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Entry version 202 (13 Nov 2019)
Sequence version 1 (21 Jul 1986)
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Protein

PTS system mannitol-specific EIICBA component

Gene

mtlA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport (PubMed:368051, PubMed:6427236, PubMed:2123863). Also able to use D-mannonic acid (PubMed:6427236).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=66 µM for mannitol phosphorylation1 Publication
  1. Vmax=21.7 nmol/min/mg enzyme toward mannitol1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei384Phosphocysteine intermediate; for EIIB activity2 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei538Stabilizes the transition state in the phosphoryl transfer from HPr to EIIA1 Publication1
Active sitei554Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation3 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:MTLA-MONOMER
ECOL316407:JW3573-MONOMER
MetaCyc:MTLA-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00550

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.A.2.1.2 the pts fructose-mannitol (fru) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PTS system mannitol-specific EIICBA component1 Publication
Alternative name(s):
EIICBA-Mtl1 Publication
Short name:
EII-Mtl1 Publication
Including the following 3 domains:
Mannitol permease IIC component1 Publication
Alternative name(s):
PTS system mannitol-specific EIIC component1 Publication
Mannitol-specific phosphotransferase enzyme IIB component1 Publication (EC:2.7.1.1971 Publication1 Publication)
Alternative name(s):
PTS system mannitol-specific EIIB component1 Publication
Mannitol-specific phosphotransferase enzyme IIA component1 Publication
Alternative name(s):
PTS system mannitol-specific EIIA component1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtlA1 Publication
Ordered Locus Names:b3599, JW3573
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23Cytoplasmic1 PublicationAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 45Helical1 PublicationAdd BLAST22
Topological domaini46 – 49Periplasmic1 Publication4
Transmembranei50 – 70Helical1 PublicationAdd BLAST21
Topological domaini71 – 133Cytoplasmic1 PublicationAdd BLAST63
Transmembranei134 – 155Helical1 PublicationAdd BLAST22
Topological domaini156 – 164Periplasmic1 Publication9
Transmembranei165 – 185Helical1 PublicationAdd BLAST21
Topological domaini186 – 272Cytoplasmic1 PublicationAdd BLAST87
Transmembranei273 – 292Helical1 PublicationAdd BLAST20
Topological domaini293 – 312Periplasmic1 PublicationAdd BLAST20
Transmembranei313 – 334Helical1 PublicationAdd BLAST22
Topological domaini335 – 637Cytoplasmic1 PublicationAdd BLAST303

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001866141 – 637PTS system mannitol-specific EIICBA componentAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei384Phosphocysteine; by EIIAPROSITE-ProRule annotation3 Publications1 Publication1
Modified residuei554Phosphohistidine; by HPr4 Publications1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

An intramolecular phosphotransfer takes places between His-554 and Cys-384.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P00550

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P00550

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00550

PRoteomics IDEntifications database

More...
PRIDEi
P00550

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by mannitol. Repressed by MltR.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260741, 18 interactors

Database of interacting proteins

More...
DIPi
DIP-10267N

Protein interaction database and analysis system

More...
IntActi
P00550, 3 interactors

Molecular INTeraction database

More...
MINTi
P00550

STRING: functional protein association networks

More...
STRINGi
511145.b3599

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1637
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00550

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 341PTS EIIC type-2PROSITE-ProRule annotationAdd BLAST330
Domaini378 – 473PTS EIIB type-2PROSITE-ProRule annotationAdd BLAST96
Domaini494 – 636PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST143

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation
The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.PROSITE-ProRule annotation
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CTS Bacteria
COG2213 LUCA
COG4668 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252814

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00550

KEGG Orthology (KO)

