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Protein

Phosphoglycerate kinase 1

Gene

PGK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).2 Publications

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (epd), Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP)
  2. Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase (pgk), Phosphoglycerate kinase, Phosphoglycerate kinase (HEL-S-68p), Phosphoglycerate kinase (HEL-S-272), Phosphoglycerate kinase
  3. no protein annotated in this organism
  4. Gamma-enolase (ENO2), Alpha-enolase (ENO1), Enolase 4 (ENO4), Beta-enolase (ENO3)
  5. Pyruvate kinase PKM (PKM), Pyruvate kinase PKLR (PKLR), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase, Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase, Pyruvate kinase (pyk), Pyruvate kinase (PKM), Pyruvate kinase, Pyruvate kinase (HEL-S-30), Pyruvate kinase, Pyruvate kinase (PKM2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Substrate1
Binding sitei123Substrate1
Binding sitei171Substrate1
Binding sitei220ATP1
Binding sitei313ATP; via carbonyl oxygen1
Binding sitei344ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 376ATP4

GO - Molecular functioni

  • ADP binding Source: GO_Central
  • ATP binding Source: UniProtKB
  • phosphoglycerate kinase activity Source: CAFA
  • protein-disulfide reductase activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS02359-MONOMER
ReactomeiR-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis
SABIO-RKiP00558
SIGNORiP00558
UniPathwayi
UPA00109;UER00185

Protein family/group databases

MoonDBiP00558 Curated
MoonProtiP00558

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Alternative name(s):
Cell migration-inducing gene 10 protein
Primer recognition protein 2
Short name:
PRP 2
Gene namesi
Name:PGK1
Synonyms:PGKA
ORF Names:MIG10, OK/SW-cl.110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102144.13
HGNCiHGNC:8896 PGK1
MIMi311800 gene
neXtProtiNX_P00558

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Phosphoglycerate kinase 1 deficiency (PGK1D)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.
See also OMIM:300653
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant dbSNP:rs137852531EnsemblClinVar.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant dbSNP:rs137852532EnsemblClinVar.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant dbSNP:rs137852538EnsemblClinVar.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant dbSNP:rs137852529EnsemblClinVar.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant dbSNP:rs431905501EnsemblClinVar.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant dbSNP:rs137852535EnsemblClinVar.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant dbSNP:rs137852533EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNETi5230
MalaCardsiPGK1
MIMi300653 phenotype
OpenTargetsiENSG00000102144
Orphaneti713 Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
PharmGKBiPA33234

Chemistry databases

ChEMBLiCHEMBL2886
DrugBankiDB04510 3-Phosphoglyceric Acid
DB00709 Lamivudine

Polymorphism and mutation databases

BioMutaiPGK1
DMDMi52788229

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001458312 – 417Phosphoglycerate kinase 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei6N6-succinyllysineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei48N6-acetyllysine; alternateCombined sources1
Modified residuei48N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei76PhosphotyrosineBy similarity1
Modified residuei86N6-acetyllysineCombined sources1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysine; alternateCombined sources1
Modified residuei131N6-malonyllysine; alternate1 Publication1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei191N6-succinyllysineBy similarity1
Modified residuei196PhosphotyrosineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei291N6-acetyllysineCombined sources1
Modified residuei361N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP00558
PaxDbiP00558
PeptideAtlasiP00558
PRIDEiP00558
ProteomicsDBi51266
TopDownProteomicsiP00558-1 [P00558-1]

2D gel databases

DOSAC-COBS-2DPAGEiP00558
OGPiP00558
REPRODUCTION-2DPAGEiIPI00169383
P00558
UCD-2DPAGEiP00558

PTM databases

iPTMnetiP00558
PhosphoSitePlusiP00558
SwissPalmiP00558

Expressioni

Tissue specificityi

Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men.1 Publication

Gene expression databases

BgeeiENSG00000102144 Expressed in 232 organ(s), highest expression level in material anatomical entity
CleanExiHS_PGK1
ExpressionAtlasiP00558 baseline and differential
GenevisibleiP00558 HS

