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Entry version 229 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

HPRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.4 µM for IMP1 Publication
  2. KM=0.45 µM for hypoxanthine1 Publication
  3. KM=25 µM for pyrophosphate1 Publication
  4. KM=31 µM for phosphoribosylpyrophosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine. This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei69GMP1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei138Proton acceptorCurated1
Binding sitei166GMP1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi194Magnesium1
Binding sitei194GMP; via carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi134 – 142GMP1 Publication9
Nucleotide bindingi186 – 188GMP1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS09275-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.4.2.8, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P00492

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-74217, Purine salvage

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P00492

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00591;UER00648

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.82 Publications)
Short name:
HGPRT
Short name:
HGPRTase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPRT1
Synonyms:HPRT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:5157, HPRT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
308000, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P00492

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000165704

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lesch-Nyhan syndrome (LNS)15 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0067518V → G in LNS; HB. 1
Natural variantiVAR_0716098Missing in LNS; Asia. 1 Publication1
Natural variantiVAR_00675216G → D in LNS; FG. 1
Natural variantiVAR_01231228Missing in LNS; Asia. 2 Publications1
Natural variantiVAR_00675641L → P in LNS; Detroit. Corresponds to variant dbSNP:rs137852480EnsemblClinVar.1
Natural variantiVAR_00675742I → F in LNS; Isar. 1 Publication1
Natural variantiVAR_00675842I → T in LNS; Heapey. 1
Natural variantiVAR_00675943 – 44MD → RN in LNS; Salamanca. 2
Natural variantiVAR_07161144D → Y in LNS; Japan. 1 Publication1
Natural variantiVAR_00676045R → K in LNS; RJK 2163. 1 PublicationCorresponds to variant dbSNP:rs137852491EnsemblClinVar.1
Natural variantiVAR_00676350A → P in LNS; LW. Corresponds to variant dbSNP:rs1556026984EnsemblClinVar.1
Natural variantiVAR_00676250A → V in LNS; 1265. 1 Publication1
Natural variantiVAR_00676551R → P in LNS; Banbury. 1
Natural variantiVAR_00676954M → L in LNS; Japan-1. 1 Publication1
Natural variantiVAR_00677057M → T in LNS; Montreal. 1 PublicationCorresponds to variant dbSNP:rs137852495EnsemblClinVar.1
Natural variantiVAR_07161364A → P in LNS; Asia. 2 Publications1
Natural variantiVAR_07161465L → P in LNS; Asia. 2 Publications1
Natural variantiVAR_00677370G → E in LNS; New Haven/1510, Asia. 3 PublicationsCorresponds to variant dbSNP:rs137852487EnsemblClinVar.1
Natural variantiVAR_00677471G → R in LNS; Yale. 1 PublicationCorresponds to variant dbSNP:rs137852488EnsemblClinVar.1
Natural variantiVAR_07161572Y → C in LNS; Asia. 2 Publications1
Natural variantiVAR_00677574F → L in LNS; Flint/RJK 892/DW/Perth/1522, Japan. 4 PublicationsCorresponds to variant dbSNP:rs137852481EnsemblClinVar.1
Natural variantiVAR_07161678L → Q in LNS; Asia. 2 Publications1
Natural variantiVAR_071617107 – 110Missing in LNS; Asia. 1 Publication4
Natural variantiVAR_006780130V → D in LNS; Midland/RJK 896. 2 PublicationsCorresponds to variant dbSNP:rs137852483EnsemblClinVar.1
Natural variantiVAR_006781131L → S in LNS; RJK 1784. 1 Publication1
Natural variantiVAR_006783132I → T in LNS; Runcorn. 1
Natural variantiVAR_006785143M → K in LNS; RJK 1210. 1 PublicationCorresponds to variant dbSNP:rs137852496EnsemblClinVar.1
Natural variantiVAR_006786143M → MA in LNS; RW. 1
Natural variantiVAR_071619147L → P in LNS; Asia. 2 Publications1
Natural variantiVAR_071620159K → E in LNS; Asia. 2 Publications1
Natural variantiVAR_071621159K → KV in LNS; Asia. 1 Publication1
Natural variantiVAR_006788162S → R in LNS; Farnham. 1
