UniProtKB - P00505 (AATM_HUMAN)
Protein
Aspartate aminotransferase, mitochondrial
Gene
GOT2
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.2 Publications
Miscellaneous
In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Catalytic activityi
Cofactori
pH dependencei
Optimum pH is 8.5.1 Publication
Temperature dependencei
Optimum temperature is 47.5 degrees Celsius.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 65 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 162 | SubstrateBy similarity | 1 | |
Binding sitei | 215 | SubstrateBy similarity | 1 | |
Binding sitei | 407 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- amino acid binding Source: Ensembl
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- kynurenine-oxoglutarate transaminase activity Source: UniProtKB-EC
- L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB
- phospholipid binding Source: Ensembl
- pyridoxal phosphate binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- 2-oxoglutarate metabolic process Source: UniProtKB
- 4-hydroxyproline catabolic process Source: BHF-UCL
- aspartate biosynthetic process Source: Ensembl
- aspartate catabolic process Source: UniProtKB
- aspartate metabolic process Source: UniProtKB
- cellular amino acid biosynthetic process Source: Reactome
- fatty acid transport Source: UniProtKB
- female pregnancy Source: Ensembl
- gluconeogenesis Source: Reactome
- glutamate catabolic process to 2-oxoglutarate Source: Ensembl
- glutamate catabolic process to aspartate Source: Ensembl
- glutamate metabolic process Source: UniProtKB
- glyoxylate metabolic process Source: Reactome
- lactation Source: Ensembl
- oxaloacetate metabolic process Source: Ensembl
- response to ethanol Source: UniProtKB
- response to insulin Source: Ensembl
- response to morphine Source: Ensembl
- response to muscle activity Source: Ensembl
Keywordsi
Molecular function | Aminotransferase, Transferase |
Biological process | Lipid transport, Transport |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04858-MONOMER |
PathwayCommonsi | P00505 |
Reactomei | R-HSA-1614558, Degradation of cysteine and homocysteine R-HSA-389661, Glyoxylate metabolism and glycine degradation R-HSA-70263, Gluconeogenesis R-HSA-8963693, Aspartate and asparagine metabolism R-HSA-8964539, Glutamate and glutamine metabolism |
Protein family/group databases
TCDBi | 9.A.70.1.1, the aspartate amino transferase (aat) family |
Names & Taxonomyi
Protein namesi | Recommended name: Aspartate aminotransferase, mitochondrial (EC:2.6.1.12 Publications, EC:2.6.1.7)Short name: mAspAT Alternative name(s): Fatty acid-binding protein Short name: FABP-1 Glutamate oxaloacetate transaminase 2 Kynurenine aminotransferase 4 Kynurenine aminotransferase IV Kynurenine--oxoglutarate transaminase 4 Kynurenine--oxoglutarate transaminase IV Plasma membrane-associated fatty acid-binding protein Short name: FABPpm Transaminase A |
Gene namesi | Name:GOT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125166.12 |
HGNCi | HGNC:4433, GOT2 |
MIMi | 138150, gene |
neXtProti | NX_P00505 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Mitochondrion
- Mitochondrion matrix 1 Publication
Note: Exposure to alcohol promotes translocation to the cell membrane.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrial inner membrane Source: Ensembl
- mitochondrial matrix Source: Reactome
- mitochondrion Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- T-tubule Source: Ensembl
Other locations
- cell surface Source: Ensembl
- perikaryon Source: Ensembl
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Membrane, MitochondrionPathology & Biotechi
Involvement in diseasei
Epileptic encephalopathy, early infantile, 82 (EIEE82)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE82 is an autosomal recessive metabolic encephalopathy characterized by epilepsy from the first year of life, global developmental delay, hypotonia and feeding difficulties apparent soon after birth, and intellectual and motor disabilities. Other features include poor overall growth, progressive microcephaly and biochemical abnormalities, including increased serum lactate and ammonia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083488 | 209 | Missing in EIEE82; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083489 | 262 | R → G in EIEE82; decreased glutamate oxaloacetate transferase activity. 1 Publication | 1 | |
Natural variantiVAR_083490 | 337 | R → G in EIEE82; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1247507359EnsemblClinVar. | 1 | |
Natural variantiVAR_083491 | 366 | G → V in EIEE82; unknown pathological significance; decreased glutamate oxaloacetate transferase activity. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, EpilepsyOrganism-specific databases
DisGeNETi | 2806 |
MalaCardsi | GOT2 |
MIMi | 618721, phenotype |
OpenTargetsi | ENSG00000125166 |
PharmGKBi | PA28818 |
Miscellaneous databases
Pharosi | P00505, Tbio |
Chemistry databases
DrugBanki | DB02783, 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate DB00128, Aspartic acid DB00151, Cysteine DB00142, Glutamic acid DB00114, Pyridoxal phosphate |
DrugCentrali | P00505 |
Polymorphism and mutation databases
BioMutai | GOT2 |
