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Protein

Lysozyme C

Gene

LYZ

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.PROSITE-ProRule annotation1 Publication

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei531
Active sitei701
Binding sitei119Substrate1

GO - Molecular functioni

  • beta-N-acetylglucosaminidase activity Source: AgBase
  • identical protein binding Source: IntAct
  • lysozyme activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17 1306
ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-6803157 Antimicrobial peptides
SABIO-RKiP00698

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Allergen Gal d IV
Allergen: Gal d 4
Gene namesi
Name:LYZ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3294 Gal d 4.0101
362 Gal d 4

Chemistry databases

ChEMBLiCHEMBL1932892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001849519 – 147Lysozyme CAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 145
Disulfide bondi48 ↔ 133
Disulfide bondi82 ↔ 98
Disulfide bondi94 ↔ 112

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP00698
PRIDEiP00698

PTM databases

CarbonylDBiP00698
iPTMnetiP00698

Expressioni

Tissue specificityi

In the egg white and polymorphonuclear leukocytes.

Gene expression databases

BgeeiENSGALG00000009963 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiP00698 baseline and differential

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676478, 1 interactor
DIPiDIP-46258N
IntActiP00698, 6 interactors
MINTiP00698
STRINGi9031.ENSGALP00000016177

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00698
SMRiP00698
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00698

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP00698
KOiK13915
OMAiKWESNYN
OrthoDBiEOG091G0R9V
PhylomeDBiP00698
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00698-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSLLILVLC FLPLAALGKV FGRCELAAAM KRHGLDNYRG YSLGNWVCAA
60 70 80 90 100
KFESNFNTQA TNRNTDGSTD YGILQINSRW WCNDGRTPGS RNLCNIPCSA
110 120 130 140
LLSSDITASV NCAKKIVSDG NGMNAWVAWR NRCKGTDVQA WIRGCRL
Length:147
Mass (Da):16,239
Last modified:July 21, 1986 - v1
Checksum:i81E85743FF579468
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → V in CAA23711 (PubMed:6934509).Curated1
Sequence conflicti121N → D AA sequence (PubMed:14063294).Curated1
Sequence conflicti124N → S in CAA23711 (PubMed:6934509).Curated1
Sequence conflicti132R → S in AAA48944 (PubMed:383714).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00885 Genomic DNA Translation: AAA48943.1
V00428 mRNA Translation: CAA23711.1
AF410481 Genomic DNA Translation: AAL69327.1
M10640 mRNA Translation: AAA48944.1
PIRiA93859 LZCH
RefSeqiNP_990612.1, NM_205281.1
UniGeneiGga.713

Genome annotation databases

EnsembliENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963
GeneIDi396218
KEGGigga:396218

Similar proteinsi

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00885 Genomic DNA Translation: AAA48943.1
V00428 mRNA Translation: CAA23711.1
AF410481 Genomic DNA Translation: AAL69327.1
M10640 mRNA Translation: AAA48944.1
PIRiA93859 LZCH
RefSeqiNP_990612.1, NM_205281.1
UniGeneiGga.713