Natural variantiVAR_006790176P → L in LNS; Marlow. Corresponds to variant dbSNP:rs137852493EnsemblClinVar.1
Natural variantiVAR_006791177D → V in LNS; Roanne. 1 Publication1
Natural variantiVAR_006792177D → Y in LNS; RJK 2185. 1 PublicationCorresponds to variant dbSNP:rs137852492EnsemblClinVar.1
Natural variantiVAR_006793179Missing in LNS; Michigan. 1
Natural variantiVAR_006795188V → A in GOUT-HPRT AND LNS; Asia. 3 Publications1
Natural variantiVAR_006798194D → N in LNS; Kinston/RJK 2188. 2 PublicationsCorresponds to variant dbSNP:rs267606863EnsemblClinVar.1
Natural variantiVAR_006800199F → V in LNS; New Briton/RJK 950. 1 PublicationCorresponds to variant dbSNP:rs137852486EnsemblClinVar.1
Natural variantiVAR_006803201D → Y in LNS; GM. 1
Natural variantiVAR_006804204H → D in LNS; RJK 1874. 1 PublicationCorresponds to variant dbSNP:rs137852490EnsemblClinVar.1
Natural variantiVAR_006805204H → R in LNS; 779. 1 Publication1
Natural variantiVAR_006806206C → Y in LNS; Reading/RJK 1727. 1 Publication1
Gout HPRT-related (GOUT-HPRT)12 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by partial enzyme activity and hyperuricemia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0067507G → D in GOUT-HPRT; Gravesend. 1
Natural variantiVAR_00675316G → S in GOUT-HPRT; Urangan. Corresponds to variant dbSNP:rs137852499EnsemblClinVar.1
Natural variantiVAR_00675420D → V in GOUT-HPRT; Mashad; strongly reduces enzymatic activity. 1 Publication1
Natural variantiVAR_07161023C → F in GOUT-HPRT; Reduces enzymatic activity. 1 Publication1
Natural variantiVAR_00675523C → W in GOUT-HPRT; JS. 1
Natural variantiVAR_00676148R → H in GOUT-HPRT; AD and DD. Corresponds to variant dbSNP:rs387906725EnsemblClinVar.1
Natural variantiVAR_00676451R → G in GOUT-HPRT; Toronto. 1 PublicationCorresponds to variant dbSNP:rs137852494EnsemblClinVar.1
Natural variantiVAR_00676753V → A in GOUT-HPRT; MG. 1
Natural variantiVAR_00676853V → M in GOUT-HPRT; TE. 1
Natural variantiVAR_00677158G → R in GOUT-HPRT; Toowong. Corresponds to variant dbSNP:rs137852500EnsemblClinVar.1
Natural variantiVAR_07161260H → R in GOUT-HPRT; Reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs1228634091Ensembl.1
Natural variantiVAR_00677678L → V in GOUT-HPRT; Swan. Corresponds to variant dbSNP:rs137852501EnsemblClinVar.1
Natural variantiVAR_00677780D → V in GOUT-HPRT; Arlington. Corresponds to variant dbSNP:rs137852478EnsemblClinVar.1
Natural variantiVAR_006778104S → R in GOUT-HPRT; Munich. 2 PublicationsCorresponds to variant dbSNP:rs137852485EnsemblClinVar.1
Natural variantiVAR_006779110S → L in GOUT-HPRT; London. 2 PublicationsCorresponds to variant dbSNP:rs137852482EnsemblClinVar.1
Natural variantiVAR_071618124T → P in GOUT-HPRT; Asia. 1 Publication1
Natural variantiVAR_006782132I → M in GOUT-HPRT; Ann-Arbor. 1 PublicationCorresponds to variant dbSNP:rs137852477EnsemblClinVar.1
Natural variantiVAR_006784135D → G in GOUT-HPRT; Yeronga. 1
Natural variantiVAR_006787161A → S in GOUT-HPRT; Milwaukee/RJK 949. 1 PublicationCorresponds to variant dbSNP:rs137852484EnsemblClinVar.1
Natural variantiVAR_006789168T → I in GOUT-HPRT; Brisbane. 1 PublicationCorresponds to variant dbSNP:rs137852498EnsemblClinVar.1
Natural variantiVAR_006794179 – 180VG → GR in GOUT-HPRT; Japan-2. 2
Natural variantiVAR_006796183I → T in GOUT-HPRT; JF. 1 Publication1
Natural variantiVAR_071622185D → G in GOUT-HPRT; Asia. 1 Publication1
Natural variantiVAR_006795188V → A in GOUT-HPRT AND LNS; Asia. 3 Publications1
Natural variantiVAR_071623192A → V in GOUT-HPRT; Asia. 2 Publications1
Natural variantiVAR_006797194D → E in GOUT-HPRT; Moose-Jaw; results in cooperativity and decreased substrate affinities. 1 PublicationCorresponds to variant dbSNP:rs137852504EnsemblClinVar.1
Natural variantiVAR_006799195Y → C in GOUT-HPRT; Dirranbandi, Asia. 2 Publications1
Natural variantiVAR_006801201D → G in GOUT-HPRT; Ashville. 1 PublicationCorresponds to variant dbSNP:rs137852479EnsemblClinVar.1
Natural variantiVAR_006802201D → N in GOUT-HPRT; RB. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69K → A: Reduced affinity for hypoxanthine, phosphoribosylpyrophosphate and IMP. Reduced catalytic activity. 1 Publication1