DMDMi | 308153643 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 29 | MitochondrionCombined sources1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000001215 | 30 – 430 | Aspartate aminotransferase, mitochondrialAdd BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 59 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 73 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 73 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 82 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 90 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 90 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 96 | 3'-nitrotyrosine; alternateBy similarity | 1 | |
Modified residuei | 96 | Phosphotyrosine; alternateCombined sources | 1 | |
Modified residuei | 107 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 107 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 122 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 122 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 159 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 185 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 185 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 227 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 234 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 279 | N6-(pyridoxal phosphate)lysine; alternateBy similarity | 1 | |
Modified residuei | 279 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 296 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 296 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 302 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 309 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 309 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 313 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 333 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 338 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 338 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 345 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 363 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 363 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 364 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 387 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 396 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 396 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 404 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 404 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, Nitration, PhosphoproteinProteomic databases
CPTACi | CPTAC-518 CPTAC-519 |
EPDi | P00505 |
jPOSTi | P00505 |
MassIVEi | P00505 |
MaxQBi | P00505 |
PaxDbi | P00505 |
PeptideAtlasi | P00505 |
PRIDEi | P00505 |
ProteomicsDBi | 17864 51258 [P00505-1] |
TopDownProteomicsi | P00505-1 [P00505-1] |
2D gel databases
UCD-2DPAGEi | P00505 |
PTM databases
iPTMneti | P00505 |
MetOSitei | P00505 |
PhosphoSitePlusi | P00505 |
SwissPalmi | P00505 |
Expressioni
Inductioni
Up-regulated by long-time exposure to alcohol.1 Publication
Gene expression databases
Bgeei | ENSG00000125166, Expressed in vastus lateralis and 244 other tissues |
ExpressionAtlasi | P00505, baseline and differential |
Genevisiblei | P00505, HS |
Organism-specific databases
HPAi | ENSG00000125166, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homodimer.
GO - Molecular functioni
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109068, 42 interactors |
IntActi | P00505, 17 interactors |
MINTi | P00505 |
STRINGi | 9606.ENSP00000245206 |
Miscellaneous databases
RNActi | P00505, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P00505 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1411, Eukaryota |
GeneTreei | ENSGT00950000183082 |
HOGENOMi | CLU_032440_1_2_1 |
InParanoidi | P00505 |
OMAi | VGACTIV |
OrthoDBi | 1104596at2759 |
PhylomeDBi | P00505 |
TreeFami | TF300641 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR000796, Asp_trans IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11879, PTHR11879, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PRINTSi | PR00799, TRANSAMINASE |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P00505-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA
60 70 80 90 100
FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG
110 120 130 140 150
GLAEFCKASA ELALGENSEV LKSGRFVTVQ TISGTGALRI GASFLQRFFK
160 170 180 190 200
FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR YYDPKTCGFD FTGAVEDISK
210 220 230 240 250
IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA
260 270 280 290 300
SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE
310 320 330 340 350
AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR
360 370 380 390 400
IIGMRTQLVS NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI
410 420 430
YMTKDGRISV AGVTSSNVGY LAHAIHQVTK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BRE7 | H3BRE7_HUMAN | Aspartate transaminase | GOT2 | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 – 111 | AE → EA AA sequence (PubMed:4052435).Curated | 2 | |
Sequence conflicti | 255 | D → N AA sequence (PubMed:4052435).Curated | 1 | |
Sequence conflicti | 258 | A → T in BAD96991 (Ref. 3) Curated | 1 | |
Sequence conflicti | 305 | E → Q AA sequence (PubMed:4052435).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055494 | 2 | A → S. Corresponds to variant dbSNP:rs11558171Ensembl. | 1 | |
