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UniProtKB - P00505 (AATM_HUMAN)

Entry version 221 (29 Sep 2021)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
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Protein

Aspartate aminotransferase, mitochondrial

Gene

GOT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.

2 Publications

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 8.5.1 Publication

Temperature dependencei

Optimum temperature is 47.5 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei65Substrate; via amide nitrogenBy similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei215SubstrateBy similarity1
Binding sitei407SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
Biological processLipid transport, Transport
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS04858-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.6.1.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P00505

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1614558, Degradation of cysteine and homocysteine
R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-70263, Gluconeogenesis
R-HSA-8963693, Aspartate and asparagine metabolism
R-HSA-8964539, Glutamate and glutamine metabolism

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.70.1.1, the aspartate amino transferase (aat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate aminotransferase, mitochondrial (EC:2.6.1.12 Publications, EC:2.6.1.7By similarity)
Short name:
mAspAT
Alternative name(s):
Fatty acid-binding protein
Short name:
FABP-1
Glutamate oxaloacetate transaminase 2
Kynurenine aminotransferase 4
Kynurenine aminotransferase IV
Kynurenine--oxoglutarate transaminase 4
Kynurenine--oxoglutarate transaminase IV
Plasma membrane-associated fatty acid-binding protein
Short name:
FABPpm
Transaminase A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOT2Imported
Synonyms:KYAT4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4433, GOT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P00505

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125166

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental and epileptic encephalopathy 82 (DEE82)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE82 is an autosomal recessive metabolic encephalopathy characterized by epilepsy from the first year of life, global developmental delay, hypotonia and feeding difficulties apparent soon after birth, and intellectual and motor disabilities. Other features include poor overall growth, progressive microcephaly and biochemical abnormalities, including increased serum lactate and ammonia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083488209Missing in DEE82; unknown pathological significance. 1 Publication1
Natural variantiVAR_083489262R → G in DEE82; decreased glutamate oxaloacetate transferase activity. 1 PublicationCorresponds to variant dbSNP:rs752927520EnsemblClinVar.1
Natural variantiVAR_083490337R → G in DEE82; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1247507359EnsemblClinVar.1
Natural variantiVAR_083491366G → V in DEE82; unknown pathological significance; decreased glutamate oxaloacetate transferase activity. 1 PublicationCorresponds to variant dbSNP:rs1597696047EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		2806

MalaCards human disease database

More...MalaCardsi		GOT2
MIMi618721, phenotype

Open Targets

More...OpenTargetsi		ENSG00000125166

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28818

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P00505, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4524033

Drug and drug target database

More...DrugBanki		DB02783, 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB00128, Aspartic acid
DB00151, Cysteine
DB00142, Glutamic acid
DB00114, Pyridoxal phosphate

DrugCentral

More...DrugCentrali		P00505

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153643

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionCombined sources1 PublicationAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000121530 – 430Aspartate aminotransferase, mitochondrialAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphothreonineCombined sources1
Modified residuei59N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysine; alternateCombined sources1
Modified residuei73N6-succinyllysine; alternateBy similarity1
Modified residuei82N6-acetyllysineBy similarity1
Modified residuei90N6-acetyllysine; alternateCombined sources1
Modified residuei90N6-succinyllysine; alternateBy similarity1
Modified residuei963'-nitrotyrosine; alternateBy similarity1
Modified residuei96Phosphotyrosine; alternateCombined sources1
Modified residuei107N6-acetyllysine; alternateBy similarity1
Modified residuei107N6-succinyllysine; alternateBy similarity1
Modified residuei122N6-acetyllysine; alternateBy similarity1
Modified residuei122N6-succinyllysine; alternateBy similarity1
Modified residuei143PhosphoserineCombined sources1
Modified residuei159N6-acetyllysine; alternateCombined sources1
Modified residuei159N6-succinyllysine; alternateBy similarity1
Modified residuei185N6-acetyllysine; alternateBy similarity1
Modified residuei185N6-succinyllysine; alternateBy similarity1
Modified residuei227N6-succinyllysineBy similarity1
Modified residuei234N6-acetyllysineCombined sources1
Modified residuei279N6-(pyridoxal phosphate)lysine; alternateBy similarity1
Modified residuei279N6-acetyllysine; alternateBy similarity1
Modified residuei296N6-acetyllysine; alternateCombined sources1
Modified residuei296N6-succinyllysine; alternateBy similarity1
Modified residuei302N6-acetyllysineBy similarity1
Modified residuei309N6-acetyllysine; alternateBy similarity1
Modified residuei309N6-succinyllysine; alternateBy similarity1
Modified residuei313Asymmetric dimethylarginineBy similarity1
Modified residuei333PhosphothreonineCombined sources1
Modified residuei338N6-acetyllysine; alternateBy similarity1
Modified residuei338N6-succinyllysine; alternateBy similarity1
Modified residuei345N6-acetyllysineBy similarity1
Modified residuei363N6-acetyllysine; alternateBy similarity1
Modified residuei363N6-succinyllysine; alternateBy similarity1
Modified residuei364N6-acetyllysineBy similarity1
Modified residuei387N6-acetyllysineBy similarity1
Modified residuei396N6-acetyllysine; alternateCombined sources1
Modified residuei396N6-succinyllysine; alternateBy similarity1
Modified residuei404N6-acetyllysine; alternateCombined sources1
Modified residuei404N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Methylation, Nitration, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-518
CPTAC-519

