UniProtKB - P00742 (FA10_HUMAN)
Coagulation factor X
F10
Functioni
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Catalytic activityi
- Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. EC:3.4.21.6
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 276 | Charge relay system | 1 | |
Active sitei | 322 | Charge relay system | 1 | |
Active sitei | 419 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipid binding Source: BHF-UCL
- serine-type endopeptidase activity Source: BHF-UCL
GO - Biological processi
- blood coagulation Source: GO_Central
- blood coagulation, common pathway Source: ComplexPortal
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: BHF-UCL
- proteolysis Source: ComplexPortal
- zymogen activation Source: ComplexPortal
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 3.4.21.6, 2681 |
PathwayCommonsi | P00742 |
Reactomei | R-HSA-140834, Extrinsic Pathway of Fibrin Clot Formation R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-9672383, Defective factor IX causes thrombophilia R-HSA-9672396, Defective cofactor function of FVIIIa variant R-HSA-9673202, Defective F9 variant does not activate FX |
SABIO-RKi | P00742 |
SignaLinki | P00742 |
SIGNORi | P00742 |
Protein family/group databases
MEROPSi | S01.216 |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor X (EC:3.4.21.6)Alternative name(s): Stuart factor Stuart-Prower factor Cleaved into the following 3 chains: |
Gene namesi | Name:F10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3528, F10 |
MIMi | 613872, gene |
neXtProti | NX_P00742 |
VEuPathDBi | HostDB:ENSG00000126218 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- intrinsic component of external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- membrane Source: ComplexPortal
- serine-type endopeptidase complex Source: ComplexPortal
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Factor X deficiency (FA10D)21 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065428 | 47 | E → G in FA10D; St. Louis II; strongly reduced activity; not activated by factor VIIa and tissue factor. 1 PublicationCorresponds to variant dbSNP:rs121964943Ensembl. | 1 | |
Natural variantiVAR_065429 | 51 | G → V in FA10D. 1 PublicationCorresponds to variant dbSNP:rs751782758Ensembl. | 1 | |
Natural variantiVAR_065430 | 54 | E → G in FA10D; Ketchikan. 1 PublicationCorresponds to variant dbSNP:rs121964944EnsemblClinVar. | 1 | |
Natural variantiVAR_065431 | 54 | E → K in FA10D; Vorarlberg; converts prothrombin at a normal rate but shows decreased affinity for calcium. 2 PublicationsCorresponds to variant dbSNP:rs121964939EnsemblClinVar. | 1 | |
Natural variantiVAR_065432 | 72 | E → Q in FA10D; Tokyo. 1 PublicationCorresponds to variant dbSNP:rs121964945Ensembl. | 1 | |
Natural variantiVAR_065433 | 91 | E → K in FA10D; Riyadh. 1 PublicationCorresponds to variant dbSNP:rs1477329751Ensembl. | 1 | |
Natural variantiVAR_065434 | 142 | E → K in FA10D; uncertain pathological significance; detected in patients carrying K-54 or P-374; slightly reduced activity. 3 PublicationsCorresponds to variant dbSNP:rs61753266EnsemblClinVar. | 1 | |
Natural variantiVAR_065435 | 149 | C → Y in FA10D. 1 Publication | 1 | |
Natural variantiVAR_065436 | 151 | C → Y in FA10D. 1 Publication | 1 | |
Natural variantiVAR_075212 | 176 – 186 | Missing in FA10D; unknown pathological significance. 1 PublicationAdd BLAST | 11 | |
Natural variantiVAR_075213 | 262 | G → D in FA10D; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1393705267Ensembl. | 1 | |
Natural variantiVAR_065437 | 289 | G → R in FA10D; may affect splicing. 1 PublicationCorresponds to variant dbSNP:rs121964946Ensembl. | 1 | |
Natural variantiVAR_065438 | 304 | E → K in FA10D. 1 PublicationCorresponds to variant dbSNP:rs747292771Ensembl. | 1 | |
Natural variantiVAR_065439 | 322 | D → N in FA10D; Stockton; 50% decrease in specific activity. 2 PublicationsCorresponds to variant dbSNP:rs121964942Ensembl. | 1 | |