Keywords - Diseasei

Disease variant, Gout

Organism-specific databases

DisGeNET

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DisGeNETi
3251

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
HPRT1

MalaCards human disease database

More...
MalaCardsi
HPRT1
MIMi300322, phenotype
300323, phenotype

Open Targets

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OpenTargetsi
ENSG00000165704

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79233, Hypoxanthine guanine phosphoribosyltransferase partial deficiency
510, Lesch-Nyhan syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P00492, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2360

Drug and drug target database

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DrugBanki
DB03153, 3H-pyrazolo[4,3-d]pyrimidin-7-ol
DB02309, 5-monophosphate-9-beta-D-ribofuranosyl xanthine
DB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate
DB04356, 9-Deazaguanine
DB00993, Azathioprine
DB01033, Mercaptopurine
DB00352, Tioguanine

DrugCentral

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DrugCentrali
P00492

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HPRT1

Domain mapping of disease mutations (DMDM)

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DMDMi
123497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001395852 – 218Hypoxanthine-guanine phosphoribosyltransferaseAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei103N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei142PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-216

Encyclopedia of Proteome Dynamics

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EPDi
P00492

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P00492

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P00492

MaxQB - The MaxQuant DataBase

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MaxQBi
P00492

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00492

PeptideAtlas

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PeptideAtlasi
P00492

PRoteomics IDEntifications database

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PRIDEi
P00492

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51257

Consortium for Top Down Proteomics

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TopDownProteomicsi
P00492

2D gel databases

USC-OGP 2-DE database

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OGPi
P00492

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00218493

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P00492, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00492

MetOSite database of methionine sulfoxide sites

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MetOSitei
P00492

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00492

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P00492

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165704, Expressed in oocyte and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00492, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P00492, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000165704, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109488, 70 interactors

Protein interaction database and analysis system

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IntActi
P00492, 30 interactors

Molecular INTeraction database

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MINTi
P00492

STRING: functional protein association networks

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STRINGi
9606.ENSP00000298556

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P00492

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P00492, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P00492

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00492

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3367, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_073615_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P00492

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMDWMAV

Database of Orthologous Groups

More...
OrthoDBi
1537610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P00492

