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Protein

Ceruloplasmin

Gene

CP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cationNote: Binds 6 Cu cations per monomer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi120Copper 1; type 21
Metal bindingi122Copper 2; type 31
Metal bindingi180Copper 2; type 31
Metal bindingi182Copper 3; type 31
Metal bindingi295Copper 4; type 11
Metal bindingi338Copper 4; type 11
Metal bindingi343Copper 4; type 11
Metal bindingi656Copper 5; type 11
Metal bindingi699Copper 5; type 11
Metal bindingi704Copper 5; type 11
Metal bindingi709Copper 5; type 11
Metal bindingi994Copper 6; type 11
Metal bindingi997Copper 1; type 21
Metal bindingi999Copper 3; type 31
Metal bindingi1039Copper 3; type 31
Metal bindingi1040Copper 6; type 11
Metal bindingi1041Copper 2; type 31
Metal bindingi1045Copper 6; type 11
Metal bindingi1050Copper 6; type 11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • copper ion binding Source: InterPro
  • ferroxidase activity Source: Reactome
  • oxidoreductase activity, oxidizing metal ions Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00590-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.16.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-425410 Metal ion SLC transporters
R-HSA-5619060 Defective CP causes aceruloplasminemia (ACERULOP)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-917937 Iron uptake and transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P00450

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P00450

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.105.1.2 the multi-copper-containing ferrooxidase (mcfo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ceruloplasmin (EC:1.16.3.1)
Alternative name(s):
Ferroxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000047457.13

Human Gene Nomenclature Database

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HGNCi
HGNC:2295 CP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
117700 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P00450

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aceruloplasminemia (ACERULOP)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
See also OMIM:604290
Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

Organism-specific databases

DisGeNET

More...
DisGeNETi
1356

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CP

MalaCards human disease database

More...
MalaCardsi
CP
MIMi604290 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
48818 Aceruloplasminemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26815

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00055 Drotrecogin alfa

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000291220 – 1065CeruloplasminAdd BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) (complex) asparagine6 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi174 ↔ 200Curated
Disulfide bondi276 ↔ 357Curated
Glycosylationi358N-linked (GlcNAc...) (complex) asparagine4 Publications1
Glycosylationi397N-linked (GlcNAc...) (complex) asparagine5 Publications1
Disulfide bondi534 ↔ 560Curated
Glycosylationi588N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi637 ↔ 718Curated
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei722Phosphoserine; by FAM20C1 Publication1
Glycosylationi762N-linked (GlcNAc...) (complex) asparagine4 Publications1
Disulfide bondi874 ↔ 900Curated
Glycosylationi926N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P00450

MaxQB - The MaxQuant DataBase

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MaxQBi
P00450

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00450

PeptideAtlas

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PeptideAtlasi
P00450

PRoteomics IDEntifications database

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PRIDEi
P00450

ProteomicsDB human proteome resource

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ProteomicsDBi
51251

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P00450

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P00450

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P00450

GlyConnect protein glycosylation platform

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GlyConnecti
85

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00450

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00450

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
P00450

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P00450

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047457 Expressed in 185 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P00450 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P00450 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008591
HPA001834

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107748, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P00450

Protein interaction database and analysis system

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IntActi
P00450, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264613

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11065
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P00450

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00450

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P00450

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 357F5/8 type A 1Add BLAST338
Domaini20 – 200Plastocyanin-like 1Add BLAST181
Domaini209 – 357Plastocyanin-like 2Add BLAST149
Domaini370 – 718F5/8 type A 2Add BLAST349
Domaini370 – 560Plastocyanin-like 3Add BLAST191
Domaini570 – 718Plastocyanin-like 4Add BLAST149
Domaini730 – 1061F5/8 type A 3Add BLAST332
Domaini730 – 900Plastocyanin-like 5Add BLAST171
Domaini908 – 1061Plastocyanin-like 6Add BLAST154

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1263 Eukaryota
COG2132 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231499

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003674

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P00450

KEGG Orthology (KO)

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KOi
K13624

Database of Orthologous Groups

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OrthoDBi
EOG091G00QL

Database for complete collections of gene phylogenies

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PhylomeDBi
P00450

TreeFam database of animal gene trees

More...
TreeFami
TF329807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.420, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027150 CP
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin

