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Entry version 220 (02 Jun 2021)
Sequence version 2 (30 May 2006)
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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:9305964, PubMed:23438750).

Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 5'-deaza-1'-aza-2c-deoxy-1'-(9-methylene)-Immucilin-G (DADMe-ImmG).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 57 sec(-1) with inosine as substrate (PubMed:9305964). kcat is 47 sec(-1) with inosine as substrate (PubMed:23438750). kcat is 70 sec(-1) with hypoxanthine as substrate (PubMed:9305964). kcat is 28 sec(-1) with guanosine as substrate (PubMed:9305964). kcat is 48 sec(-1) with guanine as substrate (PubMed:9305964). kcat is 0.0024 sec(-1) with adenosine as substrate (PubMed:9305964). kcat is 0.31 sec(-1) with adenine as substrate (PubMed:9305964).2 Publications
  1. KM=45 µM for inosine (at 30 degrees Celsius and pH 7)1 Publication
  2. KM=68 µM for inosine (at 25 degrees Celsius and pH 7.4)1 Publication
  3. KM=10 µM for hypoxanthine (at 30 degrees Celsius and pH 7)1 Publication
  4. KM=6 µM for guanosine (at 30 degrees Celsius and pH 7)1 Publication
  5. KM=12 µM for guanine (at 30 degrees Celsius and pH 7)1 Publication
  6. KM=650 µM for adenosine (at 30 degrees Celsius and pH 7)1 Publication
  7. KM=440 µM for adenine (at 30 degrees Celsius and pH 7)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: purine nucleoside salvage

    This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33PhosphateCombined sources2 Publications1 Publication1
    Binding sitei64PhosphateBy similarity1
    Binding sitei88Purine nucleosideCombined sources2 Publications1
    Binding sitei116Phosphate; via amide nitrogenCombined sources1 Publication2 Publications1
    Binding sitei201Purine nucleosideCombined sources1 Publication2 Publications1
    Binding sitei219Purine nucleosideCombined sources1 Publication1
    Binding sitei220PhosphateCombined sources1 Publication2 Publications1
    Binding sitei243Purine nucleosideCombined sources1 Publication2 Publications1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei243Important for substrate specificity1 Publication1
    Binding sitei257Purine nucleosideCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processPurine salvage

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS02151-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.2.1, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P00491

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6798695, Neutrophil degranulation
    R-HSA-74217, Purine salvage
    R-HSA-74259, Purine catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P00491

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    P00491

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00606

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Purine nucleoside phosphorylase (EC:2.4.2.12 Publications)
    Short name:
    PNP
    Alternative name(s):
    Inosine phosphorylase
    Inosine-guanosine phosphorylase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PNP
    Synonyms:NP
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7892, PNP

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    164050, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P00491

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000198805.11

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Purine nucleoside phosphorylase deficiency (PNPD)3 Publications
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionA disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00224489E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar.1
    Natural variantiVAR_002245128D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar.1
    Natural variantiVAR_002246174A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar.1
    Natural variantiVAR_010653192Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar.1
    Natural variantiVAR_002247234R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64H → W: Reduces catalytic activity towards inosine. 1 Publication1
    Mutagenesisi201E → A or Q: Severe loss of catalytic activity. 1 Publication1
    Mutagenesisi243N → A: Reduces catalytic activity. 1 Publication1
    Mutagenesisi243N → D: Reduces catalytic activity towards inosine, hypoxanthine, guanosine and guanine. Increases catalytic activity towards adenosine and adenine. 1 Publication1
    Mutagenesisi257H → W: Reduces catalytic activity towards inosine. 1 Publication1

    Keywords - Diseasei

    Disease variant

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4860

    MalaCards human disease database

    More...
    MalaCardsi
    PNP
    MIMi613179, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000198805

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    760, Purine nucleoside phosphorylase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA31694

