Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

Mos

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137ATPPROSITE-ProRule annotation1
Active sitei245Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 124ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of MAPKK activity Source: UniProtKB
  • chromatin organization Source: UniProtKB
  • establishment of meiotic spindle orientation Source: UniProtKB
  • meiotic spindle organization Source: UniProtKB
  • negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProtKB
  • positive regulation of MAPK cascade Source: GO_Central
  • protein autophosphorylation Source: UniProtKB
  • regulation of meiotic nuclear division Source: MGI

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:Mos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97052 Mos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863451 – 390Proto-oncogene serine/threonine-protein kinase mosAdd BLAST390

Proteomic databases

PaxDbiP00536
PRIDEiP00536

PTM databases

iPTMnetiP00536
PhosphoSitePlusiP00536

Expressioni

Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

CleanExiMM_MOS

Interactioni

Protein-protein interaction databases

IntActiP00536, 1 interactor
STRINGi10090.ENSMUSP00000100789

Structurei

3D structure databases

ProteinModelPortaliP00536
SMRiP00536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 386Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOVERGENiHBG052499
InParanoidiP00536

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P00536-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLVLRIKEE GKGTGEGSNL QPCSQTSLAV PTHFSLVSHV TVPSEGVMPS
60 70 80 90 100
PLSLCRYLPR ELSPSVDSRS CSIPLVAPRK AGKLFLGTTP PRAPGLPRRL
110 120 130 140 150
AWFSIDWEQV CLMHRLGSGG FGSVYKATYH GVPVAIKQVN KCTKDLRASQ
160 170 180 190 200
RSFWAELNIA RLRHDNIVRV VAASTRTPED SNSLGTIIME FGGNVTLHQV
210 220 230 240 250
IYGATRSPEP LSCREQLSLG KCLKYSLDVV NGLLFLHSQS ILHLDLKPAN
260 270 280 290 300
ILISEQDVCK ISDFGCSQKL QDLRCRQASP HHIGGTYTHQ APEILKGEIA
310 320 330 340 350
TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PSLAGAVFTA
360 370 380 390
SLTGKTLQNI IQSCWEARAL QRPGAELLQR DLKAFRGALG
Length:390
Mass (Da):42,875
Last modified:July 27, 2011 - v2
Checksum:i2F38ABEA747BDA38
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UHW1F6UHW1_MOUSE
Moloney sarcoma oncogene
Mos
343Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15G → GI no nucleotide entry (PubMed:6173134).Curated1
Sequence conflicti15G → GI no nucleotide entry (PubMed:6292737).Curated1
Sequence conflicti21Missing no nucleotide entry (PubMed:6173134).Curated1
Sequence conflicti21Missing no nucleotide entry (PubMed:6292737).Curated1
Sequence conflicti272D → V no nucleotide entry (PubMed:6173134).Curated1
Sequence conflicti374G → C no nucleotide entry (PubMed:6173134).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807387 Genomic DNA No translation available.
PIRiA00645 TVMSM
UniGeneiMm.459300

Genome annotation databases

UCSCiuc008rwo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807387 Genomic DNA No translation available.
PIRiA00645 TVMSM
UniGeneiMm.459300

3D structure databases

ProteinModelPortaliP00536
SMRiP00536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00536, 1 interactor
STRINGi10090.ENSMUSP00000100789

PTM databases

iPTMnetiP00536
PhosphoSitePlusiP00536

Proteomic databases

PaxDbiP00536
PRIDEiP00536

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008rwo.1 mouse

Organism-specific databases

MGIiMGI:97052 Mos

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOVERGENiHBG052499
InParanoidiP00536

Enzyme and pathway databases

BRENDAi2.7.10.2 3474

Miscellaneous databases

PROiPR:P00536
SOURCEiSearch...

Gene expression databases

CleanExiMM_MOS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOS_MOUSE
AccessioniPrimary (citable) accession number: P00536
Secondary accession number(s): E9PV67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again