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
132LX-ray1.80A19-147[»]
193LX-ray1.33A19-147[»]
194LX-ray1.40A19-147[»]
1A2YX-ray1.50C19-147[»]
1AKIX-ray1.50A19-147[»]
1AT5X-ray1.80A19-147[»]
1AT6X-ray1.80A19-147[»]
1AZFX-ray1.80A19-147[»]
1B0DX-ray1.84A19-147[»]
1B2KX-ray1.60A/B19-147[»]
1BGIX-ray1.70A19-147[»]
1BHZX-ray3.90A19-147[»]
1BVKX-ray2.70C/F19-147[»]
1BVXX-ray1.80A19-147[»]
1BWHX-ray1.80A19-147[»]
1BWIX-ray1.80A19-147[»]
1BWJX-ray1.80A19-147[»]
1C08X-ray2.30C19-147[»]
1C10X-ray2.03A19-147[»]
1DPWX-ray1.64A19-147[»]
1DPXX-ray1.65A19-147[»]
1DQJX-ray2.00C19-147[»]
1E8LNMR-A19-147[»]
1F0WX-ray1.90A19-147[»]
1F10X-ray1.70A19-147[»]
1F3JX-ray3.10P/Q29-42[»]
1FDLX-ray2.50Y19-147[»]
1FLQX-ray1.80A19-147[»]
1FLUX-ray1.78A19-147[»]
1FLWX-ray1.81A19-147[»]
1FLYX-ray1.83A19-147[»]
1FN5X-ray1.78A19-147[»]
1G7HX-ray1.85C19-147[»]
1G7IX-ray1.80C19-147[»]
1G7JX-ray1.75C19-147[»]
1G7LX-ray2.00C19-147[»]
1G7MX-ray1.90C19-147[»]
1GPQX-ray1.60C/D19-147[»]
1GWDX-ray1.77A19-147[»]
1GXVNMR-219-147[»]
1GXXNMR-A19-147[»]
1H6MX-ray1.64A19-147[»]
1H87X-ray1.72A19-147[»]
1HC0X-ray1.82A19-147[»]
1HELX-ray1.70A19-147[»]
1HEMX-ray1.80A19-147[»]
1HENX-ray1.80A19-147[»]
1HEOX-ray1.80A19-147[»]
1HEPX-ray1.80A19-147[»]
1HEQX-ray1.80A19-147[»]
1HERX-ray1.80A19-147[»]
1HEWX-ray1.75A19-147[»]
1HF4X-ray1.45A/B19-147[»]
1HSWX-ray2.00A19-147[»]
1HSXX-ray1.90A19-147[»]
1IC4X-ray2.50Y19-147[»]
1IC5X-ray2.30Y19-147[»]
1IC7X-ray2.10Y19-147[»]
1IEEX-ray0.94A19-147[»]
1IO5neutron diffraction2.00A19-147[»]
1IOQX-ray1.79A19-147[»]
1IORX-ray1.76A19-147[»]
1IOSX-ray1.76A19-147[»]
1IOTX-ray1.75A19-147[»]
1IR7X-ray1.90A19-147[»]
1IR8X-ray1.63A19-147[»]
1IR9X-ray1.90A19-147[»]
1J1OX-ray1.80Y19-147[»]
1J1PX-ray1.80Y19-147[»]
1J1XX-ray1.80Y19-147[»]
1JA2X-ray2.87A19-147[»]
1JA4X-ray2.94A19-147[»]
1JA6X-ray2.96A19-147[»]
1JA7X-ray2.98A19-147[»]
1JISX-ray1.90A19-147[»]
1JITX-ray1.90A19-147[»]
1JIYX-ray1.90A19-147[»]
1JJ0X-ray1.90A19-147[»]
1JJ1X-ray1.90A19-147[»]
1JJ3X-ray1.90A/B19-147[»]
1JPOX-ray2.10A19-147[»]
1JTOX-ray2.50L/M19-147[»]
1JTTX-ray2.10L19-147[»]
1KIPX-ray2.10C19-147[»]
1KIQX-ray1.85C19-147[»]
1KIRX-ray2.00C19-147[»]
1KXWX-ray1.96A19-147[»]
1KXXX-ray1.71A19-147[»]
1KXYX-ray1.79A19-147[»]
1LCNX-ray1.63A/B19-147[»]
1LJ3X-ray2.00A/B19-147[»]
1LJ4X-ray1.95A/B19-147[»]
1LJEX-ray2.00A/B19-147[»]
1LJFX-ray1.80A/B19-147[»]
1LJGX-ray1.90A/B19-147[»]
1LJHX-ray1.80A/B19-147[»]
1LJIX-ray2.00A/B19-147[»]
1LJJX-ray2.00A/B19-147[»]
1LJKX-ray2.10A/B19-147[»]
1LKRX-ray1.60A/B19-147[»]
1LKSX-ray1.10A19-147[»]
1LMAX-ray1.75A19-147[»]
1LPIX-ray2.00A19-147[»]
1LSAX-ray1.70A19-147[»]
1LSBX-ray1.70A19-147[»]
1LSCX-ray1.70A19-147[»]
1LSDX-ray1.70A19-147[»]
1LSEX-ray1.70A19-147[»]
1LSFX-ray1.70A19-147[»]
1LSGX-ray2.40A19-147[»]
1LSMX-ray1.70A19-147[»]
1LSNX-ray1.90A19-147[»]
1LSYX-ray1.90A1-147[»]
1LSZX-ray2.00A1-147[»]
1LYOX-ray1.93A19-147[»]
1LYSX-ray1.72A/B19-147[»]
1LYZX-ray2.00A19-147[»]
1LZ8X-ray1.53A19-147[»]
