The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P00491 (PNPH_HUMAN)
Protein
Purine nucleoside phosphorylase
Gene
PNP
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:9305964, PubMed:23438750).
Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964).
2 PublicationsCatalytic activityi
Activity regulationi
Inhibited by 5'-deaza-1'-aza-2c-deoxy-1'-(9-methylene)-Immucilin-G (DADMe-ImmG).1 Publication
Kineticsi
kcat is 57 sec(-1) with inosine as substrate (PubMed:9305964). kcat is 47 sec(-1) with inosine as substrate (PubMed:23438750). kcat is 70 sec(-1) with hypoxanthine as substrate (PubMed:9305964). kcat is 28 sec(-1) with guanosine as substrate (PubMed:9305964). kcat is 48 sec(-1) with guanine as substrate (PubMed:9305964). kcat is 0.0024 sec(-1) with adenosine as substrate (PubMed:9305964). kcat is 0.31 sec(-1) with adenine as substrate (PubMed:9305964).2 Publications
- KM=45 µM for inosine (at 30 degrees Celsius and pH 7)1 Publication
- KM=68 µM for inosine (at 25 degrees Celsius and pH 7.4)1 Publication
- KM=10 µM for hypoxanthine (at 30 degrees Celsius and pH 7)1 Publication
- KM=6 µM for guanosine (at 30 degrees Celsius and pH 7)1 Publication
- KM=12 µM for guanine (at 30 degrees Celsius and pH 7)1 Publication
- KM=650 µM for adenosine (at 30 degrees Celsius and pH 7)1 Publication
- KM=440 µM for adenine (at 30 degrees Celsius and pH 7)1 Publication
: purine nucleoside salvage Pathwayi
This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | PhosphateCombined sources2 Publications1 Publication | 1 | |
Binding sitei | 64 | PhosphateBy similarity | 1 | |
Binding sitei | 88 | Purine nucleosideCombined sources2 Publications | 1 | |
Binding sitei | 116 | Phosphate; via amide nitrogenCombined sources1 Publication2 Publications | 1 | |
Binding sitei | 201 | Purine nucleosideCombined sources1 Publication2 Publications | 1 | |
Binding sitei | 219 | Purine nucleosideCombined sources1 Publication | 1 | |
Binding sitei | 220 | PhosphateCombined sources1 Publication2 Publications | 1 | |
Binding sitei | 243 | Purine nucleosideCombined sources1 Publication2 Publications | 1 | |
Sitei | 243 | Important for substrate specificity1 Publication | 1 | |
Binding sitei | 257 | Purine nucleosideCombined sources1 Publication | 1 |
GO - Molecular functioni
- guanosine phosphorylase activity Source: RHEA
- identical protein binding Source: IntAct
- nucleoside binding Source: UniProtKB
- phosphate ion binding Source: UniProtKB
- purine nucleobase binding Source: UniProtKB
- purine-nucleoside phosphorylase activity Source: UniProtKB
GO - Biological processi
- allantoin metabolic process Source: MGI
- dAMP catabolic process Source: MGI
- deoxyadenosine catabolic process Source: MGI
- deoxyinosine catabolic process Source: MGI
- immune response Source: UniProtKB
- IMP catabolic process Source: MGI
- inosine catabolic process Source: UniProtKB
- nicotinamide riboside catabolic process Source: UniProtKB
- nucleobase-containing compound metabolic process Source: UniProtKB
- nucleotide biosynthetic process Source: UniProtKB
- positive regulation of alpha-beta T cell differentiation Source: MGI
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of T cell proliferation Source: MGI
- purine-containing compound salvage Source: UniProtKB
- purine ribonucleoside salvage Source: UniProtKB-KW
- response to xenobiotic stimulus Source: UniProtKB
- urate biosynthetic process Source: MGI
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Purine salvage |
Enzyme and pathway databases
BRENDAi | 2.4.2.1, 2681 |
PathwayCommonsi | P00491 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-74217, Purine salvage R-HSA-74259, Purine catabolism |
SABIO-RKi | P00491 |
SignaLinki | P00491 |
UniPathwayi | UPA00606 |
Names & Taxonomyi
