GOT2

Functionⁱ

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.1 Publication

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Catalytic activityⁱ

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.1 Publication

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.

Cofactorⁱ

pyridoxal 5'-phosphate

pH dependenceⁱ

Optimum pH is 8.5.1 Publication

Temperature dependenceⁱ

Optimum temperature is 47.5 degrees Celsius.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	65	Substrate; via amide nitrogenBy similarity	1
Binding siteⁱ	162	SubstrateBy similarity	1
Binding siteⁱ	215	SubstrateBy similarity	1
Binding siteⁱ	407	SubstrateBy similarity	1

GO - Molecular functionⁱ

4-hydroxyglutamate transaminase activity Source: Reactome
amino acid binding Source: Ensembl
enzyme binding Source: Ensembl
kynurenine-oxoglutarate transaminase activity Source: UniProtKB-EC
L-aspartate:2-oxoglutarate aminotransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
phospholipid binding Source: Ensembl
protein homodimerization activity Source: Ensembl
pyridoxal phosphate binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

2-oxoglutarate metabolic process Source: UniProtKB
4-hydroxyproline catabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 21998747
aspartate biosynthetic process Source: Ensembl
aspartate catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 2567216
aspartate metabolic process Source: UniProtKB
cellular amino acid biosynthetic process Source: Reactome
fatty acid transport
Source: UniProtKB
Inferred from expression patternⁱ
- 9537447
female pregnancy Source: Ensembl
gluconeogenesis Source: Reactome
glutamate catabolic process to 2-oxoglutarate Source: Ensembl
glutamate catabolic process to aspartate Source: Ensembl
glutamate metabolic process Source: UniProtKB
glyoxylate metabolic process Source: Reactome
lactation Source: Ensembl
oxaloacetate metabolic process Source: Ensembl
response to ethanol
Source: UniProtKB
Inferred from direct assayⁱ
- 9537447
response to insulin Source: Ensembl
response to morphine Source: Ensembl
response to muscle activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminotransferase, Transferase
Biological process	Lipid transport, Transport
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04858-MONOMER
Reactomeⁱ	R-HSA-1614558 Degradation of cysteine and homocysteine R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-70263 Gluconeogenesis R-HSA-70614 Amino acid synthesis and interconversion (transamination)

Protein family/group databases

TCDBⁱ	9.A.70.1.1 the aspartate amino transferase (aat) family

TCDBⁱ

9.A.70.1.1 the aspartate amino transferase (aat) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aspartate aminotransferase, mitochondrial (EC:2.6.1.11 Publication, EC:2.6.1.7) Short name: mAspAT Alternative name(s): Fatty acid-binding protein Short name: FABP-1 Glutamate oxaloacetate transaminase 2 Kynurenine aminotransferase 4 Kynurenine aminotransferase IV Kynurenine--oxoglutarate transaminase 4 Kynurenine--oxoglutarate transaminase IV Plasma membrane-associated fatty acid-binding protein Short name: FABPpm Transaminase A
Gene namesⁱ	Name:GOT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125166.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4433 GOT2
MIMⁱ	138150 gene
neXtProtⁱ	NX_P00505

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2806
Open Targets More...OpenTargetsⁱ	ENSG00000125166
PharmGKBⁱ	PA28818

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB00114 Pyridoxal Phosphate

DrugBankⁱ

DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB00128 L-Aspartic Acid
DB00142 L-Glutamic Acid
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaⁱ	GOT2
DMDMⁱ	308153643

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 29	MitochondrionCombined sources1 PublicationAdd BLAST		29
ChainⁱPRO_0000001215	30 – 430	Aspartate aminotransferase, mitochondrialAdd BLAST		401

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	48	PhosphothreonineCombined sources	1
Modified residueⁱ	59	N6-acetyllysineBy similarity	1
Modified residueⁱ	73	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	73	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	82	N6-acetyllysineBy similarity	1
Modified residueⁱ	90	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	90	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	96	Nitrated tyrosine; alternateBy similarity	1
Modified residueⁱ	96	Phosphotyrosine; alternateCombined sources	1
Modified residueⁱ	107	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	107	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	122	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	122	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	159	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	159	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	185	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	185	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	227	N6-succinyllysineBy similarity	1
Modified residueⁱ	234	N6-acetyllysineCombined sources	1
Modified residueⁱ	279	N6-(pyridoxal phosphate)lysine; alternateBy similarity	1
Modified residueⁱ	279	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	296	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	296	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	302	N6-acetyllysineBy similarity	1
Modified residueⁱ	309	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	309	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	313	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	333	PhosphothreonineCombined sources	1
Modified residueⁱ	338	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	338	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	345	N6-acetyllysineBy similarity	1
Modified residueⁱ	363	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	363	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	364	N6-acetyllysineBy similarity	1
Modified residueⁱ	387	N6-acetyllysineBy similarity	1
Modified residueⁱ	396	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	396	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	404	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	404	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Nitration, Phosphoprotein