1LZ9X-ray1.70A19-147[»]
1LZAX-ray1.60A19-147[»]
1LZBX-ray1.50A19-147[»]
1LZCX-ray1.80A19-147[»]
1LZDX-ray1.80A19-147[»]
1LZEX-ray1.80A19-147[»]
1LZGX-ray1.80A19-147[»]
1LZHX-ray6.00A/B19-147[»]
1LZNneutron diffraction1.70A19-147[»]
1LZTX-ray1.97A19-147[»]
1MELX-ray2.50L/M19-147[»]
1MLCX-ray2.50E/F19-147[»]
1N4FX-ray1.78A19-147[»]
1NBYX-ray1.80C19-147[»]
1NBZX-ray1.85C19-147[»]
1NDGX-ray1.90C19-147[»]
1NDMX-ray2.10C19-147[»]
1P2CX-ray2.00C/F19-147[»]
1PS5X-ray2.00A19-147[»]
1QIOX-ray1.20A19-147[»]
1QTKX-ray2.03A19-147[»]
1RCMX-ray1.90A/B19-147[»]
1RFPX-ray1.75A19-147[»]
1RI8X-ray1.85B19-147[»]
1RJCX-ray1.40B19-147[»]
1SF4X-ray2.98A19-147[»]
1SF6X-ray3.22A19-147[»]
1SF7X-ray3.22A19-147[»]
1SFBX-ray3.22A19-147[»]
1SFGX-ray3.22A19-147[»]
1SQ2X-ray1.45L19-147[»]
1T3PX-ray1.60A19-147[»]
1T6VX-ray1.70L/M19-147[»]
1UA6X-ray1.90Y19-147[»]
1UC0X-ray1.85A19-147[»]
1UCOX-ray2.00A/B19-147[»]
1UIAX-ray1.76A19-147[»]
1UIBX-ray1.76A19-147[»]
1UICX-ray1.95A19-147[»]
1UIDX-ray1.95A19-147[»]
1UIEX-ray1.95A19-147[»]
1UIFX-ray1.85A19-147[»]
1UIGX-ray1.95A19-147[»]
1UIHX-ray1.75A19-147[»]
1UUZX-ray1.80C/D19-147[»]
1V7SX-ray1.14A19-147[»]
1V7TX-ray1.13A/B19-147[»]
1VATX-ray1.60A19-147[»]
1VAUX-ray1.50A19-147[»]
1VDPX-ray1.70A/B19-147[»]
1VDQX-ray1.50A19-147[»]
1VDSX-ray1.60A19-147[»]
1VDTX-ray1.70A19-147[»]
1VEDX-ray1.90A19-147[»]
1VFBX-ray1.80C19-147[»]
1W6ZX-ray1.65A19-147[»]
1WTMX-ray1.33A19-147[»]
1WTNX-ray1.13A19-147[»]
1XEIX-ray2.10A19-147[»]
1XEJX-ray2.10A19-147[»]
1XEKX-ray2.30A19-147[»]
1XFPX-ray1.50L19-147[»]
1XGPX-ray2.10C19-147[»]
1XGQX-ray2.10C19-147[»]
1XGRX-ray2.10C19-147[»]
1XGTX-ray2.10C19-147[»]
1XGUX-ray2.10C19-147[»]
1YIKX-ray1.75A19-147[»]
1YILX-ray1.60A19-147[»]
1YKXX-ray1.90X19-147[»]
1YKYX-ray1.90X19-147[»]
1YKZX-ray1.80X19-147[»]
1YL0X-ray1.90X19-147[»]
1YL1X-ray1.90X19-147[»]
1YQVX-ray1.70Y19-147[»]
1Z55X-ray1.90A19-147[»]
1ZMYX-ray3.00L/M19-147[»]
1ZV5X-ray2.00L19-147[»]
1ZVHX-ray1.50L19-147[»]
1ZVYX-ray1.63B19-147[»]
2A6UX-ray-A19-147[»]
2A7DX-ray1.66A19-147[»]
2A7FX-ray1.85A19-147[»]
2AUBX-ray1.70A19-147[»]
2B5ZX-ray1.60A19-147[»]
2BLXX-ray1.40A19-147[»]
2BLYX-ray1.40A19-147[»]
2BPUX-ray1.35A19-147[»]
2C8OX-ray1.50A19-147[»]
2C8PX-ray1.50A19-147[»]
2CDSX-ray2.00A19-147[»]
2CGIX-ray1.35A19-147[»]
2D4IX-ray1.16A/B19-147[»]
2D4JX-ray1.16A19-147[»]
2D4KX-ray1.15A/N19-147[»]
2D6BX-ray1.25A19-147[»]
2D91X-ray2.10A19-147[»]
2DQCX-ray1.80Y19-147[»]
2DQDX-ray1.80Y19-147[»]
2DQEX-ray1.90Y19-147[»]
2DQFX-ray2.50C/F19-147[»]
2DQGX-ray2.30Y19-147[»]
2DQHX-ray2.30Y19-147[»]
2DQIX-ray2.00Y19-147[»]
2DQJX-ray1.80Y19-147[»]
2EIZX-ray1.90C19-147[»]
2EKSX-ray2.00C19-147[»]
2EPEX-ray2.50A19-147[»]
2F2NX-ray1.60A19-147[»]
2F30X-ray1.65A19-147[»]
2F4AX-ray1.95A19-147[»]
2F4GX-ray1.65A19-147[»]
2FBBX-ray1.46A19-147[»]
2G4PX-ray1.84A19-147[»]
2G4QX-ray1.84A19-147[»]
2H9JX-ray1.75A19-147[»]
2H9KX-ray1.75A19-147[»]
2HFMmodel-Y19-147[»]
2HS7X-ray-A19-147[»]
2HS9X-ray-A19-147[»]
