UniProtKB - P00727 (AMPL_BOVIN)

BLAST

>sp|P00727|AMPL_BOVIN Cytosol aminopeptidase OS=Bos taurus OX=9913 GN=LAP3 PE=1 SV=3
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFN
KLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKEN
IRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGS
EDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWI
EEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMD
LMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQV
DNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFE
ASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL
DIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA

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History
Entry version 166 (12 Sep 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Cytosol aminopeptidase

Gene

LAP3

Organism

Bos taurus (Bovine)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activityⁱ

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.

Release of N-terminal proline from a peptide.

Cofactorⁱ

Note: Binds 2 zinc ions per subunit. One zinc ion is tightly bound and essential for enzyme activity, while the second metal coordination site can be occupied by zinc, magnesium or manganese to give enzymes of different activities.

Activity regulationⁱ

Inhibited by bestatin.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	282	Zinc 2	1
Metal bindingⁱ	287	Zinc 1	1
Metal bindingⁱ	287	Zinc 2	1
Active siteⁱ	294		1
Metal bindingⁱ	305	Zinc 2	1
Metal bindingⁱ	364	Zinc 1	1
Metal bindingⁱ	366	Zinc 1	1
Metal bindingⁱ	366	Zinc 2	1
Active siteⁱ	368		1

GO - Molecular functionⁱ

aminopeptidase activity Source: UniProtKB-KW
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 11785981
manganese ion binding Source: InterPro
metalloexopeptidase activity Source: InterPro
peptidase activity Source: AgBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminopeptidase, Hydrolase, Protease
Ligand	Magnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	3.4.11.1 908
SABIO-RKⁱ	P00727

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M17.001

MEROPSⁱ

M17.001

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytosol aminopeptidase (EC:3.4.11.1) Alternative name(s): Leucine aminopeptidase 3 Short name: LAP-3 Leucyl aminopeptidase Peptidase S Proline aminopeptidase (EC:3.4.11.5) Prolyl aminopeptidase
Gene namesⁱ	Name:LAP3
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 6

Organism-specific databases

VGNCⁱ	VGNC:30786 LAP3

VGNCⁱ

VGNC:30786 LAP3

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1671610

ChEMBLⁱ

CHEMBL1671610

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000165824	1 – 519	Cytosol aminopeptidaseAdd BLAST	519
Isoform 3 (identifier: P00727-3)
Initiator methionineⁱ		Removed5 Publications

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	42	PhosphoserineBy similarity	1
Modified residueⁱ	45	N6-succinyllysineBy similarity	1
Modified residueⁱ	54	PhosphoserineBy similarity	1
Modified residueⁱ	61	N6-succinyllysineBy similarity	1
Modified residueⁱ	103	N6-succinyllysineBy similarity	1
Modified residueⁱ	180	PhosphoserineBy similarity	1
Modified residueⁱ	194	PhosphoserineBy similarity	1
Modified residueⁱ	238	PhosphoserineBy similarity	1
Modified residueⁱ	455	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	455	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	476	N6-succinyllysineBy similarity	1
Modified residueⁱ	489	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	489	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P00727
PeptideAtlas More...PeptideAtlasⁱ	P00727
PRIDEⁱ	P00727

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000005989 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P00727 baseline and differential

Interactionⁱ

Subunit structureⁱ

Homohexamer.

