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Protein

Alkaline phosphatase

Gene

phoA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi73Magnesium1
Metal bindingi73Zinc 21
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei124Phosphoserine intermediate1
Metal bindingi175Magnesium1
Metal bindingi177Magnesium1
Metal bindingi344Magnesium1
Metal bindingi349Zinc 11
Metal bindingi353Zinc 11
Metal bindingi391Zinc 21
Metal bindingi392Zinc 21
Metal bindingi434Zinc 11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:ALKAPHOSPHA-MONOMER
MetaCyc:ALKAPHOSPHA-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.1 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00634

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alkaline phosphatase (EC:3.1.3.1)
Short name:
APase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:phoA
Ordered Locus Names:b0383, JW0374
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10727 phoA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4217

Drug and drug target database

More...
DrugBanki
DB03498 Mercaptomethyl Phosphonate
DB02823 Phosphonoacetic Acid
DB04522 Phosphonoserine
DB04031 Serine Vanadate

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002401222 – 471Alkaline phosphataseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 200
Disulfide bondi308 ↔ 358

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P00634

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00634

PRoteomics IDEntifications database

More...
PRIDEi
P00634

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isozymes 1 and 3 are a dimer of identical chains, isozyme 2 is a dimer of heterogeneous chains, one of each of the subunits from isozymes 1 and 3.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259827, 50 interactors

Database of interacting proteins

More...
DIPi
DIP-10496N

Protein interaction database and analysis system

More...
IntActi
P00634, 7 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_0340

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJAX-ray2.50A/B23-471[»]
1AJBX-ray2.50A/B23-471[»]
1AJCX-ray2.50A/B23-471[»]
1AJDX-ray2.50A/B23-471[»]
1ALHX-ray2.50A/B26-471[»]
1ALIX-ray2.20A/B23-471[»]
1ALJX-ray2.60A/B23-471[»]
1ALKX-ray2.00A/B23-471[»]
1ANIX-ray2.50A/B26-471[»]
1ANJX-ray2.30A/B26-471[»]
1B8JX-ray1.90A/B23-471[»]
1ED8X-ray1.75A/B23-471[»]
1ED9X-ray1.75A/B23-471[»]
1ELXX-ray2.60A/B23-471[»]
1ELYX-ray2.80A/B23-471[»]
1ELZX-ray2.80A/B23-471[»]
1EW8X-ray2.20A/B23-471[»]
1EW9X-ray2.00A/B23-471[»]
1HJKX-ray2.30A/B23-471[»]
1HQAX-ray2.25A/B23-471[»]
1KH4X-ray2.40A/B23-471[»]
1KH5X-ray2.00A/B23-471[»]
1KH7X-ray2.40A/B23-471[»]
1KH9X-ray2.50A/B23-471[»]
1KHJX-ray2.30A/B23-471[»]
1KHKX-ray2.50A/B23-471[»]
1KHLX-ray2.50A/B23-471[»]
1KHNX-ray2.60A/B23-471[»]
1URAX-ray2.04A/B26-471[»]
1URBX-ray2.14A/B26-471[»]
1Y6VX-ray1.60A/B23-471[»]
1Y7AX-ray1.77A/B23-471[»]
2ANHX-ray2.40A/B26-471[»]
2G9YX-ray2.00A/B23-471[»]
2GA3X-ray2.20A/B23-471[»]
2MLXNMR-B220-310[»]
2MLYNMR-B1-150[»]
2MLZNMR-B360-471[»]
3BDFX-ray1.40A/B22-471[»]
3BDGX-ray1.40A/B22-471[»]
3BDHX-ray1.85A/B22-471[»]
3CMRX-ray2.05A/B23-471[»]
3DPCX-ray2.30A/B23-471[»]
3DYCX-ray2.30A/B23-471[»]
3TG0X-ray1.20A/B/C/D23-471[»]
4KM4X-ray2.80A/B26-470[»]
4YR1X-ray2.24A/B31-471[»]
5C66X-ray2.03A/B23-471[»]
5GADelectron microscopy3.70k1-18[»]
5GAFelectron microscopy4.30k1-18[»]
5GAGelectron microscopy3.80k1-18[»]
5GAHelectron microscopy3.80k1-18[»]
5JTLNMR-E1-471[»]
5JTMNMR-E/F/G/H1-25[»]
5JTNNMR-E/F91-145[»]
5JTONMR-E/F/G/H271-310[»]
5JTPNMR-E/F/G/H450-471[»]
5TPQX-ray2.45A/B30-471[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P00634

