PNP

Functionⁱ

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.1 Publication

Catalytic activityⁱ

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Pathwayⁱ: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	33	PhosphateBy similarity	1
Binding siteⁱ	64	PhosphateBy similarity	1
Binding siteⁱ	116	Phosphate; via amide nitrogenBy similarity	1
Binding siteⁱ	201	Purine nucleosideBy similarity	1
Binding siteⁱ	220	PhosphateBy similarity	1
Binding siteⁱ	243	Purine nucleosideBy similarity	1

GO - Molecular functionⁱ

drug binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18938130
nucleoside binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9305962
phosphate ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18938130
purine nucleobase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9305962
purine-nucleoside phosphorylase activity
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16930574
inosine catabolic process
Source: MGI
Inferred from direct assayⁱ
- 16964310
interleukin-2 secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16930574
NAD biosynthesis via nicotinamide riboside salvage pathway
Source: UniProtKB
Inferred from genetic interactionⁱ
- 19001417
neutrophil degranulation Source: Reactome
nicotinamide riboside catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19001417
nucleobase-containing compound metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 3029074
positive regulation of alpha-beta T cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 16964310
positive regulation of T cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 16964310
purine-containing compound salvage Source: Reactome
purine nucleotide catabolic process Source: Reactome
response to drug
Source: UniProtKB
Inferred from direct assayⁱ
- 18938130
urate biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 16964310

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase

Molecular function

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02151-MONOMER
BRENDAⁱ	2.4.2.1 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-74217 Purine salvage R-HSA-74259 Purine catabolism
SABIO-RKⁱ	P00491
SignaLinkⁱ	P00491
UniPathwayⁱ	UPA00606

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Purine nucleoside phosphorylase (EC:2.4.2.1) Short name: PNP Alternative name(s): Inosine phosphorylase Inosine-guanosine phosphorylase
Gene namesⁱ	Name:PNP Synonyms:NP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198805.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7892 PNP
MIMⁱ	164050 gene
neXtProtⁱ	NX_P00491

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Purine nucleoside phosphorylase deficiency (PNPD)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_002244	89	E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar.	1
Natural variantⁱVAR_002245	128	D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar.	1
Natural variantⁱVAR_002246	174	A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar.	1
Natural variantⁱVAR_010653	192	Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar.	1
Natural variantⁱVAR_002247	234	R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4860
MalaCards human disease database More...MalaCardsⁱ	PNP
MIMⁱ	613179 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000198805
Orphanetⁱ	760 Purine nucleoside phosphorylase deficiency
PharmGKBⁱ	PA31694

Chemistry databases

ChEMBLⁱ	CHEMBL4338
Drug and drug target database More...DrugBankⁱ	DB03609 3-Deoxyguanosine DB01667 8-azaguanine DB02796 9-Deazainosine DB00242 Cladribine DB00900 Didanosine DB02377 Guanine DB02857 Guanosine DB04076 Hypoxanthine DB02230 Immucillin-G DB04335 Inosine DB03881 MT-Immucillin-H DB02568 Peldesine DB03101 Ribose-1-Phosphate
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2841

Polymorphism and mutation databases

BioMutaⁱ	PNP
DMDMⁱ	108935929

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184536	1 – 289	Purine nucleoside phosphorylaseAdd BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication		1
Modified residueⁱ	251	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P00491
PaxDbⁱ	P00491
PeptideAtlas More...PeptideAtlasⁱ	P00491
PRIDEⁱ	P00491
ProteomicsDBⁱ	51256
TopDownProteomicsⁱ	P00491

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P00491

OGPⁱ

P00491

PTM databases

iPTMnetⁱ	P00491
PhosphoSitePlusⁱ	P00491
SwissPalmⁱ	P00491

Expressionⁱ

Tissue specificityⁱ

Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198805 Expressed in 197 organ(s), highest expression level in corpus epididymis
CleanExⁱ	HS_NP
ExpressionAtlasⁱ	P00491 baseline and differential
Genevisibleⁱ	P00491 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001625

HPAⁱ

HPA001625

Interactionⁱ

Subunit structureⁱ

Homotrimer.