Encyclopedia of Proteome Dynamics

More...EPDi		P00505

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P00505

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P00505

MaxQB - The MaxQuant DataBase

More...MaxQBi		P00505

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P00505

PeptideAtlas

More...PeptideAtlasi		P00505

PRoteomics IDEntifications database

More...PRIDEi		P00505

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17864
51258 [P00505-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P00505-1 [P00505-1]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P00505

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P00505, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P00505

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P00505

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P00505

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P00505

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by long-time exposure to alcohol.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125166, Expressed in vastus lateralis and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P00505, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P00505, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125166, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109068, 49 interactors

Protein interaction database and analysis system

More...IntActi		P00505, 18 interactors

Molecular INTeraction database

More...MINTi		P00505

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000245206

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P00505, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P00505

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1411, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032440_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P00505

Identification of Orthologs from Complete Genome Data

More...OMAi		VGACTIV

Database of Orthologous Groups

More...OrthoDBi		1104596at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P00505

TreeFam database of animal gene trees

More...TreeFami		TF300641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004839, Aminotransferase_I/II
IPR000796, Asp_trans
IPR004838, NHTrfase_class1_PyrdxlP-BS
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major
IPR015422, PyrdxlP-dep_Trfase_small

The PANTHER Classification System

More...PANTHERi		PTHR11879, PTHR11879, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00155, Aminotran_1_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00799, TRANSAMINASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53383, SSF53383, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00105, AA_TRANSFER_CLASS_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P00505-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA 
        60         70         80         90        100
FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG 
       110        120        130        140        150
GLAEFCKASA ELALGENSEV LKSGRFVTVQ TISGTGALRI GASFLQRFFK 
       160        170        180        190        200
FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR YYDPKTCGFD FTGAVEDISK 
       210        220        230        240        250
IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA 
       260        270        280        290        300
SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE 
       310        320        330        340        350
AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR 
       360        370        380        390        400
IIGMRTQLVS NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI 
       410        420        430
YMTKDGRISV AGVTSSNVGY LAHAIHQVTK
Length:430
Mass (Da):47,518
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF559567ABF2DB346
GO
Isoform 2 (identifier: P00505-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-125: Missing.

Show »
Length:387
Mass (Da):43,030
Checksum:iFF09030A2B5C4E62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRE7H3BRE7_HUMAN
Aspartate aminotransferase, mitocho...
GOT2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110 – 111AE → EA AA sequence (PubMed:4052435).Curated2
Sequence conflicti255D → N AA sequence (PubMed:4052435).Curated1
Sequence conflicti258A → T in BAD96991 (Ref. 3) Curated1
Sequence conflicti305E → Q AA sequence (PubMed:4052435).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554942A → S. Corresponds to variant dbSNP:rs11558171Ensembl.1
Natural variantiVAR_031710188G → S. Corresponds to variant dbSNP:rs11076256Ensembl.1
Natural variantiVAR_083488209Missing in DEE82; unknown pathological significance. 1 Publication1
Natural variantiVAR_083489262R → G in DEE82; decreased glutamate oxaloacetate transferase activity. 1 PublicationCorresponds to variant dbSNP:rs752927520EnsemblClinVar.1
Natural variantiVAR_083490337R → G in DEE82; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1247507359EnsemblClinVar.1
Natural variantiVAR_031711346V → G3 PublicationsCorresponds to variant dbSNP:rs30842Ensembl.1
Natural variantiVAR_083491366G → V in DEE82; unknown pathological significance; decreased glutamate oxaloacetate transferase activity. 1 PublicationCorresponds to variant dbSNP:rs1597696047EnsemblClinVar.1
Natural variantiVAR_031712428V → A1 PublicationCorresponds to variant dbSNP:rs17849335Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05484883 – 125Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M22632 mRNA Translation: AAA35568.1
AK295993 mRNA Translation: BAG58768.1
AK223271 mRNA Translation: BAD96991.1
AC012183 Genomic DNA No translation available.
BC000525 mRNA Translation: AAH00525.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10801.1 [P00505-1]
CCDS67045.1 [P00505-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A31873, XNHUDM

