UniProtKB - P00582 (DPO1_ECOLI)

BLAST

>sp|P00582|DPO1_ECOLI DNA polymerase I OS=Escherichia coli (strain K12) OX=83333 GN=polA PE=1 SV=1
MVQIPQNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLIMQYKPTHAAV
VFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLLAVSGVEADDVIGT
LAREAEKAGRPVLISTGDKDMAQLVTPNITLINTMTNTILGPEEVVNKYGVPPELIIDFL
ALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLSFRGAKTMAAKLEQNK
EVAYLSYQLATIKTDVELELTCEQLEVQQPAAEELLGLFKKYEFKRWTADVEAGKWLQAK
GAKPAAKPQETSVADEAPEVTATVISYDNYVTILDEETLKAWIAKLEKAPVFAFDTETDS
LDNISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQN
LKYDRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKG
KNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLNVFENIEMPLVPVLSRI
ERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQGIKPLK
KTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYH
QAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRD
KGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIP
RKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNGARRAAAE
RAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQI
HQLMENCTRLDVPLLVEVGSGENWDQAH

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History
Entry version 192 (07 Nov 2018)
Sequence version 1 (21 Jul 1986)
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Protein

DNA polymerase I

Gene

polA

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functionⁱ

3'-5' exonuclease activity
Source: EcoCyc
Inferred from direct assayⁱ
- 4552924
- 4890763
5'-3' exonuclease activity
Source: EcoCyc
Inferred from direct assayⁱ
- 4552925
- 4890763
DNA binding
Source: EcoCyc
Inferred from direct assayⁱ
- 4890764
DNA-directed DNA polymerase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 13563462

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

base-excision repair
Source: EcoCyc
Inferred from direct assayⁱ
- 23630273
DNA-dependent DNA replication
Source: EcoCyc
Inferred from direct assayⁱ
- 6262323
DNA repair
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 169227
DNA replication
Source: EcoCyc
Inferred from direct assayⁱ
- 4552924

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological process	DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10746-MONOMER MetaCyc:EG10746-MONOMER
BRENDAⁱ	2.7.7.7 2026
SABIO-RKⁱ	P00582

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA polymerase I (EC:2.7.7.7) Short name: POL I
Gene namesⁱ	Name:polA Synonyms:resA Ordered Locus Names:b3863, JW3835
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10746 polA

EcoGeneⁱ

EG10746 polA

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm
Source: EcoCyc
Inferred from direct assayⁱ
- 16858726
cytosol
Source: EcoCyc
Inferred from direct assayⁱ
- 18304323

View the complete GO annotation on QuickGO ...

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4298
Drug and drug target database More...DrugBankⁱ	DB00548 Azelaic Acid DB08432 THYMIDINE-5'-THIOPHOSPHATE

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000101239	1 – 928	DNA polymerase IAdd BLAST		928

Proteomic databases

EPDⁱ	P00582
PaxDbⁱ	P00582
PRIDEⁱ	P00582

2D gel databases

SWISS-2DPAGEⁱ	P00582

SWISS-2DPAGEⁱ

P00582

Interactionⁱ

Subunit structureⁱ

Single-chain monomer with multiple functions.

Protein-protein interaction databases

BioGridⁱ	4262182, 125 interactors
Database of interacting proteins More...DIPⁱ	DIP-10524N
IntActⁱ	P00582, 33 interactors
STRINGⁱ	316385.ECDH10B_4052

