UniProtKB - P00429 (CX6B1_BOVIN)
Cytochrome c oxidase subunit 6B1
COX6B1
Functioni
: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Biological processi
- oxidative phosphorylation Source: UniProtKB-UniPathway
Enzyme and pathway databases
BRENDAi | 1.9.3.1, 908 |
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 6B1Alternative name(s): Cytochrome c oxidase polypeptide VII Cytochrome c oxidase subunit AED Cytochrome c oxidase subunit VIb isoform 1 Short name: COX VIb-1 |
Gene namesi | Name:COX6B1 Synonyms:COX6B |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Peripheral membrane protein 2 Publications; Intermembrane side 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: AgBase
- mitochondrion Source: AgBase
Other locations
- respiratory chain complex IV Source: UniProtKB
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000194911 | 2 – 86 | Cytochrome c oxidase subunit 6B1Add BLAST | 85 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Disulfide bondi | 30 ↔ 65 | 4 Publications | ||
Disulfide bondi | 40 ↔ 54 | 4 Publications | ||
Modified residuei | 62 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bondProteomic databases
PaxDbi | P00429 |
PeptideAtlasi | P00429 |
PRIDEi | P00429 |
PTM databases
iPTMneti | P00429 |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A2 (or COX6A1), COX6B1 (or COX6B2), COX6C, COX7A1 (or COX7A2), COX7B, COX7C, COX8B and NDUFA4, which are encoded in the nuclear genome (PubMed:8638158). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:26698328, PubMed:27830641).
3 PublicationsProtein-protein interaction databases
CORUMi | P00429 |
DIPi | DIP-38988N |
IntActi | P00429, 3 interactors |
STRINGi | 9913.ENSBTAP00000007369 |
Structurei
Secondary structure
3D structure databases
SMRi | P00429 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P00429 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 73 | CHCHPROSITE-ProRule annotationAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 30 – 40 | Cx9C motifPROSITE-ProRule annotationAdd BLAST | 11 | |
Motifi | 54 – 65 | Cx10C motifPROSITE-ProRule annotationAdd BLAST | 12 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3057, Eukaryota |
InParanoidi | P00429 |
OrthoDBi | 1586678at2759 |
Family and domain databases
CDDi | cd00926, Cyt_c_Oxidase_VIb, 1 hit |
Gene3Di | 1.10.10.140, 1 hit |
InterProi | View protein in InterPro IPR003213, Cyt_c_oxidase_su6B IPR036549, Cyt_c_oxidase_su6B_sf |
PANTHERi | PTHR11387, PTHR11387, 1 hit |
Pfami | View protein in Pfam PF02297, COX6B, 1 hit |
PIRSFi | PIRSF000278, Cyt_c_oxidase_6B, 1 hit |
SUPFAMi | SSF47694, SSF47694, 1 hit |
PROSITEi | View protein in PROSITE PS51808, CHCH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPISWV STWDDRRAEG TFPGKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15112 mRNA Translation: CAA33211.1 BC102366 mRNA Translation: AAI02367.1 |
PIRi | S05432, OGBO7 |
RefSeqi | NP_788848.1, NM_176675.3 |
Genome annotation databases
GeneIDi | 100270792 |
KEGGi | bta:100270792 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15112 mRNA Translation: CAA33211.1 BC102366 mRNA Translation: AAI02367.1 |
PIRi | S05432, OGBO7 |
RefSeqi | NP_788848.1, NM_176675.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OCC | X-ray | 2.80 | H/U | 2-86 | [»] | |
1OCO | X-ray | 2.80 | H/U | 2-86 | [»] | |
1OCR | X-ray | 2.35 | H/U | 2-86 | [»] | |
1OCZ | X-ray | 2.90 | H/U | 2-86 | [»] | |
1V54 | X-ray | 1.80 | H/U | 2-86 | [»] | |
1V55 | X-ray | 1.90 | H/U | 2-86 | [»] | |