Protein namesi | Recommended name: Purine nucleoside phosphorylase (EC:2.4.2.12 Publications)Short name: PNP Alternative name(s): Inosine phosphorylase Inosine-guanosine phosphorylase |
Gene namesi | Name:PNP Synonyms:NP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7892, PNP |
MIMi | 164050, gene |
neXtProti | NX_P00491 |
VEuPathDBi | HostDB:ENSG00000198805 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Purine nucleoside phosphorylase deficiency (PNPD)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002244 | 89 | E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar. | 1 | |
Natural variantiVAR_002245 | 128 | D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar. | 1 | |
Natural variantiVAR_002246 | 174 | A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar. | 1 | |
Natural variantiVAR_010653 | 192 | Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar. | 1 | |
Natural variantiVAR_002247 | 234 | R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | H → W: Reduces catalytic activity towards inosine. 1 Publication | 1 | |
Mutagenesisi | 201 | E → A or Q: Severe loss of catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 243 | N → A: Reduces catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 243 | N → D: Reduces catalytic activity towards inosine, hypoxanthine, guanosine and guanine. Increases catalytic activity towards adenosine and adenine. 1 Publication | 1 | |
Mutagenesisi | 257 | H → W: Reduces catalytic activity towards inosine. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4860 |
MalaCardsi | PNP |
MIMi | 613179, phenotype |
OpenTargetsi | ENSG00000198805 |
Orphaneti | 760, Purine nucleoside phosphorylase deficiency |
PharmGKBi | PA31694 |
Miscellaneous databases
Pharosi | P00491, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4338 |
DrugBanki | DB03881, (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium DB03551, (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium DB02222, 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine DB02391, 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One DB03609, 3'-deoxyguanosine DB01667, 8-azaguanine DB04260, 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine DB02796, 9-deazainosine DB04753, 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DB00640, Adenosine DB00242, Cladribine DB00900, Didanosine DB06185, Forodesine DB02377, Guanine DB02857, Guanosine DB04754, GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DB04757, GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE DB04076, Hypoxanthine DB02230, Immucillin-G DB04335, Inosine DB02568, Peldesine DB03101, Ribose-1-Phosphate |
DrugCentrali | P00491 |
GuidetoPHARMACOLOGYi | 2841 |
Genetic variation databases
BioMutai | PNP |
DMDMi | 108935929 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184536 | 1 – 289 | Purine nucleoside phosphorylaseAdd BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 251 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-570 CPTAC-571 |
EPDi | P00491 |
jPOSTi | P00491 |
MassIVEi | P00491 |
PaxDbi | P00491 |
PeptideAtlasi | P00491 |
PRIDEi | P00491 |
ProteomicsDBi | 51256 |
TopDownProteomicsi | P00491 |
2D gel databases
OGPi | P00491 |
PTM databases
GlyGeni | P00491, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P00491 |
MetOSitei | P00491 |
PhosphoSitePlusi | P00491 |
SwissPalmi | P00491 |
Expressioni
Tissue specificityi
Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.1 Publication
Gene expression databases
Bgeei | ENSG00000198805, Expressed in corpus epididymis and 212 other tissues |
ExpressionAtlasi | P00491, baseline and differential |
Genevisiblei | P00491, HS |
Organism-specific databases
HPAi | ENSG00000198805, Tissue enhanced (bone marrow, epididymis) |
Interactioni
Subunit structurei
Homotrimer.