TreeFam database of animal gene trees

More...
TreeFami
TF313367

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06223, PRTases_typeI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.2020, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005904, Hxn_phspho_trans
IPR000836, PRibTrfase_dom
IPR029057, PRTase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00156, Pribosyltran, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53271, SSF53271, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01203, HGPRTase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00103, PUR_PYR_PR_TRANSFER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P00492-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA
60 70 80 90 100
RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI
110 120 130 140 150
RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV
160 170 180 190 200
RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR
210
DLNHVCVISE TGKAKYKA
Length:218
Mass (Da):24,579
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1928EE69517CCB40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0067507G → D in GOUT-HPRT; Gravesend. 1
Natural variantiVAR_0067518V → G in LNS; HB. 1
Natural variantiVAR_0716098Missing in LNS; Asia. 1 Publication1
Natural variantiVAR_00675216G → D in LNS; FG. 1
Natural variantiVAR_00675316G → S in GOUT-HPRT; Urangan. Corresponds to variant dbSNP:rs137852499EnsemblClinVar.1
Natural variantiVAR_00675420D → V in GOUT-HPRT; Mashad; strongly reduces enzymatic activity. 1 Publication1
Natural variantiVAR_07161023C → F in GOUT-HPRT; Reduces enzymatic activity. 1 Publication1
Natural variantiVAR_00675523C → W in GOUT-HPRT; JS. 1
Natural variantiVAR_01231228Missing in LNS; Asia. 2 Publications1
Natural variantiVAR_00675641L → P in LNS; Detroit. Corresponds to variant dbSNP:rs137852480EnsemblClinVar.1
Natural variantiVAR_00675742I → F in LNS; Isar. 1 Publication1
Natural variantiVAR_00675842I → T in LNS; Heapey. 1
Natural variantiVAR_00675943 – 44MD → RN in LNS; Salamanca. 2
Natural variantiVAR_07161144D → Y in LNS; Japan. 1 Publication1
Natural variantiVAR_00676045R → K in LNS; RJK 2163. 1 PublicationCorresponds to variant dbSNP:rs137852491EnsemblClinVar.1
Natural variantiVAR_00676148R → H in GOUT-HPRT; AD and DD. Corresponds to variant dbSNP:rs387906725EnsemblClinVar.1
Natural variantiVAR_00676350A → P in LNS; LW. Corresponds to variant dbSNP:rs1556026984EnsemblClinVar.1
Natural variantiVAR_00676250A → V in LNS; 1265. 1 Publication1
Natural variantiVAR_00676451R → G in GOUT-HPRT; Toronto. 1 PublicationCorresponds to variant dbSNP:rs137852494EnsemblClinVar.1
Natural variantiVAR_00676551R → P in LNS; Banbury. 1
Natural variantiVAR_00676652D → G in Edinburgh. 1 PublicationCorresponds to variant dbSNP:rs137852502EnsemblClinVar.1
Natural variantiVAR_00676753V → A in GOUT-HPRT; MG. 1
Natural variantiVAR_00676853V → M in GOUT-HPRT; TE. 1
Natural variantiVAR_00676954M → L in LNS; Japan-1. 1 Publication1
Natural variantiVAR_00677057M → T in LNS; Montreal. 1 PublicationCorresponds to variant dbSNP:rs137852495EnsemblClinVar.1
Natural variantiVAR_00677158G → R in GOUT-HPRT; Toowong. Corresponds to variant dbSNP:rs137852500EnsemblClinVar.1
Natural variantiVAR_07161260H → R in GOUT-HPRT; Reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs1228634091Ensembl.1
Natural variantiVAR_00677261H → R Enzyme activity 37% of normal; asymptomatic. 1 Publication1
Natural variantiVAR_07161364A → P in LNS; Asia. 2 Publications1
Natural variantiVAR_07161465L → P in LNS; Asia. 2 Publications1
Natural variantiVAR_00677370G → E in LNS; New Haven/1510, Asia. 3 PublicationsCorresponds to variant dbSNP:rs137852487EnsemblClinVar.1
Natural variantiVAR_00677471G → R in LNS; Yale. 1 PublicationCorresponds to variant dbSNP:rs137852488EnsemblClinVar.1
Natural variantiVAR_07161572Y → C in LNS; Asia. 2 Publications1
Natural variantiVAR_00677574F → L in LNS; Flint/RJK 892/DW/Perth/1522, Japan. 4 PublicationsCorresponds to variant dbSNP:rs137852481EnsemblClinVar.1
Natural variantiVAR_07161678L → Q in LNS; Asia. 2 Publications1