2HSOX-ray-A19-147[»]
2HTXX-ray1.56A19-147[»]
2HU1X-ray1.63A19-147[»]
2HU3X-ray1.30A19-147[»]
2HUBX-ray1.20A19-147[»]
2I25X-ray1.80L/M19-147[»]
2I26X-ray2.50L/M/Q19-147[»]
2I6ZX-ray1.90A19-147[»]
2IFFX-ray2.65Y19-147[»]
2LYMX-ray2.00A19-147[»]
2LYOX-ray1.93A19-147[»]
2LYZX-ray2.00A19-147[»]
2LZHX-ray6.00A19-147[»]
2LZTX-ray1.97A19-147[»]
2PC2X-ray1.54A19-147[»]
2Q0MX-ray1.70X19-147[»]
2VB1X-ray0.65A19-147[»]
2W1LX-ray1.51A19-147[»]
2W1MX-ray1.78A19-147[»]
2W1XX-ray1.70A19-147[»]
2W1YX-ray1.73A19-147[»]
2WARX-ray1.80A19-147[»]
2X0AX-ray1.52A19-147[»]
2XBRX-ray1.29A19-147[»]
2XBSX-ray1.37A19-147[»]
2XJWX-ray1.67A19-147[»]
2XTHX-ray1.80A19-147[»]
2YBHX-ray2.00A19-147[»]
2YBIX-ray2.00A19-147[»]
2YBJX-ray2.00A19-147[»]
2YBLX-ray2.00A19-147[»]
2YBMX-ray2.00A19-147[»]
2YBNX-ray2.00A19-147[»]
2YDGX-ray2.00A19-147[»]
2YSSX-ray2.40C19-147[»]
2YVBX-ray1.62A19-147[»]
2Z12X-ray1.15A19-147[»]
2Z18X-ray1.15A19-147[»]
2Z19X-ray1.15A19-147[»]
2ZNWX-ray2.71Y/Z19-147[»]
2ZNXX-ray2.30Y/Z19-147[»]
2ZQ3X-ray1.60A19-147[»]
2ZQ4X-ray2.00A19-147[»]
2ZYPX-ray1.18A19-147[»]
3A34X-ray1.65A19-147[»]
3A3QX-ray2.00A19-147[»]
3A3RX-ray1.90X19-147[»]
3A67X-ray1.80Y19-147[»]
3A6BX-ray1.80Y19-147[»]
3A6CX-ray1.80Y19-147[»]
3A8ZX-ray1.40A19-147[»]
3A90X-ray1.45A19-147[»]
3A91X-ray1.55A19-147[»]
3A92X-ray1.50A19-147[»]
3A93X-ray1.55A19-147[»]
3A94X-ray1.55A19-147[»]
3A95X-ray1.50A19-147[»]
3A96X-ray1.75A19-147[»]
3AGGX-ray1.60G19-147[»]
3AGHX-ray1.49A19-147[»]
3AGIX-ray1.20A19-147[»]
3AJNX-ray1.05A19-147[»]
3ATNX-ray1.17A19-147[»]
3ATOX-ray1.17A19-147[»]
3AW6X-ray2.10A19-147[»]
3AW7X-ray2.10A19-147[»]
3AZ4X-ray1.62A19-147[»]
3AZ5X-ray2.34A19-147[»]
3AZ6X-ray1.50A19-147[»]
3AZ7X-ray2.10A19-147[»]
3B6LX-ray2.30A1-147[»]
3B72X-ray1.50A1-147[»]
3D9AX-ray1.20C19-147[»]
3E3DX-ray1.55A19-147[»]
3EMSX-ray1.65A19-147[»]
3EXDX-ray1.49A19-147[»]
3F6ZX-ray2.50A/C19-147[»]
3G3AX-ray2.20B/D/F/H19-147[»]
3G3BX-ray2.40B/D/F/H19-147[»]
3HFMX-ray3.00Y19-147[»]
3IJUX-ray1.60A19-147[»]
3IJVX-ray1.70A19-147[»]
3J4Gelectron microscopy2.90A19-147[»]
3J6Kelectron microscopy2.50A19-147[»]
3KAMX-ray1.59A19-147[»]
3LYMX-ray2.00A19-147[»]
3LYOX-ray1.93A19-147[»]
3LYTX-ray1.90A/B19-147[»]
3LYZX-ray2.00A19-147[»]
3LZTX-ray0.93A19-147[»]
3M18X-ray1.95B19-147[»]
3M3UX-ray2.35A19-147[»]
3MBEX-ray2.89P/Q29-45[»]
3N9AX-ray1.40A19-147[»]
3N9CX-ray1.50A19-147[»]
3N9EX-ray1.38A19-147[»]
3OJPX-ray1.81A19-147[»]
3OK0X-ray1.82A19-147[»]
3OTPX-ray3.76G/H/I/J/K/L36-76[»]
3P4ZX-ray1.60A19-147[»]
3P64X-ray1.30A19-147[»]
3P65X-ray2.10A19-147[»]
3P66X-ray1.36A19-147[»]
3P68X-ray1.60A19-147[»]
3QE8X-ray1.49A/B19-147[»]
3QNGX-ray1.55A19-147[»]
3QY4X-ray1.65A19-146[»]
3RNXX-ray1.86A19-147[»]
3RT5X-ray1.75X19-147[»]
3RU5X-ray1.35A19-147[»]
3RW8X-ray1.86A19-147[»]
3RZ4X-ray1.80A19-147[»]
3SP3X-ray1.80A19-147[»]
3T6UX-ray2.21A19-147[»]
3TMUX-ray1.90A1-147[»]
3TMVX-ray1.90A1-147[»]
3TMWX-ray1.90A1-147[»]
3TMXX-ray1.90A1-147[»]
3TXBX-ray1.59A19-147[»]