Proteomic databases

EPDⁱ	P00505
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00505
PaxDbⁱ	P00505
PeptideAtlas More...PeptideAtlasⁱ	P00505
PRIDEⁱ	P00505
ProteomicsDBⁱ	51258
TopDownProteomicsⁱ	P00505-1 [P00505-1]

2D gel databases

UCD-2DPAGEⁱ	P00505

UCD-2DPAGEⁱ

P00505

PTM databases

iPTMnetⁱ	P00505
PhosphoSitePlusⁱ	P00505
SwissPalmⁱ	P00505

Expressionⁱ

Inductionⁱ

Up-regulated by long-time exposure to alcohol.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000125166 Expressed in 231 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_GOT2
ExpressionAtlasⁱ	P00505 baseline and differential
Genevisibleⁱ	P00505 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018139

HPAⁱ

HPA018139

Interactionⁱ

Subunit structureⁱ

Homodimer.

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109068, 22 interactors
IntActⁱ	P00505, 10 interactors
Molecular INTeraction database More...MINTⁱ	P00505
STRINGⁱ	9606.ENSP00000245206

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	43 – 53	Combined sources	11
Helixⁱ	78 – 88	Combined sources	11
Turnⁱ	89 – 91	Combined sources	3
Helixⁱ	103 – 114	Combined sources	12
Helixⁱ	119 – 123	Combined sources	5
Beta strandⁱ	126 – 132	Combined sources	7
Helixⁱ	133 – 148	Combined sources	16
Beta strandⁱ	153 – 159	Combined sources	7
Helixⁱ	165 – 172	Combined sources	8
Beta strandⁱ	175 – 180	Combined sources	6
Turnⁱ	184 – 187	Combined sources	4
Helixⁱ	191 – 198	Combined sources	8
Beta strandⁱ	206 – 213	Combined sources	8
Helixⁱ	223 – 236	Combined sources	14
Beta strandⁱ	239 – 246	Combined sources	8
Turnⁱ	247 – 251	Combined sources	5
Helixⁱ	254 – 257	Combined sources	4
Helixⁱ	259 – 266	Combined sources	8
Beta strandⁱ	272 – 276	Combined sources	5
Turnⁱ	278 – 280	Combined sources	3
Turnⁱ	284 – 287	Combined sources	4
Beta strandⁱ	288 – 294	Combined sources	7
Helixⁱ	298 – 315	Combined sources	18
Beta strandⁱ	316 – 318	Combined sources	3
Helixⁱ	321 – 332	Combined sources	12
Helixⁱ	334 – 364	Combined sources	31
Helixⁱ	372 – 376	Combined sources	5
Beta strandⁱ	379 – 383	Combined sources	5
Helixⁱ	388 – 398	Combined sources	11
Beta strandⁱ	406 – 409	Combined sources	4
Helixⁱ	410 – 412	Combined sources	3
Helixⁱ	415 – 428	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P00505
SMRⁱ	P00505
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1411 Eukaryota COG1448 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014081
HOGENOMⁱ	HOG000185898
HOVERGENⁱ	HBG000951
InParanoidⁱ	P00505
KEGG Orthology (KO) More...KOⁱ	K14455
OMAⁱ	RVGACTI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06G3
PhylomeDBⁱ	P00505
TreeFamⁱ	TF300641

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 2 hits
InterProⁱ	View protein in InterPro IPR004839 Aminotransferase_I/II IPR000796 Asp_trans IPR004838 NHTrfase_class1_PyrdxlP-BS IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR11879 PTHR11879, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit
PRINTSⁱ	PR00799 TRANSAMINASE
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
PROSITEⁱ	View protein in PROSITE PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P00505-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA 
        60         70         80         90        100
FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG 
       110        120        130        140        150
GLAEFCKASA ELALGENSEV LKSGRFVTVQ TISGTGALRI GASFLQRFFK 
       160        170        180        190        200
FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR YYDPKTCGFD FTGAVEDISK 
       210        220        230        240        250
IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA 
       260        270        280        290        300
SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE 
       310        320        330        340        350
AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR 
       360        370        380        390        400
IIGMRTQLVS NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI 
       410        420        430
YMTKDGRISV AGVTSSNVGY LAHAIHQVTK

Length:430

Mass (Da):47,518

Last modified:October 5, 2010 - v3

Checksum:ⁱF559567ABF2DB346

GO

Isoform 2 (identifier: P00505-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
83-125: Missing.