Natural variantiVAR_065440 | 327 | R → W in FA10D. 1 PublicationCorresponds to variant dbSNP:rs770119164Ensembl. | 1 | |
Natural variantiVAR_065441 | 338 | V → M in FA10D. 1 PublicationCorresponds to variant dbSNP:rs121964947Ensembl. | 1 | |
Natural variantiVAR_065442 | 350 | E → K in FA10D. 1 PublicationCorresponds to variant dbSNP:rs372309538Ensembl. | 1 | |
Natural variantiVAR_065443 | 358 | T → M in FA10D; Roma. 2 PublicationsCorresponds to variant dbSNP:rs768222784Ensembl. | 1 | |
Natural variantiVAR_065444 | 363 | G → S in FA10D. 1 PublicationCorresponds to variant dbSNP:rs1595099527EnsemblClinVar. | 1 | |
Natural variantiVAR_065445 | 366 | R → C in FA10D; San Antonio. 1 PublicationCorresponds to variant dbSNP:rs104894392EnsemblClinVar. | 1 | |
Natural variantiVAR_065446 | 374 | S → P in FA10D; Marseille; decreased cleavage by factor IXa; normal catalytic efficiency for prothrombin. 3 PublicationsCorresponds to variant dbSNP:rs121964941Ensembl. | 1 | |
Natural variantiVAR_072751 | 382 | V → A in FA10D; partial loss of activity. 2 Publications | 1 | |
Natural variantiVAR_065447 | 383 | P → S in FA10D; Friuli. 1 PublicationCorresponds to variant dbSNP:rs121964940Ensembl. | 1 | |
Natural variantiVAR_065448 | 390 | C → F in FA10D; Padua 4. 1 PublicationCorresponds to variant dbSNP:rs199778916Ensembl. | 1 | |
Natural variantiVAR_065449 | 404 | C → R in FA10D. 1 PublicationCorresponds to variant dbSNP:rs1595099645EnsemblClinVar. | 1 | |
Natural variantiVAR_065450 | 406 | G → S in FA10D; almost complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs376163818Ensembl. | 1 | |
Natural variantiVAR_065451 | 420 | G → R in FA10D; Padua 3. 1 PublicationCorresponds to variant dbSNP:rs750759634Ensembl. | 1 | |
Natural variantiVAR_072752 | 421 | G → D in FA10D; significant loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs758726161Ensembl. | 1 | |
Natural variantiVAR_065452 | 448 | K → N in FA10D; San Giovanni Rotondo. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2159 |
MalaCardsi | F10 |
MIMi | 227600, phenotype |
OpenTargetsi | ENSG00000126218 |
Orphaneti | 328, Congenital factor X deficiency |
PharmGKBi | PA27940 |
Miscellaneous databases
Pharosi | P00742, Tclin |
Chemistry databases
ChEMBLi | CHEMBL244 |
DrugBanki | DB07211, (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE DB08746, 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE DB07974, 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE DB07277, 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE DB07605, 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE DB08487, 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE DB08495, 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE DB04673, 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE DB08745, 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE DB08488, 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE DB07804, 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE DB08174, 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE DB08173, 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE DB07872, 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide DB07843, 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE DB07848, 5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide DB07875, 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide DB08143, 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE DB07847, 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE DB07844, 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE DB13884, Albutrepenonacog alfa DB13151, Anti-inhibitor coagulant complex DB13192, Antihemophilic factor human DB00025, Antihemophilic factor, human recombinant DB11166, Antithrombin Alfa DB06605, Apixaban DB09258, Bemiparin DB12364, Betrixaban DB00100, Coagulation Factor IX (Recombinant) DB13152, Coagulation Factor IX Human DB13150, Coagulation factor VII human