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Protein

Cytochrome c peroxidase, mitochondrial

Gene

CCP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Miscellaneous

Present with 6730 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.

Cofactori

heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei115Transition state stabilizer1
Active sitei119Proton acceptor1
Metal bindingi242Iron (heme axial ligand)1
Active sitei258Tryptophan radical intermediate1

GO - Molecular functioni

  • cytochrome-c peroxidase activity Source: SGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • hydrogen peroxide catabolic process Source: GO_Central
  • response to reactive oxygen species Source: GO_Central

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YKR066C-MONOMER
BRENDAi1.11.1.5 984
SABIO-RKiP00431

Protein family/group databases

PeroxiBasei2361 SceCcP01

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c peroxidase, mitochondrial (EC:1.11.1.5)
Short name:
CCP
Gene namesi
Name:CCP1
Synonyms:CCP, CPO
Ordered Locus Names:YKR066C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR066C
SGDiS000001774 CCP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi258W → F: Substantially diminished activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 67Mitochondrion1 PublicationAdd BLAST67
ChainiPRO_000002363468 – 361Cytochrome c peroxidase, mitochondrialAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphotyrosineCombined sources1

Keywords - PTMi

Organic radical, Phosphoprotein

Proteomic databases

MaxQBiP00431
PaxDbiP00431
PRIDEiP00431

PTM databases

iPTMnetiP00431

Miscellaneous databases

PMAP-CutDBiP00431

Interactioni

Subunit structurei

Forms a one-to-one complex with cytochrome c.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34197, 69 interactors
DIPiDIP-6251N
IntActiP00431, 18 interactors
MINTiP00431
STRINGi4932.YKR066C

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi83 – 99Combined sources17
Turni100 – 102Combined sources3
Helixi103 – 106Combined sources4
Helixi110 – 121Combined sources12
Turni126 – 128Combined sources3
Beta strandi131 – 133Combined sources3
Helixi137 – 139Combined sources3
Helixi141 – 144Combined sources4
Helixi147 – 149Combined sources3
Turni150 – 152Combined sources3
Helixi153 – 165Combined sources13
Beta strandi167 – 169Combined sources3
Helixi171 – 185Combined sources15
Helixi202 – 204Combined sources3
Turni208 – 210Combined sources3
Helixi218 – 226Combined sources9
Turni227 – 229Combined sources3
Helixi232 – 239Combined sources8
Helixi240 – 243Combined sources4
Beta strandi244 – 247Combined sources4
Helixi249 – 252Combined sources4
Beta strandi256 – 260Combined sources5
Beta strandi262 – 264Combined sources3
Helixi268 – 275Combined sources8
Beta strandi278 – 282Combined sources5
Beta strandi284 – 286Combined sources3
Beta strandi288 – 292Combined sources5
Turni293 – 295Combined sources3
Beta strandi296 – 298Combined sources3
Helixi300 – 307Combined sources8
Helixi309 – 319Combined sources11
Helixi322 – 338Combined sources17
Beta strandi345 – 347Combined sources3
Helixi356 – 359Combined sources4

3D structure databases

ProteinModelPortaliP00431
SMRiP00431
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00431

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000189824
InParanoidiP00431
KOiK00428
OMAiSLMMLPT
OrthoDBiEOG092C3FU5

Family and domain databases

InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR002207 Peroxidase_I
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00459 ASPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAVRLLPS LGRTAHKRSL YLFSAAAAAA AAATFAYSQS QKRSSSSPGG
60 70 80 90 100
GSNHGWNNWG KAAALASTTP LVHVASVEKG RSYEDFQKVY NAIALKLRED
110 120 130 140 150
DEYDNYIGYG PVLVRLAWHT SGTWDKHDNT GGSYGGTYRF KKEFNDPSNA
160 170 180 190 200
GLQNGFKFLE PIHKEFPWIS SGDLFSLGGV TAVQEMQGPK IPWRCGRVDT
210 220 230 240 250
PEDTTPDNGR LPDADKDADY VRTFFQRLNM NDREVVALMG AHALGKTHLK
260 270 280 290 300
NSGYEGPWGA ANNVFTNEFY LNLLNEDWKL EKNDANNEQW DSKSGYMMLP
310 320 330 340 350
TDYSLIQDPK YLSIVKEYAN DQDKFFKDFS KAFEKLLENG ITFPKDAPSP
360
FIFKTLEEQG L
Length:361
Mass (Da):40,353
Last modified:June 1, 1994 - v2
Checksum:iA5D26385DA6F0A0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41Q → H in AAA88709 (PubMed:8196765).Curated1
Sequence conflicti62A → P in AAA88709 (PubMed:8196765).Curated1
Sequence conflicti145 – 146ND → DN AA sequence (PubMed:6257176).Curated2
Sequence conflicti231Missing AA sequence (PubMed:6257176).Curated1
Sequence conflicti273L → M in AAS56247 (PubMed:17322287).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti33A → AA in allele 2. 1
Natural varianti120T → I in allele 2. 1
Natural varianti219D → G in allele 2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01468 Genomic DNA Translation: AAA88709.1
X62422 Genomic DNA Translation: CAA44288.1
Z28291 Genomic DNA Translation: CAA82145.1
AY557921 Genomic DNA Translation: AAS56247.1
J01321 Genomic DNA Translation: AAA88710.1
BK006944 Genomic DNA Translation: DAA09217.1
PIRiS19064 OPBYC
RefSeqiNP_012992.1, NM_001179856.1

Genome annotation databases

EnsemblFungiiYKR066C; YKR066C; YKR066C
GeneIDi853940
KEGGisce:YKR066C

Similar proteinsi

Entry informationi

Entry nameiCCPR_YEAST
AccessioniPrimary (citable) accession number: P00431
Secondary accession number(s): D6VXC7, Q6Q5M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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