NCBI Reference Sequences

More...RefSeqi		NP_001273149.1, NM_001286220.1 [P00505-2]
NP_002071.2, NM_002080.3 [P00505-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1]
ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2806

UCSC genome browser

More...UCSCi		uc002eof.2, human [P00505-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22632 mRNA Translation: AAA35568.1
AK295993 mRNA Translation: BAG58768.1
AK223271 mRNA Translation: BAD96991.1
AC012183 Genomic DNA No translation available.
BC000525 mRNA Translation: AAH00525.1
CCDSiCCDS10801.1 [P00505-1]
CCDS67045.1 [P00505-2]
PIRiA31873, XNHUDM
RefSeqiNP_001273149.1, NM_001286220.1 [P00505-2]
NP_002071.2, NM_002080.3 [P00505-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AX8X-ray2.99A/B/C/D30-430[»]
SMRiP00505
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109068, 49 interactors
IntActiP00505, 18 interactors
MINTiP00505
STRINGi9606.ENSP00000245206

Chemistry databases

ChEMBLiCHEMBL4524033
DrugBankiDB02783, 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB00128, Aspartic acid
DB00151, Cysteine
DB00142, Glutamic acid
DB00114, Pyridoxal phosphate
DrugCentraliP00505

Protein family/group databases

TCDBi9.A.70.1.1, the aspartate amino transferase (aat) family

PTM databases

GlyGeniP00505, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP00505
MetOSiteiP00505
PhosphoSitePlusiP00505
SwissPalmiP00505

Genetic variation databases

BioMutaiGOT2
DMDMi308153643

2D gel databases

UCD-2DPAGEiP00505

Proteomic databases

CPTACiCPTAC-518
CPTAC-519
EPDiP00505
jPOSTiP00505
MassIVEiP00505
MaxQBiP00505
PaxDbiP00505
PeptideAtlasiP00505
PRIDEiP00505
ProteomicsDBi17864
51258 [P00505-1]
TopDownProteomicsiP00505-1 [P00505-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15396, 637 antibodies

The DNASU plasmid repository

More...DNASUi		2806

Genome annotation databases

EnsembliENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1]
ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2]
GeneIDi2806
KEGGihsa:2806
UCSCiuc002eof.2, human [P00505-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2806
DisGeNETi2806

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOT2
HGNCiHGNC:4433, GOT2
HPAiENSG00000125166, Tissue enhanced (skeletal)
MalaCardsiGOT2
MIMi138150, gene
618721, phenotype
neXtProtiNX_P00505
OpenTargetsiENSG00000125166
PharmGKBiPA28818
VEuPathDBiHostDB:ENSG00000125166

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1411, Eukaryota
GeneTreeiENSGT00950000183082
HOGENOMiCLU_032440_1_2_1
InParanoidiP00505
OMAiVGACTIV
OrthoDBi1104596at2759
PhylomeDBiP00505
TreeFamiTF300641

Enzyme and pathway databases

BioCyciMetaCyc:HS04858-MONOMER
BRENDAi2.6.1.1, 2681
PathwayCommonsiP00505
ReactomeiR-HSA-1614558, Degradation of cysteine and homocysteine
R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-70263, Gluconeogenesis
R-HSA-8963693, Aspartate and asparagine metabolism
R-HSA-8964539, Glutamate and glutamine metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2806, 146 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GOT2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GOT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2806
PharosiP00505, Tbio

Protein Ontology

More...PROi		PR:P00505
RNActiP00505, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125166, Expressed in vastus lateralis and 245 other tissues
ExpressionAtlasiP00505, baseline and differential
GenevisibleiP00505, HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839, Aminotransferase_I/II
IPR000796, Asp_trans
IPR004838, NHTrfase_class1_PyrdxlP-BS
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major
IPR015422, PyrdxlP-dep_Trfase_small
PANTHERiPTHR11879, PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155, Aminotran_1_2, 1 hit
PRINTSiPR00799, TRANSAMINASE
SUPFAMiSSF53383, SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105, AA_TRANSFER_CLASS_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAATM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00505
Secondary accession number(s): B4DJA6
, E7ERW2, Q53FL3, Q9BWA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 221 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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