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Protein

Coagulation factor XIII A chain

Gene

F13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.1 Publication

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation1 Publication

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3151 Publication1
Active sitei3741 Publication1
Active sitei3971 Publication1
Metal bindingi437Calcium1 Publication1
Metal bindingi439Calcium1 Publication1
Metal bindingi486Calcium1 Publication1
Metal bindingi491Calcium1 Publication1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBlood coagulation, Hemostasis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.131 Publication)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13A1
Synonyms:F13A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124491.15
HGNCiHGNC:3531 F13A1
MIMi134570 gene+phenotype
neXtProtiNX_P00488

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Involvement in diseasei

Factor XIII subunit A deficiency (FA13AD)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
See also OMIM:613225
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07761938R → Q in FA13AD; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 1 PublicationCorresponds to variant dbSNP:rs759324596Ensembl.1
Natural variantiVAR_074280167P → L in FA13AD; mild; no effect on intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077620168Y → C in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074281172R → Q in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074282274G → V in FA13AD. 1 Publication1
Natural variantiVAR_077621290P → R in FA13AD; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; loss of alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074283343H → Y in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074284347A → D in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074285376W → R in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074286414S → L in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074287416Q → R in FA13AD; mild; no effect on intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074288530L → P in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077622541R → Q in FA13AD; decreased intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077623593G → S in FA13AD; no effect on intracellular protein abundance; increased protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074289602Q → K in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; loss of alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077624612R → H in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077625669D → G in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_007474682R → H in FA13AD. 1 Publication1
Natural variantiVAR_074290704R → Q in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074291716R → G in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2162
MalaCardsiF13A1
MIMi134570 gene+phenotype
613225 phenotype
Orphaneti331 Congenital factor XIII deficiency
PharmGKBiPA162

Chemistry databases

ChEMBLiCHEMBL4530
DrugBankiDB00130 L-Glutamine
DB02340 N-Acetyl-Serine

Polymorphism and mutation databases

BioMutaiF13A1
DMDMi119720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
PropeptideiPRO_00000336462 – 38Activation peptideAdd BLAST37
ChainiPRO_000003364739 – 732Coagulation factor XIII A chainAdd BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Glycosylationi614N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

The activation peptide is released by thrombin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage; by thrombin; to produce active factor XIII-A2

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

EPDiP00488
MaxQBiP00488
PaxDbiP00488
PeptideAtlasiP00488
PRIDEiP00488
ProteomicsDBi51255
TopDownProteomicsiP00488

2D gel databases

OGPiP00488

PTM databases

iPTMnetiP00488
PhosphoSitePlusiP00488

Miscellaneous databases

PMAP-CutDBiP00488

Expressioni

Gene expression databases

BgeeiENSG00000124491 Expressed in 215 organ(s), highest expression level in esophagus
CleanExiHS_F13A1
ExpressionAtlasiP00488 baseline and differential
GenevisibleiP00488 HS

Organism-specific databases

HPAiCAB002155
HPA001804

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.2 Publications

Protein-protein interaction databases

BioGridi108460, 11 interactors
DIPiDIP-377N
IntActiP00488, 10 interactors
MINTiP00488
STRINGi9606.ENSP00000264870

Chemistry databases

BindingDBiP00488

Structurei

Secondary structure

1732
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00488
SMRiP00488
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00488