3TXDX-ray1.53A19-147[»]
3TXEX-ray1.70A19-147[»]
3TXFX-ray1.69A19-147[»]
3TXGX-ray1.70A19-147[»]
3TXHX-ray1.69A19-147[»]
3TXIX-ray1.60A19-147[»]
3TXJX-ray2.48A19-147[»]
3TXKX-ray3.00A19-147[»]
3ULRX-ray1.65A19-147[»]
3W6AX-ray1.77A19-147[»]
3WL2X-ray0.96A/B19-147[»]
3WMKX-ray1.46A19-147[»]
3WPJX-ray2.00A19-147[»]
3WPKX-ray2.00A19-147[»]
3WPLX-ray2.00A19-147[»]
3WU7X-ray2.00A19-147[»]
3WU8X-ray2.00A19-147[»]
3WU9X-ray2.00A19-147[»]
3WUAX-ray2.00A19-147[»]
3WULX-ray2.00A19-147[»]
3WUMX-ray2.00A19-147[»]
3WUNX-ray2.40A19-147[»]
3WVXX-ray1.58A19-147[»]
3WVYX-ray1.56A19-147[»]
3WW5X-ray1.53A19-147[»]
3WW6X-ray1.53A19-147[»]
3WXTX-ray2.00A19-147[»]
3WXUX-ray2.00A19-147[»]
3ZEKX-ray1.43A19-147[»]
3ZVQX-ray2.00A19-88[»]
B90-147[»]
4A7DX-ray1.50A19-147[»]
4A8Aelectron microscopy14.20M19-147[»]
4A8Belectron microscopy13.00M/N/O/P/Q/R19-147[»]
4AGAX-ray1.50A19-147[»]
4AXTX-ray1.10A19-147[»]
4B0DX-ray1.10A19-147[»]
4B1AX-ray1.67A19-147[»]
4B49X-ray1.15A19-147[»]
4B4EX-ray1.00A19-147[»]
4B4IX-ray1.20A19-147[»]
4B4JX-ray1.25A19-147[»]
4BADX-ray1.35A19-147[»]
4BAFX-ray1.51A19-147[»]
4BAPX-ray1.21A19-147[»]
4BS7X-ray1.70A19-147[»]
4C3WX-ray1.28A19-147[»]
4CJ2X-ray1.50A/B1-147[»]
4D9ZX-ray1.71A19-147[»]
4DC4X-ray2.65A/B/C19-147[»]
4DD0X-ray1.70A19-147[»]
4DD1X-ray1.70A/B19-147[»]
4DD2X-ray1.55A19-147[»]
4DD3X-ray1.70A19-147[»]
4DD7X-ray1.60A19-147[»]
4DD9X-ray1.60A19-147[»]
4DDAX-ray2.48A19-147[»]
4DDBX-ray3.00A19-147[»]
4DDCX-ray1.80A/B19-147[»]
4DT3X-ray1.80A19-147[»]
4E3UX-ray1.50A19-147[»]
4EOFX-ray1.83A19-147[»]
4ET8X-ray1.90A19-147[»]
4ET9X-ray1.90A19-147[»]
4ETAX-ray1.91A19-147[»]
4ETBX-ray1.91A19-147[»]
4ETCX-ray1.91A19-147[»]
4ETDX-ray1.90A19-147[»]
4ETEX-ray1.90A19-147[»]
4FJRX-ray1.86A19-147[»]
4G49X-ray2.40A19-147[»]
4G4BX-ray2.10A19-147[»]
4G4CX-ray2.00A19-147[»]
4G4HX-ray2.00A19-147[»]
4GCBX-ray1.80A19-147[»]
4GCCX-ray2.00A19-147[»]
4GCDX-ray2.80A19-147[»]
4GCEX-ray2.90A19-147[»]
4GCFX-ray3.50A19-147[»]
4GLAX-ray2.75A/B19-147[»]
4GLVX-ray2.57A/C/E/G19-147[»]
4GN3X-ray1.95A/C/E/G/I/K/M/O/Q19-147[»]
4GN4X-ray1.86A19-147[»]
4GN5X-ray1.86C/D19-147[»]
4H1PX-ray2.30A19-147[»]
4H8XX-ray1.20A19-147[»]
4H8YX-ray1.20A19-147[»]
4H8ZX-ray1.20A19-147[»]
4H90X-ray1.20A19-147[»]
4H91X-ray1.20A19-147[»]
4H92X-ray1.20A19-147[»]
4H93X-ray1.20A19-147[»]
4H94X-ray1.20A19-147[»]
4H9AX-ray1.20A19-147[»]
4H9BX-ray1.20A19-147[»]
4H9CX-ray1.20A19-147[»]
4H9EX-ray1.20A19-147[»]
4H9FX-ray1.20A19-147[»]
4H9HX-ray1.20A19-147[»]
4H9IX-ray1.20A19-147[»]
4HP0X-ray1.19A19-147[»]
4HPIX-ray1.19A19-147[»]
4HSFX-ray1.82A19-147[»]
4HTKX-ray1.20A19-147[»]
4HTNX-ray1.30A19-147[»]
4HTQX-ray1.40A19-147[»]
4HV1X-ray2.30A19-147[»]
4HV2X-ray2.50A19-147[»]
4I8SX-ray2.00A19-147[»]
4IASX-ray2.60A19-147[»]
4IATX-ray2.00A19-147[»]
4II8X-ray1.88A19-147[»]
4J1AX-ray1.79A19-147[»]
4J1BX-ray1.66A19-147[»]
4J7VX-ray1.54A19-147[»]
4KXIX-ray2.00A19-147[»]
4LFPX-ray1.72A19-147[»]
4LFXX-ray2.10A19-147[»]