DB00036, Coagulation factor VIIa Recombinant Human DB09075, Edoxaban DB13923, Emicizumab DB01225, Enoxaparin DB06920, Eribaxaban DB00569, Fondaparinux DB03847, gamma-carboxy-L-glutamic acid DB07278, GW-813893 DB01109, Heparin DB06406, Idraparinux DB09332, Kappadione DB06245, Lanoteplase DB13998, Lonoctocog alfa DB05713, LY-517717 DB13999, Moroctocog alfa DB07630, N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE DB07629, N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE DB07973, N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE DB07800, N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE DB12598, Nafamostat DB13933, Nonacog beta pegol DB06635, Otamixaban DB09141, Protamine sulfate DB13149, Protein S human DB11311, Prothrombin DB06228, Rivaroxaban DB06552, rNAPc2 DB05362, SSR-126517E DB07261, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE DB08426, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE DB09109, Turoctocog alfa DB14738, Turoctocog alfa pegol |
DrugCentrali | P00742 |
GuidetoPHARMACOLOGYi | 2359 |
Genetic variation databases
BioMutai | F10 |
DMDMi | 119761 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
PropeptideiPRO_0000027786 | 32 – 40 | 1 Publication | 9 | |
ChainiPRO_0000027787 | 41 – 488 | Coagulation factor XAdd BLAST | 448 | |
ChainiPRO_0000027788 | 41 – 179 | Factor X light chainAdd BLAST | 139 | |
ChainiPRO_0000027789 | 183 – 488 | Factor X heavy chainAdd BLAST | 306 | |
PropeptideiPRO_0000027790 | 183 – 234 | Activation peptideAdd BLAST | 52 | |
ChainiPRO_0000027791 | 235 – 488 | Activated factor Xa heavy chainAdd BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 46 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 47 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 54 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 56 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 57 ↔ 62 | By similarity | ||
Modified residuei | 59 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 60 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 65 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 66 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 69 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 72 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 79 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 90 ↔ 101 | |||
Disulfide bondi | 95 ↔ 110 | |||
Modified residuei | 103 | (3R)-3-hydroxyaspartate1 Publication | 1 | |
Disulfide bondi | 112 ↔ 121 | |||
Disulfide bondi | 129 ↔ 140 | |||
Disulfide bondi | 136 ↔ 149 | |||
Disulfide bondi | 151 ↔ 164 | |||
Disulfide bondi | 172 ↔ 342 | Interchain (between light and heavy chains) | ||
Glycosylationi | 199 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 211 | O-linked (GalNAc...) threonine1 Publication | 1 | |
GlycosylationiCAR_000012 | 221 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
GlycosylationiCAR_000013 | 231 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 241 ↔ 246 | |||
Disulfide bondi | 261 ↔ 277 | |||
Disulfide bondi | 390 ↔ 404 | |||
Disulfide bondi | 415 ↔ 443 |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, ZymogenProteomic databases
CPTACi | non-CPTAC-2649 |
jPOSTi | P00742 |
MassIVEi | P00742 |
PaxDbi | P00742 |
PeptideAtlasi | P00742 |
PRIDEi | P00742 |
ProteomicsDBi | 51275 |
PTM databases
GlyConnecti | 102, 16 N-Linked glycans (2 sites), 1 O-Linked glycan |
GlyGeni | P00742, 14 sites, 26 N-linked glycans (2 sites), 4 O-linked glycans (11 sites) |
iPTMneti | P00742 |
PhosphoSitePlusi | P00742 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000126218, Expressed in right lobe of liver and 146 other tissues |
ExpressionAtlasi | P00742, baseline and differential |
Genevisiblei | P00742, HS |
Organism-specific databases
HPAi | ENSG00000126218, Tissue enhanced (liver) |
Interactioni
Subunit structurei
The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds.
Forms a heterodimer with SERPINA5.