Natural variantiVAR_00677678L → V in GOUT-HPRT; Swan. Corresponds to variant dbSNP:rs137852501EnsemblClinVar.1
Natural variantiVAR_00677780D → V in GOUT-HPRT; Arlington. Corresponds to variant dbSNP:rs137852478EnsemblClinVar.1
Natural variantiVAR_006778104S → R in GOUT-HPRT; Munich. 2 PublicationsCorresponds to variant dbSNP:rs137852485EnsemblClinVar.1
Natural variantiVAR_071617107 – 110Missing in LNS; Asia. 1 Publication4
Natural variantiVAR_006779110S → L in GOUT-HPRT; London. 2 PublicationsCorresponds to variant dbSNP:rs137852482EnsemblClinVar.1
Natural variantiVAR_071618124T → P in GOUT-HPRT; Asia. 1 Publication1
Natural variantiVAR_006780130V → D in LNS; Midland/RJK 896. 2 PublicationsCorresponds to variant dbSNP:rs137852483EnsemblClinVar.1
Natural variantiVAR_006781131L → S in LNS; RJK 1784. 1 Publication1
Natural variantiVAR_006782132I → M in GOUT-HPRT; Ann-Arbor. 1 PublicationCorresponds to variant dbSNP:rs137852477EnsemblClinVar.1
Natural variantiVAR_006783132I → T in LNS; Runcorn. 1
Natural variantiVAR_006784135D → G in GOUT-HPRT; Yeronga. 1
Natural variantiVAR_006785143M → K in LNS; RJK 1210. 1 PublicationCorresponds to variant dbSNP:rs137852496EnsemblClinVar.1
Natural variantiVAR_006786143M → MA in LNS; RW. 1
Natural variantiVAR_071619147L → P in LNS; Asia. 2 Publications1
Natural variantiVAR_071620159K → E in LNS; Asia. 2 Publications1
Natural variantiVAR_071621159K → KV in LNS; Asia. 1 Publication1
Natural variantiVAR_006787161A → S in GOUT-HPRT; Milwaukee/RJK 949. 1 PublicationCorresponds to variant dbSNP:rs137852484EnsemblClinVar.1
Natural variantiVAR_006788162S → R in LNS; Farnham. 1
Natural variantiVAR_006789168T → I in GOUT-HPRT; Brisbane. 1 PublicationCorresponds to variant dbSNP:rs137852498EnsemblClinVar.1
Natural variantiVAR_006790176P → L in LNS; Marlow. Corresponds to variant dbSNP:rs137852493EnsemblClinVar.1
Natural variantiVAR_006791177D → V in LNS; Roanne. 1 Publication1
Natural variantiVAR_006792177D → Y in LNS; RJK 2185. 1 PublicationCorresponds to variant dbSNP:rs137852492EnsemblClinVar.1
Natural variantiVAR_006794179 – 180VG → GR in GOUT-HPRT; Japan-2. 2
Natural variantiVAR_006793179Missing in LNS; Michigan. 1
Natural variantiVAR_006796183I → T in GOUT-HPRT; JF. 1 Publication1
Natural variantiVAR_071622185D → G in GOUT-HPRT; Asia. 1 Publication1
Natural variantiVAR_006795188V → A in GOUT-HPRT AND LNS; Asia. 3 Publications1
Natural variantiVAR_071623192A → V in GOUT-HPRT; Asia. 2 Publications1
Natural variantiVAR_006797194D → E in GOUT-HPRT; Moose-Jaw; results in cooperativity and decreased substrate affinities. 1 PublicationCorresponds to variant dbSNP:rs137852504EnsemblClinVar.1
Natural variantiVAR_006798194D → N in LNS; Kinston/RJK 2188. 2 PublicationsCorresponds to variant dbSNP:rs267606863EnsemblClinVar.1
Natural variantiVAR_006799195Y → C in GOUT-HPRT; Dirranbandi, Asia. 2 Publications1
Natural variantiVAR_006800199F → V in LNS; New Briton/RJK 950. 1 PublicationCorresponds to variant dbSNP:rs137852486EnsemblClinVar.1
Natural variantiVAR_006801201D → G in GOUT-HPRT; Ashville. 1 PublicationCorresponds to variant dbSNP:rs137852479EnsemblClinVar.1
Natural variantiVAR_006802201D → N in GOUT-HPRT; RB. 1
Natural variantiVAR_006803201D → Y in LNS; GM. 1
Natural variantiVAR_006804204H → D in LNS; RJK 1874. 1 PublicationCorresponds to variant dbSNP:rs137852490EnsemblClinVar.1
Natural variantiVAR_006805204H → R in LNS; 779. 1 Publication1
Natural variantiVAR_006806206C → Y in LNS; Reading/RJK 1727. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31642 mRNA Translation: AAA52690.1
M26434 Genomic DNA Translation: AAA36012.1
AK313435 mRNA Translation: BAG36226.1
BT019350 mRNA Translation: AAV38157.1
AY780550 Genomic DNA Translation: AAV31777.1
AC004383 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11761.1
BC000578 mRNA Translation: AAH00578.1
M12452 Genomic DNA Translation: AAA52691.1
S79313 Genomic DNA Translation: AAB21289.1
L29383 mRNA Translation: AAB59391.1
L29382 mRNA Translation: AAB59392.1
S60300 mRNA Translation: AAC60591.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14641.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A32728, RTHUG