Chemistry databases

BindingDBⁱ

P00582

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	327 – 332	Combined sources	6
Helixⁱ	336 – 347	Combined sources	12
Beta strandⁱ	349 – 359	Combined sources	11
Turnⁱ	363 – 365	Combined sources	3
Beta strandⁱ	368 – 376	Combined sources	9
Beta strandⁱ	379 – 384	Combined sources	6
Helixⁱ	398 – 409	Combined sources	12
Beta strandⁱ	416 – 420	Combined sources	5
Helixⁱ	421 – 429	Combined sources	9
Turnⁱ	430 – 432	Combined sources	3
Beta strandⁱ	438 – 441	Combined sources	4
Helixⁱ	442 – 449	Combined sources	8
Helixⁱ	451 – 453	Combined sources	3
Helixⁱ	458 – 465	Combined sources	8
Helixⁱ	473 – 477	Combined sources	5
Helixⁱ	480 – 482	Combined sources	3
Helixⁱ	486 – 488	Combined sources	3
Helixⁱ	491 – 515	Combined sources	25
Helixⁱ	520 – 528	Combined sources	9
Helixⁱ	530 – 543	Combined sources	14
Beta strandⁱ	545 – 547	Combined sources	3
Helixⁱ	549 – 573	Combined sources	25
Beta strandⁱ	574 – 576	Combined sources	3
Turnⁱ	582 – 585	Combined sources	4
Helixⁱ	587 – 590	Combined sources	4
Turnⁱ	591 – 593	Combined sources	3
Turnⁱ	608 – 610	Combined sources	3
Helixⁱ	613 – 617	Combined sources	5
Turnⁱ	618 – 620	Combined sources	3
Helixⁱ	623 – 639	Combined sources	17
Turnⁱ	640 – 643	Combined sources	4
Helixⁱ	644 – 647	Combined sources	4
Turnⁱ	650 – 652	Combined sources	3
Beta strandⁱ	653 – 655	Combined sources	3
Beta strandⁱ	658 – 662	Combined sources	5
Beta strandⁱ	665 – 667	Combined sources	3
Beta strandⁱ	670 – 674	Combined sources	5
Helixⁱ	676 – 678	Combined sources	3
Beta strandⁱ	681 – 683	Combined sources	3
Helixⁱ	684 – 691	Combined sources	8
Beta strandⁱ	699 – 706	Combined sources	8
Helixⁱ	709 – 717	Combined sources	9
Helixⁱ	721 – 728	Combined sources	8
Helixⁱ	733 – 741	Combined sources	9
Helixⁱ	746 – 748	Combined sources	3
Helixⁱ	751 – 765	Combined sources	15
Helixⁱ	772 – 777	Combined sources	6
Turnⁱ	781 – 783	Combined sources	3
Helixⁱ	784 – 794	Combined sources	11
Helixⁱ	796 – 812	Combined sources	17
Beta strandⁱ	813 – 816	Combined sources	4
Beta strandⁱ	822 – 824	Combined sources	3
Turnⁱ	826 – 829	Combined sources	4
Helixⁱ	833 – 870	Combined sources	38
Beta strandⁱ	873 – 880	Combined sources	8
Beta strandⁱ	883 – 889	Combined sources	7
Turnⁱ	890 – 892	Combined sources	3
Helixⁱ	893 – 906	Combined sources	14
Beta strandⁱ	910 – 912	Combined sources	3
Beta strandⁱ	916 – 923	Combined sources	8
Helixⁱ	924 – 927	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P00582
SMRⁱ	P00582
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P00582

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 323	5'-3' exonucleaseAdd BLAST		323
Domainⁱ	324 – 517	3'-5' exonucleaseAdd BLAST		194

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	324 – 928	Klenow fragmentAdd BLAST		605
Regionⁱ	521 – 928	PolymeraseAdd BLAST		408

Sequence similaritiesⁱ

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105C2M Bacteria COG0258 LUCA COG0749 LUCA
HOGENOMⁱ	HOG000020998
InParanoidⁱ	P00582
KEGG Orthology (KO) More...KOⁱ	K02335
PhylomeDBⁱ	P00582