Organism-specific databases

HPAiCAB010065
HPA045385
HPA073644
HPA073656

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi111251, 132 interactors
DIPiDIP-33679N
IntActiP00558, 45 interactors
MINTiP00558
STRINGi9606.ENSP00000362413

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00558
SMRiP00558
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00558

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate binding3
Regioni63 – 66Substrate binding4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
GeneTreeiENSGT00390000008820
HOGENOMiHOG000227107
HOVERGENiHBG008177
InParanoidiP00558
KOiK00927
OMAiDMIFDIG
OrthoDBiEOG091G08S6
PhylomeDBiP00558
TreeFamiTF300489

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P00558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC
60 70 80 90 100
LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV
110 120 130 140 150
GPEVEKACAN PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIEAF
160 170 180 190 200
RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA
210 220 230 240 250
LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN
260 270 280 290 300
MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ
310 320 330 340 350
ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR
360 370 380 390 400
GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL
410
ELLEGKVLPG VDALSNI
Length:417
Mass (Da):44,615
Last modified:January 23, 2007 - v3
Checksum:iB5DFC7B5FA01767C
GO
Isoform 2 (identifier: P00558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):41,429
Checksum:i2A0D80F12CCEB825
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Missing AA sequence (PubMed:7391027).Curated1
Sequence conflicti370I → T in CAG32997 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant dbSNP:rs137852531EnsemblClinVar.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant dbSNP:rs137852532EnsemblClinVar.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant dbSNP:rs137852538EnsemblClinVar.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant dbSNP:rs137852529EnsemblClinVar.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant dbSNP:rs431905501EnsemblClinVar.1
Natural variantiVAR_006083268D → N in Munchen; 21% of activity. 2 PublicationsCorresponds to variant dbSNP:rs137852528EnsemblClinVar.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant dbSNP:rs137852535EnsemblClinVar.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant dbSNP:rs137852533EnsemblClinVar.1
Natural variantiVAR_006087352T → N1 PublicationCorresponds to variant dbSNP:rs137852530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561591 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00572 mRNA Translation: CAA23835.1
L00160 mRNA Translation: AAA60078.1
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA Translation: AAA60079.1
AY423725 mRNA Translation: AAS00488.1
AB062432 mRNA Translation: BAB93495.1
AK291081 mRNA Translation: BAF83770.1
AK301740 mRNA Translation: BAH13545.1
AK312280 mRNA Translation: BAG35209.1
CR456716 mRNA Translation: CAG32997.1
AL049589 Genomic DNA Translation: CAI42951.1
CH471104 Genomic DNA Translation: EAW98604.1
BC023234 mRNA Translation: AAH23234.1
BC103752 mRNA Translation: AAI03753.1
BC104837 mRNA Translation: AAI04838.1
BC113568 mRNA Translation: AAI13569.1
M34017 Genomic DNA Translation: AAA60103.1
CCDSiCCDS14438.1 [P00558-1]
PIRiI59050 KIHUG
RefSeqiNP_000282.1, NM_000291.3 [P00558-1]
UniGeneiHs.78771

Genome annotation databases

EnsembliENST00000373316; ENSP00000362413; ENSG00000102144 [P00558-1]
ENST00000644362; ENSP00000496140; ENSG00000102144 [P00558-2]
GeneIDi5230
KEGGihsa:5230

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Phosphoglycerate kinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00572 mRNA Translation: CAA23835.1
L00160 mRNA Translation: AAA60078.1
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA Translation: AAA60079.1
AY423725 mRNA Translation: AAS00488.1
AB062432 mRNA Translation: BAB93495.1
AK291081 mRNA Translation: BAF83770.1
AK301740 mRNA Translation: BAH13545.1
AK312280 mRNA Translation: BAG35209.1
CR456716 mRNA Translation: CAG32997.1
AL049589 Genomic DNA Translation: CAI42951.1
CH471104 Genomic DNA Translation: EAW98604.1
BC023234 mRNA Translation: AAH23234.1
BC103752 mRNA Translation: AAI03753.1
BC104837 mRNA Translation: AAI04838.1
BC113568 mRNA Translation: AAI13569.1
M34017 Genomic DNA Translation: AAA60103.1
CCDSiCCDS14438.1 [P00558-1]
PIRiI59050 KIHUG
RefSeqiNP_000282.1, NM_000291.3 [P00558-1]
UniGeneiHs.78771