Natural variantiVAR_031710 | 188 | G → S. Corresponds to variant dbSNP:rs11076256Ensembl. | 1 | |
Natural variantiVAR_083488 | 209 | Missing in EIEE82; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083489 | 262 | R → G in EIEE82; decreased glutamate oxaloacetate transferase activity. 1 Publication | 1 | |
Natural variantiVAR_083490 | 337 | R → G in EIEE82; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1247507359EnsemblClinVar. | 1 | |
Natural variantiVAR_031711 | 346 | V → G3 PublicationsCorresponds to variant dbSNP:rs30842Ensembl. | 1 | |
Natural variantiVAR_083491 | 366 | G → V in EIEE82; unknown pathological significance; decreased glutamate oxaloacetate transferase activity. 1 Publication | 1 | |
Natural variantiVAR_031712 | 428 | V → A1 PublicationCorresponds to variant dbSNP:rs17849335Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054848 | 83 – 125 | Missing in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22632 mRNA Translation: AAA35568.1 AK295993 mRNA Translation: BAG58768.1 AK223271 mRNA Translation: BAD96991.1 AC012183 Genomic DNA No translation available. BC000525 mRNA Translation: AAH00525.1 |
CCDSi | CCDS10801.1 [P00505-1] CCDS67045.1 [P00505-2] |
PIRi | A31873, XNHUDM |
RefSeqi | NP_001273149.1, NM_001286220.1 [P00505-2] NP_002071.2, NM_002080.3 [P00505-1] |
Genome annotation databases
Ensembli | ENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1] ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2] |
GeneIDi | 2806 |
KEGGi | hsa:2806 |
UCSCi | uc002eof.2, human [P00505-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22632 mRNA Translation: AAA35568.1 AK295993 mRNA Translation: BAG58768.1 AK223271 mRNA Translation: BAD96991.1 AC012183 Genomic DNA No translation available. BC000525 mRNA Translation: AAH00525.1 |
CCDSi | CCDS10801.1 [P00505-1] CCDS67045.1 [P00505-2] |
PIRi | A31873, XNHUDM |
RefSeqi | NP_001273149.1, NM_001286220.1 [P00505-2] NP_002071.2, NM_002080.3 [P00505-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5AX8 | X-ray | 2.99 | A/B/C/D | 30-430 | [»] | |
SMRi | P00505 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109068, 42 interactors |
IntActi | P00505, 17 interactors |
MINTi | P00505 |
STRINGi | 9606.ENSP00000245206 |
Chemistry databases
DrugBanki | DB02783, 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate DB00128, Aspartic acid DB00151, Cysteine DB00142, Glutamic acid DB00114, Pyridoxal phosphate |
DrugCentrali | P00505 |
Protein family/group databases
TCDBi | 9.A.70.1.1, the aspartate amino transferase (aat) family |
PTM databases
iPTMneti | P00505 |
MetOSitei | P00505 |
PhosphoSitePlusi | P00505 |
SwissPalmi | P00505 |
Polymorphism and mutation databases
BioMutai | GOT2 |
DMDMi | 308153643 |
2D gel databases
UCD-2DPAGEi | P00505 |
Proteomic databases
CPTACi | CPTAC-518 CPTAC-519 |
EPDi | P00505 |
jPOSTi | P00505 |
MassIVEi | P00505 |
MaxQBi | P00505 |
PaxDbi | P00505 |
PeptideAtlasi | P00505 |
PRIDEi | P00505 |
ProteomicsDBi | 17864 51258 [P00505-1] |
TopDownProteomicsi | P00505-1 [P00505-1] |
Protocols and materials databases
Antibodypediai | 15396, 619 antibodies |
DNASUi | 2806 |
Genome annotation databases
Ensembli | ENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1] ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2] |
GeneIDi | 2806 |
KEGGi | hsa:2806 |
UCSCi | uc002eof.2, human [P00505-1] |
Organism-specific databases
CTDi | 2806 |
DisGeNETi | 2806 |
EuPathDBi | HostDB:ENSG00000125166.12 |
GeneCardsi | GOT2 |
HGNCi | HGNC:4433, GOT2 |
HPAi | ENSG00000125166, Tissue enhanced (skeletal) |
MalaCardsi | GOT2 |
MIMi | 138150, gene 618721, phenotype |
neXtProti | NX_P00505 |
OpenTargetsi | ENSG00000125166 |
PharmGKBi | PA28818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1411, Eukaryota |
GeneTreei | ENSGT00950000183082 |
HOGENOMi | CLU_032440_1_2_1 |
InParanoidi | P00505 |
OMAi | VGACTIV |
OrthoDBi | 1104596at2759 |
PhylomeDBi | P00505 |
TreeFami | TF300641 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04858-MONOMER |
PathwayCommonsi | P00505 |
Reactomei | R-HSA-1614558, Degradation of cysteine and homocysteine R-HSA-389661, Glyoxylate metabolism and glycine degradation R-HSA-70263, Gluconeogenesis R-HSA-8963693, Aspartate and asparagine metabolism R-HSA-8964539, Glutamate and glutamine metabolism |
Miscellaneous databases
BioGRID-ORCSi | 2806, 143 hits in 845 CRISPR screens |
ChiTaRSi | GOT2, human |
GeneWikii | GOT2 |
GenomeRNAii | 2806 |
Pharosi | P00505, Tbio |
PROi | PR:P00505 |
RNActi | P00505, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125166, Expressed in vastus lateralis and 244 other tissues |
ExpressionAtlasi | P00505, baseline and differential |
Genevisiblei | P00505, HS |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR000796, Asp_trans IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11879, PTHR11879, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PRINTSi | PR00799, TRANSAMINASE |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AATM_HUMAN | |
Accessioni | P00505Primary (citable) accession number: P00505 Secondary accession number(s): B4DJA6 Q9BWA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 217 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations