021 KRINGLE_1, 5 hits PS50070 KRINGLE_2, 5 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLMN_HUMAN
Accessionⁱ	P00747Primary (citable) accession number: P00747 Secondary accession number(s): Q15146, Q5TEH4, Q6PA00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 1, 1989
	Last modified:	November 13, 2019
	This is version 246 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - P00747 (PLMN_HUMAN)

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Plasminogen

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

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Polymorphism and mutation databases

2D gel databases

Proteomic databases

Genome annotation databases

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Phylogenomic databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