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09898 H3TH_53EXO, 1 hit
Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR002562 3'-5'_exonuclease_dom IPR020046 5-3_exonucl_a-hlix_arch_N IPR036279 5-3_exonuclease_C_sf IPR002421 5-3_exonuclease_N IPR019760 DNA-dir_DNA_pol_A_CS IPR001098 DNA-dir_DNA_pol_A_palm_dom IPR020045 DNA_polI_H3TH IPR018320 DNA_polymerase_1 IPR002298 DNA_polymerase_A IPR008918 HhH2 IPR029060 PIN-like_dom_sf IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf
PANTHERⁱ	PTHR10133 PTHR10133, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01367 5_3_exonuc, 1 hit PF02739 5_3_exonuc_N, 1 hit PF00476 DNA_pol_A, 1 hit PF01612 DNA_pol_A_exo1, 1 hit
PRINTSⁱ	PR00868 DNAPOLI
SMARTⁱ	View protein in SMART SM00474 35EXOc, 1 hit SM00475 53EXOc, 1 hit SM00279 HhH2, 1 hit SM00482 POLAc, 1 hit
SUPFAMⁱ	SSF47807 SSF47807, 1 hit SSF53098 SSF53098, 1 hit SSF88723 SSF88723, 1 hit
TIGRFAMsⁱ	TIGR00593 pola, 1 hit
PROSITEⁱ	View protein in PROSITE PS00447 DNA_POLYMERASE_A, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P00582-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVQIPQNPLI LVDGSSYLYR AYHAFPPLTN SAGEPTGAMY GVLNMLRSLI 
        60         70         80         90        100
MQYKPTHAAV VFDAKGKTFR DELFEHYKSH RPPMPDDLRA QIEPLHAMVK 
       110        120        130        140        150
AMGLPLLAVS GVEADDVIGT LAREAEKAGR PVLISTGDKD MAQLVTPNIT 
       160        170        180        190        200
LINTMTNTIL GPEEVVNKYG VPPELIIDFL ALMGDSSDNI PGVPGVGEKT 
       210        220        230        240        250
AQALLQGLGG LDTLYAEPEK IAGLSFRGAK TMAAKLEQNK EVAYLSYQLA 
       260        270        280        290        300
TIKTDVELEL TCEQLEVQQP AAEELLGLFK KYEFKRWTAD VEAGKWLQAK 
       310        320        330        340        350
GAKPAAKPQE TSVADEAPEV TATVISYDNY VTILDEETLK AWIAKLEKAP 
       360        370        380        390        400
VFAFDTETDS LDNISANLVG LSFAIEPGVA AYIPVAHDYL DAPDQISRER 
       410        420        430        440        450
ALELLKPLLE DEKALKVGQN LKYDRGILAN YGIELRGIAF DTMLESYILN 
       460        470        480        490        500
SVAGRHDMDS LAERWLKHKT ITFEEIAGKG KNQLTFNQIA LEEAGRYAAE 
       510        520        530        540        550
DADVTLQLHL KMWPDLQKHK GPLNVFENIE MPLVPVLSRI ERNGVKIDPK 
       560        570        580        590        600
VLHNHSEELT LRLAELEKKA HEIAGEEFNL SSTKQLQTIL FEKQGIKPLK 
       610        620        630        640        650
KTPGGAPSTS EEVLEELALD YPLPKVILEY RGLAKLKSTY TDKLPLMINP 
       660        670        680        690        700
KTGRVHTSYH QAVTATGRLS STDPNLQNIP VRNEEGRRIR QAFIAPEDYV 
       710        720        730        740        750
IVSADYSQIE LRIMAHLSRD KGLLTAFAEG KDIHRATAAE VFGLPLETVT 
       760        770        780        790        800
SEQRRSAKAI NFGLIYGMSA FGLARQLNIP RKEAQKYMDL YFERYPGVLE 
       810        820        830        840        850
YMERTRAQAK EQGYVETLDG RRLYLPDIKS SNGARRAAAE RAAINAPMQG 
       860        870        880        890        900
TAADIIKRAM IAVDAWLQAE QPRVRMIMQV HDELVFEVHK DDVDAVAKQI 
       910        920 
HQLMENCTRL DVPLLVEVGS GENWDQAH

Length:928

Mass (Da):103,118

Last modified:July 21, 1986 - v1

Checksum:ⁱDAAE1C448A59030C

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V00317 Genomic DNA Translation: CAA23607.1 L19201 Genomic DNA Translation: AAB02998.1 U00096 Genomic DNA Translation: AAC76861.1 AP009048 Genomic DNA Translation: BAE77445.1 J01663 Genomic DNA Translation: AAA24402.1 J01664 Genomic DNA Translation: AAA24404.1
PIRⁱ	A92360 DJECI
NCBI Reference Sequences More...RefSeqⁱ	NP_418300.1, NC_000913.3 WP_000250006.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76861; AAC76861; b3863 BAE77445; BAE77445; BAE77445
GeneIDⁱ	948356
KEGGⁱ	ecj:JW3835 eco:b3863
PATRICⁱ	fig\|1411691.4.peg.2851

Protein	Similar proteins		Species	Score	Length	Source
P00582	DNA polymerase I		Shigella sp.		928	UniRef100_P00582
DNA polymerase I		Escherichia coli O145 str. RM9872		928
DNA polymerase I		Escherichia coli M8		928
DNA polymerase I		SHIBO		928
DNA polymerase I		ECOLX		928
+86

Protein	Similar proteins		Species	Score	Length	Source
P00582	DNA polymerase I		SALTY		928	UniRef90_P00582
DNA polymerase I		Shigella sp.		928
DNA polymerase I		Escherichia coli O145 str. RM9872		928
DNA polymerase I		Escherichia coli M8		928
DNA polymerase I		SHIBO		928
+1993