Protein-protein interaction databases

BioGridⁱ	110921, 39 interactors
CORUMⁱ	P00491
Database of interacting proteins More...DIPⁱ	DIP-50406N
IntActⁱ	P00491, 14 interactors
STRINGⁱ	9606.ENSP00000354532

Chemistry databases

BindingDBⁱ

P00491

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 20	Combined sources	14
Beta strandⁱ	26 – 31	Combined sources	6
Helixⁱ	36 – 41	Combined sources	6
Beta strandⁱ	43 – 49	Combined sources	7
Helixⁱ	50 – 52	Combined sources	3
Beta strandⁱ	53 – 55	Combined sources	3
Helixⁱ	62 – 65	Combined sources	4
Beta strandⁱ	67 – 73	Combined sources	7
Beta strandⁱ	76 – 83	Combined sources	8
Helixⁱ	87 – 89	Combined sources	3
Helixⁱ	93 – 96	Combined sources	4
Helixⁱ	98 – 106	Combined sources	9
Beta strandⁱ	110 – 119	Combined sources	10
Beta strandⁱ	121 – 123	Combined sources	3
Beta strandⁱ	129 – 137	Combined sources	9
Helixⁱ	138 – 141	Combined sources	4
Turnⁱ	153 – 155	Combined sources	3
Turnⁱ	163 – 166	Combined sources	4
Helixⁱ	168 – 179	Combined sources	12
Turnⁱ	180 – 182	Combined sources	3
Beta strandⁱ	188 – 194	Combined sources	7
Beta strandⁱ	197 – 199	Combined sources	3
Helixⁱ	203 – 211	Combined sources	9
Beta strandⁱ	215 – 221	Combined sources	7
Helixⁱ	222 – 230	Combined sources	9
Beta strandⁱ	234 – 244	Combined sources	11
Beta strandⁱ	248 – 250	Combined sources	3
Helixⁱ	257 – 266	Combined sources	10
Helixⁱ	268 – 280	Combined sources	13
Turnⁱ	285 – 287	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P00491
SMRⁱ	P00491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P00491

EvolutionaryTraceⁱ

P00491

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	84 – 86	Phosphate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the PNP/MTAP phosphorylase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3984 Eukaryota COG0005 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074740
HOVERGENⁱ	HBG002460
InParanoidⁱ	P00491
KEGG Orthology (KO) More...KOⁱ	K03783
OMAⁱ	VLISDHI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GEE
PhylomeDBⁱ	P00491
TreeFamⁱ	TF300049

Family and domain databases

InterProⁱ	View protein in InterPro IPR000845 Nucleoside_phosphorylase_d IPR035994 Nucleoside_phosphorylase_sf IPR011270 Pur_Nuc_Pase_Ino/Guo-sp IPR011268 Purine_phosphorylase IPR018099 Purine_phosphorylase-2_CS
PANTHERⁱ	PTHR11904 PTHR11904, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01048 PNP_UDP_1, 1 hit
PIRSFⁱ	PIRSF000477 PurNPase, 1 hit
SUPFAMⁱ	SSF53167 SSF53167, 1 hit
TIGRFAMsⁱ	TIGR01700 PNPH, 1 hit TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEⁱ	View protein in PROSITE PS01240 PNP_MTAP_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P00491-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY 
        60         70         80         90        100
GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV 
       110        120        130        140        150
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP 
       160        170        180        190        200
NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF 
       210        220        230        240        250
ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE 
       260        270        280 
SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS

Length:289

Mass (Da):32,118

Last modified:May 30, 2006 - v2

Checksum:ⁱ91622FB1D26479D3

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V5M2	G3V5M2_HUMAN	Purine nucleoside phosphorylase Purine nucleoside phosphorylase	PNP	221	Annotation score:
G3V393	G3V393_HUMAN	Purine nucleoside phosphorylase Purine nucleoside phosphorylase	PNP	61	Annotation score:
G3V2H3	G3V2H3_HUMAN	Purine nucleoside phosphorylase Purine nucleoside phosphorylase	PNP	93	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_002243	51	G → S5 PublicationsCorresponds to variant dbSNP:rs1049564EnsemblClinVar.	1
Natural variantⁱVAR_002244	89	E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar.	1
Natural variantⁱVAR_002245	128	D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar.	1
Natural variantⁱVAR_002246	174	A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar.	1
Natural variantⁱVAR_010653	192	Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar.	1
Natural variantⁱVAR_002247	234	R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00737 mRNA Translation: CAA25320.1 M13953 , J02672, M13951, M13952 Genomic DNA Translation: AAA36460.1 AY817667 Genomic DNA Translation: AAV68044.1 AK313490 mRNA Translation: BAG36272.1 CR407607 mRNA Translation: CAG28535.1 CH471078 Genomic DNA Translation: EAW66458.1 CH471078 Genomic DNA Translation: EAW66459.1 BC104206 mRNA Translation: AAI04207.1 BC104207 mRNA Translation: AAI04208.1 BC106074 mRNA Translation: AAI06075.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9552.1
PIRⁱ	A00578 PHHUPN
NCBI Reference Sequences More...RefSeqⁱ	NP_000261.2, NM_000270.3
UniGeneⁱ	Hs.75514