« Hide

        10         20         30         40         50
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA 
        60         70         80         90        100
FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKFVTVQTIS GTGALRIGAS 
       110        120        130        140        150
FLQRFFKFSR DVFLPKPTWG NHTPIFRDAG MQLQGYRYYD PKTCGFDFTG 
       160        170        180        190        200
AVEDISKIPE QSVLLLHACA HNPTGVDPRP EQWKEIATVV KKRNLFAFFD 
       210        220        230        240        250
MAYQGFASGD GDKDAWAVRH FIEQGINVCL CQSYAKNMGL YGERVGAFTM 
       260        270        280        290        300
VCKDADEAKR VESQLKILIR PMYSNPPLNG ARIAAAILNT PDLRKQWLQE 
       310        320        330        340        350
VKVMADRIIG MRTQLVSNLK KEGSTHNWQH ITDQIGMFCF TGLKPEQVER 
       360        370        380 
LIKEFSIYMT KDGRISVAGV TSSNVGYLAH AIHQVTK

Show »

Length:387

Mass (Da):43,030

Checksum:ⁱFF09030A2B5C4E62

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BRE7	H3BRE7_HUMAN		Aspartate aminotransferase, mitocho... Aspartate aminotransferase, mitochondrial	GOT2	59	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	110 – 111	AE → EA AA sequence (PubMed:4052435).Curated	2
Sequence conflictⁱ	255	D → N AA sequence (PubMed:4052435).Curated	1
Sequence conflictⁱ	258	A → T in BAD96991 (Ref. 3) Curated	1
Sequence conflictⁱ	305	E → Q AA sequence (PubMed:4052435).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055494	2	A → S. Corresponds to variant dbSNP:rs11558171Ensembl.	1
Natural variantⁱVAR_031710	188	G → S. Corresponds to variant dbSNP:rs11076256Ensembl.	1
Natural variantⁱVAR_031711	346	V → G3 PublicationsCorresponds to variant dbSNP:rs30842Ensembl.	1
Natural variantⁱVAR_031712	428	V → A1 PublicationCorresponds to variant dbSNP:rs17849335Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054848	83 – 125	Missing in isoform 2. 1 PublicationAdd BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22632 mRNA Translation: AAA35568.1 AK295993 mRNA Translation: BAG58768.1 AK223271 mRNA Translation: BAD96991.1 AC012183 Genomic DNA No translation available. BC000525 mRNA Translation: AAH00525.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10801.1 [P00505-1] CCDS67045.1 [P00505-2]
PIRⁱ	A31873 XNHUDM
NCBI Reference Sequences More...RefSeqⁱ	NP_001273149.1, NM_001286220.1 [P00505-2] NP_002071.2, NM_002080.3 [P00505-1]
UniGeneⁱ	Hs.599470

Genome annotation databases

Ensemblⁱ	ENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1] ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2]
GeneIDⁱ	2806
KEGGⁱ	hsa:2806
UCSC genome browser More...UCSCⁱ	uc002eof.2 human [P00505-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00505	Aspartate aminotransferase, mitochondrial		RAT		430	UniRef90_P00507
Aspartate aminotransferase, mitochondrial		BOVIN		430
Aspartate aminotransferase, mitochondrial		MACFA		430
Aspartate aminotransferase, mitochondrial	)	MOUSE		430
Aspartate aminotransferase, mitochondrial		PIG		430
+139
P00505-2	Aspartate aminotransferase		PANTR		387	UniRef90_P00505-2
Aspartate aminotransferase		SAIBB		387
Aspartate aminotransferase		Cebus capucinus imitator		387
Aspartate aminotransferase		MACMU		387
Aspartate aminotransferase		PAPAN		387
+24

Protein	Similar proteins		Species	Score	Length	Source
P00505	Aspartate aminotransferase, mitochondrial		RAT		430	UniRef50_P00507
Aspartate aminotransferase, mitochondrial	)	MOUSE		430
Aspartate aminotransferase, mitochondrial		BOVIN		430
Aspartate aminotransferase, mitochondrial		PONAB		430
Aspartate aminotransferase, mitochondrial		PIG		430
+289
P00505-2	Aspartate aminotransferase, mitochondrial		DICDI		426	UniRef50_P00505-2
Aspartate aminotransferase		RHIRO		387
Aspartate aminotransferase		RHIBE		387
Aspartate aminotransferase		ODORO		387
Aspartate aminotransferase		LEPWE		387
+446