Protein	Similar proteins		Species	Score	Length	Source
P00582	DNA polymerase I		SALTY		928	UniRef50_P00582
DNA polymerase I		HAEIN		930
DNA polymerase I		Shigella sp.		928
DNA polymerase I		Escherichia coli O145 str. RM9872		928
DNA polymerase I		Escherichia coli M8		928
+6114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V00317 Genomic DNA Translation: CAA23607.1 L19201 Genomic DNA Translation: AAB02998.1 U00096 Genomic DNA Translation: AAC76861.1 AP009048 Genomic DNA Translation: BAE77445.1 J01663 Genomic DNA Translation: AAA24402.1 J01664 Genomic DNA Translation: AAA24404.1
PIRⁱ	A92360 DJECI
RefSeqⁱ	NP_418300.1, NC_000913.3 WP_000250006.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1D8Y	X-ray	2.08	A	324-928	[»]
	1D9D	X-ray	2.18	A	324-928	[»]
	1D9F	X-ray	3.00	A	324-928	[»]
	1DPI	X-ray	2.80	A	324-928	[»]
	1KFD	X-ray	3.90	A	324-928	[»]
	1KFS	X-ray	2.10	A	324-928	[»]
	1KLN	X-ray	3.20	A	324-928	[»]
	1KRP	X-ray	2.20	A	324-928	[»]
	1KSP	X-ray	2.30	A	324-928	[»]
	1QSL	X-ray	2.20	A	324-928	[»]
	2KFN	X-ray	2.03	A	324-928	[»]
	2KFZ	X-ray	2.03	A	324-928	[»]
	2KZM	X-ray	2.60	A	324-928	[»]
	2KZZ	X-ray	2.25	A	324-928	[»]
ProteinModelPortalⁱ	P00582
SMRⁱ	P00582
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262182, 125 interactors
DIPⁱ	DIP-10524N
IntActⁱ	P00582, 33 interactors
STRINGⁱ	316385.ECDH10B_4052

Chemistry databases

BindingDBⁱ	P00582
ChEMBLⁱ	CHEMBL4298
DrugBankⁱ	DB00548 Azelaic Acid DB08432 THYMIDINE-5'-THIOPHOSPHATE

2D gel databases

SWISS-2DPAGEⁱ	P00582

SWISS-2DPAGEⁱ

P00582

Proteomic databases

EPDⁱ	P00582
PaxDbⁱ	P00582
PRIDEⁱ	P00582

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76861; AAC76861; b3863 BAE77445; BAE77445; BAE77445
GeneIDⁱ	948356
KEGGⁱ	ecj:JW3835 eco:b3863
PATRICⁱ	fig\|1411691.4.peg.2851

Organism-specific databases

EchoBASEⁱ	EB0739
EcoGeneⁱ	EG10746 polA

Phylogenomic databases

eggNOGⁱ	ENOG4105C2M Bacteria COG0258 LUCA COG0749 LUCA
HOGENOMⁱ	HOG000020998
InParanoidⁱ	P00582
KOⁱ	K02335
PhylomeDBⁱ	P00582

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10746-MONOMER MetaCyc:EG10746-MONOMER
BRENDAⁱ	2.7.7.7 2026
SABIO-RKⁱ	P00582

Miscellaneous databases

EvolutionaryTraceⁱ	P00582
Protein Ontology More...PROⁱ	PR:P00582

Family and domain databases

CDDⁱ	cd09898 H3TH_53EXO, 1 hit
Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR002562 3'-5'_exonuclease_dom IPR020046 5-3_exonucl_a-hlix_arch_N IPR036279 5-3_exonuclease_C_sf IPR002421 5-3_exonuclease_N IPR019760 DNA-dir_DNA_pol_A_CS IPR001098 DNA-dir_DNA_pol_A_palm_dom IPR020045 DNA_polI_H3TH IPR018320 DNA_polymerase_1 IPR002298 DNA_polymerase_A IPR008918 HhH2 IPR029060 PIN-like_dom_sf IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf
PANTHERⁱ	PTHR10133 PTHR10133, 1 hit
Pfamⁱ	View protein in Pfam PF01367 5_3_exonuc, 1 hit PF02739 5_3_exonuc_N, 1 hit PF00476 DNA_pol_A, 1 hit PF01612 DNA_pol_A_exo1, 1 hit
PRINTSⁱ	PR00868 DNAPOLI
SMARTⁱ	View protein in SMART SM00474 35EXOc, 1 hit SM00475 53EXOc, 1 hit SM00279 HhH2, 1 hit SM00482 POLAc, 1 hit
SUPFAMⁱ	SSF47807 SSF47807, 1 hit SSF53098 SSF53098, 1 hit SSF88723 SSF88723, 1 hit
TIGRFAMsⁱ	TIGR00593 pola, 1 hit
PROSITEⁱ	View protein in PROSITE PS00447 DNA_POLYMERASE_A, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DPO1_ECOLI
Accessionⁱ	P00582Primary (citable) accession number: P00582 Secondary accession number(s): Q2M8G1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

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UniProtKB - P00582 (DPO1_ECOLI)

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DNA polymerase I

polA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