Genome annotation databases

Ensemblⁱ	ENST00000361505; ENSP00000354532; ENSG00000198805
GeneIDⁱ	4860
KEGGⁱ	hsa:4860

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00491	Purine nucleoside phosphorylase		HUMAN		289	UniRef100_P00491

Protein	Similar proteins		Species	Score	Length	Source
P00491	Purine nucleoside phosphorylase		HUMAN		289	UniRef90_P00491
Purine nucleoside phosphorylase		MACMU		290
Uncharacterized protein (Fragment)		MACFA		285
Uncharacterized protein		MANLE		96
Purine nucleoside phosphorylase		MACNE		289
+34

Protein	Similar proteins		Species	Score	Length	Source
P00491	Purine nucleoside phosphorylase		MOUSE		289	UniRef50_P00491
Purine nucleoside phosphorylase	)	BOVIN		289
Purine nucleoside phosphorylase		HUMAN		289
Purine nucleoside phosphorylase		MACMU		290
Uncharacterized protein (Fragment)		MACFA		285
+177

Cross-referencesⁱ

Web resourcesⁱ

NPbase

NP mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00737 mRNA Translation: CAA25320.1 M13953 , J02672, M13951, M13952 Genomic DNA Translation: AAA36460.1 AY817667 Genomic DNA Translation: AAV68044.1 AK313490 mRNA Translation: BAG36272.1 CR407607 mRNA Translation: CAG28535.1 CH471078 Genomic DNA Translation: EAW66458.1 CH471078 Genomic DNA Translation: EAW66459.1 BC104206 mRNA Translation: AAI04207.1 BC104207 mRNA Translation: AAI04208.1 BC106074 mRNA Translation: AAI06075.1
CCDSⁱ	CCDS9552.1
PIRⁱ	A00578 PHHUPN
RefSeqⁱ	NP_000261.2, NM_000270.3
UniGeneⁱ	Hs.75514

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M73	X-ray	2.30	E	2-289	[»]
	1PF7	X-ray	2.60	E	1-289	[»]
	1PWY	X-ray	2.80	E	2-289	[»]
	1RCT	X-ray	2.80	E	2-289	[»]
	1RFG	X-ray	2.90	E	2-289	[»]
	1RR6	X-ray	2.50	A	1-289	[»]
	1RSZ	X-ray	2.20	A	1-289	[»]
	1RT9	X-ray	2.30	A	1-289	[»]
	1ULA	X-ray	2.75	A	1-289	[»]
	1ULB	X-ray	2.75	A	1-289	[»]
	1V2H	X-ray	2.70	E	2-289	[»]
	1V3Q	X-ray	2.80	E	2-289	[»]
	1V41	X-ray	2.85	E	2-289	[»]
	1V45	X-ray	2.86	E	2-289	[»]
	1YRY	X-ray	2.80	E	1-289	[»]
	2A0W	X-ray	2.28	A	1-289	[»]
	2A0X	X-ray	2.28	A	1-289	[»]
	2A0Y	X-ray	2.28	A	1-289	[»]
	2OC4	X-ray	2.59	A	1-289	[»]
	2OC9	X-ray	2.59	A	1-289	[»]
	2ON6	X-ray	2.50	A	1-289	[»]
	2Q7O	X-ray	2.90	E	1-289	[»]
	3BGS	X-ray	2.10	A	1-289	[»]
	3D1V	X-ray	2.70	A	1-289	[»]
	3GB9	X-ray	2.30	A/B/C	1-289	[»]
	3GGS	X-ray	2.52	A/B/C	1-289	[»]
	3INY	X-ray	2.75	A	1-289	[»]
	3K8O	X-ray	2.40	E/Q/S/T/U/Y	1-289	[»]
	3K8Q	X-ray	2.50	A	1-289	[»]
	3PHB	X-ray	2.30	E/Q/S/T/U/Y	1-289	[»]
	4EAR	X-ray	1.70	A/B/C	1-289	[»]
	4EB8	X-ray	2.30	A/B/C	1-289	[»]
	4ECE	X-ray	2.60	A/B/C/D/E/F	1-289	[»]
	4GKA	X-ray	2.20	A/B/C/D/E/F	1-289	[»]
	5ETJ	X-ray	2.30	A/B/C/D/E/F	1-289	[»]
	5UGF	X-ray	2.20	A/B/C/D/E/F	1-289	[»]
ProteinModelPortalⁱ	P00491
SMRⁱ	P00491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110921, 39 interactors
CORUMⁱ	P00491
DIPⁱ	DIP-50406N
IntActⁱ	P00491, 14 interactors
STRINGⁱ	9606.ENSP00000354532