Binary interactionsi
P00742
With | #Exp. | IntAct |
---|---|---|
NOTCH2NLC [P0DPK4] | 3 | EBI-719750,EBI-22310682 |
SERPINA10 [Q9UK55] | 2 | EBI-719750,EBI-3941758 |
UBQLN2 [Q9UHD9] | 3 | EBI-719750,EBI-947187 |
Protein-protein interaction databases
BioGRIDi | 108457, 43 interactors |
ComplexPortali | CPX-6215, Coagulation factor Xa complex |
CORUMi | P00742 |
DIPi | DIP-29896N |
ELMi | P00742 |
IntActi | P00742, 15 interactors |
MINTi | P00742 |
STRINGi | 9606.ENSP00000364709 |
Chemistry databases
BindingDBi | P00742 |
Miscellaneous databases
RNActi | P00742, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P00742 |
SMRi | P00742 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00742 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 85 | GlaPROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 86 – 122 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 125 – 165 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 235 – 467 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 233 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 183 – 203 | O-glycosylated at one siteAdd BLAST | 21 | |
Regioni | 476 – 485 | O-glycosylated at one site | 10 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QS4N, Eukaryota |
GeneTreei | ENSGT00940000157694 |
HOGENOMi | CLU_006842_19_5_1 |
InParanoidi | P00742 |
OMAi | HCLHQAK |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P00742 |
TreeFami | TF327329 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK
60 70 80 90 100
GHLERECMEE TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK
110 120 130 140 150
CKDGLGEYTC TCLEGFEGKN CELFTRKLCS LDNGDCDQFC HEEQNSVVCS
160 170 180 190 200
CARGYTLADN GKACIPTGPY PCGKQTLERR KRSVAQATSS SGEAPDSITW
210 220 230 240 250
KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE CKDGECPWQA
260 270 280 290 300
LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE
310 320 330 340 350
AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE
360 370 380 390 400
STLMTQKTGI VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ
410 420 430 440 450
NMFCAGYDTK QEDACQGDSG GPHVTRFKDT YFVTGIVSWG EGCARKGKYG
460 470 480
IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE VITSSPLK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JVE8 | Q5JVE8_HUMAN | Coagulation factor X | F10 | 332 | Annotation score: | ||
B7ZBK1 | B7ZBK1_HUMAN | Coagulation factor X | F10 | 334 | Annotation score: | ||
F8WBM7 | F8WBM7_HUMAN | Coagulation factor X | F10 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 285 – 288 | KVRV → E in AAA51984 (PubMed:3011603).Curated | 4 | |
Sequence conflicti | 285 – 288 | KVRV → E in AAA52486 (PubMed:6587384).Curated | 4 | |
Sequence conflicti | 442 | G → S in AAA52490 (PubMed:2582420).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014162 | 7 | L → I1 PublicationCorresponds to variant dbSNP:rs5963Ensembl. | 1 | |
Natural variantiVAR_014163 | 30 | Q → H1 PublicationCorresponds to variant dbSNP:rs5961EnsemblClinVar. | 1 | |
Natural variantiVAR_065428 | 47 | E → G in FA10D; St. Louis II; strongly reduced activity; not activated by factor VIIa and tissue factor. 1 PublicationCorresponds to variant dbSNP:rs121964943Ensembl. | 1 | |
Natural variantiVAR_065429 | 51 | G → V in FA10D. 1 PublicationCorresponds to variant dbSNP:rs751782758Ensembl. | 1 | |
Natural variantiVAR_065430 | 54 | E → G in FA10D; Ketchikan. 1 PublicationCorresponds to variant dbSNP:rs121964944EnsemblClinVar. | 1 | |
Natural variantiVAR_065431 | 54 | E → K in FA10D; Vorarlberg; converts prothrombin at a normal rate but shows decreased affinity for calcium. 2 PublicationsCorresponds to variant dbSNP:rs121964939EnsemblClinVar. | 1 | |