The PANTHER Classification System

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PANTHERi
PTHR44048:SF5 PTHR44048:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 3 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P00450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE
60 70 80 90 100
HSNIYLQNGP DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE
110 120 130 140 150
TGDKVYVHLK NLASRPYTFH SHGITYYKEH EGAIYPDNTT DFQRADDKVY
160 170 180 190 200
PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH SHIDAPKDIA SGLIGPLIIC
210 220 230 240 250
KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC SEPEKVDKDN
260 270 280 290 300
EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH
310 320 330 340 350
GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA
360 370 380 390 400
FFQVQECNKS SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA
410 420 430 440 450
PGSDSAVFFE QGTTRIGGSY KKLVYREYTD ASFTNRKERG PEEEHLGILG
460 470 480 490 500
PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV RFNKNNEGTY YSPNYNPQSR
510 520 530 540 550
SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY SAVDPTKDIF
560 570 580 590 600
TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF
610 620 630 640 650
TTAPDQVDKE DEDFQESNKM HSMNGFMYGN QPGLTMCKGD SVVWYLFSAG
660 670 680 690 700
NEADVHGIYF SGNTYLWRGE RRDTANLFPQ TSLTLHMWPD TEGTFNVECL
710 720 730 740 750
TTDHYTGGMK QKYTVNQCRR QSEDSTFYLG ERTYYIAAVE VEWDYSPQRE
760 770 780 790 800
WEKELHHLQE QNVSNAFLDK GEFYIGSKYK KVVYRQYTDS TFRVPVERKA
810 820 830 840 850
EEEHLGILGP QLHADVGDKV KIIFKNMATR PYSIHAHGVQ TESSTVTPTL
860 870 880 890 900
PGETLTYVWK IPERSGAGTE DSACIPWAYY STVDQVKDLY SGLIGPLIVC
910 920 930 940 950
RRPYLKVFNP RRKLEFALLF LVFDENESWY LDDNIKTYSD HPEKVNKDDE
960 970 980 990 1000
EFIESNKMHA INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG
1010 1020 1030 1040 1050
HSFQYKHRGV YSSDVFDIFP GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM
1060
ETTYTVLQNE DTKSG
Length:1,065
Mass (Da):122,205
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F2F1294E2D30F58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFZ2E9PFZ2_HUMAN
Ceruloplasmin
CP
946Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE86D6RE86_HUMAN
Ceruloplasmin
CP
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5R1H7C5R1_HUMAN
Ceruloplasmin
CP
852Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5N5H7C5N5_HUMAN
Ceruloplasmin
CP
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1060E → EGEYP in AAA51975 (PubMed:3486416).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02565563I → T Retained in the ER due to impaired N-glycosylation; may present a vulnerability factor for iron induced oxidative stress in Parkinson disease. 2 Publications1
Natural variantiVAR_032815367R → C. Corresponds to variant dbSNP:rs34624984EnsemblClinVar.1
Natural variantiVAR_025656477P → L1 PublicationCorresponds to variant dbSNP:rs35331711EnsemblClinVar.1
Natural variantiVAR_025657544D → E Reduced ferroxidase activity; may present a vulnerability factor for iron induced oxidative stress in Parkinson disease. 2 PublicationsCorresponds to variant dbSNP:rs701753EnsemblClinVar.1
Natural variantiVAR_025658551T → I1 Publication1
Natural variantiVAR_025659793R → H2 Publications1
Natural variantiVAR_025660841T → R1 PublicationCorresponds to variant dbSNP:rs56033670EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M13699 mRNA Translation: AAA51976.1
DQ314867 Genomic DNA Translation: ABC40726.1
D45045 Genomic DNA Translation: BAA08085.1
D00025 mRNA Translation: BAA00019.1
X04135 mRNA Translation: CAA27752.1
X04136 mRNA Translation: CAA27753.1
X04137 mRNA Translation: CAA27754.1
X04138 mRNA Translation: CAA27755.1
AF132978 Genomic DNA Translation: AAF02483.1
M13536 mRNA Translation: AAA51975.1
J05506 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3141.1

