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Entry version 223 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Phosphoglycerate kinase 1

Gene

PGK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by heterocyclic compound CBR-470-0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.2 Publications
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  2. Phosphoglycerate kinase, Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase (HEL-S-68p), Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase (HEL-S-272), Phosphoglycerate kinase, Phosphoglycerate kinase
  3. no protein annotated in this organism
  4. Alpha-enolase (ENO1), Beta-enolase (ENO3), Enolase 4 (ENO4), Gamma-enolase (ENO2)
  5. Pyruvate kinase, Pyruvate kinase, Pyruvate kinase PKLR (PKLR), Pyruvate kinase, Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKLR), Pyruvate kinase (PKM2), Pyruvate kinase (HEL-S-30), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase, Pyruvate kinase (PKM)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39Substrate1 Publication1
Binding sitei123Substrate1 Publication1
Binding sitei171Substrate1 Publication1
Binding sitei220ATP1 Publication1
Binding sitei313ATP; via carbonyl oxygen1 Publication1
Binding sitei344ATP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi373 – 376ATP1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS02359-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00558

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P00558

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00185

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P00558 Curated

MoonProt database of moonlighting proteins

More...
MoonProti
P00558

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.31 Publication)
Alternative name(s):
Cell migration-inducing gene 10 protein
Primer recognition protein 2
Short name:
PRP 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGK1
Synonyms:PGKA
ORF Names:MIG10, OK/SW-cl.110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8896 PGK1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
311800 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00558

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Phosphoglycerate kinase 1 deficiency (PGK1D)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant dbSNP:rs137852531EnsemblClinVar.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant dbSNP:rs137852532EnsemblClinVar.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant dbSNP:rs137852538EnsemblClinVar.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant dbSNP:rs137852529EnsemblClinVar.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant dbSNP:rs431905501EnsemblClinVar.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant dbSNP:rs137852535EnsemblClinVar.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant dbSNP:rs137852533EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
5230

MalaCards human disease database

More...
MalaCardsi
PGK1
MIMi300653 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102144

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
713 Glycogen storage disease due to phosphoglycerate kinase 1 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33234

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P00558

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2886

Drug and drug target database

More...
DrugBanki
DB04510 3-phospho-D-glyceric acid
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB11638 Artenimol
DB09130 Copper
DB00709 Lamivudine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PGK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52788229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001458312 – 417Phosphoglycerate kinase 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei6N6-succinyllysineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei48N6-acetyllysine; alternateCombined sources1
Modified residuei48N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei76PhosphotyrosineBy similarity1
Modified residuei86N6-acetyllysineCombined sources1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysine; alternateCombined sources1
Modified residuei131N6-malonyllysine; alternate1 Publication1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei191N6-succinyllysineBy similarity1
Modified residuei196PhosphotyrosineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei291N6-acetyllysineCombined sources1
Modified residuei361N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-562
CPTAC-563

Encyclopedia of Proteome Dynamics

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EPDi
P00558

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P00558

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P00558

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00558

PeptideAtlas

More...
PeptideAtlasi
P00558

PRoteomics IDEntifications database

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PRIDEi
P00558

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51266 [P00558-1]
6847

Consortium for Top Down Proteomics

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TopDownProteomicsi
P00558-1 [P00558-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P00558

USC-OGP 2-DE database

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OGPi
P00558

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00169383
P00558

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P00558

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00558

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P00558

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P00558

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102144 Expressed in 232 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00558 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P00558 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010065
HPA045385
HPA073644
HPA073656

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111251, 148 interactors

Database of interacting proteins

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DIPi
DIP-33679N

Protein interaction database and analysis system

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IntActi
P00558, 48 interactors

Molecular INTeraction database

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MINTi
P00558

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362413

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P00558

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00558

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00558

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 26Substrate binding1 Publication3
Regioni63 – 66Substrate binding1 Publication4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1367 Eukaryota
COG0126 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000227107

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00558

KEGG Orthology (KO)