More...
KOi
K02798
K02799
K02800

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00550

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05567 PTS_IIB_mannitol, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR036095 PTS_EIIB-like_sf
IPR013011 PTS_EIIB_2
IPR003501 PTS_EIIB_2/3
IPR029503 PTS_EIIB_mannitol
IPR003352 PTS_EIIC
IPR013014 PTS_EIIC_2
IPR004718 PTS_IIC_mtl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
PF02378 PTS_EIIC, 1 hit
PF02302 PTS_IIB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52794 SSF52794, 1 hit
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00851 mtlA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit
PS51099 PTS_EIIB_TYPE_2, 1 hit
PS51104 PTS_EIIC_TYPE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDIKIKVQ SFGRFLSNMV MPNIGAFIAW GIITALFIPT GWLPNETLAK
60 70 80 90 100
LVGPMITYLL PLLIGYTGGK LVGGERGGVV GAITTMGVIV GADMPMFLGS
110 120 130 140 150
MIAGPLGGWC IKHFDRWVDG KIKSGFEMLV NNFSAGIIGM ILAILAFLGI
160 170 180 190 200
GPIVEALSKM LAAGVNFMVV HDMLPLASIF VEPAKILFLN NAINHGIFSP
210 220 230 240 250
LGIQQSHELG KSIFFLIEAN PGPGMGVLLA YMFFGRGSAK QSAGGAAIIH
260 270 280 290 300
FLGGIHEIYF PYVLMNPRLI LAVILGGMTG VFTLTILGGG LVSPASPGSI
310 320 330 340 350
LAVLAMTPKG AYFANIAGVC AAMAVSFVVS AILLKTSKVK EEDDIEAATR
360 370 380 390 400
RMQDMKAESK GASPLSAGDV TNDLSHVRKI IVACDAGMGS SAMGAGVLRK
410 420 430 440 450
KIQDAGLSQI SVTNSAINNL PPDVDLVITH RDLTERAMRQ VPQAQHISLT
460 470 480 490 500
NFLDSGLYTS LTERLVAAQR HTANEEKVKD SLKDSFDDSS ANLFKLGAEN
510 520 530 540 550
IFLGRKAATK EEAIRFAGEQ LVKGGYVEPE YVQAMLDREK LTPTYLGESI
560 570 580 590 600
AVPHGTVEAK DRVLKTGVVF CQYPEGVRFG EEEDDIARLV IGIAARNNEH
610 620 630
IQVITSLTNA LDDESVIERL AHTTSVDEVL ELLAGRK
Length:637
Mass (Da):67,972
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA992992D534BF98D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01503 Genomic DNA Translation: CAA24748.1
U00039 Genomic DNA Translation: AAB18576.1
U00096 Genomic DNA Translation: AAC76623.1
AP009048 Genomic DNA Translation: BAE77694.1
X06794 Genomic DNA Translation: CAA29953.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A00661 WQEC2M

NCBI Reference Sequences

More...
RefSeqi
NP_418056.1, NC_000913.3
WP_000093247.1, NZ_SSZK01000022.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76623; AAC76623; b3599
BAE77694; BAE77694; BAE77694

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948118

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3573
eco:b3599

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3108

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01503 Genomic DNA Translation: CAA24748.1
U00039 Genomic DNA Translation: AAB18576.1
U00096 Genomic DNA Translation: AAC76623.1
AP009048 Genomic DNA Translation: BAE77694.1
X06794 Genomic DNA Translation: CAA29953.1
PIRiA00661 WQEC2M
RefSeqiNP_418056.1, NC_000913.3
WP_000093247.1, NZ_SSZK01000022.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3AX-ray1.80A/B/C/D491-637[»]
1J6TNMR-A491-637[»]
1VKRNMR-A367-489[»]
1VRVNMR-A375-475[»]
2FEWNMR-A491-637[»]
B375-475[»]
SMRiP00550
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260741, 18 interactors
DIPiDIP-10267N
IntActiP00550, 3 interactors
MINTiP00550
STRINGi511145.b3599

Protein family/group databases

TCDBi4.A.2.1.2 the pts fructose-mannitol (fru) family

PTM databases

iPTMnetiP00550

Proteomic databases

EPDiP00550
jPOSTiP00550
PaxDbiP00550
PRIDEiP00550

Genome annotation databases

EnsemblBacteriaiAAC76623; AAC76623; b3599
BAE77694; BAE77694; BAE77694
GeneIDi948118
KEGGiecj:JW3573
eco:b3599
PATRICifig|1411691.4.peg.3108

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0610

Phylogenomic databases

eggNOGiENOG4105CTS Bacteria
COG2213 LUCA
COG4668 LUCA
HOGENOMiHOG000252814
InParanoidiP00550
KOiK02798
K02799
K02800
PhylomeDBiP00550

Enzyme and pathway databases

BioCyciEcoCyc:MTLA-MONOMER
ECOL316407:JW3573-MONOMER
MetaCyc:MTLA-MONOMER
SABIO-RKiP00550

Miscellaneous databases

EvolutionaryTraceiP00550

Protein Ontology

More...
PROi
PR:P00550

Family and domain databases

CDDicd05567 PTS_IIB_mannitol, 1 hit
Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR036095 PTS_EIIB-like_sf
IPR013011 PTS_EIIB_2
IPR003501 PTS_EIIB_2/3
IPR029503 PTS_EIIB_mannitol
IPR003352 PTS_EIIC
IPR013014 PTS_EIIC_2
IPR004718 PTS_IIC_mtl
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
PF02378 PTS_EIIC, 1 hit
PF02302 PTS_IIB, 1 hit
SUPFAMiSSF52794 SSF52794, 1 hit
SSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00851 mtlA, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit
PS51099 PTS_EIIB_TYPE_2, 1 hit
PS51104 PTS_EIIC_TYPE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTM3C_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00550
Secondary accession number(s): Q2M7R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 13, 2019
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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