1 PublicationBinary interactionsi
P00491
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110921, 60 interactors |
CORUMi | P00491 |
DIPi | DIP-50406N |
IntActi | P00491, 30 interactors |
MINTi | P00491 |
STRINGi | 9606.ENSP00000354532 |
Chemistry databases
BindingDBi | P00491 |
Miscellaneous databases
RNActi | P00491, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P00491 |
SMRi | P00491 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00491 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 86 | Phosphate bindingCombined sources2 Publications1 Publication | 3 |
Sequence similaritiesi
Belongs to the PNP/MTAP phosphorylase family.Curated
Phylogenomic databases
eggNOGi | KOG3984, Eukaryota |
GeneTreei | ENSGT00950000182991 |
HOGENOMi | CLU_054456_1_2_1 |
InParanoidi | P00491 |
OMAi | EGVYAQF |
OrthoDBi | 1078969at2759 |
PhylomeDBi | P00491 |
TreeFami | TF300049 |
Family and domain databases
CDDi | cd09009, PNP-EcPNPII_like, 1 hit |
Gene3Di | 3.40.50.1580, 1 hit |
InterProi | View protein in InterPro IPR000845, Nucleoside_phosphorylase_d IPR035994, Nucleoside_phosphorylase_sf IPR011270, Pur_Nuc_Pase_Ino/Guo-sp IPR011268, Purine_phosphorylase IPR018099, Purine_phosphorylase-2_CS |
PANTHERi | PTHR11904, PTHR11904, 1 hit |
Pfami | View protein in Pfam PF01048, PNP_UDP_1, 1 hit |
PIRSFi | PIRSF000477, PurNPase, 1 hit |
SUPFAMi | SSF53167, SSF53167, 1 hit |
TIGRFAMsi | TIGR01700, PNPH, 1 hit TIGR01697, PNPH-PUNA-XAPA, 1 hit |
PROSITEi | View protein in PROSITE PS01240, PNP_MTAP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P00491-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY
60 70 80 90 100
GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV
110 120 130 140 150
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP
160 170 180 190 200
NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF
210 220 230 240 250
ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
260 270 280
SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V5M2 | G3V5M2_HUMAN | Purine-nucleoside phosphorylase | PNP | 221 | Annotation score: | ||
G3V393 | G3V393_HUMAN | Purine-nucleoside phosphorylase | PNP | 61 | Annotation score: | ||
G3V2H3 | G3V2H3_HUMAN | Purine nucleoside phosphorylase | PNP | 93 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002243 | 51 | G → S5 PublicationsCorresponds to variant dbSNP:rs1049564EnsemblClinVar. | 1 | |
Natural variantiVAR_002244 | 89 | E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar. | 1 | |
Natural variantiVAR_002245 | 128 | D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar. | 1 | |
Natural variantiVAR_002246 | 174 | A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar. | 1 | |
Natural variantiVAR_010653 | 192 | Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar. | 1 | |
Natural variantiVAR_002247 | 234 | R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00737 mRNA Translation: CAA25320.1 M13953 , J02672, M13951, M13952 Genomic DNA Translation: AAA36460.1 AY817667 Genomic DNA Translation: AAV68044.1 AK313490 mRNA Translation: BAG36272.1 CR407607 mRNA Translation: CAG28535.1 CH471078 Genomic DNA Translation: EAW66458.1 CH471078 Genomic DNA Translation: EAW66459.1 BC104206 mRNA Translation: AAI04207.1 BC104207 mRNA Translation: AAI04208.1 BC106074 mRNA Translation: AAI06075.1 |
CCDSi | CCDS9552.1 |
PIRi | A00578, PHHUPN |
RefSeqi | NP_000261.2, NM_000270.3 |
Genome annotation databases