4LGKX-ray1.96A19-147[»]
4LT0X-ray2.10A19-147[»]
4LT1X-ray2.30A19-147[»]
4LT2X-ray2.00A19-147[»]
4LT3X-ray2.00A19-147[»]
4LYBX-ray1.21A19-147[»]
4LYCX-ray1.35A19-147[»]
4LYMX-ray2.10A19-147[»]
4LYOX-ray2.05A19-147[»]
4LYTX-ray1.90A/B19-147[»]
4LYZX-ray2.00A19-147[»]
4LZTX-ray0.95A19-147[»]
4M4OX-ray2.00A19-147[»]
4M6DX-ray2.68A/C/E/G/I/K19-147[»]
4MR1X-ray1.99A19-147[»]
4N0JX-ray1.90A/B20-147[»]
4N1CX-ray1.70C19-147[»]
4N1EX-ray2.23I/J/K/L19-147[»]
4N5RX-ray2.10A19-147[»]
4N8ZX-ray1.20A19-147[»]
4N9RX-ray1.55A19-147[»]
4NEBX-ray1.48A19-147[»]
4NFVX-ray1.63A19-147[»]
4NG1X-ray1.82A19-147[»]
4NG8X-ray1.09A19-147[»]
4NGIX-ray1.70A19-147[»]
4NGJX-ray1.10A19-147[»]
4NGKX-ray1.50A19-147[»]
4NGLX-ray1.52A19-147[»]
4NGOX-ray1.58A19-147[»]
4NGVX-ray1.64A19-147[»]
4NGWX-ray1.37A19-147[»]
4NGYX-ray1.35A19-147[»]
4NGZX-ray1.70A19-147[»]
4NHIX-ray1.34A19-147[»]
4NHPX-ray1.42A19-147[»]
4NHQX-ray1.92A19-147[»]
4NHSX-ray1.99A19-147[»]
4NHTX-ray1.65A19-147[»]
4NIJX-ray1.86A19-147[»]
4NSGX-ray2.00A19-147[»]
4NSHX-ray2.10A19-147[»]
4NSIX-ray2.30A19-147[»]
4NSJX-ray1.70A19-147[»]
4NWEX-ray1.58A19-147[»]
4NWHX-ray1.65A19-147[»]
4NY5X-ray1.85A19-147[»]
4O34X-ray2.09A19-147[»]
4OOOX-ray2.15A19-147[»]
4OOTX-ray1.80A19-147[»]
4OWAX-ray1.80A/B19-147[»]
4OWBX-ray1.69A19-147[»]
4OWCX-ray1.62A19-147[»]
4OWEX-ray1.41A19-147[»]
4OWHX-ray1.48A19-147[»]
4P2EX-ray1.60A19-147[»]
4PGJX-ray2.60B/D19-147[»]
4PHIX-ray1.81A/B/C/D19-147[»]
4PPOX-ray1.73A19-147[»]
4PRQX-ray1.72A/B/C/D19-147[»]
4PRUX-ray2.20A/B19-147[»]
4QEQX-ray1.38A19-147[»]
4QGZX-ray2.51A19-147[»]
4QY9X-ray2.05A19-147[»]
4R0FX-ray1.94A/B19-147[»]
4R6CX-ray1.70A19-147[»]
4RDSX-ray1.23A19-147[»]
4RLMX-ray1.90A19-147[»]
4RLNX-ray2.17A19-147[»]
4RW1X-ray1.90A19-147[»]
4RW2X-ray2.30A19-147[»]
4TSAX-ray2.27A19-147[»]
4TSBX-ray1.95A19-147[»]
4TSCX-ray1.92A19-147[»]
4TTDX-ray2.15A/B19-147[»]
4TUNX-ray1.92A/B19-147[»]
4TWSX-ray1.45A19-147[»]
4U3XX-ray2.26B/D19-147[»]
4UWNX-ray1.67A19-147[»]
4UWUX-ray1.78A19-147[»]
4UWVX-ray1.77A19-147[»]
4W94X-ray1.55A19-147[»]
4W96X-ray1.50A19-147[»]
4WG1X-ray1.70A1-147[»]
4WG7X-ray1.70A1-147[»]
4WL6X-ray1.85A1-147[»]
4WL7X-ray1.95A1-147[»]
4WLDX-ray1.54A19-147[»]
4WLTX-ray1.60A19-147[»]
4WLXX-ray1.60A19-147[»]
4WLYX-ray1.62A19-147[»]
4WM1X-ray1.60A19-147[»]
4WM2X-ray1.60A19-147[»]
4WM3X-ray1.55A19-147[»]
4WM4X-ray1.60A19-147[»]
4WM5X-ray1.60A19-147[»]
4WM6X-ray1.85A/B/C/D19-147[»]
4WMGX-ray2.50A19-147[»]
4WO6X-ray2.00A19-147[»]
4WO9X-ray1.99A19-147[»]
4WOAX-ray1.80A19-147[»]
4X3BX-ray2.10A19-147[»]
4XADX-ray1.25A19-147[»]
4XENX-ray1.55A19-147[»]
4XJBX-ray1.80A19-147[»]
4XJDX-ray1.80A19-147[»]
4XJFX-ray1.80A19-147[»]
4XJGX-ray1.80A19-147[»]
4XJHX-ray2.00A19-147[»]
4XJIX-ray2.00A19-147[»]
4XN6X-ray1.35A19-147[»]
4XYYX-ray1.38A19-147[»]
4YEMX-ray1.47A19-147[»]
4YENX-ray2.00A19-147[»]
4YEOX-ray0.98A19-146[»]
4YM8X-ray2.10A19-147[»]
4YOPX-ray2.10A19-147[»]
4Z3MX-ray2.15A19-147[»]
4Z41X-ray1.89A19-147[»]
4Z46X-ray1.85A19-147[»]