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00634

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00634

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alkaline phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105G6Z Bacteria
COG1785 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000099117

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00634

KEGG Orthology (KO)

More...
KOi
K01077

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00634

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16012 ALP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11596 PTHR11596, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00245 Alk_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00113 ALKPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00098 alkPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649 SSF53649, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P00634-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQSTIALAL LPLLFTPVTK ARTPEMPVLE NRAAQGDITA PGGARRLTGD
60 70 80 90 100
QTAALRDSLS DKPAKNIILL IGDGMGDSEI TAARNYAEGA GGFFKGIDAL
110 120 130 140 150
PLTGQYTHYA LNKKTGKPDY VTDSAASATA WSTGVKTYNG ALGVDIHEKD
160 170 180 190 200
HPTILEMAKA AGLATGNVST AELQDATPAA LVAHVTSRKC YGPSATSEKC
210 220 230 240 250
PGNALEKGGK GSITEQLLNA RADVTLGGGA KTFAETATAG EWQGKTLREQ
260 270 280 290 300
AQARGYQLVS DAASLNSVTE ANQQKPLLGL FADGNMPVRW LGPKATYHGN
310 320 330 340 350
IDKPAVTCTP NPQRNDSVPT LAQMTDKAIE LLSKNEKGFF LQVEGASIDK
360 370 380 390 400
QDHAANPCGQ IGETVDLDEA VQRALEFAKK EGNTLVIVTA DHAHASQIVA
410 420 430 440 450
PDTKAPGLTQ ALNTKDGAVM VMSYGNSEED SQEHTGSQLR IAAYGPHAAN
460 470
VVGLTDQTDL FYTMKAALGL K
Length:471
Mass (Da):49,439
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A8DE1F29D9D9253
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10L → V in AAA23431 (PubMed:3912261).Curated1
Sequence conflicti78 – 80SEI → WGS in AAA24359 (PubMed:6273802).Curated3
Sequence conflicti198E → Q AA sequence (PubMed:7022451).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti22Missing in isozyme 3. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04586 Genomic DNA Translation: CAA28257.1
M13345 Genomic DNA Translation: AAA83893.1
M29664 Genomic DNA Translation: AAA24364.1
M29665 Genomic DNA Translation: AAA24365.1
U73857 Genomic DNA Translation: AAB18107.1
U00096 Genomic DNA Translation: AAC73486.2
AP009048 Genomic DNA Translation: BAE76164.1
M33536 Genomic DNA Translation: AAA24372.1
J01659 Genomic DNA Translation: AAA24359.2
J01660 Genomic DNA Translation: AAA24360.1
J01661 Genomic DNA Translation: AAA24361.1
J05005 Genomic DNA Translation: AAA24362.1
M14399 mRNA Translation: AAA23431.1
M13763 Genomic DNA Translation: AAA24358.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A00776 PAECA

NCBI Reference Sequences

More...
RefSeqi
NP_414917.2, NC_000913.3
WP_000814403.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73486; AAC73486; b0383
BAE76164; BAE76164; BAE76164