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP00488
KOiK03917
OrthoDBiEOG091G030K
PhylomeDBiP00488
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR034810 Factor_XIII_A
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PANTHERiPTHR11590:SF42 PTHR11590:SF42, 1 hit
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P00488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETSRTAFG GRRAVPPNNS NAAEDDLPTV ELQGVVPRGV NLQEFLNVTS
60 70 80 90 100
VHLFKERWDT NKVDHHTDKY ENNKLIVRRG QSFYVQIDFS RPYDPRRDLF
110 120 130 140 150
RVEYVIGRYP QENKGTYIPV PIVSELQSGK WGAKIVMRED RSVRLSIQSS
160 170 180 190 200
PKCIVGKFRM YVAVWTPYGV LRTSRNPETD TYILFNPWCE DDAVYLDNEK
210 220 230 240 250
EREEYVLNDI GVIFYGEVND IKTRSWSYGQ FEDGILDTCL YVMDRAQMDL
260 270 280 290 300
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNIYAYGVPP SAWTGSVDIL
310 320 330 340 350
LEYRSSENPV RYGQCWVFAG VFNTFLRCLG IPARIVTNYF SAHDNDANLQ
360 370 380 390 400
MDIFLEEDGN VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP
410 420 430 440 450
QENSDGMYRC GPASVQAIKH GHVCFQFDAP FVFAEVNSDL IYITAKKDGT
460 470 480 490 500
HVVENVDATH IGKLIVTKQI GGDGMMDITD TYKFQEGQEE ERLALETALM
510 520 530 540 550
YGAKKPLNTE GVMKSRSNVD MDFEVENAVL GKDFKLSITF RNNSHNRYTI
560 570 580 590 600
TAYLSANITF YTGVPKAEFK KETFDVTLEP LSFKKEAVLI QAGEYMGQLL
610 620 630 640 650
EQASLHFFVT ARINETRDVL AKQKSTVLTI PEIIIKVRGT QVVGSDMTVT
660 670 680 690 700
VQFTNPLKET LRNVWVHLDG PGVTRPMKKM FREIRPNSTV QWEEVCRPWV
710 720 730
SGHRKLIASM SSDSLRHVYG ELDVQIQRRP SM
Length:732
Mass (Da):83,267
Last modified:January 23, 2007 - v4
Checksum:i51A83A9B8B1370D4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4W5H0Y4W5_HUMAN
Coagulation factor XIII A chain
F13A1
102Annotation score:
Q9NQP5Q9NQP5_HUMAN
Coagulation factor XIII A chain
F13A1
138Annotation score:
A6PVK5A6PVK5_HUMAN
Coagulation factor XIII A chain
F13A1
185Annotation score:
H0Y796H0Y796_HUMAN
Coagulation factor XIII A chain
F13A1
147Annotation score:

Sequence cautioni

The sequence AAA52489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92089 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Missing AA sequence (PubMed:4811064).Curated1
Sequence conflicti89F → L in AAA52488 (PubMed:3026437).Curated1

Polymorphismi

There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and F13A*2B. In addition two other intermediate forms (F13A*2A and F13A*2B) seem to exist. The sequence shown is that of F13A*2B.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01392735V → L Higher specific activity. 3 PublicationsCorresponds to variant dbSNP:rs5985EnsemblClinVar.1
Natural variantiVAR_07761938R → Q in FA13AD; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 1 PublicationCorresponds to variant dbSNP:rs759324596Ensembl.1
Natural variantiVAR_02091040V → I1 Publication1
Natural variantiVAR_074280167P → L in FA13AD; mild; no effect on intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077620168Y → C in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074281172R → Q in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_020911205Y → F1 PublicationCorresponds to variant dbSNP:rs3024477Ensembl.1
Natural variantiVAR_074282274G → V in FA13AD. 1 Publication1
Natural variantiVAR_077621290P → R in FA13AD; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; loss of alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074283343H → Y in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074284347A → D in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074285376W → R in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074286414S → L in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074287416Q → R in FA13AD; mild; no effect on intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074288530L → P in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; loss of fibrin gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077622541R → Q in FA13AD; decreased intracellular protein abundance; no effect on protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_013928551T → I1 PublicationCorresponds to variant dbSNP:rs5984Ensembl.1
Natural variantiVAR_007471565P → L in allele F13A*1A, allele F13A*2A and allele F13*(2)A. 3 PublicationsCorresponds to variant dbSNP:rs5982EnsemblClinVar.1
Natural variantiVAR_013929589L → Q1 PublicationCorresponds to variant dbSNP:rs5983Ensembl.1
Natural variantiVAR_077623593G → S in FA13AD; no effect on intracellular protein abundance; increased protein-glutamine gamma-glutamyltransferase activity; no effect on alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074289602Q → K in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; loss of alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; loss of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_077624612R → H in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; no effect on fibrin alpha chain and gamma chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_060545650T → I1 PublicationCorresponds to variant dbSNP:rs17852475Ensembl.1
Natural variantiVAR_007472651V → I in allele F13A*2A and allele F13A*2B. 3 PublicationsCorresponds to variant dbSNP:rs5987EnsemblClinVar.1
Natural variantiVAR_007473652Q → E in allele F13A*1A and allele F13A*1B. 5 PublicationsCorresponds to variant dbSNP:rs5988Ensembl.1
Natural variantiVAR_077625669D → G in FA13AD; decreased intracellular protein abundance; decreased protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_007474682R → H in FA13AD. 1 Publication1
Natural variantiVAR_074290704R → Q in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1
Natural variantiVAR_074291716R → G in FA13AD; mild; decreased intracellular protein abundance; loss of protein-glutamine gamma-glutamyltransferase activity; decreased alpha-2-antiplasmin to fibrin cross-linking activity; decreased rate of fibrin gamma chain cross-linking activity; decreased rate of fibrin alpha chain cross-linking activity; decreased clot fiber thickness. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14539 mRNA Translation: AAA52489.1 Different initiation.
M14354 mRNA Translation: AAA52488.1
M22001
, M21987, M21988, M21989, M21990, M21991, M21992, M21993, M21995, M21996, M21997, M21998, M21999, M22000 Genomic DNA Translation: AAA52415.1
AB208852 mRNA Translation: BAD92089.1 Different initiation.
AF418272 Genomic DNA Translation: AAL12161.1
AL157775 Genomic DNA No translation available.
AL391420 Genomic DNA No translation available.
AL133326 Genomic DNA No translation available.
BC027963 mRNA Translation: AAH27963.1
CCDSiCCDS4496.1
PIRiA35583 EKHUX
RefSeqiNP_000120.2, NM_000129.3
UniGeneiHs.335513