4Z98X-ray1.55A19-147[»]
4ZEEX-ray1.95A19-147[»]
4ZFPX-ray1.96A19-147[»]
4ZIXX-ray1.89A19-147[»]
5A3Eelectron microscopy2.50A19-147[»]
5A3ZX-ray1.59A/B1-147[»]
5AMYX-ray1.80A19-147[»]
5APCX-ray1.70A19-147[»]
5APDX-ray1.70A19-147[»]
5APEX-ray1.70A19-147[»]
5APFX-ray1.70A19-147[»]
5B05X-ray1.80A19-147[»]
5B06X-ray1.80A19-147[»]
5B07X-ray1.80A19-147[»]
5B1FX-ray2.30A19-147[»]
5B1GX-ray2.30A19-147[»]
5B59X-ray2.00A19-147[»]
5B5JX-ray1.26A19-147[»]
5C6IX-ray1.90A19-147[»]
5C6JX-ray2.10A19-147[»]
5C6LX-ray2.10A19-147[»]
5D5CX-ray1.70A19-147[»]
5D5FX-ray1.50A19-147[»]
5DL9X-ray1.38A19-147[»]
5DLAX-ray1.22A19-147[»]
5DM9X-ray2.30A19-147[»]
5E4PX-ray1.79A19-147[»]
5E9RX-ray2.25A19-147[»]
5EBHX-ray1.20A19-147[»]
5F14X-ray1.15A19-147[»]
5F16X-ray1.20A19-147[»]
5F81X-ray2.13A19-147[»]
5F9UX-ray1.85A19-147[»]
5F9XX-ray1.94A19-147[»]
5FCPX-ray1.55A19-147[»]
5FDJX-ray1.80A19-147[»]
5FEKX-ray1.80A19-147[»]
5FELX-ray1.80A19-147[»]
5FHWX-ray1.52A19-147[»]
5FSTX-ray1.20A19-147[»]
5GWBX-ray2.00A19-147[»]
5H6AX-ray1.75A19-147[»]
5H6CX-ray1.75A19-147[»]
5H6DX-ray1.75A19-147[»]
5H6EX-ray1.75A19-147[»]
5HLLX-ray1.70A19-147[»]
5HMJX-ray1.30A19-147[»]
5HMVX-ray0.98A19-146[»]
5HNCX-ray1.76A19-147[»]
5HNLX-ray2.42A19-147[»]
5HQ1X-ray1.00A19-146[»]
5I4WX-ray1.60A19-147[»]
5I4XX-ray1.61A19-147[»]
5I4YX-ray1.61A19-147[»]
5I53X-ray1.61A19-147[»]
5I54X-ray1.61A19-147[»]
5I5QX-ray1.42A19-147[»]
5IDDX-ray1.13A19-147[»]
5IELX-ray1.15A19-147[»]
5IHGX-ray1.75A19-147[»]
5II3X-ray1.78A19-147[»]
5ILCX-ray1.75A19-147[»]
5ILFX-ray1.85A19-147[»]
5J7CX-ray2.54A/B19-147[»]
5JENX-ray2.30B/D19-147[»]
5K2KX-ray1.65A19-147[»]
5K2NX-ray1.40A19-147[»]
5K2PX-ray1.24A19-147[»]
5K2QX-ray1.10A19-147[»]
5K2RX-ray1.60A19-147[»]
5K2SX-ray1.55A19-147[»]
5K7Oelectron microscopy1.80A19-147[»]
5KJ9X-ray1.20A19-147[»]
5KKIX-ray1.70A19-147[»]
5KKJX-ray2.00A19-147[»]
5KXKX-ray1.20A19-147[»]
5KXLX-ray1.20A19-147[»]
5KXMX-ray1.20A19-147[»]
5KXNX-ray1.20A19-147[»]
5KXOX-ray1.20A19-147[»]
5KXPX-ray1.20A19-147[»]
5KXRX-ray1.20A19-147[»]
5KXSX-ray1.20A19-147[»]
5KXTX-ray1.20A19-147[»]
5KXWX-ray1.20A19-147[»]
5KXXX-ray1.20A19-147[»]
5KXYX-ray1.20A19-147[»]
5KXZX-ray1.20A19-147[»]
5KY1X-ray1.20A19-147[»]
5L3HX-ray1.70A19-147[»]
5L3IX-ray1.70A19-147[»]
5L9JX-ray1.50A19-147[»]
5LA5X-ray1.70A19-147[»]
5LA8X-ray2.00A19-147[»]
5LAFX-ray1.50A19-147[»]
5LAGX-ray1.60A19-147[»]
5LANX-ray1.65A19-147[»]
5LINX-ray1.50A19-147[»]
5LIOX-ray1.50A19-147[»]
5LVGX-ray2.00A19-147[»]
5LVHX-ray1.55A19-147[»]
5LVIX-ray1.70A19-147[»]
5LVJX-ray1.60A19-147[»]
5LXWX-ray1.00A19-147[»]
5LYMX-ray1.80A/B19-147[»]
5LYTX-ray1.90A19-147[»]
5LYZX-ray2.00A19-147[»]
5M1YX-ray1.90A/B19-147[»]
5MJJX-ray1.75A19-147[»]
5MYYX-ray1.10A19-147[»]
5NBJX-ray1.27A19-147[»]
5NE0X-ray1.57A19-147[»]
5NJ1X-ray1.85A19-147[»]
5NJMX-ray1.50A19-147[»]
5NJPX-ray1.70A19-147[»]
5NJQX-ray1.70A19-147[»]
5NJRX-ray1.70A19-147[»]
5NJSX-ray1.70A19-147[»]
5O4Welectron microscopy2.11A/B19-147[»]