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P00491, Tclin

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4338

    Drug and drug target database

    More...
    DrugBanki
    DB03881, (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium
    DB03551, (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium
    DB02222, 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine
    DB02391, 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One
    DB03609, 3'-deoxyguanosine
    DB01667, 8-azaguanine
    DB04260, 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
    DB02796, 9-deazainosine
    DB04753, 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
    DB00242, Cladribine
    DB00900, Didanosine
    DB06185, Forodesine
    DB02377, Guanine
    DB02857, Guanosine
    DB04754, GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
    DB04757, GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
    DB04076, Hypoxanthine
    DB02230, Immucillin-G
    DB04335, Inosine
    DB02568, Peldesine
    DB03101, Ribose-1-Phosphate

    DrugCentral

    More...
    DrugCentrali
    P00491

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2841

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PNP

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    108935929

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001845361 – 289Purine nucleoside phosphorylaseAdd BLAST289

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
    Modified residuei251PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-570
    CPTAC-571

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P00491

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P00491

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P00491

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P00491

    PeptideAtlas

    More...
    PeptideAtlasi
    P00491

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P00491

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    51256

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P00491

    2D gel databases

    USC-OGP 2-DE database

    More...
    OGPi
    P00491

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P00491

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    P00491

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P00491

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P00491

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000198805, Expressed in corpus epididymis and 212 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P00491, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P00491, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000198805, Tissue enhanced (epididymis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    110921, 53 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    P00491

    Database of interacting proteins

    More...
    DIPi
    DIP-50406N

    Protein interaction database and analysis system

    More...
    IntActi
    P00491, 28 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000354532

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P00491

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P00491, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1289
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P00491

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P00491

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 86Phosphate bindingCombined sources2 Publications1 Publication3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3984, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182991

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_054456_1_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P00491

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EGVYAQF

    Database of Orthologous Groups

    More...
    OrthoDBi
    1078969at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P00491

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300049

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09009, PNP-EcPNPII_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.1580, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000845, Nucleoside_phosphorylase_d
    IPR035994, Nucleoside_phosphorylase_sf
    IPR011270, Pur_Nuc_Pase_Ino/Guo-sp
    IPR011268, Purine_phosphorylase
    IPR018099, Purine_phosphorylase-2_CS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11904, PTHR11904, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01048, PNP_UDP_1, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000477, PurNPase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53167, SSF53167, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01700, PNPH, 1 hit
    TIGR01697, PNPH-PUNA-XAPA, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01240, PNP_MTAP_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P00491-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY
    60 70 80 90 100
    GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV
    110 120 130 140 150
    RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP
    160 170 180 190 200
    NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF
    210 220 230 240 250
    ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
    260 270 280
    SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS
    Length:289
    Mass (Da):32,118
    Last modified:May 30, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91622FB1D26479D3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G3V5M2G3V5M2_HUMAN
    Inosine-guanosine phosphorylase
    PNP
    221Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V393G3V393_HUMAN
    Inosine-guanosine phosphorylase
    PNP
    61Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V2H3G3V2H3_HUMAN
    Purine nucleoside phosphorylase
    PNP
    93Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00224351G → S5 PublicationsCorresponds to variant dbSNP:rs1049564EnsemblClinVar.1
    Natural variantiVAR_00224489E → K in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894453EnsemblClinVar.1
    Natural variantiVAR_002245128D → G in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894450EnsemblClinVar.1
    Natural variantiVAR_002246174A → P in PNPD. Corresponds to variant dbSNP:rs104894454EnsemblClinVar.1
    Natural variantiVAR_010653192Y → C in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894452EnsemblClinVar.1
    Natural variantiVAR_002247234R → P in PNPD. 1 PublicationCorresponds to variant dbSNP:rs104894451EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X00737 mRNA Translation: CAA25320.1
    M13953 M13952 Genomic DNA Translation: AAA36460.1
    AY817667 Genomic DNA Translation: AAV68044.1
    AK313490 mRNA Translation: BAG36272.1
    CR407607 mRNA Translation: CAG28535.1
    CH471078 Genomic DNA Translation: EAW66458.1
    CH471078 Genomic DNA Translation: EAW66459.1
    BC104206 mRNA Translation: AAI04207.1
    BC104207 mRNA Translation: AAI04208.1
    BC106074 mRNA Translation: AAI06075.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS9552.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A00578, PHHUPN