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KOi
K00927

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQDNRRF

Database of Orthologous Groups

More...
OrthoDBi
838642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00558

TreeFam database of animal gene trees

More...
TreeFami
TF300489

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00318 Phosphoglycerate_kinase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1260, 3 hits

HAMAP database of protein families

More...
HAMAPi
MF_00145 Phosphoglyc_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11406 PTHR11406, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00162 PGK, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000724 Pgk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00477 PHGLYCKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53748 SSF53748, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P00558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC
60 70 80 90 100
LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV
110 120 130 140 150
GPEVEKACAN PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIEAF
160 170 180 190 200
RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA
210 220 230 240 250
LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN
260 270 280 290 300
MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ
310 320 330 340 350
ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR
360 370 380 390 400
GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL
410
ELLEGKVLPG VDALSNI
Length:417
Mass (Da):44,615
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5DFC7B5FA01767C
GO
Isoform 2 (identifier: P00558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):41,429
Checksum:i2A0D80F12CCEB825
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39Missing AA sequence (PubMed:7391027).Curated1
Sequence conflicti370I → T in CAG32997 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant dbSNP:rs137852531EnsemblClinVar.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant dbSNP:rs137852532EnsemblClinVar.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant dbSNP:rs137852538EnsemblClinVar.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant dbSNP:rs137852529EnsemblClinVar.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant dbSNP:rs431905501EnsemblClinVar.1
Natural variantiVAR_006083268D → N in Munchen; 21% of activity. 2 PublicationsCorresponds to variant dbSNP:rs137852528EnsemblClinVar.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant dbSNP:rs137852535EnsemblClinVar.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant dbSNP:rs137852533EnsemblClinVar.1
Natural variantiVAR_006087352T → N1 PublicationCorresponds to variant dbSNP:rs137852530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561591 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00572 mRNA Translation: CAA23835.1
L00160 mRNA Translation: AAA60078.1
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA Translation: AAA60079.1
AY423725 mRNA Translation: AAS00488.1
AB062432 mRNA Translation: BAB93495.1
AK291081 mRNA Translation: BAF83770.1
AK301740 mRNA Translation: BAH13545.1
AK312280 mRNA Translation: BAG35209.1
CR456716 mRNA Translation: CAG32997.1
AL049589 Genomic DNA Translation: CAI42951.1
CH471104 Genomic DNA Translation: EAW98604.1
BC023234 mRNA Translation: AAH23234.1
BC103752 mRNA Translation: AAI03753.1
BC104837 mRNA Translation: AAI04838.1
BC113568 mRNA Translation: AAI13569.1
M34017 Genomic DNA Translation: AAA60103.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14438.1 [P00558-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I59050 KIHUG

NCBI Reference Sequences

More...
RefSeqi
NP_000282.1, NM_000291.3 [P00558-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373316; ENSP00000362413; ENSG00000102144 [P00558-1]
ENST00000644362; ENSP00000496140; ENSG00000102144 [P00558-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5230