GO - Molecular functionⁱ

disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 11785981

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000007860

STRINGⁱ

9913.ENSBTAP00000007860

Chemistry databases

BindingDBⁱ

P00727

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 40	Combined sources	7
Beta strandⁱ	47 – 49	Combined sources	3
Helixⁱ	54 – 62	Combined sources	9
Turnⁱ	63 – 65	Combined sources	3
Helixⁱ	66 – 73	Combined sources	8
Beta strandⁱ	83 – 90	Combined sources	8
Beta strandⁱ	93 – 100	Combined sources	8
Turnⁱ	110 – 113	Combined sources	4
Helixⁱ	116 – 134	Combined sources	19
Beta strandⁱ	138 – 142	Combined sources	5
Helixⁱ	148 – 159	Combined sources	12
Beta strandⁱ	174 – 181	Combined sources	8
Helixⁱ	183 – 204	Combined sources	22
Turnⁱ	207 – 209	Combined sources	3
Helixⁱ	212 – 226	Combined sources	15
Beta strandⁱ	228 – 235	Combined sources	8
Helixⁱ	237 – 242	Combined sources	6
Helixⁱ	246 – 252	Combined sources	7
Beta strandⁱ	255 – 257	Combined sources	3
Beta strandⁱ	260 – 267	Combined sources	8
Beta strandⁱ	269 – 271	Combined sources	3
Beta strandⁱ	277 – 281	Combined sources	5
Beta strandⁱ	283 – 287	Combined sources	5
Helixⁱ	299 – 304	Combined sources	6
Helixⁱ	307 – 321	Combined sources	15
Beta strandⁱ	325 – 337	Combined sources	13
Beta strandⁱ	348 – 351	Combined sources	4
Beta strandⁱ	357 – 361	Combined sources	5
Turnⁱ	363 – 366	Combined sources	4
Helixⁱ	367 – 379	Combined sources	13
Beta strandⁱ	384 – 390	Combined sources	7
Helixⁱ	394 – 400	Combined sources	7
Beta strandⁱ	405 – 410	Combined sources	6
Helixⁱ	412 – 425	Combined sources	14
Beta strandⁱ	429 – 431	Combined sources	3
Helixⁱ	436 – 443	Combined sources	8
Beta strandⁱ	446 – 453	Combined sources	8
Beta strandⁱ	455 – 457	Combined sources	3
Helixⁱ	460 – 469	Combined sources	10
Beta strandⁱ	475 – 481	Combined sources	7
Helixⁱ	483 – 485	Combined sources	3
Beta strandⁱ	486 – 492	Combined sources	7
Beta strandⁱ	497 – 499	Combined sources	3
Helixⁱ	504 – 515	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P00727
SMRⁱ	P00727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P00727

EvolutionaryTraceⁱ

P00727

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2597 Eukaryota COG0260 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063255
HOGENOMⁱ	HOG000243129
HOVERGENⁱ	HBG003320
InParanoidⁱ	P00727
KEGG Orthology (KO) More...KOⁱ	K11142
OMAⁱ	MKNTGPR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ERB
TreeFamⁱ	TF314954

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00433 Peptidase_M17, 1 hit
HAMAPⁱ	MF_00181 Cytosol_peptidase_M17, 1 hit
InterProⁱ	View protein in InterPro IPR011356 Leucine_aapep/pepB IPR000819 Peptidase_M17_C IPR023042 Peptidase_M17_leu_NH2_pept IPR008283 Peptidase_M17_N
PANTHERⁱ	PTHR11963 PTHR11963, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00883 Peptidase_M17, 1 hit PF02789 Peptidase_M17_N, 1 hit
PRINTSⁱ	PR00481 LAMNOPPTDASE
PROSITEⁱ	View protein in PROSITE PS00631 CYTOSOL_AP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative initiation. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P00727-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLLPLPAAA RVAVRHLSVK RLWAPGPAAA DMTKGLVLGI YSKEKEEDEP 
        60         70         80         90        100
QFTSAGENFN KLVSGKLREI LNISGPPLKA GKTRTFYGLH EDFPSVVVVG 
       110        120        130        140        150
LGKKTAGIDE QENWHEGKEN IRAAVAAGCR QIQDLEIPSV EVDPCGDAQA 
       160        170        180        190        200
AAEGAVLGLY EYDDLKQKRK VVVSAKLHGS EDQEAWQRGV LFASGQNLAR 
       210        220        230        240        250
RLMETPANEM TPTKFAEIVE ENLKSASIKT DVFIRPKSWI EEQEMGSFLS 
       260        270        280        290        300
VAKGSEEPPV FLEIHYKGSP NASEPPLVFV GKGITFDSGG ISIKAAANMD 
       310        320        330        340        350
LMRADMGGAA TICSAIVSAA KLDLPINIVG LAPLCENMPS GKANKPGDVV 
       360        370        380        390        400
RARNGKTIQV DNTDAEGRLI LADALCYAHT FNPKVIINAA TLTGAMDIAL 
       410        420        430        440        450
GSGATGVFTN SSWLWNKLFE ASIETGDRVW RMPLFEHYTR QVIDCQLADV 
       460        470        480        490        500
NNIGKYRSAG ACTAAAFLKE FVTHPKWAHL DIAGVMTNKD EVPYLRKGMA 
       510 
GRPTRTLIEF LFRFSQDSA

Note: No experimental confirmation available.

Length:519

Mass (Da):56,289

Last modified:January 23, 2007 - v3

Checksum:ⁱCDA6AED4D937F624

Isoform 2 (identifier: P00727-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
11-31: Missing.

