Cyclin-dependent kinase 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• cyclin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• cyclin-dependent protein serine/threonine kinase activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 2142620
  • 27068241
• histone binding Source: SGDInferred from direct assayⁱ
  • 20855529
• protein serine/threonine kinase activity Source: SGDInferred from direct assayⁱ
  • 16096060
  • 22521784
  • 22563681
  • 22689984
  • 23314252
  • 24319056
  • 25602519
  • 27203178
• RNA polymerase II complex binding Source: SGDInferred from direct assayⁱ
  • 22689984

GO - Biological processⁱ

• 7-methylguanosine mRNA capping Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 22689984
• cell division Source: UniProtKB-KW
• cellular protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 21098119
• DNA double-strand break processing Source: SGDInferred from mutant phenotypeⁱ
  • 21841787
• double-strand break repair via nonhomologous end joining Source: SGDInferred from mutant phenotypeⁱ
  • 22563681
• G1/S transition of mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• meiotic DNA double-strand break processing Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 20150422
• mitotic sister chromatid biorientation Source: SGDInferred from genetic interactionⁱ
  • 22056777
• mitotic spindle assembly Source: SGDInferred from genetic interactionⁱ
  • 21558801
• negative regulation of DNA replication origin binding Source: SGDInferred from genetic interactionⁱ
  • 29388912
• negative regulation of double-strand break repair via nonhomologous end joining Source: SGDInferred from mutant phenotypeⁱ
  • 19699692
• negative regulation of meiotic cell cycle Source: SGDInferred from mutant phenotypeⁱ
  • 12081645
• negative regulation of mitotic cell cycle Source: SGDInferred from direct assayⁱ
  • 10074450
• negative regulation of sister chromatid cohesion Source: SGDInferred from mutant phenotypeⁱ
  • 21549314
• negative regulation of transcription, DNA-templated Source: SGDInferred from direct assayⁱ
  • 14993267
• negative regulation of transcription by RNA polymerase II Source: SGDInferred from mutant phenotypeⁱ
  • 22056777
• peptidyl-serine phosphorylation Source: SGDInferred from direct assayⁱ
  • 23314252
  • 25602519
  • 27203178
• peptidyl-threonine phosphorylation Source: SGDInferred from direct assayⁱ
  • 27068241
• phosphorylation of RNA polymerase II C-terminal domain Source: SGDInferred from direct assayⁱ
  • 22689984
• positive regulation of cell proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of glycogen catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 27203179
• positive regulation of meiotic cell cycle Source: SGDInferred from direct assayⁱ
  • 16814718
• positive regulation of mitotic cell cycle Source: SGDInferred from mutant phenotypeⁱ
  • 2165600
  • 7002718
• positive regulation of mitotic spindle pole body separation Source: SGDInferred from mutant phenotypeⁱ
  • 16688214
  • 8887667
• positive regulation of nuclear cell cycle DNA replication Source: SGDInferred from direct assayⁱ
  • 14747467
• positive regulation of transcription, DNA-templated Source: SGDInferred from direct assayⁱ
  • 1652372
• positive regulation of transcription by RNA polymerase II Source: SGDInferred from mutant phenotypeⁱ
  • 22689984
• positive regulation of trehalose catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 27203179
• positive regulation of triglyceride catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 19150427
• post-Golgi vesicle-mediated transport Source: SGDInferred from mutant phenotypeⁱ
  • 22767578
• protein localization to nuclear periphery Source: SGDInferred from mutant phenotypeⁱ
  • 20702586
• protein localization to nucleus Source: SGDInferred from mutant phenotypeⁱ
  • 19188495
• protein localization to spindle microtubule Source: SGDInferred from mutant phenotypeⁱ
  • 22521784
• protein phosphorylation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of budding cell apical bud growth Source: SGDInferred from mutant phenotypeⁱ
  • 17417630
• regulation of double-strand break repair via homologous recombination Source: SGDInferred from mutant phenotypeⁱ
  • 15496928
• regulation of filamentous growth Source: SGDInferred from mutant phenotypeⁱ
  • 9891070
• regulation of G2/M transition of mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of nucleosome density Source: SGDInferred from mutant phenotypeⁱ
  • 20855529
• regulation of protein localization to chromatin Source: SGDInferred from direct assayⁱ
  • 25602519
• regulation of spindle assembly Source: SGDInferred from mutant phenotypeⁱ
  • 21558801
• regulation of telomere maintenance via telomerase Source: SGDInferred from genetic interactionⁱ
  • 19135888
• synaptonemal complex assembly Source: SGDInferred from mutant phenotypeⁱ
  • 20825495

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cyclin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• histone binding Source: SGDInferred from direct assayⁱ
  • 20855529
• RNA polymerase II complex binding Source: SGDInferred from direct assayⁱ
  • 22689984

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MSGELANYKR LEKVGEGTYG VVYKALDLRP GQGQRVVALK KIRLESEDEG 
        60         70         80         90        100
VPSTAIREIS LLKELKDDNI VRLYDIVHSD AHKLYLVFEF LDLDLKRYME 
       110        120        130        140        150
GIPKDQPLGA DIVKKFMMQL CKGIAYCHSH RILHRDLKPQ NLLINKDGNL 
       160        170        180        190        200
KLGDFGLARA FGVPLRAYTH EIVTLWYRAP EVLLGGKQYS TGVDTWSIGC 
       210        220        230        240        250
IFAEMCNRKP IFSGDSEIDQ IFKIFRVLGT PNEAIWPDIV YLPDFKPSFP 
       260        270        280        290 
QWRRKDLSQV VPSLDPRGID LLDKLLAYDP INRISARRAA IHPYFQES   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
3. Yeast chromosome II
   Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names