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5230

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Phosphoglycerate kinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00572 mRNA Translation: CAA23835.1
L00160 mRNA Translation: AAA60078.1
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA Translation: AAA60079.1
AY423725 mRNA Translation: AAS00488.1
AB062432 mRNA Translation: BAB93495.1
AK291081 mRNA Translation: BAF83770.1
AK301740 mRNA Translation: BAH13545.1
AK312280 mRNA Translation: BAG35209.1
CR456716 mRNA Translation: CAG32997.1
AL049589 Genomic DNA Translation: CAI42951.1
CH471104 Genomic DNA Translation: EAW98604.1
BC023234 mRNA Translation: AAH23234.1
BC103752 mRNA Translation: AAI03753.1
BC104837 mRNA Translation: AAI04838.1
BC113568 mRNA Translation: AAI13569.1
M34017 Genomic DNA Translation: AAA60103.1
CCDSiCCDS14438.1 [P00558-1]
PIRiI59050 KIHUG
RefSeqiNP_000282.1, NM_000291.3 [P00558-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WZBX-ray1.47A2-417[»]
2WZCX-ray1.50A2-417[»]
2WZDX-ray1.56A1-417[»]
2X13X-ray1.74A2-417[»]
2X14X-ray1.90A2-417[»]
2X15X-ray2.10A2-417[»]
2XE6X-ray1.74A1-417[»]
2XE7X-ray2.20A1-417[»]
2XE8X-ray1.79A1-417[»]
2Y3IX-ray2.90A/D1-416[»]
2YBEX-ray2.00A1-417[»]
2ZGVX-ray2.00A1-417[»]
3C39X-ray1.85A/B1-417[»]
3C3AX-ray2.30A/B1-417[»]
3C3BX-ray1.80A/B1-417[»]
3C3CX-ray2.40A/B1-417[»]
3ZOZX-ray1.95A1-417[»]
4AXXX-ray1.74A1-417[»]
4O33X-ray2.10A1-417[»]
5M1RX-ray1.64A2-417[»]
5M3UX-ray1.81A2-417[»]
5M6ZX-ray1.67A2-417[»]
5MXMX-ray2.05A2-417[»]
5NP8X-ray1.90A1-417[»]
5O7DX-ray1.84A1-417[»]
SMRiP00558
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111251, 148 interactors
DIPiDIP-33679N
IntActiP00558, 48 interactors
MINTiP00558
STRINGi9606.ENSP00000362413

Chemistry databases

BindingDBiP00558
ChEMBLiCHEMBL2886
DrugBankiDB04510 3-phospho-D-glyceric acid
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB11638 Artenimol
DB09130 Copper
DB00709 Lamivudine

Protein family/group databases

MoonDBiP00558 Curated
MoonProtiP00558

PTM databases

iPTMnetiP00558
PhosphoSitePlusiP00558
SwissPalmiP00558

Polymorphism and mutation databases

BioMutaiPGK1
DMDMi52788229

2D gel databases

DOSAC-COBS-2DPAGEiP00558
OGPiP00558
REPRODUCTION-2DPAGEiIPI00169383
P00558
UCD-2DPAGEiP00558

Proteomic databases

CPTACiCPTAC-562
CPTAC-563
EPDiP00558
jPOSTiP00558
MassIVEiP00558
PaxDbiP00558
PeptideAtlasiP00558
PRIDEiP00558
ProteomicsDBi51266 [P00558-1]
6847
TopDownProteomicsiP00558-1 [P00558-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5230

Genome annotation databases

EnsembliENST00000373316; ENSP00000362413; ENSG00000102144 [P00558-1]
ENST00000644362; ENSP00000496140; ENSG00000102144 [P00558-2]
GeneIDi5230
KEGGihsa:5230

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5230
DisGeNETi5230

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PGK1
HGNCiHGNC:8896 PGK1
HPAiCAB010065
HPA045385
HPA073644
HPA073656
MalaCardsiPGK1
MIMi300653 phenotype
311800 gene
neXtProtiNX_P00558
OpenTargetsiENSG00000102144
Orphaneti713 Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
PharmGKBiPA33234

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
GeneTreeiENSGT00390000008820
HOGENOMiHOG000227107
InParanoidiP00558
KOiK00927
OMAiVQDNRRF
OrthoDBi838642at2759
PhylomeDBiP00558
TreeFamiTF300489

Enzyme and pathway databases

UniPathwayiUPA00109;UER00185
BioCyciMetaCyc:HS02359-MONOMER
ReactomeiR-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis
SABIO-RKiP00558
SIGNORiP00558

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PGK1 human
EvolutionaryTraceiP00558

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PGK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5230
PharosiP00558

Protein Ontology

More...
PROi
PR:P00558

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102144 Expressed in 232 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiP00558 baseline and differential
GenevisibleiP00558 HS

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00558
Secondary accession number(s): A8K4W6
, B7Z7A9, Q5J7W1, Q6IBT6, Q8NI87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 223 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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