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000261.2, NM_000270.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000361505; ENSP00000354532; ENSG00000198805

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4860

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4860

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NPbase

    NP mutation db

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X00737 mRNA Translation: CAA25320.1
    M13953 M13952 Genomic DNA Translation: AAA36460.1
    AY817667 Genomic DNA Translation: AAV68044.1
    AK313490 mRNA Translation: BAG36272.1
    CR407607 mRNA Translation: CAG28535.1
    CH471078 Genomic DNA Translation: EAW66458.1
    CH471078 Genomic DNA Translation: EAW66459.1
    BC104206 mRNA Translation: AAI04207.1
    BC104207 mRNA Translation: AAI04208.1
    BC106074 mRNA Translation: AAI06075.1
    CCDSiCCDS9552.1
    PIRiA00578, PHHUPN
    RefSeqiNP_000261.2, NM_000270.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1M73X-ray2.30E2-289[»]
    1PF7X-ray2.60E1-289[»]
    1PWYX-ray2.80E2-289[»]
    1RCTX-ray2.80E2-289[»]
    1RFGX-ray2.90E2-289[»]
    1RR6X-ray2.50A1-289[»]
    1RSZX-ray2.20A1-289[»]
    1RT9X-ray2.30A1-289[»]
    1ULAX-ray2.75A1-289[»]
    1ULBX-ray2.75A1-289[»]
    1V2HX-ray2.70E2-289[»]
    1V3QX-ray2.80E2-289[»]
    1V41X-ray2.85E2-289[»]
    1V45X-ray2.86E2-289[»]
    1YRYX-ray2.80E1-289[»]
    2A0WX-ray2.28A1-289[»]
    2A0XX-ray2.28A1-289[»]
    2A0YX-ray2.28A1-289[»]
    2OC4X-ray2.59A1-289[»]
    2OC9X-ray2.59A1-289[»]
    2ON6X-ray2.50A1-289[»]
    2Q7OX-ray2.90E1-289[»]
    3BGSX-ray2.10A1-289[»]
    3D1VX-ray2.70A1-289[»]
    3GB9X-ray2.30A/B/C1-289[»]
    3GGSX-ray2.52A/B/C1-289[»]
    3INYX-ray2.75A1-289[»]
    3K8OX-ray2.40E/Q/S/T/U/Y1-289[»]
    3K8QX-ray2.50A1-289[»]
    3PHBX-ray2.30E/Q/S/T/U/Y1-289[»]
    4EARX-ray1.70A/B/C1-289[»]
    4EB8X-ray2.30A/B/C1-289[»]
    4ECEX-ray2.60A/B/C/D/E/F1-289[»]
    4GKAX-ray2.20A/B/C/D/E/F1-289[»]
    5ETJX-ray2.30A/B/C/D/E/F1-289[»]
    5UGFX-ray2.20A/B/C/D/E/F1-289[»]
    SMRiP00491
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi110921, 53 interactors
    CORUMiP00491
    DIPiDIP-50406N
    IntActiP00491, 28 interactors
    STRINGi9606.ENSP00000354532

    Chemistry databases

    BindingDBiP00491
    ChEMBLiCHEMBL4338
    DrugBankiDB03881, (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium
    DB03551, (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium
    DB02222, 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine
    DB02391, 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One
    DB03609, 3'-deoxyguanosine
    DB01667, 8-azaguanine
    DB04260, 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
    DB02796, 9-deazainosine
    DB04753, 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
    DB00242, Cladribine
    DB00900, Didanosine
    DB06185, Forodesine
    DB02377, Guanine
    DB02857, Guanosine
    DB04754, GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
    DB04757, GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
    DB04076, Hypoxanthine
    DB02230, Immucillin-G
    DB04335, Inosine
    DB02568, Peldesine
    DB03101, Ribose-1-Phosphate
    DrugCentraliP00491
    GuidetoPHARMACOLOGYi2841