Chemistry databases

BindingDBⁱ	P00491
ChEMBLⁱ	CHEMBL4338
DrugBankⁱ	DB03609 3-Deoxyguanosine DB01667 8-azaguanine DB02796 9-Deazainosine DB00242 Cladribine DB00900 Didanosine DB02377 Guanine DB02857 Guanosine DB04076 Hypoxanthine DB02230 Immucillin-G DB04335 Inosine DB03881 MT-Immucillin-H DB02568 Peldesine DB03101 Ribose-1-Phosphate
GuidetoPHARMACOLOGYⁱ	2841

PTM databases

iPTMnetⁱ	P00491
PhosphoSitePlusⁱ	P00491
SwissPalmⁱ	P00491

Polymorphism and mutation databases

BioMutaⁱ	PNP
DMDMⁱ	108935929

2D gel databases

OGPⁱ	P00491

OGPⁱ

P00491

Proteomic databases

EPDⁱ	P00491
PaxDbⁱ	P00491
PeptideAtlasⁱ	P00491
PRIDEⁱ	P00491
ProteomicsDBⁱ	51256
TopDownProteomicsⁱ	P00491

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361505; ENSP00000354532; ENSG00000198805
GeneIDⁱ	4860
KEGGⁱ	hsa:4860

Organism-specific databases

CTDⁱ	4860
DisGeNETⁱ	4860
EuPathDBⁱ	HostDB:ENSG00000198805.11
GeneCardsⁱ	PNP
HGNCⁱ	HGNC:7892 PNP
HPAⁱ	HPA001625
MalaCardsⁱ	PNP
MIMⁱ	164050 gene 613179 phenotype
neXtProtⁱ	NX_P00491
OpenTargetsⁱ	ENSG00000198805
Orphanetⁱ	760 Purine nucleoside phosphorylase deficiency
PharmGKBⁱ	PA31694
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3984 Eukaryota COG0005 LUCA
GeneTreeⁱ	ENSGT00550000074740
HOVERGENⁱ	HBG002460
InParanoidⁱ	P00491
KOⁱ	K03783
OMAⁱ	VLISDHI
OrthoDBⁱ	EOG091G0GEE
PhylomeDBⁱ	P00491
TreeFamⁱ	TF300049

Enzyme and pathway databases

UniPathwayⁱ	UPA00606
BioCycⁱ	MetaCyc:HS02151-MONOMER
BRENDAⁱ	2.4.2.1 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-74217 Purine salvage R-HSA-74259 Purine catabolism
SABIO-RKⁱ	P00491
SignaLinkⁱ	P00491

Miscellaneous databases

ChiTaRSⁱ	PNP human
EvolutionaryTraceⁱ	P00491
GeneWikiⁱ	Purine_nucleoside_phosphorylase
GenomeRNAiⁱ	4860
Protein Ontology More...PROⁱ	PR:P00491
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198805 Expressed in 197 organ(s), highest expression level in corpus epididymis
CleanExⁱ	HS_NP
ExpressionAtlasⁱ	P00491 baseline and differential
Genevisibleⁱ	P00491 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000845 Nucleoside_phosphorylase_d IPR035994 Nucleoside_phosphorylase_sf IPR011270 Pur_Nuc_Pase_Ino/Guo-sp IPR011268 Purine_phosphorylase IPR018099 Purine_phosphorylase-2_CS
PANTHERⁱ	PTHR11904 PTHR11904, 1 hit
Pfamⁱ	View protein in Pfam PF01048 PNP_UDP_1, 1 hit
PIRSFⁱ	PIRSF000477 PurNPase, 1 hit
SUPFAMⁱ	SSF53167 SSF53167, 1 hit
TIGRFAMsⁱ	TIGR01700 PNPH, 1 hit TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEⁱ	View protein in PROSITE PS01240 PNP_MTAP_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PNPH_HUMAN
Accessionⁱ	P00491Primary (citable) accession number: P00491 Secondary accession number(s): B2R8S5 , D3DS00, Q15160, Q5PZ03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	May 30, 2006
	Last modified:	September 12, 2018
	This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P00491 (PNPH_HUMAN)

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Purine nucleoside phosphorylase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: purine nucleoside salvage

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: purine nucleoside salvage

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