Natural variantiVAR_065432 | 72 | E → Q in FA10D; Tokyo. 1 PublicationCorresponds to variant dbSNP:rs121964945Ensembl. | 1 | |
Natural variantiVAR_065433 | 91 | E → K in FA10D; Riyadh. 1 PublicationCorresponds to variant dbSNP:rs1477329751Ensembl. | 1 | |
Natural variantiVAR_065434 | 142 | E → K in FA10D; uncertain pathological significance; detected in patients carrying K-54 or P-374; slightly reduced activity. 3 PublicationsCorresponds to variant dbSNP:rs61753266EnsemblClinVar. | 1 | |
Natural variantiVAR_065435 | 149 | C → Y in FA10D. 1 Publication | 1 | |
Natural variantiVAR_065436 | 151 | C → Y in FA10D. 1 Publication | 1 | |
Natural variantiVAR_020176 | 152 | A → T1 PublicationCorresponds to variant dbSNP:rs3211772Ensembl. | 1 | |
Natural variantiVAR_075212 | 176 – 186 | Missing in FA10D; unknown pathological significance. 1 PublicationAdd BLAST | 11 | |
Natural variantiVAR_020177 | 192 | G → R1 PublicationCorresponds to variant dbSNP:rs3211783EnsemblClinVar. | 1 | |
Natural variantiVAR_075213 | 262 | G → D in FA10D; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1393705267Ensembl. | 1 | |
Natural variantiVAR_065437 | 289 | G → R in FA10D; may affect splicing. 1 PublicationCorresponds to variant dbSNP:rs121964946Ensembl. | 1 | |
Natural variantiVAR_065438 | 304 | E → K in FA10D. 1 PublicationCorresponds to variant dbSNP:rs747292771Ensembl. | 1 | |
Natural variantiVAR_065439 | 322 | D → N in FA10D; Stockton; 50% decrease in specific activity. 2 PublicationsCorresponds to variant dbSNP:rs121964942Ensembl. | 1 | |
Natural variantiVAR_065440 | 327 | R → W in FA10D. 1 PublicationCorresponds to variant dbSNP:rs770119164Ensembl. | 1 | |
Natural variantiVAR_065441 | 338 | V → M in FA10D. 1 PublicationCorresponds to variant dbSNP:rs121964947Ensembl. | 1 | |
Natural variantiVAR_065442 | 350 | E → K in FA10D. 1 PublicationCorresponds to variant dbSNP:rs372309538Ensembl. | 1 | |
Natural variantiVAR_065443 | 358 | T → M in FA10D; Roma. 2 PublicationsCorresponds to variant dbSNP:rs768222784Ensembl. | 1 | |
Natural variantiVAR_065444 | 363 | G → S in FA10D. 1 PublicationCorresponds to variant dbSNP:rs1595099527EnsemblClinVar. | 1 | |
Natural variantiVAR_065445 | 366 | R → C in FA10D; San Antonio. 1 PublicationCorresponds to variant dbSNP:rs104894392EnsemblClinVar. | 1 | |
Natural variantiVAR_065446 | 374 | S → P in FA10D; Marseille; decreased cleavage by factor IXa; normal catalytic efficiency for prothrombin. 3 PublicationsCorresponds to variant dbSNP:rs121964941Ensembl. | 1 | |
Natural variantiVAR_072751 | 382 | V → A in FA10D; partial loss of activity. 2 Publications | 1 | |
Natural variantiVAR_065447 | 383 | P → S in FA10D; Friuli. 1 PublicationCorresponds to variant dbSNP:rs121964940Ensembl. | 1 | |
Natural variantiVAR_065448 | 390 | C → F in FA10D; Padua 4. 1 PublicationCorresponds to variant dbSNP:rs199778916Ensembl. | 1 | |
Natural variantiVAR_065449 | 404 | C → R in FA10D. 1 PublicationCorresponds to variant dbSNP:rs1595099645EnsemblClinVar. | 1 | |
Natural variantiVAR_065450 | 406 | G → S in FA10D; almost complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs376163818Ensembl. | 1 | |
Natural variantiVAR_065451 | 420 | G → R in FA10D; Padua 3. 1 PublicationCorresponds to variant dbSNP:rs750759634Ensembl. | 1 | |
Natural variantiVAR_072752 | 421 | G → D in FA10D; significant loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs758726161Ensembl. | 1 | |
