F9 - Coagulation factor IX precursor - Bos taurus (Bovine)

Functionⁱ

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca²⁺ ions, phospholipids, and factor VIIIa.1 Publication

Catalytic activityⁱ

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	47	Calcium 1; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	48	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	53	Calcium 1; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	53	Calcium 2; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	54	Calcium 2; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	54	Calcium 3; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	61	Calcium 4 or magnesium 1; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	63	Calcium 1; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	63	Calcium 2; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	63	Calcium 3; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	66	Calcium 4 or magnesium 1; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	67	Calcium 1; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	72	Calcium 5 or magnesium 2; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	73	Calcium 2; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	73	Calcium 3; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	76	Calcium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	76	Calcium 5 or magnesium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	82	Calcium 6 or magnesium 3; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	86	Calcium 6 or magnesium 3; via 4-carboxyglutamateCombined sources1 Publication	1
Metal bindingⁱ	93	Calcium 7By similarity	1
Metal bindingⁱ	94	Calcium 7; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	96	Calcium 7By similarity	1
Metal bindingⁱ	110	Calcium 7By similarity	1
Metal bindingⁱ	111	Calcium 7; via carbonyl oxygenBy similarity	1
Active siteⁱ	268	Charge relay systemBy similarity	1
Metal bindingⁱ	282	Calcium 8By similarity	1
Metal bindingⁱ	284	Calcium 8; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	289	Calcium 8By similarity	1
Metal bindingⁱ	292	Calcium 8By similarity	1
Active siteⁱ	316	Charge relay systemBy similarity	1
Active siteⁱ	412	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12695512
endopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 6782101
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12695512
serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: UniProtKB
proteolysis Source: UniProtKB
zymogen activation
Source: UniProtKB
Inferred from direct assayⁱ
- 6782101

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease
Biological process	Blood coagulation, Hemostasis
Ligand	Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-BTA-140834 Extrinsic Pathway of Fibrin Clot Formation R-BTA-140837 Intrinsic Pathway of Fibrin Clot Formation R-BTA-159740 Gamma-carboxylation of protein precursors R-BTA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-BTA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
SABIO-RKⁱ	P00741

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.214

MEROPSⁱ

S01.214

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coagulation factor IX (EC:3.4.21.22) Alternative name(s): Christmas factor Cleaved into the following 2 chains: Coagulation factor IXa light chain Coagulation factor IXa heavy chain
Gene namesⁱ	Name:F9
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome X

Organism-specific databases

VGNCⁱ	VGNC:28691 F9

VGNCⁱ

VGNC:28691 F9

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Hemophilia

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST	25
ChainⁱPRO_0000027741	26 – 462	Coagulation factor IXAdd BLAST	437
PropeptideⁱPRO_0000433084	29 – 46	By similarityAdd BLAST	18
ChainⁱPRO_0000027742	47 – 192	Coagulation factor IXa light chainAdd BLAST	146
PropeptideⁱPRO_0000027743	193 – 227	Activation peptideAdd BLAST	35
ChainⁱPRO_0000027744	228 – 462	Coagulation factor IXa heavy chainAdd BLAST	235

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	54	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	61	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	63	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Disulfide bondⁱ	64 ↔ 69	Combined sources1 Publication
Modified residueⁱ	66	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	67	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	72	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	73	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	76	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	79	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Modified residueⁱ	82	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Glycosylationⁱ	85	O-linked (GalNAc...) threonineBy similarity	1
Modified residueⁱ	86	4-carboxyglutamatePROSITE-ProRule annotationCombined sources2 Publications	1
Disulfide bondⁱ	97 ↔ 108	By similarity
GlycosylationⁱCAR_000008	99	O-linked (Glc...) serine; alternate3 Publications	1
Glycosylationⁱ	99	O-linked (Xyl...) serine; alternateBy similarity3 Publications	1
Disulfide bondⁱ	102 ↔ 117	By similarity
Modified residueⁱ	110	(3R)-3-hydroxyaspartate1 Publication	1
Modified residueⁱ	114	PhosphoserineBy similarity	1
Disulfide bondⁱ	119 ↔ 128	By similarity
Disulfide bondⁱ	134 ↔ 145	By similarity
Disulfide bondⁱ	141 ↔ 155	By similarity
Disulfide bondⁱ	157 ↔ 170	By similarity
Disulfide bondⁱ	178 ↔ 336	Interchain (between light and heavy chains)By similarity
Modified residueⁱ	202	SulfotyrosineBy similarity	1
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	205	PhosphoserineBy similarity	1
Glycosylationⁱ	214	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	219	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	253 ↔ 269	By similarity
Glycosylationⁱ	307	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	383 ↔ 397	By similarity
Disulfide bondⁱ	408 ↔ 436	By similarity