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WZBX-ray1.47A2-417[»]
2WZCX-ray1.50A2-417[»]
2WZDX-ray1.56A1-417[»]
2X13X-ray1.74A2-417[»]
2X14X-ray1.90A2-417[»]
2X15X-ray2.10A2-417[»]
2XE6X-ray1.74A1-417[»]
2XE7X-ray2.20A1-417[»]
2XE8X-ray1.79A1-417[»]
2Y3IX-ray2.90A/D1-416[»]
2YBEX-ray2.00A1-417[»]
2ZGVX-ray2.00A1-417[»]
3C39X-ray1.85A/B1-417[»]
3C3AX-ray2.30A/B1-417[»]
3C3BX-ray1.80A/B1-417[»]
3C3CX-ray2.40A/B1-417[»]
3ZOZX-ray1.95A1-417[»]
4AXXX-ray1.74A1-417[»]
4O33X-ray2.10A1-417[»]
5M1RX-ray1.64A2-417[»]
5M3UX-ray1.81A2-417[»]
5M6ZX-ray1.67A2-417[»]
5MXMX-ray2.05A2-417[»]
5NP8X-ray1.90A1-417[»]
5O7DX-ray1.84A1-417[»]
ProteinModelPortaliP00558
SMRiP00558
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111251, 132 interactors
DIPiDIP-33679N
IntActiP00558, 45 interactors
MINTiP00558
STRINGi9606.ENSP00000362413

Chemistry databases

ChEMBLiCHEMBL2886
DrugBankiDB04510 3-Phosphoglyceric Acid
DB00709 Lamivudine

Protein family/group databases

MoonDBiP00558 Curated
MoonProtiP00558

PTM databases

iPTMnetiP00558
PhosphoSitePlusiP00558
SwissPalmiP00558

Polymorphism and mutation databases

BioMutaiPGK1
DMDMi52788229

2D gel databases

DOSAC-COBS-2DPAGEiP00558
OGPiP00558
REPRODUCTION-2DPAGEiIPI00169383
P00558
UCD-2DPAGEiP00558

Proteomic databases

EPDiP00558
PaxDbiP00558
PeptideAtlasiP00558
PRIDEiP00558
ProteomicsDBi51266
TopDownProteomicsiP00558-1 [P00558-1]

Protocols and materials databases

DNASUi5230
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373316; ENSP00000362413; ENSG00000102144 [P00558-1]
ENST00000644362; ENSP00000496140; ENSG00000102144 [P00558-2]
GeneIDi5230
KEGGihsa:5230

Organism-specific databases

CTDi5230
DisGeNETi5230
EuPathDBiHostDB:ENSG00000102144.13
GeneCardsiPGK1
HGNCiHGNC:8896 PGK1
HPAiCAB010065
HPA045385
HPA073644
HPA073656
MalaCardsiPGK1
MIMi300653 phenotype
311800 gene
neXtProtiNX_P00558
OpenTargetsiENSG00000102144
Orphaneti713 Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
PharmGKBiPA33234
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
GeneTreeiENSGT00390000008820
HOGENOMiHOG000227107
HOVERGENiHBG008177
InParanoidiP00558
KOiK00927
OMAiDMIFDIG
OrthoDBiEOG091G08S6
PhylomeDBiP00558
TreeFamiTF300489

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

BioCyciMetaCyc:HS02359-MONOMER
ReactomeiR-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis
SABIO-RKiP00558
SIGNORiP00558

Miscellaneous databases

ChiTaRSiPGK1 human
EvolutionaryTraceiP00558
GeneWikiiPGK1
GenomeRNAii5230
PROiPR:P00558
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102144 Expressed in 232 organ(s), highest expression level in material anatomical entity
CleanExiHS_PGK1
ExpressionAtlasiP00558 baseline and differential
GenevisibleiP00558 HS

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGK1_HUMAN
AccessioniPrimary (citable) accession number: P00558
Secondary accession number(s): A8K4W6
, B7Z7A9, Q5J7W1, Q6IBT6, Q8NI87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 214 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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