5O4Xelectron microscopy2.11A/B19-147[»]
5O6QX-ray1.45A19-147[»]
5OB6X-ray1.88A19-147[»]
5OB7X-ray2.10A19-147[»]
5OB8X-ray1.85A19-147[»]
5OB9X-ray2.38A19-147[»]
5OCVelectron microscopy2.20A/B19-147[»]
5OERX-ray1.90A19-147[»]
5OLEX-ray1.78A19-147[»]
5OOVX-ray1.36B19-147[»]
5OOYX-ray1.72B/F19-147[»]
5OP1X-ray2.28B19-147[»]
5T3FX-ray1.45A19-147[»]
5TK0X-ray1.79A19-146[»]
5UVJX-ray2.05A19-147[»]
5V4GX-ray1.20A19-147[»]
5V4HX-ray1.22A19-147[»]
5V4IX-ray1.50A19-147[»]
5WR9X-ray1.80A19-147[»]
5WRAX-ray1.45A19-147[»]
5WRBX-ray2.01A19-147[»]
5YINX-ray1.66A19-147[»]
5YKYX-ray1.88A19-147[»]
6APMX-ray2.05A19-147[»]
6B7UX-ray1.58A19-147[»]
6B7VX-ray1.48A19-147[»]
6B7WX-ray1.48A19-147[»]
6BO1X-ray1.24A19-147[»]
6BO2X-ray1.48A19-147[»]
6BREX-ray1.86A19-147[»]
6D6EX-ray2.00A19-147[»]
6D6FX-ray2.00A19-147[»]
6D6GX-ray2.00A19-147[»]
6D6HX-ray2.00A19-147[»]
6F1LX-ray1.30A19-145[»]
6F1MX-ray1.48A19-147[»]
6F1OX-ray0.96A19-147[»]
6F1PX-ray1.12A19-147[»]
6F1RX-ray1.10A19-147[»]
6F9XX-ray1.25A19-145[»]
6F9YX-ray1.20A19-145[»]
6F9ZX-ray1.20A19-145[»]
6FA0X-ray1.30A19-145[»]
6FSJX-ray1.20A19-147[»]
6G5VX-ray1.96A19-147[»]
6G5YX-ray1.49A19-147[»]
6G8AX-ray1.14C19-147[»]
6GOBX-ray1.96A19-147[»]
6GOHX-ray2.43A19-147[»]
6GOIX-ray1.99A19-147[»]
6GOJX-ray2.25A19-147[»]
6H0KX-ray2.20A19-147[»]
6H0LX-ray1.90A19-147[»]
6H3Belectron microscopy1.90A19-147[»]
6LYTX-ray1.90A19-147[»]
6LYZX-ray2.00A19-147[»]
7LYZX-ray2.50A19-147[»]
8LYZX-ray2.50A19-147[»]
9LYZX-ray2.50A19-147[»]
ProteinModelPortaliP00698
SMRiP00698
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676478, 1 interactor
DIPiDIP-46258N
IntActiP00698, 6 interactors
MINTiP00698
STRINGi9031.ENSGALP00000016177

Chemistry databases

ChEMBLiCHEMBL1932892

Protein family/group databases

Allergomei3294 Gal d 4.0101
362 Gal d 4
CAZyiGH22 Glycoside Hydrolase Family 22

PTM databases

CarbonylDBiP00698
iPTMnetiP00698

Proteomic databases

PaxDbiP00698
PRIDEiP00698

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963
GeneIDi396218
KEGGigga:396218

Organism-specific databases

CTDi4069

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP00698
KOiK13915
OMAiKWESNYN
OrthoDBiEOG091G0R9V
PhylomeDBiP00698
TreeFamiTF324882

Enzyme and pathway databases

BRENDAi3.2.1.17 1306
ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-6803157 Antimicrobial peptides
SABIO-RKiP00698

Miscellaneous databases

EvolutionaryTraceiP00698
PROiPR:P00698

Gene expression databases

BgeeiENSGALG00000009963 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiP00698 baseline and differential

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYSC_CHICK
AccessioniPrimary (citable) accession number: P00698
Secondary accession number(s): Q90884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Allergens
    Nomenclature of allergens and list of entries
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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