Post-translational modificationⁱ

Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.By similarity

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.1 Publication

Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	192 – 193	Cleavage; by factor XIa		2
Siteⁱ	227 – 228	Cleavage; by factor XIa		2

Keywords - PTMⁱ

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

PaxDbⁱ	P00741
PRIDEⁱ	P00741

PTM databases

GlyConnectⁱ	97
iPTMnetⁱ	P00741
UniCarbKBⁱ	P00741

Miscellaneous databases

PMAP-CutDBⁱ	P00741

PMAP-CutDBⁱ

P00741

Expressionⁱ

Tissue specificityⁱ

Detected in blood plasma (at protein level) (PubMed:12695512).1 Publication

Gene expression databases

Bgeeⁱ	ENSBTAG00000004003 Expressed in 2 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P00741 baseline and differential

Interactionⁱ

Subunit structureⁱ

Heterodimer of a light chain and a heavy chain; disulfide-linked, Interacts with SERPINC1 (By similarity). Interacts with the heterodimeric snake venom coagulation factor IX-binding protein (PubMed:12695512).By similarity1 Publication

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000005227

STRINGⁱ

9913.ENSBTAP00000005227

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	50 – 52	Combined sources	3
Helixⁱ	53 – 55	Combined sources	3
Helixⁱ	60 – 64	Combined sources	5
Helixⁱ	71 – 78	Combined sources	8
Helixⁱ	81 – 91	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P00741
SMRⁱ	P00741
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P00741

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	47 – 92	GlaPROSITE-ProRule annotationAdd BLAST	46
Domainⁱ	93 – 129	EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	130 – 171	EGF-like 2PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	228 – 460	Peptidase S1PROSITE-ProRule annotationAdd BLAST	233

Domainⁱ

Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain (PubMed:12695512). Calcium can also bind, with stronger affinity, to another site beyond the Gla domain (By similarity). Under physiological ion concentrations, Ca²⁺ is displaced by Mg²⁺ from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein (PubMed:12695512).By similarity1 Publication

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

EGF-like domain, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118890
HOGENOMⁱ	HOG000251821
HOVERGENⁱ	HBG013304
InParanoidⁱ	P00741
OMAⁱ	VTPICIA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5
TreeFamⁱ	TF327329

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR035694 Coagulation_factor_IX IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR44064:SF4 PTHR44064:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P00741-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWCLNMIMAE SPGLVTICLL GYLLSAECTV FLDRENATKI LHRPKRYNSG 
        60         70         80         90        100
KLEEFVRGNL ERECKEEKCS FEEAREVFEN TEKTTEFWKQ YVDGDQCESN 
       110        120        130        140        150
PCLNGGMCKD DINSYECWCQ AGFEGTNCEL DATCSIKNGR CKQFCKRDTD 
       160        170        180        190        200
NKVVCSCTDG YRLAEDQKSC EPAVPFPCGR VSVSHISKKL TRAETIFSNT 
       210        220        230        240        250
NYENSSEAEI IWDNVTQSNQ SFDEFSRVVG GEDAERGQFP WQVLLHGEIA 
       260        270        280        290        300
AFCGGSIVNE KWVVTAAHCI KPGVKITVVA GEHNTEKPEP TEQKRNVIRA 
       310        320        330        340        350
IPYHSYNASI NKYSHDIALL ELDEPLELNS YVTPICIADR DYTNIFLKFG 
       360        370        380        390        400
YGYVSGWGKV FNRGRSASIL QYLKVPLVDR ATCLRSTKFS IYSHMFCAGY 
       410        420        430        440        450
HEGGKDSCQG DSGGPHVTEV EGTSFLTGII SWGEECAMKG KYGIYTKVSR 
       460 
YVNWIKEKTK LT

