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Protein

Lysozyme g

Gene
N/A
Organism
Anser anser anser (Western greylag goose)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei731
Active sitei861

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17 360

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismiAnser anser anser (Western greylag goose)
Taxonomic identifieri8844 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnserinaeAnser

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935131 – 185Lysozyme gAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 60
Disulfide bondi18 ↔ 29

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00718
SMRiP00718
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00718

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 23 family.Curated

Phylogenomic databases

HOVERGENiHBG006299

Family and domain databases

CDDicd01021 GEWL, 1 hit
InterProiView protein in InterPro
IPR002152 Glyco_hydro_23
IPR023346 Lysozyme-like_dom_sf
IPR008258 Transglycosylase_SLT_dom_1
PfamiView protein in Pfam
PF01464 SLT, 1 hit
PIRSFiPIRSF001065 Lysozyme_g, 1 hit
PRINTSiPR00749 LYSOZYMEG
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

P00718-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RTDCYGNVNR IDTTGASCKT AKPEGLSYCG VSASKKIAER DLQAMDRYKT
60 70 80 90 100
IIKKVGEKLC VEPAVIAGII SRESHAGKVL KNGWGDRGNG FGLMQVDKRS
110 120 130 140 150
HKPQGTWNGE VHITQGTTIL INFIKTIQKK FPSWTKDQQL KGGISAYNAG
160 170 180
AGNVRSYARM DIGTTHDDYA NDVVARAQYY KQHGY
Length:185
Mass (Da):20,373
Last modified:July 21, 1986 - v1
Checksum:i0B2F0C9B2A66C324
GO

Sequence databases

PIRiA00873 LZGSG

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA00873 LZGSG

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
153LX-ray1.60A1-185[»]
154LX-ray1.60A1-185[»]
ProteinModelPortaliP00718
SMRiP00718
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006299

Enzyme and pathway databases

BRENDAi3.2.1.17 360

Miscellaneous databases

EvolutionaryTraceiP00718

Family and domain databases

CDDicd01021 GEWL, 1 hit
InterProiView protein in InterPro
IPR002152 Glyco_hydro_23
IPR023346 Lysozyme-like_dom_sf
IPR008258 Transglycosylase_SLT_dom_1
PfamiView protein in Pfam
PF01464 SLT, 1 hit
PIRSFiPIRSF001065 Lysozyme_g, 1 hit
PRINTSiPR00749 LYSOZYMEG
SUPFAMiSSF53955 SSF53955, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYG_ANSAN
AccessioniPrimary (citable) accession number: P00718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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