2DYR | X-ray | 1.80 | H/U | 2-86 | [»] | |
2DYS | X-ray | 2.20 | H/U | 2-86 | [»] | |
2EIJ | X-ray | 1.90 | H/U | 2-86 | [»] | |
2EIK | X-ray | 2.10 | H/U | 2-86 | [»] | |
2EIL | X-ray | 2.10 | H/U | 2-86 | [»] | |
2EIM | X-ray | 2.60 | H/U | 2-86 | [»] | |
2EIN | X-ray | 2.70 | H/U | 2-86 | [»] | |
2OCC | X-ray | 2.30 | H/U | 2-86 | [»] | |
2Y69 | X-ray | 1.95 | H/U | 1-86 | [»] | |
2YBB | electron microscopy | 19.00 | S | 2-86 | [»] | |
2ZXW | X-ray | 2.50 | H/U | 2-86 | [»] | |
3ABK | X-ray | 2.00 | H/U | 2-86 | [»] | |
3ABL | X-ray | 2.10 | H/U | 2-86 | [»] | |
3ABM | X-ray | 1.95 | H/U | 2-86 | [»] | |
3AG1 | X-ray | 2.20 | H/U | 2-86 | [»] | |
3AG2 | X-ray | 1.80 | H/U | 2-86 | [»] | |
3AG3 | X-ray | 1.80 | H/U | 2-86 | [»] | |
3AG4 | X-ray | 2.05 | H/U | 2-86 | [»] | |
3ASN | X-ray | 3.00 | H/U | 2-86 | [»] | |
3ASO | X-ray | 2.30 | H/U | 2-86 | [»] | |
3WG7 | X-ray | 1.90 | H/U | 2-86 | [»] | |
3X2Q | X-ray | 2.00 | H/U | 2-86 | [»] | |
5B1A | X-ray | 1.50 | H/U | 2-86 | [»] | |
5B1B | X-ray | 1.60 | H/U | 2-86 | [»] | |
5B3S | X-ray | 1.68 | H/U | 2-86 | [»] | |
5GPN | electron microscopy | 5.40 | 5 | 2-86 | [»] | |
5IY5 | X-ray | 2.00 | H/U | 8-86 | [»] | |
5LUF | electron microscopy | 9.10 | 5 | 2-86 | [»] | |
5W97 | X-ray | 2.30 | H/h | 2-86 | [»] | |
5WAU | X-ray | 1.95 | H/h | 2-86 | [»] | |
5X19 | X-ray | 2.20 | H/U | 2-86 | [»] | |
5X1B | X-ray | 2.40 | H/U | 2-86 | [»] | |
5X1F | X-ray | 2.20 | H/U | 2-86 | [»] | |
5XDQ | X-ray | 1.77 | H/U | 2-86 | [»] | |
5XDX | X-ray | 1.99 | H/U | 2-86 | [»] | |
5XTH | electron microscopy | 3.90 | 4 | 12-86 | [»] | |
5XTI | electron microscopy | 17.40 | 4/B4 | 12-86 | [»] | |
5Z84 | X-ray | 1.85 | H/U | 2-86 | [»] | |
5Z85 | X-ray | 1.85 | H/U | 2-86 | [»] | |
5Z86 | X-ray | 1.85 | H/U | 2-86 | [»] | |
5ZCO | X-ray | 1.90 | H/U | 2-86 | [»] | |
5ZCP | X-ray | 1.65 | H/U | 2-86 | [»] | |
5ZCQ | X-ray | 1.65 | H/U | 2-86 | [»] | |
6J8M | X-ray | 1.90 | H/U | 2-86 | [»] | |
6JUW | X-ray | 1.80 | H/U | 8-86 | [»] | |
6JY3 | X-ray | 1.85 | H | 2-86 | [»] | |
6JY4 | X-ray | 1.95 | H | 2-86 | [»] | |
6NKN | X-ray | 2.50 | H/U | 2-86 | [»] | |
6NMF | X-ray | 2.80 | H/U | 2-86 | [»] | |
6NMP | X-ray | 2.90 | H/U | 2-86 | [»] | |
SMRi | P00429 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P00429 |
DIPi | DIP-38988N |
IntActi | P00429, 3 interactors |
STRINGi | 9913.ENSBTAP00000007369 |
PTM databases
iPTMneti | P00429 |
Proteomic databases
PaxDbi | P00429 |
PeptideAtlasi | P00429 |
PRIDEi | P00429 |
Genome annotation databases
GeneIDi | 100270792 |
KEGGi | bta:100270792 |
Organism-specific databases
CTDi | 1340 |
Phylogenomic databases
eggNOGi | KOG3057, Eukaryota |
InParanoidi | P00429 |
OrthoDBi | 1586678at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
BRENDAi | 1.9.3.1, 908 |
Miscellaneous databases
EvolutionaryTracei | P00429 |
Family and domain databases
CDDi | cd00926, Cyt_c_Oxidase_VIb, 1 hit |
Gene3Di | 1.10.10.140, 1 hit |
InterProi | View protein in InterPro IPR003213, Cyt_c_oxidase_su6B IPR036549, Cyt_c_oxidase_su6B_sf |
PANTHERi | PTHR11387, PTHR11387, 1 hit |
Pfami | View protein in Pfam PF02297, COX6B, 1 hit |
PIRSFi | PIRSF000278, Cyt_c_oxidase_6B, 1 hit |
SUPFAMi | SSF47694, SSF47694, 1 hit |
PROSITEi | View protein in PROSITE PS51808, CHCH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CX6B1_BOVIN | |
Accessioni | P00429Primary (citable) accession number: P00429 Secondary accession number(s): Q54A32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families