CFD

Functionⁱ

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Catalytic activityⁱ

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	66	Charge relay system	1
Active siteⁱ	114	Charge relay system	1
Active siteⁱ	208	Charge relay system	1

GO - Molecular functionⁱ

serine-type endopeptidase activity Source: Reactome
serine-type peptidase activity
Source: ProtInc
Traceable author statementⁱ
- 1374388

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation
Source: ProtInc
Traceable author statementⁱ
- 1374388
complement activation, alternative pathway Source: Reactome
neutrophil degranulation Source: Reactome
platelet degranulation Source: Reactome
proteolysis
Source: ProtInc
Traceable author statementⁱ
- 1374388

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease
Biological process	Complement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

BRENDAⁱ	3.4.21.46 2681
Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-173736 Alternative complement activation R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.191

MEROPSⁱ

S01.191

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement factor D (EC:3.4.21.46) Alternative name(s): Adipsin C3 convertase activator Properdin factor D
Gene namesⁱ	Name:CFD Synonyms:DF, PFD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197766.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2771 CFD
MIMⁱ	134350 gene
neXtProtⁱ	NX_P00746

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Complement factor D deficiency (CFDD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1675
MalaCards human disease database More...MalaCardsⁱ	CFD
MIMⁱ	613912 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000197766
Orphanetⁱ	169467 Recurrent Neisseria infections due to factor D deficiency
PharmGKBⁱ	PA142

Chemistry databases

ChEMBLⁱ	CHEMBL2176771
Drug and drug target database More...DrugBankⁱ	DB03058 2-Aminobenzyl alcohol
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2842

Polymorphism and mutation databases

BioMutaⁱ	CFD
DMDMⁱ	158515408

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
PropeptideⁱPRO_0000027560	21 – 25	Activation peptideSequence analysis	5
ChainⁱPRO_0000027561	26 – 253	Complement factor DAdd BLAST	228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	51 ↔ 67
Disulfide bondⁱ	148 ↔ 214
Disulfide bondⁱ	179 ↔ 195
Disulfide bondⁱ	204 ↔ 229

Keywords - PTMⁱ

Disulfide bond, Zymogen

Proteomic databases

PaxDbⁱ	P00746
PeptideAtlas More...PeptideAtlasⁱ	P00746
PRIDEⁱ	P00746
ProteomicsDBⁱ	51276

PTM databases

iPTMnetⁱ	P00746
PhosphoSitePlusⁱ	P00746

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197766
CleanExⁱ	HS_CFD
ExpressionAtlasⁱ	P00746 baseline and differential
Genevisibleⁱ	P00746 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052799

HPAⁱ

HPA052799

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108039, 2 interactors
IntActⁱ	P00746, 2 interactors
STRINGⁱ	9606.ENSP00000332139

Chemistry databases

BindingDBⁱ

P00746

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	40 – 45	Combined sources	6
Beta strandⁱ	48 – 57	Combined sources	10
Beta strandⁱ	60 – 63	Combined sources	4
Helixⁱ	65 – 68	Combined sources	4
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	76 – 81	Combined sources	6
Beta strandⁱ	83 – 87	Combined sources	5
Beta strandⁱ	93 – 102	Combined sources	10
Helixⁱ	108 – 113	Combined sources	6
Beta strandⁱ	116 – 122	Combined sources	7
Beta strandⁱ	127 – 129	Combined sources	3
Beta strandⁱ	147 – 154	Combined sources	8
Turnⁱ	156 – 159	Combined sources	4
Beta strandⁱ	167 – 174	Combined sources	8
Helixⁱ	176 – 179	Combined sources	4
Turnⁱ	182 – 187	Combined sources	6
Beta strandⁱ	193 – 196	Combined sources	4
Beta strandⁱ	199 – 202	Combined sources	4
Turnⁱ	205 – 209	Combined sources	5
Beta strandⁱ	211 – 214	Combined sources	4
Beta strandⁱ	217 – 222	Combined sources	6
Beta strandⁱ	226 – 228	Combined sources	3
Beta strandⁱ	231 – 233	Combined sources	3
Beta strandⁱ	236 – 240	Combined sources	5
Helixⁱ	241 – 244	Combined sources	4
Helixⁱ	245 – 252	Combined sources	8

3D structure databases

ProteinModelPortalⁱ	P00746
SMRⁱ	P00746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P00746

EvolutionaryTraceⁱ

P00746

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 253	Peptidase S1PROSITE-ProRule annotationAdd BLAST		228

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118895
HOVERGENⁱ	HBG013304
InParanoidⁱ	P00746
KEGG Orthology (KO) More...KOⁱ	K01334
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P00746
TreeFamⁱ	TF333630

