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Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

MOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87ATPPROSITE-ProRule annotation1
Active sitei201Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 74ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
SignaLinkiP00540

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:MOS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000172680.1
HGNCiHGNC:7199 MOS
MIMi190060 gene
neXtProtiNX_P00540

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4342
OpenTargetsiENSG00000172680
PharmGKBiPA30907

Chemistry databases

ChEMBLiCHEMBL1075184

Polymorphism and mutation databases

BioMutaiMOS
DMDMi125497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863441 – 346Proto-oncogene serine/threonine-protein kinase mosAdd BLAST346

Proteomic databases

PaxDbiP00540
PeptideAtlasiP00540
PRIDEiP00540
ProteomicsDBi51265

PTM databases

iPTMnetiP00540
PhosphoSitePlusiP00540

Expressioni

Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

BgeeiENSG00000172680 Expressed in 13 organ(s), highest expression level in oocyte
CleanExiHS_MOS
GenevisibleiP00540 HS

Organism-specific databases

HPAiHPA040424

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110483, 37 interactors
IntActiP00540, 75 interactors
MINTiP00540
STRINGi9606.ENSP00000310722

Structurei

3D structure databases

ProteinModelPortaliP00540
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 341Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00930000150812
HOGENOMiHOG000290647
HOVERGENiHBG052499
InParanoidiP00540
KOiK04367
OMAiSQRSFWA
OrthoDBiEOG091G0PY9
PhylomeDBiP00540
TreeFamiTF331103

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P00540-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL
60 70 80 90 100
AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR
110 120 130 140 150
RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV
160 170 180 190 200
IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL
210 220 230 240 250
DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL
260 270 280 290 300
LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
310 320 330 340
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
Length:346
Mass (Da):37,820
Last modified:July 21, 1986 - v1
Checksum:i68B1AB906ED4B308
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04081396R → L1 PublicationCorresponds to variant dbSNP:rs34532635Ensembl.1
Natural variantiVAR_040814105A → S2 PublicationsCorresponds to variant dbSNP:rs35392772Ensembl.1
Natural variantiVAR_040815123A → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040816300S → P1 PublicationCorresponds to variant dbSNP:rs56300224Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA Translation: AAA52029.1
BC069569 mRNA Translation: AAH69569.1
BC069590 mRNA Translation: AAH69590.1
BC106737 mRNA Translation: AAI06738.1
BC106738 mRNA Translation: AAI06739.1
CCDSiCCDS6164.1
PIRiA00649 TVHUMS
RefSeqiNP_005363.1, NM_005372.1
UniGeneiHs.533432

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680
GeneIDi4342
KEGGihsa:4342
UCSCiuc011leb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA Translation: AAA52029.1
BC069569 mRNA Translation: AAH69569.1
BC069590 mRNA Translation: AAH69590.1
BC106737 mRNA Translation: AAI06738.1
BC106738 mRNA Translation: AAI06739.1
CCDSiCCDS6164.1
PIRiA00649 TVHUMS
RefSeqiNP_005363.1, NM_005372.1
UniGeneiHs.533432

3D structure databases

ProteinModelPortaliP00540
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110483, 37 interactors
IntActiP00540, 75 interactors
MINTiP00540
STRINGi9606.ENSP00000310722

Chemistry databases

ChEMBLiCHEMBL1075184

PTM databases

iPTMnetiP00540
PhosphoSitePlusiP00540

Polymorphism and mutation databases

BioMutaiMOS
DMDMi125497

Proteomic databases

PaxDbiP00540
PeptideAtlasiP00540
PRIDEiP00540
ProteomicsDBi51265

Protocols and materials databases

DNASUi4342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680
GeneIDi4342
KEGGihsa:4342
UCSCiuc011leb.2 human

Organism-specific databases

CTDi4342
DisGeNETi4342
EuPathDBiHostDB:ENSG00000172680.1
GeneCardsiMOS
HGNCiHGNC:7199 MOS
HPAiHPA040424
MIMi190060 gene
neXtProtiNX_P00540
OpenTargetsiENSG00000172680
PharmGKBiPA30907
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00930000150812
HOGENOMiHOG000290647
HOVERGENiHBG052499
InParanoidiP00540
KOiK04367
OMAiSQRSFWA
OrthoDBiEOG091G0PY9
PhylomeDBiP00540
TreeFamiTF331103

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
SignaLinkiP00540

Miscellaneous databases

GeneWikiiMOS_(gene)
GenomeRNAii4342
PROiPR:P00540
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172680 Expressed in 13 organ(s), highest expression level in oocyte
CleanExiHS_MOS
GenevisibleiP00540 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOS_HUMAN
AccessioniPrimary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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