Natural variantiVAR_065452 | 448 | K → N in FA10D; San Giovanni Rotondo. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03194 mRNA Translation: AAA52490.1 M57285 mRNA Translation: AAA52421.1 AF503510 Genomic DNA Translation: AAM19347.1 BC046125 mRNA Translation: AAH46125.1 N00045 , L00390, L00391, L00392, L00393, L00394, L00395, L00396 Genomic DNA Translation: AAA52764.1 M22613 mRNA Translation: AAA51984.1 K01886 mRNA Translation: AAA52486.1 M33297 Genomic DNA Translation: AAA52636.1 |
CCDSi | CCDS9530.1 |
PIRi | A24478, EXHU |
RefSeqi | NP_000495.1, NM_000504.3 NP_001299603.1, NM_001312674.1 NP_001299604.1, NM_001312675.1 |
Genome annotation databases
Ensembli | ENST00000375559.8; ENSP00000364709.3; ENSG00000126218.12 |
GeneIDi | 2159 |
KEGGi | hsa:2159 |
MANE-Selecti | ENST00000375559.8; ENSP00000364709.3; NM_000504.4; NP_000495.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Factor X entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03194 mRNA Translation: AAA52490.1 M57285 mRNA Translation: AAA52421.1 AF503510 Genomic DNA Translation: AAM19347.1 BC046125 mRNA Translation: AAH46125.1 N00045 , L00390, L00391, L00392, L00393, L00394, L00395, L00396 Genomic DNA Translation: AAA52764.1 M22613 mRNA Translation: AAA51984.1 K01886 mRNA Translation: AAA52486.1 M33297 Genomic DNA Translation: AAA52636.1 |
CCDSi | CCDS9530.1 |
PIRi | A24478, EXHU |
RefSeqi | NP_000495.1, NM_000504.3 NP_001299603.1, NM_001312674.1 NP_001299604.1, NM_001312675.1 |
3D structure databases
Protein-protein interaction databases
BioGRIDi | 108457, 43 interactors |
ComplexPortali | CPX-6215, Coagulation factor Xa complex |
CORUMi | P00742 |
DIPi | DIP-29896N |
ELMi | P00742 |
IntActi | P00742, 15 interactors |
MINTi | P00742 |
STRINGi | 9606.ENSP00000364709 |
Chemistry databases
BindingDBi | P00742 |
ChEMBLi | CHEMBL244 |
DrugBanki | DB07211, (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE DB08746, 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE DB07974, 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE DB07277, 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE DB07605, 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE DB08487, 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE DB08495, 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE DB04673, 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE DB08745, 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE DB08488, 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE DB07804, 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE DB08174, 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE DB08173, 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE DB07872, 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide DB07843, 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE DB07848, 5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide DB07875, 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide DB08143, 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE DB07847, 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE DB07844, 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE DB13884, Albutrepenonacog alfa DB13151, Anti-inhibitor coagulant complex DB13192, Antihemophilic factor human DB00025, Antihemophilic factor, human recombinant DB11166, Antithrombin Alfa DB06605, Apixaban DB09258, Bemiparin DB12364, Betrixaban DB00100, Coagulation Factor IX (Recombinant) DB13152, Coagulation Factor IX Human DB13150, Coagulation factor VII human DB00036, Coagulation factor VIIa Recombinant Human DB09075, Edoxaban DB13923, Emicizumab DB01225, Enoxaparin DB06920, Eribaxaban