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Protein

Alpha-lactalbumin

Gene

Lalba

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi97 – 108PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMilk protein
Biological processLactose biosynthesis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:Lalba
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2987 Lalba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001844920 – 159Alpha-lactalbumin1 PublicationAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 139PROSITE-ProRule annotation
Disulfide bondi47 ↔ 130PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi80 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00714
PRIDEiP00714

PTM databases

iPTMnetiP00714

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014457

Structurei

3D structure databases

ProteinModelPortaliP00714
SMRiP00714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41 Eukaryota
ENOG410ZQK6 LUCA
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP00714
KOiK00704
PhylomeDBiP00714

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000545 Lactalbumin
IPR023346 Lysozyme-like_dom_sf
PANTHERiPTHR11407:SF32 PTHR11407:SF32, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00136 LACTALBUMIN
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRFVPLFLA CISLPAFQAT EFTKCEVSHA IEDMDGYQGI SLLEWTCVLF
60 70 80 90 100
HTSGYDSQAI VKNNGSTEYG LFQISNRNWC KSSEFPESEN ICDISCDKFL
110 120 130 140 150
DDELADDIVC AKKIVAIKGI DYWKAHKPMC SEKLEQWRCE KPGAPALVVP

ALNSETPVP
Length:159
Mass (Da):17,850
Last modified:July 21, 1986 - v1
Checksum:iD2C097A0548E7BD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38 – 40QGI → EGV AA sequence (PubMed:7044414).Curated3
Sequence conflicti43L → P AA sequence (PubMed:7044414).Curated1
Sequence conflicti57 – 60SQAI → TEAS AA sequence (PubMed:7044414).Curated4
Sequence conflicti63N → D AA sequence (PubMed:7044414).Curated1
Sequence conflicti78N → D AA sequence (PubMed:7044414).Curated1
Sequence conflicti82 – 86SSEFP → ENQFV AA sequence (PubMed:7044414).Curated5
Sequence conflicti121D → N AA sequence (PubMed:7044414).Curated1
Sequence conflicti124K → L AA sequence (PubMed:7044414).Curated1
Sequence conflicti153 – 154NS → DG AA sequence (PubMed:7044414).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00461 Genomic DNA Translation: CAA25150.1
V01251 mRNA Translation: CAA24564.2
PIRiA93327 LART
RefSeqiNP_036726.1, NM_012594.1
UniGeneiRn.10479

Genome annotation databases

GeneIDi24528
KEGGirno:24528
UCSCiRGD:2987 rat

Similar proteinsi

Entry informationi

Entry nameiLALBA_RAT
AccessioniPrimary (citable) accession number: P00714
Secondary accession number(s): P00715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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