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945041

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0374
eco:b0383

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1895

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04586 Genomic DNA Translation: CAA28257.1
M13345 Genomic DNA Translation: AAA83893.1
M29664 Genomic DNA Translation: AAA24364.1
M29665 Genomic DNA Translation: AAA24365.1
U73857 Genomic DNA Translation: AAB18107.1
U00096 Genomic DNA Translation: AAC73486.2
AP009048 Genomic DNA Translation: BAE76164.1
M33536 Genomic DNA Translation: AAA24372.1
J01659 Genomic DNA Translation: AAA24359.2
J01660 Genomic DNA Translation: AAA24360.1
J01661 Genomic DNA Translation: AAA24361.1
J05005 Genomic DNA Translation: AAA24362.1
M14399 mRNA Translation: AAA23431.1
M13763 Genomic DNA Translation: AAA24358.1
PIRiA00776 PAECA
RefSeqiNP_414917.2, NC_000913.3
WP_000814403.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJAX-ray2.50A/B23-471[»]
1AJBX-ray2.50A/B23-471[»]
1AJCX-ray2.50A/B23-471[»]
1AJDX-ray2.50A/B23-471[»]
1ALHX-ray2.50A/B26-471[»]
1ALIX-ray2.20A/B23-471[»]
1ALJX-ray2.60A/B23-471[»]
1ALKX-ray2.00A/B23-471[»]
1ANIX-ray2.50A/B26-471[»]
1ANJX-ray2.30A/B26-471[»]
1B8JX-ray1.90A/B23-471[»]
1ED8X-ray1.75A/B23-471[»]
1ED9X-ray1.75A/B23-471[»]
1ELXX-ray2.60A/B23-471[»]
1ELYX-ray2.80A/B23-471[»]
1ELZX-ray2.80A/B23-471[»]
1EW8X-ray2.20A/B23-471[»]
1EW9X-ray2.00A/B23-471[»]
1HJKX-ray2.30A/B23-471[»]
1HQAX-ray2.25A/B23-471[»]
1KH4X-ray2.40A/B23-471[»]
1KH5X-ray2.00A/B23-471[»]
1KH7X-ray2.40A/B23-471[»]
1KH9X-ray2.50A/B23-471[»]
1KHJX-ray2.30A/B23-471[»]
1KHKX-ray2.50A/B23-471[»]
1KHLX-ray2.50A/B23-471[»]
1KHNX-ray2.60A/B23-471[»]
1URAX-ray2.04A/B26-471[»]
1URBX-ray2.14A/B26-471[»]
1Y6VX-ray1.60A/B23-471[»]
1Y7AX-ray1.77A/B23-471[»]
2ANHX-ray2.40A/B26-471[»]
2G9YX-ray2.00A/B23-471[»]
2GA3X-ray2.20A/B23-471[»]
2MLXNMR-B220-310[»]
2MLYNMR-B1-150[»]
2MLZNMR-B360-471[»]
3BDFX-ray1.40A/B22-471[»]
3BDGX-ray1.40A/B22-471[»]
3BDHX-ray1.85A/B22-471[»]
3CMRX-ray2.05A/B23-471[»]
3DPCX-ray2.30A/B23-471[»]
3DYCX-ray2.30A/B23-471[»]
3TG0X-ray1.20A/B/C/D23-471[»]
4KM4X-ray2.80A/B26-470[»]
4YR1X-ray2.24A/B31-471[»]
5C66X-ray2.03A/B23-471[»]
5GADelectron microscopy3.70k1-18[»]
5GAFelectron microscopy4.30k1-18[»]
5GAGelectron microscopy3.80k1-18[»]
5GAHelectron microscopy3.80k1-18[»]
5JTLNMR-E1-471[»]
5JTMNMR-E/F/G/H1-25[»]
5JTNNMR-E/F91-145[»]
5JTONMR-E/F/G/H271-310[»]
5JTPNMR-E/F/G/H450-471[»]
5TPQX-ray2.45A/B30-471[»]
ProteinModelPortaliP00634
SMRiP00634
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259827, 50 interactors
DIPiDIP-10496N
IntActiP00634, 7 interactors
STRINGi316385.ECDH10B_0340

Chemistry databases

ChEMBLiCHEMBL4217
DrugBankiDB03498 Mercaptomethyl Phosphonate
DB02823 Phosphonoacetic Acid
DB04522 Phosphonoserine
DB04031 Serine Vanadate

Proteomic databases

jPOSTiP00634
PaxDbiP00634
PRIDEiP00634

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73486; AAC73486; b0383
BAE76164; BAE76164; BAE76164
GeneIDi945041
KEGGiecj:JW0374
eco:b0383
PATRICifig|1411691.4.peg.1895

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0720
EcoGeneiEG10727 phoA

Phylogenomic databases

eggNOGiENOG4105G6Z Bacteria
COG1785 LUCA
HOGENOMiHOG000099117
InParanoidiP00634
KOiK01077
PhylomeDBiP00634

Enzyme and pathway databases

BioCyciEcoCyc:ALKAPHOSPHA-MONOMER
MetaCyc:ALKAPHOSPHA-MONOMER
BRENDAi3.1.3.1 2026
SABIO-RKiP00634

Miscellaneous databases

EvolutionaryTraceiP00634

Protein Ontology

More...
PROi
PR:P00634

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 2 hits
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00634
Secondary accession number(s): P77801
, P78051, Q2MC42, Q47041
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: January 16, 2019
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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