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR037561 Complement_factor_D IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR43890:SF17 PTHR43890:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P00746-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHSWERLAVL VLLGAAACAA PPRGRILGGR EAEAHARPYM ASVQLNGAHL 
        60         70         80         90        100
CGGVLVAEQW VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA 
       110        120        130        140        150
VPHPDSQPDT IDHDLLLLQL SEKATLGPAV RPLPWQRVDR DVAPGTLCDV 
       160        170        180        190        200
AGWGIVNHAG RRPDSLQHVL LPVLDRATCN RRTHHDGAIT ERLMCAESNR 
       210        220        230        240        250
RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR VASYAAWIDS 

VLA

Length:253

Mass (Da):27,033

Last modified:September 11, 2007 - v5

Checksum:ⁱ78B06C209DEEA362

GO

Sequence cautionⁱ

The sequence AAA35527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21	P → R in AAA35527 (PubMed:1374388).Curated	1
Sequence conflictⁱ	26	I → M in AAA35527 (PubMed:1374388).Curated	1
Sequence conflictⁱ	35	H → F AA sequence (PubMed:6987665).Curated	1
Sequence conflictⁱ	40	M → V AA sequence (PubMed:6987665).Curated	1
Sequence conflictⁱ	49	H → E AA sequence (PubMed:6363133).Curated	1
Sequence conflictⁱ	49	H → E AA sequence (PubMed:6821372).Curated	1
Sequence conflictⁱ	52	G → A in AAA35527 (PubMed:1374388).Curated	1
Sequence conflictⁱ	59	Q → R in AAA35527 (PubMed:1374388).Curated	1
Sequence conflictⁱ	63	S → T AA sequence (PubMed:6363133).Curated	1
Sequence conflictⁱ	73	D → G AA sequence (PubMed:6363133).Curated	1
Sequence conflictⁱ	83 – 86	HSLS → THLP AA sequence (PubMed:6383466).Curated	4
Sequence conflictⁱ	83 – 84	HS → ST AA sequence (PubMed:6363133).Curated	2
Sequence conflictⁱ	94 – 95	Missing AA sequence (PubMed:6363133).Curated	2
Sequence conflictⁱ	96	D → E AA sequence (PubMed:6363133).Curated	1
Sequence conflictⁱ	136	Q → G AA sequence (PubMed:6363133).Curated	1
Sequence conflictⁱ	178 – 191	TCNRR…GAITE → KCRLYDVL AA sequence (PubMed:6363133).CuratedAdd BLAST	14
Sequence conflictⁱ	243	S → T AA sequence (PubMed:6383466).Curated	1
Sequence conflictⁱ	250	S → H AA sequence (PubMed:6383466).Curated	1
Sequence conflictⁱ	250	Missing AA sequence (PubMed:6363133).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034866	213	V → G in CFDD. 1 PublicationCorresponds to variant dbSNP:rs267606720EnsemblClinVar.	1
Natural variantⁱVAR_034867	214	C → R in CFDD. 1 PublicationCorresponds to variant dbSNP:rs267606721EnsemblClinVar.	1
Natural variantⁱVAR_034868	248	I → M. Corresponds to variant dbSNP:rs2230216Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ313463 mRNA Translation: CAC48304.1 AK300963 mRNA Translation: BAG62588.1 CH471139 Genomic DNA Translation: EAW69588.1 BC034529 mRNA Translation: AAH34529.1 BC040146 mRNA Translation: AAH40146.1 BC051001 mRNA Translation: AAH51001.1 BC057807 mRNA Translation: AAH57807.1 M84526 mRNA Translation: AAA35527.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12046.1
PIRⁱ	A40197 DBHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001304264.1, NM_001317335.1 NP_001919.2, NM_001928.3
UniGeneⁱ	Hs.155597

Genome annotation databases

Ensemblⁱ	ENST00000327726; ENSP00000332139; ENSG00000197766 ENST00000617994; ENSP00000478745; ENSG00000274619
GeneIDⁱ	1675
KEGGⁱ	hsa:1675
UCSC genome browser More...UCSCⁱ	uc002lqc.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P00746	Complement factor D		GORGO		279
Complement factor D		HUMAN		260
CFD isoform 2		PONAB		260
Complement factor D		PAPAN		260
Complement factor D preproprotein		MACMU		253
+14

Protein	Similar proteins		Species	Score	Length
P00746	Complement factor D		GORGO		279
Complement factor D		PAPAN		260
CFD isoform 2		PONAB		260
Complement factor D		HUMAN		260
Complement factor D preproprotein		MACMU		253
+26

Cross-referencesⁱ

Web resourcesⁱ

CFDbase

CFD mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ313463 mRNA Translation: CAC48304.1 AK300963 mRNA Translation: BAG62588.1 CH471139 Genomic DNA Translation: EAW69588.1 BC034529 mRNA Translation: AAH34529.1 BC040146 mRNA Translation: AAH40146.1 BC051001 mRNA Translation: AAH51001.1 BC057807 mRNA Translation: AAH57807.1 M84526 mRNA Translation: AAA35527.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12046.1
PIRⁱ	A40197 DBHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001304264.1, NM_001317335.1 NP_001919.2, NM_001928.3
UniGeneⁱ	Hs.155597