Genome annotation databases

EnsembliENST00000264870; ENSP00000264870; ENSG00000124491
GeneIDi2162
KEGGihsa:2162
UCSCiuc003mwv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14539 mRNA Translation: AAA52489.1 Different initiation.
M14354 mRNA Translation: AAA52488.1
M22001
, M21987, M21988, M21989, M21990, M21991, M21992, M21993, M21995, M21996, M21997, M21998, M21999, M22000 Genomic DNA Translation: AAA52415.1
AB208852 mRNA Translation: BAD92089.1 Different initiation.
AF418272 Genomic DNA Translation: AAL12161.1
AL157775 Genomic DNA No translation available.
AL391420 Genomic DNA No translation available.
AL133326 Genomic DNA No translation available.
BC027963 mRNA Translation: AAH27963.1
CCDSiCCDS4496.1
PIRiA35583 EKHUX
RefSeqiNP_000120.2, NM_000129.3
UniGeneiHs.335513

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EVUX-ray2.01A/B2-732[»]
1EX0X-ray2.00A/B2-732[»]
1F13X-ray2.10A/B2-732[»]
1FIEX-ray2.50A/B2-732[»]
1GGTX-ray2.65A/B2-732[»]
1GGUX-ray2.10A/B2-732[»]
1GGYX-ray2.50A/B2-732[»]
1QRKX-ray2.50A/B2-732[»]
4KTYX-ray1.98A/B2-732[»]
5MHLX-ray2.40A/B2-732[»]
5MHMX-ray2.12A/B2-732[»]
5MHNX-ray2.48A/B2-732[»]
5MHOX-ray2.92A/B2-732[»]
ProteinModelPortaliP00488
SMRiP00488
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108460, 11 interactors
DIPiDIP-377N
IntActiP00488, 10 interactors
MINTiP00488
STRINGi9606.ENSP00000264870

Chemistry databases

BindingDBiP00488
ChEMBLiCHEMBL4530
DrugBankiDB00130 L-Glutamine
DB02340 N-Acetyl-Serine

PTM databases

iPTMnetiP00488
PhosphoSitePlusiP00488

Polymorphism and mutation databases

BioMutaiF13A1
DMDMi119720

2D gel databases

OGPiP00488

Proteomic databases

EPDiP00488
MaxQBiP00488
PaxDbiP00488
PeptideAtlasiP00488
PRIDEiP00488
ProteomicsDBi51255
TopDownProteomicsiP00488

Protocols and materials databases

DNASUi2162
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264870; ENSP00000264870; ENSG00000124491
GeneIDi2162
KEGGihsa:2162
UCSCiuc003mwv.4 human

Organism-specific databases

CTDi2162
DisGeNETi2162
EuPathDBiHostDB:ENSG00000124491.15
GeneCardsiF13A1
HGNCiHGNC:3531 F13A1
HPAiCAB002155
HPA001804
MalaCardsiF13A1
MIMi134570 gene+phenotype
613225 phenotype
neXtProtiNX_P00488
Orphaneti331 Congenital factor XIII deficiency
PharmGKBiPA162
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP00488
KOiK03917
OrthoDBiEOG091G030K
PhylomeDBiP00488
TreeFamiTF324278

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

ChiTaRSiF13A1 human
EvolutionaryTraceiP00488
GeneWikiiCoagulation_factor_XIII,_A1_polypeptide
GenomeRNAii2162
PMAP-CutDBiP00488
PROiPR:P00488
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124491 Expressed in 215 organ(s), highest expression level in esophagus
CleanExiHS_F13A1
ExpressionAtlasiP00488 baseline and differential
GenevisibleiP00488 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR034810 Factor_XIII_A
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PANTHERiPTHR11590:SF42 PTHR11590:SF42, 1 hit
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF13A_HUMAN
AccessioniPrimary (citable) accession number: P00488
Secondary accession number(s): Q59HA7
, Q8N6X2, Q96P24, Q9BX29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 221 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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