DB00569, Fondaparinux DB03847, gamma-carboxy-L-glutamic acid DB07278, GW-813893 DB01109, Heparin DB06406, Idraparinux DB09332, Kappadione DB06245, Lanoteplase DB13998, Lonoctocog alfa DB05713, LY-517717 DB13999, Moroctocog alfa DB07630, N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE DB07629, N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE DB07973, N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE DB07800, N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE DB12598, Nafamostat DB13933, Nonacog beta pegol DB06635, Otamixaban DB09141, Protamine sulfate DB13149, Protein S human DB11311, Prothrombin DB06228, Rivaroxaban DB06552, rNAPc2 DB05362, SSR-126517E DB07261, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE DB08426, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE DB09109, Turoctocog alfa DB14738, Turoctocog alfa pegol |
DrugCentrali | P00742 |
GuidetoPHARMACOLOGYi | 2359 |
Protein family/group databases
MEROPSi | S01.216 |
PTM databases
GlyConnecti | 102, 16 N-Linked glycans (2 sites), 1 O-Linked glycan |
GlyGeni | P00742, 14 sites, 26 N-linked glycans (2 sites), 4 O-linked glycans (11 sites) |
iPTMneti | P00742 |
PhosphoSitePlusi | P00742 |
Genetic variation databases
BioMutai | F10 |
DMDMi | 119761 |
Proteomic databases
CPTACi | non-CPTAC-2649 |
jPOSTi | P00742 |
MassIVEi | P00742 |
PaxDbi | P00742 |
PeptideAtlasi | P00742 |
PRIDEi | P00742 |
ProteomicsDBi | 51275 |
Protocols and materials databases
ABCDi | P00742, 1 sequenced antibody |
Antibodypediai | 11687, 683 antibodies from 35 providers |
DNASUi | 2159 |
Genome annotation databases
Ensembli | ENST00000375559.8; ENSP00000364709.3; ENSG00000126218.12 |
GeneIDi | 2159 |
KEGGi | hsa:2159 |
MANE-Selecti | ENST00000375559.8; ENSP00000364709.3; NM_000504.4; NP_000495.1 |
Organism-specific databases
CTDi | 2159 |
DisGeNETi | 2159 |
GeneCardsi | F10 |
HGNCi | HGNC:3528, F10 |
HPAi | ENSG00000126218, Tissue enhanced (liver) |
MalaCardsi | F10 |
MIMi | 227600, phenotype 613872, gene |
neXtProti | NX_P00742 |
OpenTargetsi | ENSG00000126218 |
Orphaneti | 328, Congenital factor X deficiency |
PharmGKBi | PA27940 |
VEuPathDBi | HostDB:ENSG00000126218 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS4N, Eukaryota |
GeneTreei | ENSGT00940000157694 |
HOGENOMi | CLU_006842_19_5_1 |
InParanoidi | P00742 |
OMAi | HCLHQAK |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P00742 |
TreeFami | TF327329 |
Enzyme and pathway databases
BRENDAi | 3.4.21.6, 2681 |
PathwayCommonsi | P00742 |
Reactomei | R-HSA-140834, Extrinsic Pathway of Fibrin Clot Formation R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-9672383, Defective factor IX causes thrombophilia R-HSA-9672396, Defective cofactor function of FVIIIa variant R-HSA-9673202, Defective F9 variant does not activate FX |
SABIO-RKi | P00742 |
SignaLinki | P00742 |
SIGNORi | P00742 |
Miscellaneous databases
BioGRID-ORCSi | 2159, 14 hits in 1076 CRISPR screens |
ChiTaRSi | F10, human |
EvolutionaryTracei | P00742 |
GeneWikii | Factor_X |
GenomeRNAii | 2159 |
Pharosi | P00742, Tclin |
PROi | PR:P00742 |
RNActi | P00742, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126218, Expressed in right lobe of liver and 146 other tissues |
ExpressionAtlasi | P00742, baseline and differential |
Genevisiblei | P00742, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FA10_HUMAN | |
Accessioni | P00742Primary (citable) accession number: P00742 Secondary accession number(s): Q14340 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 269 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families