Protein sequence database of the Protein Information Resource

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PIRi
A25443 KUHU

NCBI Reference Sequences

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RefSeqi
NP_000087.1, NM_000096.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.558314

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264613; ENSP00000264613; ENSG00000047457

Database of genes from NCBI RefSeq genomes

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GeneIDi
1356

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1356

UCSC genome browser

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UCSCi
uc003ewy.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ceruloplasmin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13699 mRNA Translation: AAA51976.1
DQ314867 Genomic DNA Translation: ABC40726.1
D45045 Genomic DNA Translation: BAA08085.1
D00025 mRNA Translation: BAA00019.1
X04135 mRNA Translation: CAA27752.1
X04136 mRNA Translation: CAA27753.1
X04137 mRNA Translation: CAA27754.1
X04138 mRNA Translation: CAA27755.1
AF132978 Genomic DNA Translation: AAF02483.1
M13536 mRNA Translation: AAA51975.1
J05506 Genomic DNA No translation available.
CCDSiCCDS3141.1
PIRiA25443 KUHU
RefSeqiNP_000087.1, NM_000096.3
UniGeneiHs.558314

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCWX-ray3.00A20-1065[»]
2J5WX-ray2.80A1-1065[»]
4EJXX-ray4.69A1-1065[»]
4ENZX-ray2.60A1-1065[»]
ProteinModelPortaliP00450
SMRiP00450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107748, 10 interactors
CORUMiP00450
IntActiP00450, 5 interactors
STRINGi9606.ENSP00000264613

Chemistry databases

DrugBankiDB00055 Drotrecogin alfa

Protein family/group databases

TCDBi8.A.105.1.2 the multi-copper-containing ferrooxidase (mcfo) family

PTM databases

CarbonylDBiP00450
GlyConnecti85
iPTMnetiP00450
PhosphoSitePlusiP00450
UniCarbKBiP00450

Polymorphism and mutation databases

BioMutaiCP
DMDMi116117

2D gel databases

DOSAC-COBS-2DPAGEiP00450
SWISS-2DPAGEiP00450

Proteomic databases

EPDiP00450
MaxQBiP00450
PaxDbiP00450
PeptideAtlasiP00450
PRIDEiP00450
ProteomicsDBi51251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264613; ENSP00000264613; ENSG00000047457
GeneIDi1356
KEGGihsa:1356
UCSCiuc003ewy.6 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1356
DisGeNETi1356
EuPathDBiHostDB:ENSG00000047457.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CP
GeneReviewsiCP
HGNCiHGNC:2295 CP
HPAiCAB008591
HPA001834
MalaCardsiCP
MIMi117700 gene
604290 phenotype
neXtProtiNX_P00450
Orphaneti48818 Aceruloplasminemia
PharmGKBiPA26815

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000231499
HOVERGENiHBG003674
InParanoidiP00450
KOiK13624
OrthoDBiEOG091G00QL
PhylomeDBiP00450
TreeFamiTF329807

Enzyme and pathway databases

BioCyciMetaCyc:HS00590-MONOMER
BRENDAi1.16.3.1 2681
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-425410 Metal ion SLC transporters
R-HSA-5619060 Defective CP causes aceruloplasminemia (ACERULOP)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-917937 Iron uptake and transport
SABIO-RKiP00450
SIGNORiP00450

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CP human
EvolutionaryTraceiP00450

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Ceruloplasmin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1356
PMAP-CutDBiP00450

Protein Ontology

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PROi
PR:P00450

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000047457 Expressed in 185 organ(s), highest expression level in liver
CleanExiHS_CP
ExpressionAtlasiP00450 baseline and differential
GenevisibleiP00450 HS

Family and domain databases

Gene3Di2.60.40.420, 6 hits
InterProiView protein in InterPro
IPR027150 CP
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
PANTHERiPTHR44048:SF5 PTHR44048:SF5, 1 hit
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 2 hits
SUPFAMiSSF49503 SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 3 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERU_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00450
Secondary accession number(s): Q14063, Q2PP18, Q9UKS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: December 5, 2018
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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