NCBI Reference Sequences

More...
RefSeqi
NP_000185.1, NM_000194.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298556; ENSP00000298556; ENSG00000165704

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3251

UCSC genome browser

More...
UCSCi
uc004exl.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Hypoxanthine-guanine phosphoribosyltransferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31642 mRNA Translation: AAA52690.1
M26434 Genomic DNA Translation: AAA36012.1
AK313435 mRNA Translation: BAG36226.1
BT019350 mRNA Translation: AAV38157.1
AY780550 Genomic DNA Translation: AAV31777.1
AC004383 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11761.1
BC000578 mRNA Translation: AAH00578.1
M12452 Genomic DNA Translation: AAA52691.1
S79313 Genomic DNA Translation: AAB21289.1
L29383 mRNA Translation: AAB59391.1
L29382 mRNA Translation: AAB59392.1
S60300 mRNA Translation: AAC60591.2
CCDSiCCDS14641.1
PIRiA32728, RTHUG
RefSeqiNP_000185.1, NM_000194.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZYX-ray2.00A/B/C/D2-218[»]
1D6NX-ray2.70A/B5-218[»]
1HMPX-ray2.50A/B2-218[»]
1Z7GX-ray1.90A/B/C/D2-218[»]
2VFAX-ray2.80A/B49-160[»]
3GEPX-ray2.60A/B2-218[»]
3GGCX-ray2.78A/B2-218[»]
3GGJX-ray2.60A/B2-218[»]
4IJQX-ray2.00A/B/C/D2-218[»]
4KN6X-ray2.73A3-218[»]
4RABX-ray2.26A/B/C/D2-218[»]
4RACX-ray2.05A/B/C/D2-218[»]
4RADX-ray2.00A/B/C/D/E/F/G/H2-218[»]
4RANX-ray2.55A/B/C/D2-218[»]
4RAOX-ray1.87A/B/C/D2-218[»]
4RAQX-ray2.53A/B/C/D2-218[»]
5BRNX-ray2.30A/B/C/D1-218[»]
5BSKX-ray2.61A/B/C/D1-218[»]
5HIAX-ray1.77A/B/C/D1-218[»]
5W8VX-ray2.35A/B/C/D5-218[»]
6BNJX-ray1.91A/B/C/D1-218[»]
SMRiP00492
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109488, 70 interactors
IntActiP00492, 30 interactors
MINTiP00492
STRINGi9606.ENSP00000298556