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BIO	X-ray	1.50	A	26-253	[»]
	1DFP	X-ray	2.40	A/B	26-253	[»]
	1DIC	X-ray	1.80	A	26-253	[»]
	1DST	X-ray	2.00	A	26-253	[»]
	1DSU	X-ray	2.00	A/B	26-253	[»]
	1FDP	X-ray	2.10	A/B/C/D	19-253	[»]
	1HFD	X-ray	2.30	A	26-253	[»]
	2XW9	X-ray	1.20	A	26-253	[»]
	2XWA	X-ray	2.80	A/B	26-253	[»]
	2XWB	X-ray	3.49	I/J	26-253	[»]
	4CBN	X-ray	1.80	A/B	26-253	[»]
	4CBO	X-ray	1.80	A/B	26-253	[»]
	4D9R	X-ray	2.42	A/B	26-253	[»]
	5FBE	X-ray	1.43	A	26-253	[»]
	5FBI	X-ray	1.47	A	26-253	[»]
	5FCK	X-ray	1.86	A	26-253	[»]
	5MT0	X-ray	1.29	A	26-253	[»]
	5MT4	X-ray	1.65	A	26-253	[»]
	5NAR	X-ray	1.55	A	26-253	[»]
	5NAT	X-ray	1.17	A	26-253	[»]
	5NAW	X-ray	1.25	A	26-253	[»]
	5NB6	X-ray	1.75	A	26-253	[»]
	5NB7	X-ray	1.33	A	26-253	[»]
	5NBA	X-ray	1.87	A	26-253	[»]
	5TCA	X-ray	3.15	A/B/C/D/E/F/G	26-253	[»]
	5TCC	X-ray	3.37	A/B/C/D/E/F/G	26-253	[»]
	6FTY	X-ray	1.67	A	26-253	[»]
	6FTZ	X-ray	1.67	A	26-253	[»]
	6FUG	X-ray	2.21	A/B/C/D/E/F	26-253	[»]
	6FUH	X-ray	1.37	A	26-253	[»]
	6FUI	X-ray	1.38	A	26-253	[»]
	6FUJ	X-ray	2.25	A/B/C/D/E/F	26-253	[»]
	6FUT	X-ray	1.50	A	26-253	[»]
ProteinModelPortalⁱ	P00746
SMRⁱ	P00746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108039, 2 interactors
IntActⁱ	P00746, 2 interactors
STRINGⁱ	9606.ENSP00000332139

Chemistry databases

BindingDBⁱ	P00746
ChEMBLⁱ	CHEMBL2176771
Drug and drug target database More...DrugBankⁱ	DB03058 2-Aminobenzyl alcohol
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2842

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.191

MEROPSⁱ

S01.191

PTM databases

iPTMnetⁱ	P00746
PhosphoSitePlusⁱ	P00746

Polymorphism and mutation databases

BioMutaⁱ	CFD
DMDMⁱ	158515408

Proteomic databases

PaxDbⁱ	P00746
PeptideAtlas More...PeptideAtlasⁱ	P00746
PRIDEⁱ	P00746
ProteomicsDBⁱ	51276

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000327726; ENSP00000332139; ENSG00000197766 ENST00000617994; ENSP00000478745; ENSG00000274619
GeneIDⁱ	1675
KEGGⁱ	hsa:1675
UCSC genome browser More...UCSCⁱ	uc002lqc.4 human

Organism-specific databases

CTDⁱ	1675
DisGeNET More...DisGeNETⁱ	1675
EuPathDBⁱ	HostDB:ENSG00000197766.7
GeneCardsⁱ	CFD
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2771 CFD
Human Protein Atlas More...HPAⁱ	HPA052799
MalaCards human disease database More...MalaCardsⁱ	CFD
MIMⁱ	134350 gene 613912 phenotype
neXtProtⁱ	NX_P00746
Open Targets More...OpenTargetsⁱ	ENSG00000197766
Orphanetⁱ	169467 Recurrent Neisseria infections due to factor D deficiency
PharmGKBⁱ	PA142
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118895
HOVERGENⁱ	HBG013304
InParanoidⁱ	P00746
KEGG Orthology (KO) More...KOⁱ	K01334
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P00746
TreeFamⁱ	TF333630

Enzyme and pathway databases

BRENDAⁱ	3.4.21.46 2681
Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-173736 Alternative complement activation R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	CFD human
EvolutionaryTraceⁱ	P00746
GenomeRNAiⁱ	1675
Protein Ontology More...PROⁱ	PR:P00746
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197766
CleanExⁱ	HS_CFD
ExpressionAtlasⁱ	P00746 baseline and differential
Genevisibleⁱ	P00746 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR037561 Complement_factor_D IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR43890:SF17 PTHR43890:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CFAD_HUMAN
Accessionⁱ	P00746Primary (citable) accession number: P00746 Secondary accession number(s): B4DV76 , Q5U5S1, Q86VJ5, Q8N4E0, Q8WZB4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	September 11, 2007
	Last modified:	July 18, 2018
	This is version 196 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P00746 (CFAD_HUMAN)

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Complement factor D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