Ensembli | ENST00000361505.10; ENSP00000354532.6; ENSG00000198805.12 |
GeneIDi | 4860 |
KEGGi | hsa:4860 |
MANE-Selecti | ENST00000361505.10; ENSP00000354532.6; NM_000270.4; NP_000261.2 |
Similar proteinsi
Cross-referencesi
Web resourcesi
NPbase NP mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00737 mRNA Translation: CAA25320.1 M13953 , J02672, M13951, M13952 Genomic DNA Translation: AAA36460.1 AY817667 Genomic DNA Translation: AAV68044.1 AK313490 mRNA Translation: BAG36272.1 CR407607 mRNA Translation: CAG28535.1 CH471078 Genomic DNA Translation: EAW66458.1 CH471078 Genomic DNA Translation: EAW66459.1 BC104206 mRNA Translation: AAI04207.1 BC104207 mRNA Translation: AAI04208.1 BC106074 mRNA Translation: AAI06075.1 |
CCDSi | CCDS9552.1 |
PIRi | A00578, PHHUPN |
RefSeqi | NP_000261.2, NM_000270.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M73 | X-ray | 2.30 | E | 2-289 | [»] | |
1PF7 | X-ray | 2.60 | E | 1-289 | [»] | |
1PWY | X-ray | 2.80 | E | 2-289 | [»] | |
1RCT | X-ray | 2.80 | E | 2-289 | [»] | |
1RFG | X-ray | 2.90 | E | 2-289 | [»] | |
1RR6 | X-ray | 2.50 | A | 1-289 | [»] | |
1RSZ | X-ray | 2.20 | A | 1-289 | [»] | |
1RT9 | X-ray | 2.30 | A | 1-289 | [»] | |
1ULA | X-ray | 2.75 | A | 1-289 | [»] | |
1ULB | X-ray | 2.75 | A | 1-289 | [»] | |
1V2H | X-ray | 2.70 | E | 2-289 | [»] | |
1V3Q | X-ray | 2.80 | E | 2-289 | [»] | |
1V41 | X-ray | 2.85 | E | 2-289 | [»] | |
1V45 | X-ray | 2.86 | E | 2-289 | [»] | |
1YRY | X-ray | 2.80 | E | 1-289 | [»] | |
2A0W | X-ray | 2.28 | A | 1-289 | [»] | |
2A0X | X-ray | 2.28 | A | 1-289 | [»] | |
2A0Y | X-ray | 2.28 | A | 1-289 | [»] | |
2OC4 | X-ray | 2.59 | A | 1-289 | [»] | |
2OC9 | X-ray | 2.59 | A | 1-289 | [»] | |
2ON6 | X-ray | 2.50 | A | 1-289 | [»] | |
2Q7O | X-ray | 2.90 | E | 1-289 | [»] | |
3BGS | X-ray | 2.10 | A | 1-289 | [»] | |
3D1V | X-ray | 2.70 | A | 1-289 | [»] | |
3GB9 | X-ray | 2.30 | A/B/C | 1-289 | [»] | |
3GGS | X-ray | 2.52 | A/B/C | 1-289 | [»] | |
3INY | X-ray | 2.75 | A | 1-289 | [»] | |
3K8O | X-ray | 2.40 | E/Q/S/T/U/Y | 1-289 | [»] | |
3K8Q | X-ray | 2.50 | A | 1-289 | [»] | |
3PHB | X-ray | 2.30 | E/Q/S/T/U/Y | 1-289 | [»] | |
4EAR | X-ray | 1.70 | A/B/C | 1-289 | [»] | |
4EB8 | X-ray | 2.30 | A/B/C | 1-289 | [»] | |
4ECE | X-ray | 2.60 | A/B/C/D/E/F | 1-289 | [»] | |
4GKA | X-ray | 2.20 | A/B/C/D/E/F | 1-289 | [»] | |
5ETJ | X-ray | 2.30 | A/B/C/D/E/F | 1-289 | [»] | |
5UGF | X-ray | 2.20 | A/B/C/D/E/F | 1-289 | [»] | |
AlphaFoldDBi | P00491 | |||||
SMRi | P00491 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110921, 60 interactors |
CORUMi | P00491 |
DIPi | DIP-50406N |
IntActi | P00491, 30 interactors |
MINTi | P00491 |
STRINGi | 9606.ENSP00000354532 |
Chemistry databases
BindingDBi | P00491 |
ChEMBLi | CHEMBL4338 |
DrugBanki | DB03881, (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium DB03551, (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium DB02222, 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine DB02391, 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One DB03609, 3'-deoxyguanosine DB01667, 8-azaguanine DB04260, 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine DB02796, 9-deazainosine DB04753, 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DB00640, Adenosine DB00242, Cladribine DB00900, Didanosine DB06185, Forodesine DB02377, Guanine DB02857, Guanosine DB04754, GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DB04757, GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE DB04076, Hypoxanthine DB02230, Immucillin-G DB04335, Inosine DB02568, Peldesine DB03101, Ribose-1-Phosphate |