    PTM databases

    iPTMnetiP00491
    MetOSiteiP00491
    PhosphoSitePlusiP00491
    SwissPalmiP00491

    Genetic variation databases

    BioMutaiPNP
    DMDMi108935929

    2D gel databases

    OGPiP00491

    Proteomic databases

    CPTACiCPTAC-570
    CPTAC-571
    EPDiP00491
    jPOSTiP00491
    MassIVEiP00491
    PaxDbiP00491
    PeptideAtlasiP00491
    PRIDEiP00491
    ProteomicsDBi51256
    TopDownProteomicsiP00491

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    766, 311 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    4860

    Genome annotation databases

    EnsembliENST00000361505; ENSP00000354532; ENSG00000198805
    GeneIDi4860
    KEGGihsa:4860

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4860
    DisGeNETi4860

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PNP
    HGNCiHGNC:7892, PNP
    HPAiENSG00000198805, Tissue enhanced (epididymis)
    MalaCardsiPNP
    MIMi164050, gene
    613179, phenotype
    neXtProtiNX_P00491
    OpenTargetsiENSG00000198805
    Orphaneti760, Purine nucleoside phosphorylase deficiency
    PharmGKBiPA31694
    VEuPathDBiHostDB:ENSG00000198805.11

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3984, Eukaryota
    GeneTreeiENSGT00950000182991
    HOGENOMiCLU_054456_1_2_1
    InParanoidiP00491
    OMAiEGVYAQF
    OrthoDBi1078969at2759
    PhylomeDBiP00491
    TreeFamiTF300049

    Enzyme and pathway databases

    UniPathwayiUPA00606
    BioCyciMetaCyc:HS02151-MONOMER
    BRENDAi2.4.2.1, 2681
    PathwayCommonsiP00491
    ReactomeiR-HSA-6798695, Neutrophil degranulation
    R-HSA-74217, Purine salvage
    R-HSA-74259, Purine catabolism
    SABIO-RKiP00491
    SignaLinkiP00491

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    4860, 8 hits in 998 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PNP, human
    EvolutionaryTraceiP00491

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Purine_nucleoside_phosphorylase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4860
    PharosiP00491, Tclin

    Protein Ontology

    More...
    PROi
    PR:P00491
    RNActiP00491, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000198805, Expressed in corpus epididymis and 212 other tissues
    ExpressionAtlasiP00491, baseline and differential
    GenevisibleiP00491, HS

    Family and domain databases

    CDDicd09009, PNP-EcPNPII_like, 1 hit
    Gene3Di3.40.50.1580, 1 hit
    InterProiView protein in InterPro
    IPR000845, Nucleoside_phosphorylase_d
    IPR035994, Nucleoside_phosphorylase_sf
    IPR011270, Pur_Nuc_Pase_Ino/Guo-sp
    IPR011268, Purine_phosphorylase
    IPR018099, Purine_phosphorylase-2_CS
    PANTHERiPTHR11904, PTHR11904, 1 hit
    PfamiView protein in Pfam
    PF01048, PNP_UDP_1, 1 hit
    PIRSFiPIRSF000477, PurNPase, 1 hit
    SUPFAMiSSF53167, SSF53167, 1 hit
    TIGRFAMsiTIGR01700, PNPH, 1 hit
    TIGR01697, PNPH-PUNA-XAPA, 1 hit
    PROSITEiView protein in PROSITE
    PS01240, PNP_MTAP_2, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNPH_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00491
    Secondary accession number(s): B2R8S5
    , D3DS00, Q15160, Q5PZ03
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: May 30, 2006
    Last modified: June 2, 2021
    This is version 220 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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