Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 188 (07 Oct 2020)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
Add a publicationFeedback
Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

MOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei87ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei201Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi66 – 74ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P00540

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P00540

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P00540

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mosCurated (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172680.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7199, MOS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190060, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4342

Open Targets

More...
OpenTargetsi
ENSG00000172680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30907

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P00540, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075184

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MOS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863441 – 346Proto-oncogene serine/threonine-protein kinase mosAdd BLAST346

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P00540

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P00540

PeptideAtlas

More...
PeptideAtlasi
P00540

PRoteomics IDEntifications database

More...
PRIDEi
P00540

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51265

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P00540

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P00540

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172680, Expressed in oocyte and 18 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P00540, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172680, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P00540
With#Exp.IntAct
ACTN2 [P35609]3EBI-1757866,EBI-77797
ASB6 [Q9NWX5]3EBI-1757866,EBI-6425205
ATRIP [Q8WXE1]3EBI-1757866,EBI-747353
BICD2 - isoform 2 [Q8TD16-2]3EBI-1757866,EBI-11975051
BORCS6 [Q96GS4]4EBI-1757866,EBI-10193358
CALCOCO2 [Q13137]8EBI-1757866,EBI-739580
CBY2 [Q8NA61]3EBI-1757866,EBI-741724
CBY2 - isoform 2 [Q8NA61-2]3EBI-1757866,EBI-11524851
CCDC102B [Q68D86]3EBI-1757866,EBI-10171570
CCDC136 - isoform 2 [Q96JN2-2]3EBI-1757866,EBI-10171416
CCNDBP1 [O95273]3EBI-1757866,EBI-748961
DYDC1 [Q8WWB3]3EBI-1757866,EBI-740680
DZIP1 [Q86YF9]3EBI-1757866,EBI-998108
FKBP5 [Q13451]2EBI-1757866,EBI-306914
GFAP [P14136]3EBI-1757866,EBI-744302
GOLGA2 [Q08379]6EBI-1757866,EBI-618309
GOLGA6A [Q9NYA3]3EBI-1757866,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-1757866,EBI-5916454
GRAP2 [O75791]3EBI-1757866,EBI-740418
HOMER3 [Q9NSC5]8EBI-1757866,EBI-748420
IKZF1 - isoform Ik7 [Q13422-7]3EBI-1757866,EBI-11522367
KCTD6 [Q8NC69]3EBI-1757866,EBI-2511344
KIFAP3 [Q92845]3EBI-1757866,EBI-954040
KIFC3 [Q9BVG8]3EBI-1757866,EBI-2125614
KRT13 [A1A4E9]3EBI-1757866,EBI-10171552
KRT15 [P19012]6EBI-1757866,EBI-739566
KRT27 [Q7Z3Y8]3EBI-1757866,EBI-3044087
KRT31 [Q15323]3EBI-1757866,EBI-948001
KRT33B [Q14525]3EBI-1757866,EBI-1049638
KRT34 [O76011]3EBI-1757866,EBI-1047093
KRT40 [Q6A162]3EBI-1757866,EBI-10171697
LZTS2 [Q9BRK4]3EBI-1757866,EBI-741037
MAP2K2 [P36507]3EBI-1757866,EBI-1056930
MEOX2 [Q6FHY5]3EBI-1757866,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-1757866,EBI-10172526
MIPOL1 [Q8TD10]3EBI-1757866,EBI-2548751
MTMR9 [Q96QG7]6EBI-1757866,EBI-744593
MTUS2 - isoform 2 [Q5JR59-3]4EBI-1757866,EBI-11522433
NOTCH2NLC [P0DPK4]3EBI-1757866,EBI-22310682
PICK1 [Q9NRD5]3EBI-1757866,EBI-79165
PPP2R5A [Q15172]4EBI-1757866,EBI-641666
PSTPIP1 [O43586]3EBI-1757866,EBI-1050964
SEC24C [P53992]4EBI-1757866,EBI-81134
SSX2IP [Q9Y2D8]3EBI-1757866,EBI-2212028
TP53BP2 [Q05BL1]3EBI-1757866,EBI-11952721
TRAF1 [Q13077]6EBI-1757866,EBI-359224
TRAF2 [Q12933]3EBI-1757866,EBI-355744
TRIM27 [P14373]3EBI-1757866,EBI-719493
USHBP1 [Q8N6Y0]6EBI-1757866,EBI-739895
ZBTB2 [Q8N680]3EBI-1757866,EBI-2515601

