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Protein

Alpha-lactalbumin

Gene

LALBA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi97 – 108Add BLAST12

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell wall macromolecule catabolic process Source: GO_Central
  • defense response to bacterium Source: ProtInc
  • defense response to Gram-negative bacterium Source: GO_Central
  • defense response to Gram-positive bacterium Source: GO_Central
  • lactose biosynthetic process Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionMilk protein
Biological processLactose biosynthesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS09571-MONOMER
ReactomeiR-HSA-5653890 Lactose synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Lysozyme-like protein 7
Gene namesi
Name:LALBA
Synonyms:LYZL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167531.6
HGNCiHGNC:6480 LALBA
MIMi149750 gene
neXtProtiNX_P00709

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3906
OpenTargetsiENSG00000167531
PharmGKBiPA30269

Protein family/group databases

Allergomei1289 Hom s ALA

Chemistry databases

DrugBankiDB03796 Palmitic Acid

Polymorphism and mutation databases

BioMutaiLALBA
DMDMi126001

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001844420 – 142Alpha-lactalbuminAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 139
Disulfide bondi47 ↔ 130
Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi80 ↔ 96
Glycosylationi90N-linked (GlcNAc...) asparagine; atypical; partial1 Publication1
Disulfide bondi92 ↔ 110

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00709
PeptideAtlasiP00709
PRIDEiP00709
ProteomicsDBi12680
51268

PTM databases

iPTMnetiP00709
PhosphoSitePlusiP00709

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000167531
CleanExiHS_LALBA
ExpressionAtlasiP00709 baseline and differential
GenevisibleiP00709 HS

Organism-specific databases

HPAiCAB026343
HPA029855
HPA029856

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

BioGridi110101, 5 interactors
STRINGi9606.ENSP00000301046

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 30Combined sources7
Helixi32 – 34Combined sources3
Helixi37 – 39Combined sources3
Helixi42 – 53Combined sources12
Beta strandi60 – 62Combined sources3
Beta strandi67 – 69Combined sources3
Turni70 – 73Combined sources4
Turni76 – 78Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi83 – 85Combined sources3
Beta strandi91 – 95Combined sources5
Helixi96 – 100Combined sources5
Helixi105 – 117Combined sources13
Turni118 – 120Combined sources3
Helixi121 – 124Combined sources4
Helixi128 – 130Combined sources3
Helixi134 – 137Combined sources4

3D structure databases

ProteinModelPortaliP00709
SMRiP00709
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00709

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41 Eukaryota
ENOG410ZQK6 LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP00709
KOiK00704
OMAiLAHKPLC
OrthoDBiEOG091G0R9V
PhylomeDBiP00709
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000545 Lactalbumin
IPR023346 Lysozyme-like_dom_sf
PANTHERiPTHR11407:SF32 PTHR11407:SF32, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00136 LACTALBUMIN
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFVPLFLV GILFPAILAK QFTKCELSQL LKDIDGYGGI ALPELICTMF
60 70 80 90 100
HTSGYDTQAI VENNESTEYG LFQISNKLWC KSSQVPQSRN ICDISCDKFL
110 120 130 140
DDDITDDIMC AKKILDIKGI DYWLAHKALC TEKLEQWLCE KL
Length:142
Mass (Da):16,225
Last modified:July 21, 1986 - v1
Checksum:i647F448733B06D65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99F → K AA sequence (PubMed:1401360).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02452646I → V1 PublicationCorresponds to variant dbSNP:rs2232565Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00270 mRNA Translation: AAA60345.1
X05153 Genomic DNA Translation: CAA28799.1
X05153 Genomic DNA Translation: CAA28800.1
AB049976 Genomic DNA Translation: BAC06860.1
CR541987 mRNA Translation: CAG46784.1
CR542017 mRNA Translation: CAG46814.1
CH471111 Genomic DNA Translation: EAW57990.1
BC069103 mRNA Translation: AAH69103.1
BC112316 mRNA Translation: AAI12317.1
BC112318 mRNA Translation: AAI12319.1
CCDSiCCDS8765.1
PIRiA27880 LAHU
RefSeqiNP_002280.1, NM_002289.2
UniGeneiHs.72938

Genome annotation databases

EnsembliENST00000301046; ENSP00000301046; ENSG00000167531
GeneIDi3906
KEGGihsa:3906
UCSCiuc001rrt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLALBA_HUMAN
AccessioniPrimary (citable) accession number: P00709
Secondary accession number(s): Q6FGX0, Q9UDK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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