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UniProtKB - P00697 (LYSC1_RAT)
Protein
Lysozyme C-1
Gene
Lyz1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function.
Miscellaneous
Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Rat has two lysozymes, type 1 and type 2 of which only type 1 is expressed; type 2 being probably a pseudogene.
Catalytic activityi
- Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. EC:3.2.1.17
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 53 | PROSITE-ProRule annotation | 1 | |
Active sitei | 71 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- hydrolase activity, acting on glycosyl bonds Source: RGD
- identical protein binding Source: RGD
- lysozyme activity Source: RGD
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: RGD
- defense response to Gram-negative bacterium Source: RGD
- defense response to Gram-positive bacterium Source: RGD
- killing of cells of another organism Source: RGD
- metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase, Milk protein |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation R-RNO-6803157, Antimicrobial peptides |
Protein family/group databases
CAZyi | GH22, Glycoside Hydrolase Family 22 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Lyz1 Synonyms:Lyz |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3026, Lyz |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: RGD
- rough endoplasmic reticulum lumen Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Golgi apparatus
- Golgi cis cisterna Source: RGD
- Golgi stack Source: RGD
Other locations
- cytoplasm Source: RGD
- microvillus Source: RGD
- secretory granule Source: RGD
- trans-Golgi network transport vesicle Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000018484 | 19 – 148 | Lysozyme C-1Add BLAST | 130 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 146 | PROSITE-ProRule annotation | ||
Disulfide bondi | 48 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 83 ↔ 99 | PROSITE-ProRule annotation | ||
Disulfide bondi | 95 ↔ 113 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P00697 |
PTM databases
iPTMneti | P00697 |
PhosphoSitePlusi | P00697 |
Expressioni
Tissue specificityi
Expressed in lung, small intestine and spleen.
Interactioni
Subunit structurei
Monomer.
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007747 |
Chemistry databases
BindingDBi | P00697 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 148 | C-type lysozymePROSITE-ProRule annotationAdd BLAST | 130 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1S1, Eukaryota |
InParanoidi | P00697 |
PhylomeDBi | P00697 |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000974, Glyco_hydro_22_lys IPR023346, Lysozyme-like_dom_sf IPR030056, Lysozyme_C |
PANTHERi | PTHR11407, PTHR11407, 1 hit PTHR11407:SF28, PTHR11407:SF28, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00137, LYSOZYME PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P00697-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKALLVLGFL LLSASVQAKI YERCQFARTL KRNGMSGYYG VSLADWVCLA
60 70 80 90 100
QHESNYNTQA RNYNPGDQST DYGIFQINSR YWCNDGKTPR AKNACGIPCS
110 120 130 140
ALLQDDITQA IQCAKRVVRD PQGIRAWVAW QRHCKNRDLS GYIRNCGV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1M8E9 | F1M8E9_RAT | Lysozyme | Lyz2 | 192 | Annotation score: | ||
A0A8I6A9R6 | A0A8I6A9R6_RAT | Putative lysozyme C-2 | Lyz2 | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | I → T AA sequence (PubMed:851497).Curated | 1 | |
Sequence conflicti | 64 | N → D AA sequence (PubMed:851497).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12459 Genomic DNA Translation: AAA41551.1 |
PIRi | A40729, LZRT |
Genome annotation databases
UCSCi | RGD:3026, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12459 Genomic DNA Translation: AAA41551.1 |
PIRi | A40729, LZRT |
3D structure databases
AlphaFoldDBi | P00697 |
SMRi | P00697 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007747 |
Chemistry databases
BindingDBi | P00697 |
ChEMBLi | CHEMBL2297 |
DrugCentrali | P00697 |
Protein family/group databases
CAZyi | GH22, Glycoside Hydrolase Family 22 |
PTM databases
iPTMneti | P00697 |
PhosphoSitePlusi | P00697 |
Proteomic databases
PaxDbi | P00697 |
Genome annotation databases
UCSCi | RGD:3026, rat |
Organism-specific databases
RGDi | 3026, Lyz |
Phylogenomic databases
eggNOGi | ENOG502S1S1, Eukaryota |
InParanoidi | P00697 |
PhylomeDBi | P00697 |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation R-RNO-6803157, Antimicrobial peptides |
Miscellaneous databases
PROi | PR:P00697 |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000974, Glyco_hydro_22_lys IPR023346, Lysozyme-like_dom_sf IPR030056, Lysozyme_C |
PANTHERi | PTHR11407, PTHR11407, 1 hit PTHR11407:SF28, PTHR11407:SF28, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00137, LYSOZYME PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LYSC1_RAT | |
Accessioni | P00697Primary (citable) accession number: P00697 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families