Chemistry databases

BindingDBiP00492
ChEMBLiCHEMBL2360
DrugBankiDB03153, 3H-pyrazolo[4,3-d]pyrimidin-7-ol
DB02309, 5-monophosphate-9-beta-D-ribofuranosyl xanthine
DB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate
DB04356, 9-Deazaguanine
DB00993, Azathioprine
DB01033, Mercaptopurine
DB00352, Tioguanine
DrugCentraliP00492

PTM databases

GlyGeniP00492, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP00492
MetOSiteiP00492
PhosphoSitePlusiP00492
SwissPalmiP00492

Genetic variation databases

BioMutaiHPRT1
DMDMi123497

2D gel databases

OGPiP00492
REPRODUCTION-2DPAGEiIPI00218493

Proteomic databases

CPTACiCPTAC-216
EPDiP00492
jPOSTiP00492
MassIVEiP00492
MaxQBiP00492
PaxDbiP00492
PeptideAtlasiP00492
PRIDEiP00492
ProteomicsDBi51257
TopDownProteomicsiP00492

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1912, 596 antibodies

The DNASU plasmid repository

More...
DNASUi
3251

Genome annotation databases

EnsembliENST00000298556; ENSP00000298556; ENSG00000165704
GeneIDi3251
KEGGihsa:3251
UCSCiuc004exl.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3251
DisGeNETi3251

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HPRT1
GeneReviewsiHPRT1
HGNCiHGNC:5157, HPRT1
HPAiENSG00000165704, Low tissue specificity
MalaCardsiHPRT1
MIMi300322, phenotype
300323, phenotype
308000, gene
neXtProtiNX_P00492
OpenTargetsiENSG00000165704
Orphaneti79233, Hypoxanthine guanine phosphoribosyltransferase partial deficiency
510, Lesch-Nyhan syndrome
PharmGKBiPA29427
VEuPathDBiHostDB:ENSG00000165704

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3367, Eukaryota
GeneTreeiENSGT00940000155028
HOGENOMiCLU_073615_3_0_1
InParanoidiP00492
OMAiTMDWMAV
OrthoDBi1537610at2759
PhylomeDBiP00492
TreeFamiTF313367

Enzyme and pathway databases

UniPathwayiUPA00591;UER00648
BioCyciMetaCyc:HS09275-MONOMER
BRENDAi2.4.2.8, 2681
PathwayCommonsiP00492
ReactomeiR-HSA-74217, Purine salvage
SABIO-RKiP00492

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3251, 10 hits in 644 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HPRT1, human
EvolutionaryTraceiP00492

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Hypoxanthine-guanine_phosphoribosyltransferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3251
PharosiP00492, Tchem

Protein Ontology

More...
PROi
PR:P00492
RNActiP00492, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165704, Expressed in oocyte and 243 other tissues
ExpressionAtlasiP00492, baseline and differential
GenevisibleiP00492, HS

Family and domain databases

CDDicd06223, PRTases_typeI, 1 hit
Gene3Di3.40.50.2020, 1 hit
InterProiView protein in InterPro
IPR005904, Hxn_phspho_trans
IPR000836, PRibTrfase_dom
IPR029057, PRTase-like
PfamiView protein in Pfam
PF00156, Pribosyltran, 1 hit
SUPFAMiSSF53271, SSF53271, 1 hit
TIGRFAMsiTIGR01203, HGPRTase, 1 hit
PROSITEiView protein in PROSITE
PS00103, PUR_PYR_PR_TRANSFER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPRT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00492
Secondary accession number(s): A6NHF0, B2R8M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 229 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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