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UniProtKB - P00597 (PA2A2_NAJKA)
Protein
Acidic phospholipase A2 2
Gene
N/A
Organism
Naja kaouthia (Monocled cobra) (Naja siamensis)
Status
Functioni
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 54 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 56 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 58 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 74 | By similarity | 1 | |
Metal bindingi | 75 | CalciumBy similarity | 1 | |
Active sitei | 120 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Acidic phospholipase A2 2 (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): CM-III NnkPLA-II Phosphatidylcholine 2-acylhydrolase |
Organismi | Naja kaouthia (Monocled cobra) (Naja siamensis) |
Taxonomic identifieri | 8649 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Naja |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 4.4 mg/kg by intravenous injection.
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000022922 | 22 – 27 | 1 Publication | 6 | |
ChainiPRO_0000022923 | 28 – 146 | Acidic phospholipase A2 2Add BLAST | 119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 98 | By similarity | ||
Disulfide bondi | 53 ↔ 145 | By similarity | ||
Disulfide bondi | 55 ↔ 71 | By similarity | ||
Disulfide bondi | 70 ↔ 126 | By similarity | ||
Disulfide bondi | 77 ↔ 119 | By similarity | ||
Disulfide bondi | 87 ↔ 112 | By similarity | ||
Disulfide bondi | 105 ↔ 117 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P00597-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPAHLLILA AVCVSSLGAS SNRPMPLNLY QFKNMIQCTV PSRSWWDFAD
60 70 80 90 100
YGCYCGRGGS GTPVDDLDRC CQVHDNCYNE AEKISGCWPY FKTYSYECSQ
110 120 130 140
GTLTCKGGNN ACAAAVCDCD RLAAICFAGA PYNNNNYNID LKARCQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | D → N AA sequence (PubMed:7460933).Curated | 1 | |
Sequence conflicti | 79 | N → D AA sequence (PubMed:7460933).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011389 mRNA Translation: BAA36404.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011389 mRNA Translation: BAA36404.1 |
3D structure databases
SMRi | P00597 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2A2_NAJKA | |
Accessioni | P00597Primary (citable) accession number: P00597 Secondary accession number(s): Q9PWS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families