Length:462

Mass (Da):52,046

Last modified:May 27, 2015 - v2

Checksum:ⁱ415B2A7BD6EA256A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F1MBC5	F1MBC5_BOVIN		Coagulation factor IX Coagulation factor IX	F9	324	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	110	D → T AA sequence (PubMed:291916).Curated		1
Sequence conflictⁱ	347	L → S AA sequence (PubMed:291916).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DAAA02067809 Genomic DNA No translation available. DAAA02067810 Genomic DNA No translation available. J00007 mRNA Translation: AAA30520.1
PIRⁱ	A14757 KFBO
NCBI Reference Sequences More...RefSeqⁱ	XP_005227591.1, XM_005227534.3
UniGeneⁱ	Bt.13106

Genome annotation databases

Ensemblⁱ	ENSBTAT00000005227; ENSBTAP00000005227; ENSBTAG00000004003

Ensemblⁱ

ENSBTAT00000005227; ENSBTAP00000005227; ENSBTAG00000004003

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00741	Coagulation factor IX (Fragment)		BOVIN		49	UniRef100_P00741

Protein	Similar proteins		Species	Score	Length	Source
P00741	Coagulation factor IX (Fragment)		BOVIN		49	UniRef90_P00741
Coagulation factor IX		wild yak		462
Coagulation factor IX		SHEEP		462
UPI000DBC4843		BUBBU		507
UPI000A1BBDD1		Odocoileus virginianus texanus		462
+2

Protein	Similar proteins		Species	Score	Length	Source
P00741	Coagulation factor IX	)	HUMAN		461	UniRef50_P00740
Coagulation factor IX		PANTR		461
Coagulation factor IX		MOUSE		471
Coagulation factor IX		RAT		462
Coagulation factor IX (Fragment)		CAVPO		285
+292

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DAAA02067809 Genomic DNA No translation available. DAAA02067810 Genomic DNA No translation available. J00007 mRNA Translation: AAA30520.1
PIRⁱ	A14757 KFBO
RefSeqⁱ	XP_005227591.1, XM_005227534.3
UniGeneⁱ	Bt.13106

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1J34	X-ray	1.55	C	47-92	[»]
	1J35	X-ray	1.80	C	47-92	[»]
ProteinModelPortalⁱ	P00741
SMRⁱ	P00741
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000005227

STRINGⁱ

9913.ENSBTAP00000005227

Protein family/group databases

MEROPSⁱ	S01.214

MEROPSⁱ

S01.214

PTM databases

GlyConnectⁱ	97
iPTMnetⁱ	P00741
UniCarbKBⁱ	P00741

Proteomic databases

PaxDbⁱ	P00741
PRIDEⁱ	P00741

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000005227; ENSBTAP00000005227; ENSBTAG00000004003

Ensemblⁱ

ENSBTAT00000005227; ENSBTAP00000005227; ENSBTAG00000004003

Organism-specific databases

CTDⁱ	2158
VGNCⁱ	VGNC:28691 F9

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00760000118890
HOGENOMⁱ	HOG000251821
HOVERGENⁱ	HBG013304
InParanoidⁱ	P00741
OMAⁱ	VTPICIA
OrthoDBⁱ	EOG091G0AH5
TreeFamⁱ	TF327329

Enzyme and pathway databases

Reactomeⁱ	R-BTA-140834 Extrinsic Pathway of Fibrin Clot Formation R-BTA-140837 Intrinsic Pathway of Fibrin Clot Formation R-BTA-159740 Gamma-carboxylation of protein precursors R-BTA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-BTA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
SABIO-RKⁱ	P00741

Miscellaneous databases

EvolutionaryTraceⁱ	P00741
PMAP-CutDBⁱ	P00741

Gene expression databases

Bgeeⁱ	ENSBTAG00000004003 Expressed in 2 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P00741 baseline and differential

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR035694 Coagulation_factor_IX IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR44064:SF4 PTHR44064:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA9_BOVIN
Accessionⁱ	P00741Primary (citable) accession number: P00741 Secondary accession number(s): F1MFL4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	May 27, 2015
	Last modified:	September 12, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P00741 (FA9_BOVIN)

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Coagulation factor IX

F9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