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110483, 64 interactors

Protein interaction database and analysis system

More...
IntActi
P00540, 79 interactors

Molecular INTeraction database

More...
MINTi
P00540

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310722

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P00540, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 341Protein kinasePROSITE-ProRule annotationAdd BLAST282

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_7_35_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00540

KEGG Orthology (KO)

More...
KOi
K04367

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQRSFWA

Database of Orthologous Groups

More...
OrthoDBi
993493at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00540

TreeFam database of animal gene trees

More...
TreeFami
TF331103

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00540-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL
60 70 80 90 100
AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR
110 120 130 140 150
RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV
160 170 180 190 200
IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL
210 220 230 240 250
DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL
260 270 280 290 300
LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
310 320 330 340
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
Length:346
Mass (Da):37,820
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68B1AB906ED4B308
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04081396R → L1 PublicationCorresponds to variant dbSNP:rs34532635Ensembl.1
Natural variantiVAR_040814105A → S2 PublicationsCorresponds to variant dbSNP:rs35392772Ensembl.1
Natural variantiVAR_040815123A → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040816300S → P1 PublicationCorresponds to variant dbSNP:rs56300224Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00119 Genomic DNA Translation: AAA52029.1
BC069569 mRNA Translation: AAH69569.1
BC069590 mRNA Translation: AAH69590.1
BC106737 mRNA Translation: AAI06738.1
BC106738 mRNA Translation: AAI06739.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6164.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A00649, TVHUMS

NCBI Reference Sequences

More...
RefSeqi
NP_005363.1, NM_005372.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311923; ENSP00000310722; ENSG00000172680

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4342

UCSC genome browser

More...
UCSCi
uc011leb.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA Translation: AAA52029.1
BC069569 mRNA Translation: AAH69569.1
BC069590 mRNA Translation: AAH69590.1
BC106737 mRNA Translation: AAI06738.1
BC106738 mRNA Translation: AAI06739.1
CCDSiCCDS6164.1
PIRiA00649, TVHUMS
RefSeqiNP_005363.1, NM_005372.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110483, 64 interactors
IntActiP00540, 79 interactors
MINTiP00540
STRINGi9606.ENSP00000310722

Chemistry databases

ChEMBLiCHEMBL1075184

PTM databases

iPTMnetiP00540
PhosphoSitePlusiP00540

Polymorphism and mutation databases

BioMutaiMOS
DMDMi125497

Proteomic databases

MassIVEiP00540
PaxDbiP00540
PeptideAtlasiP00540
PRIDEiP00540
ProteomicsDBi51265

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24550, 284 antibodies

The DNASU plasmid repository

More...
DNASUi
4342

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680
GeneIDi4342
KEGGihsa:4342
UCSCiuc011leb.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4342
DisGeNETi4342
EuPathDBiHostDB:ENSG00000172680.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MOS
HGNCiHGNC:7199, MOS
HPAiENSG00000172680, Tissue enriched (testis)
MIMi190060, gene
neXtProtiNX_P00540
OpenTargetsiENSG00000172680
PharmGKBiPA30907

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0192, Eukaryota
GeneTreeiENSGT00940000160233
HOGENOMiCLU_000288_7_35_1
InParanoidiP00540
KOiK04367
OMAiSQRSFWA
OrthoDBi993493at2759
PhylomeDBiP00540
TreeFamiTF331103

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP00540
SignaLinkiP00540
SIGNORiP00540

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4342, 10 hits in 903 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MOS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4342
PharosiP00540, Tbio

Protein Ontology

More...
PROi
PR:P00540
RNActiP00540, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172680, Expressed in oocyte and 18 other tissues
GenevisibleiP00540, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 7, 2020
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again