« Hide

        10         20         30         40         50
MFLLPLPAAA MTKGLVLGIY SKEKEEDEPQ FTSAGENFNK LVSGKLREIL 
        60         70         80         90        100
NISGPPLKAG KTRTFYGLHE DFPSVVVVGL GKKTAGIDEQ ENWHEGKENI 
       110        120        130        140        150
RAAVAAGCRQ IQDLEIPSVE VDPCGDAQAA AEGAVLGLYE YDDLKQKRKV 
       160        170        180        190        200
VVSAKLHGSE DQEAWQRGVL FASGQNLARR LMETPANEMT PTKFAEIVEE 
       210        220        230        240        250
NLKSASIKTD VFIRPKSWIE EQEMGSFLSV AKGSEEPPVF LEIHYKGSPN 
       260        270        280        290        300
ASEPPLVFVG KGITFDSGGI SIKAAANMDL MRADMGGAAT ICSAIVSAAK 
       310        320        330        340        350
LDLPINIVGL APLCENMPSG KANKPGDVVR ARNGKTIQVD NTDAEGRLIL 
       360        370        380        390        400
ADALCYAHTF NPKVIINAAT LTGAMDIALG SGATGVFTNS SWLWNKLFEA 
       410        420        430        440        450
SIETGDRVWR MPLFEHYTRQ VIDCQLADVN NIGKYRSAGA CTAAAFLKEF 
       460        470        480        490 
VTHPKWAHLD IAGVMTNKDE VPYLRKGMAG RPTRTLIEFL FRFSQDSA

Show »

Length:498

Mass (Da):54,037

Checksum:ⁱ70766756087AB1FD

Isoform 3 (identifier: P00727-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-31: Missing.

« Hide

        10         20         30         40         50
MTKGLVLGIY SKEKEEDEPQ FTSAGENFNK LVSGKLREIL NISGPPLKAG 
        60         70         80         90        100
KTRTFYGLHE DFPSVVVVGL GKKTAGIDEQ ENWHEGKENI RAAVAAGCRQ 
       110        120        130        140        150
IQDLEIPSVE VDPCGDAQAA AEGAVLGLYE YDDLKQKRKV VVSAKLHGSE 
       160        170        180        190        200
DQEAWQRGVL FASGQNLARR LMETPANEMT PTKFAEIVEE NLKSASIKTD 
       210        220        230        240        250
VFIRPKSWIE EQEMGSFLSV AKGSEEPPVF LEIHYKGSPN ASEPPLVFVG 
       260        270        280        290        300
KGITFDSGGI SIKAAANMDL MRADMGGAAT ICSAIVSAAK LDLPINIVGL 
       310        320        330        340        350
APLCENMPSG KANKPGDVVR ARNGKTIQVD NTDAEGRLIL ADALCYAHTF 
       360        370        380        390        400
NPKVIINAAT LTGAMDIALG SGATGVFTNS SWLWNKLFEA SIETGDRVWR 
       410        420        430        440        450
MPLFEHYTRQ VIDCQLADVN NIGKYRSAGA CTAAAFLKEF VTHPKWAHLD 
       460        470        480 
IAGVMTNKDE VPYLRKGMAG RPTRTLIEFL FRFSQDSA

Show »

Length:488

Mass (Da):53,011

Checksum:ⁱ11B49D671A1FBD4D

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3N0I4	G3N0I4_BOVIN		Cytosol aminopeptidase Cytosol aminopeptidase	LAP3	498	Annotation score:

Sequence cautionⁱ

The sequence AAB28170 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	77	P → S in AAB28170 (PubMed:8369298).Curated	1
Sequence conflictⁱ	414 – 415	LW → M AA sequence (PubMed:7085616).Curated	2
Sequence conflictⁱ	414 – 415	LW → M AA sequence (PubMed:7085617).Curated	2
Sequence conflictⁱ	506 – 513	Missing AA sequence (PubMed:7085616).Curated	8
Sequence conflictⁱ	506 – 513	Missing AA sequence (PubMed:7085617).Curated	8

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058150	1 – 31	Missing in isoform 3. CuratedAdd BLAST		31
Alternative sequenceⁱVSP_022634	11 – 31	Missing in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S65367 mRNA Translation: AAB28170.1 Different initiation. BC105385 mRNA Translation: AAI05386.1 AJ871963 Genomic DNA Translation: CAI44744.1
PIRⁱ	A54338 APBOL
NCBI Reference Sequences More...RefSeqⁱ	NP_776523.2, NM_174098.3 [P00727-1]
UniGeneⁱ	Bt.56962

Genome annotation databases

Ensemblⁱ	ENSBTAT00000007860; ENSBTAP00000007860; ENSBTAG00000005989 [P00727-1]
GeneIDⁱ	781648
KEGGⁱ	bta:781648

