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Protein

Alpha-lactalbumin

Gene

LALBA

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi97 – 108Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMilk protein
Biological processLactose biosynthesis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:LALBA
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001844320 – 142Alpha-lactalbuminAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 139
Disulfide bondi47 ↔ 130
Disulfide bondi80 ↔ 96
Disulfide bondi92 ↔ 110

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019835

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00713
SMRiP00713
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00713

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41 Eukaryota
ENOG410ZQK6 LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP00713
OMAiLAHKPLC
OrthoDBiEOG091G0R9V
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000545 Lactalbumin
IPR023346 Lysozyme-like_dom_sf
PANTHERiPTHR11407:SF32 PTHR11407:SF32, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00136 LACTALBUMIN
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFFPLLLV GILFPAVQAK QLTKCALSHE LNDLAGYRDI TLPEWLCIIF
60 70 80 90 100
HISGYDTQAI VKNSDHKEYG LFQINDKDFC ESSTTVQSRN ICDISCDKLL
110 120 130 140
DDDLTDDIMC VKKILDIKGI DYWLAHKPLC SDKLEQWYCE AQ
Length:142
Mass (Da):16,300
Last modified:July 1, 1989 - v2
Checksum:iE13FA2ACA8F1029E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81E → D in AAA60337 (PubMed:6285305).Curated1
Sequence conflicti124L → F in AAA60337 (PubMed:6285305).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00051 mRNA Translation: AAA60337.1
Y00726 Genomic DNA Translation: CAA68710.1
PIRiS01144 LAGP
RefSeqiNP_001166360.1, NM_001172889.1

Genome annotation databases

EnsembliENSCPOT00000019635; ENSCPOP00000019835; ENSCPOG00000027342
GeneIDi100379577

Similar proteinsi

Entry informationi

Entry nameiLALBA_CAVPO
AccessioniPrimary (citable) accession number: P00713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 22, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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