DrugCentrali | P00491 |
GuidetoPHARMACOLOGYi | 2841 |
PTM databases
GlyGeni | P00491, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P00491 |
MetOSitei | P00491 |
PhosphoSitePlusi | P00491 |
SwissPalmi | P00491 |
Genetic variation databases
BioMutai | PNP |
DMDMi | 108935929 |
2D gel databases
OGPi | P00491 |
Proteomic databases
CPTACi | CPTAC-570 CPTAC-571 |
EPDi | P00491 |
jPOSTi | P00491 |
MassIVEi | P00491 |
PaxDbi | P00491 |
PeptideAtlasi | P00491 |
PRIDEi | P00491 |
ProteomicsDBi | 51256 |
TopDownProteomicsi | P00491 |
Protocols and materials databases
Antibodypediai | 766, 320 antibodies from 35 providers |
DNASUi | 4860 |
Genome annotation databases
Ensembli | ENST00000361505.10; ENSP00000354532.6; ENSG00000198805.12 |
GeneIDi | 4860 |
KEGGi | hsa:4860 |
MANE-Selecti | ENST00000361505.10; ENSP00000354532.6; NM_000270.4; NP_000261.2 |
Organism-specific databases
CTDi | 4860 |
DisGeNETi | 4860 |
GeneCardsi | PNP |
HGNCi | HGNC:7892, PNP |
HPAi | ENSG00000198805, Tissue enhanced (bone marrow, epididymis) |
MalaCardsi | PNP |
MIMi | 164050, gene 613179, phenotype |
neXtProti | NX_P00491 |
OpenTargetsi | ENSG00000198805 |
Orphaneti | 760, Purine nucleoside phosphorylase deficiency |
PharmGKBi | PA31694 |
VEuPathDBi | HostDB:ENSG00000198805 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3984, Eukaryota |
GeneTreei | ENSGT00950000182991 |
HOGENOMi | CLU_054456_1_2_1 |
InParanoidi | P00491 |
OMAi | EGVYAQF |
OrthoDBi | 1078969at2759 |
PhylomeDBi | P00491 |
TreeFami | TF300049 |
Enzyme and pathway databases
UniPathwayi | UPA00606 |
BRENDAi | 2.4.2.1, 2681 |
PathwayCommonsi | P00491 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-74217, Purine salvage R-HSA-74259, Purine catabolism |
SABIO-RKi | P00491 |
SignaLinki | P00491 |
Miscellaneous databases
BioGRID-ORCSi | 4860, 10 hits in 1082 CRISPR screens |
ChiTaRSi | PNP, human |
EvolutionaryTracei | P00491 |
GeneWikii | Purine_nucleoside_phosphorylase |
GenomeRNAii | 4860 |
Pharosi | P00491, Tclin |
PROi | PR:P00491 |
RNActi | P00491, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198805, Expressed in corpus epididymis and 212 other tissues |
ExpressionAtlasi | P00491, baseline and differential |
Genevisiblei | P00491, HS |
Family and domain databases
CDDi | cd09009, PNP-EcPNPII_like, 1 hit |
Gene3Di | 3.40.50.1580, 1 hit |
InterProi | View protein in InterPro IPR000845, Nucleoside_phosphorylase_d IPR035994, Nucleoside_phosphorylase_sf IPR011270, Pur_Nuc_Pase_Ino/Guo-sp IPR011268, Purine_phosphorylase IPR018099, Purine_phosphorylase-2_CS |
PANTHERi | PTHR11904, PTHR11904, 1 hit |
Pfami | View protein in Pfam PF01048, PNP_UDP_1, 1 hit |
PIRSFi | PIRSF000477, PurNPase, 1 hit |
SUPFAMi | SSF53167, SSF53167, 1 hit |
TIGRFAMsi | TIGR01700, PNPH, 1 hit TIGR01697, PNPH-PUNA-XAPA, 1 hit |
PROSITEi | View protein in PROSITE PS01240, PNP_MTAP_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PNPH_HUMAN | |
Accessioni | P00491Primary (citable) accession number: P00491 Secondary accession number(s): B2R8S5 Q5PZ03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | May 30, 2006 | |
Last modified: | May 25, 2022 | |
This is version 223 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families