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00727	Isoform 3 of Cytosol aminopeptidase		BOVIN		488	UniRef100_P00727
Leucine aminopeptidase 3 (Fragment)		BUBBU		99
UPI0009532B6B		BOSIN		124
UPI000181CC86		BOVIN		487
UPI0000D4FBAB		BOVIN		486
+1

Protein	Similar proteins		Species	Score	Length	Source
P00727	Isoform 3 of Cytosol aminopeptidase		BOVIN		488	UniRef90_P00727
Leucine aminopeptidase 3 (Fragment)		BUBBU		99
cytosol aminopeptidase		PHYCD		519
Cytosol aminopeptidase		PIG		519
Cytosol aminopeptidase		MYOBR		508
+13

Protein	Similar proteins		Species	Score	Length	Source
P00727	Cytosol aminopeptidase		HUMAN		519	UniRef50_P00727
Isoform 3 of Cytosol aminopeptidase		BOVIN		488
Leucine aminopeptidase 3 (Fragment)		BUBBU		99
Cytosol aminopeptidase		PIG		519
cytosol aminopeptidase		PHYCD		519
+166

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S65367 mRNA Translation: AAB28170.1 Different initiation. BC105385 mRNA Translation: AAI05386.1 AJ871963 Genomic DNA Translation: CAI44744.1
PIRⁱ	A54338 APBOL
RefSeqⁱ	NP_776523.2, NM_174098.3 [P00727-1]
UniGeneⁱ	Bt.56962

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BLL	X-ray	2.40	E	33-519	[»]
	1BPM	X-ray	2.90	A	33-519	[»]
	1BPN	X-ray	2.90	A	33-519	[»]
	1LAM	X-ray	1.60	A	33-516	[»]
	1LAN	X-ray	1.90	A	33-516	[»]
	1LAP	X-ray	2.70	A	33-519	[»]
	1LCP	X-ray	1.65	A/B	33-516	[»]
	2EWB	X-ray	1.85	A	33-518	[»]
	2J9A	X-ray	1.73	A	33-519	[»]
ProteinModelPortalⁱ	P00727
SMRⁱ	P00727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000007860

STRINGⁱ

9913.ENSBTAP00000007860

Chemistry databases

BindingDBⁱ	P00727
ChEMBLⁱ	CHEMBL1671610

Protein family/group databases

MEROPSⁱ	M17.001

MEROPSⁱ

M17.001

Proteomic databases

PaxDbⁱ	P00727
PeptideAtlasⁱ	P00727
PRIDEⁱ	P00727

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000007860; ENSBTAP00000007860; ENSBTAG00000005989 [P00727-1]
GeneIDⁱ	781648
KEGGⁱ	bta:781648

Organism-specific databases

CTDⁱ	51056
VGNCⁱ	VGNC:30786 LAP3

Phylogenomic databases

eggNOGⁱ	KOG2597 Eukaryota COG0260 LUCA
GeneTreeⁱ	ENSGT00530000063255
HOGENOMⁱ	HOG000243129
HOVERGENⁱ	HBG003320
InParanoidⁱ	P00727
KOⁱ	K11142
OMAⁱ	MKNTGPR
OrthoDBⁱ	EOG091G0ERB
TreeFamⁱ	TF314954

Enzyme and pathway databases

BRENDAⁱ	3.4.11.1 908
SABIO-RKⁱ	P00727

Miscellaneous databases

EvolutionaryTraceⁱ	P00727

EvolutionaryTraceⁱ

P00727

Gene expression databases

Bgeeⁱ	ENSBTAG00000005989 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P00727 baseline and differential

Family and domain databases

CDDⁱ	cd00433 Peptidase_M17, 1 hit
HAMAPⁱ	MF_00181 Cytosol_peptidase_M17, 1 hit
InterProⁱ	View protein in InterPro IPR011356 Leucine_aapep/pepB IPR000819 Peptidase_M17_C IPR023042 Peptidase_M17_leu_NH2_pept IPR008283 Peptidase_M17_N
PANTHERⁱ	PTHR11963 PTHR11963, 1 hit
Pfamⁱ	View protein in Pfam PF00883 Peptidase_M17, 1 hit PF02789 Peptidase_M17_N, 1 hit
PRINTSⁱ	PR00481 LAMNOPPTDASE
PROSITEⁱ	View protein in PROSITE PS00631 CYTOSOL_AP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AMPL_BOVIN
Accessionⁱ	P00727Primary (citable) accession number: P00727 Secondary accession number(s): Q2HJH5, Q2PC24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - P00727 (AMPL_BOVIN)

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Cytosol aminopeptidase

LAP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