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Protein

Tyrosine-protein kinase transforming protein Abl

Gene

ABL

Organism
Abelson murine leukemia virus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

This protein is synthesized as a Gag-Abl polyprotein.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157ATPPROSITE-ProRule annotation1
Active sitei249Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 142ATPPROSITE-ProRule annotation9
Nucleotide bindingi202 – 208ATPPROSITE-ProRule annotation7

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 1
SABIO-RKiP00521

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Abl (EC:2.7.10.2)
Alternative name(s):
V-abl
Gene namesi
Name:ABL
OrganismiAbelson murine leukemia virus
Taxonomic identifieri11788 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Chemistry databases

ChEMBLiCHEMBL5166
DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB05489 ACA 125
DB03878 N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
DB02567 PD173955

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880571 – 746Tyrosine-protein kinase transforming protein AblAdd BLAST746

Proteomic databases

PRIDEiP00521

Interactioni

Protein-protein interaction databases

IntActiP00521, 1 interactor

Chemistry databases

BindingDBiP00521

Structurei

3D structure databases

ProteinModelPortaliP00521
SMRiP00521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 103SH2PROSITE-ProRule annotationAdd BLAST91
Domaini128 – 379Protein kinasePROSITE-ProRule annotationAdd BLAST252

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 291Kinase activation loopBy similarityAdd BLAST25

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

P00521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
YITPVNSLEK HSWYHGPVSR NAAEYLLSSG INGSFLVRES ESSPGQRSIS
60 70 80 90 100
LRYEGRVYHY RINTASDGKL YVSSESRFNT LAELVHHHST VADGLITTLH
110 120 130 140 150
YPAPKRNKPT IYGVSPNYDK WEMERTDITM KHKLGGGQYG EVYEGVWKKY
160 170 180 190 200
SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTREPPFYII
210 220 230 240 250
TEFMTYGNLL DYLRECNRQE VSAVVLLYMA TQISSAMEYL EKKNFIHRDL
260 270 280 290 300
AARNCLVGEN HLVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN
310 320 330 340 350
KFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYELLEK DYRMERPEGC
360 370 380 390 400
PEKVYELMRA CWQWNPSDRP SFAEIHQAFE TMFQESSISD EVEKELGKRG
410 420 430 440 450
TRGGAGSMLQ APELPTKTRT CRRAAEQKAS PPSLTPKLLR RQVTASPSSG
460 470 480 490 500
LSHKKEATKG SASGMGTPAT AEPAPPSNKV GLSKASSEEM RVRRHKHSSE
510 520 530 540 550
SPGRDKGRLA KLKPAPPPPP ACTGKAGKPA QSPSQEAGEA GGPTKTKCTS
560 570 580 590 600
LAMDAVNTDP TKAGPPGEGL RKPVPPSVPK PQSTAKPPGT PTSPVSTPST
610 620 630 640 650
APAPSPLAGD QQPSSAAFIP LISTRVSLRK TRQPPERIAS GTITKGVVLD
660 670 680 690 700
STEALCLAIS RNSEQMASHS AVLEAGKNLY TFCVSYVDSI QQMRNKFAFR
710 720 730 740
EAINKLESNL RELQICPATA SSGPAATQDF SKLLSSVKEI SDIVRR
Length:746
Mass (Da):81,872
Last modified:July 21, 1986 - v1
Checksum:iB9072FFF55FE9257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01541 Genomic DNA No translation available.
K00010 Genomic RNA Translation: AAA46470.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01541 Genomic DNA No translation available.
K00010 Genomic RNA Translation: AAA46470.1

3D structure databases

ProteinModelPortaliP00521
SMRiP00521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00521, 1 interactor

Chemistry databases

BindingDBiP00521
ChEMBLiCHEMBL5166
DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB05489 ACA 125
DB03878 N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
DB02567 PD173955

Proteomic databases

PRIDEiP00521

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2 1
SABIO-RKiP00521

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABL_MLVAB
AccessioniPrimary (citable) accession number: P00521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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