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22632 mRNA Translation: AAA35568.1 AK295993 mRNA Translation: BAG58768.1 AK223271 mRNA Translation: BAD96991.1 AC012183 Genomic DNA No translation available. BC000525 mRNA Translation: AAH00525.1
CCDSⁱ	CCDS10801.1 [P00505-1] CCDS67045.1 [P00505-2]
PIRⁱ	A31873 XNHUDM
RefSeqⁱ	NP_001273149.1, NM_001286220.1 [P00505-2] NP_002071.2, NM_002080.3 [P00505-1]
UniGeneⁱ	Hs.599470

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5AX8	X-ray	2.99	A/B/C/D	30-430	[»]
ProteinModelPortalⁱ	P00505
SMRⁱ	P00505
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109068, 22 interactors
IntActⁱ	P00505, 10 interactors
MINTⁱ	P00505
STRINGⁱ	9606.ENSP00000245206

Chemistry databases

DrugBankⁱ	DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB00114 Pyridoxal Phosphate

DrugBankⁱ

DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB00128 L-Aspartic Acid
DB00142 L-Glutamic Acid
DB00114 Pyridoxal Phosphate

Protein family/group databases

TCDBⁱ	9.A.70.1.1 the aspartate amino transferase (aat) family

TCDBⁱ

9.A.70.1.1 the aspartate amino transferase (aat) family

PTM databases

iPTMnetⁱ	P00505
PhosphoSitePlusⁱ	P00505
SwissPalmⁱ	P00505

Polymorphism and mutation databases

BioMutaⁱ	GOT2
DMDMⁱ	308153643

2D gel databases

UCD-2DPAGEⁱ	P00505

UCD-2DPAGEⁱ

P00505

Proteomic databases

EPDⁱ	P00505
MaxQBⁱ	P00505
PaxDbⁱ	P00505
PeptideAtlasⁱ	P00505
PRIDEⁱ	P00505
ProteomicsDBⁱ	51258
TopDownProteomicsⁱ	P00505-1 [P00505-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2806
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000245206; ENSP00000245206; ENSG00000125166 [P00505-1] ENST00000434819; ENSP00000394100; ENSG00000125166 [P00505-2]
GeneIDⁱ	2806
KEGGⁱ	hsa:2806
UCSCⁱ	uc002eof.2 human [P00505-1]

Organism-specific databases

CTDⁱ	2806
DisGeNETⁱ	2806
EuPathDBⁱ	HostDB:ENSG00000125166.12
GeneCardsⁱ	GOT2
H-InvDBⁱ	HIX0013095
HGNCⁱ	HGNC:4433 GOT2
HPAⁱ	HPA018139
MIMⁱ	138150 gene
neXtProtⁱ	NX_P00505
OpenTargetsⁱ	ENSG00000125166
PharmGKBⁱ	PA28818
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1411 Eukaryota COG1448 LUCA
GeneTreeⁱ	ENSGT00390000014081
HOGENOMⁱ	HOG000185898
HOVERGENⁱ	HBG000951
InParanoidⁱ	P00505
KOⁱ	K14455
OMAⁱ	RVGACTI
OrthoDBⁱ	EOG091G06G3
PhylomeDBⁱ	P00505
TreeFamⁱ	TF300641

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04858-MONOMER
Reactomeⁱ	R-HSA-1614558 Degradation of cysteine and homocysteine R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-70263 Gluconeogenesis R-HSA-70614 Amino acid synthesis and interconversion (transamination)

Miscellaneous databases

ChiTaRSⁱ	GOT2 human
GeneWikiⁱ	GOT2
GenomeRNAiⁱ	2806
Protein Ontology More...PROⁱ	PR:P00505
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125166 Expressed in 231 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_GOT2
ExpressionAtlasⁱ	P00505 baseline and differential
Genevisibleⁱ	P00505 HS

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 2 hits
InterProⁱ	View protein in InterPro IPR004839 Aminotransferase_I/II IPR000796 Asp_trans IPR004838 NHTrfase_class1_PyrdxlP-BS IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR11879 PTHR11879, 1 hit
Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit
PRINTSⁱ	PR00799 TRANSAMINASE
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
PROSITEⁱ	View protein in PROSITE PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AATM_HUMAN
Accessionⁱ	P00505Primary (citable) accession number: P00505 Secondary accession number(s): B4DJA6 , E7ERW2, Q53FL3, Q9BWA3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	October 5, 2010
	Last modified:	September 12, 2018
	This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P00505 (AATM_HUMAN)

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Aspartate aminotransferase, mitochondrial

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Temperature dependencei

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Mitochondrion

Extracellular region or secreted

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

pH dependenceⁱ

Temperature dependenceⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