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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: MGI

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:27634 COX4I1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 98Mitochondrial matrixAdd BLAST76
Transmembranei99 – 124HelicalAdd BLAST26
Topological domaini125 – 169Mitochondrial intermembraneAdd BLAST45

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion2 PublicationsAdd BLAST22
ChainiPRO_000000608323 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP00423
PeptideAtlasiP00423
PRIDEiP00423

PTM databases

iPTMnetiP00423

Expressioni

Gene expression databases

BgeeiENSBTAG00000016079 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

CORUMiP00423
DIPiDIP-38979N
IntActiP00423, 3 interactors
STRINGi9913.ENSBTAP00000049613

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00423
SMRiP00423
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00423

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOVERGENiHBG051087
InParanoidiP00423
KOiK02263
OMAiEKHYVYG
OrthoDBiEOG091G0XDH
TreeFamiTF105061

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00423-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLATRVFSLI GRRAISTSVC VRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKNLSASQK ALKEKEKASW SSLSIDEKVE LYRLKFKESF AEMNRSTNEW
110 120 130 140 150
KTVVGAAMFF IGFTALLLIW EKHYVYGPIP HTFEEEWVAK QTKRMLDMKV
160
APIQGFSAKW DYDKNEWKK
Length:169
Mass (Da):19,572
Last modified:October 23, 1986 - v1
Checksum:i76D2B2D15F8D02A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34015
, L34012, L34013, L34014 Genomic DNA Translation: AAA30461.1
U11070
, U11067, U11068, U11069 Genomic DNA Translation: AAA93149.1
BT021029 mRNA Translation: AAX09046.1
BC102733 mRNA Translation: AAI02734.1
K02064 mRNA Translation: AAA30463.1
PIRiA30618 OLBO4
RefSeqiNP_001001439.1, NM_001001439.3
XP_005218495.1, XM_005218438.1
UniGeneiBt.107085
Bt.16025

Genome annotation databases

EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079
GeneIDi281090
KEGGibta:281090

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34015
, L34012, L34013, L34014 Genomic DNA Translation: AAA30461.1
U11070
, U11067, U11068, U11069 Genomic DNA Translation: AAA93149.1
BT021029 mRNA Translation: AAX09046.1
BC102733 mRNA Translation: AAI02734.1
K02064 mRNA Translation: AAA30463.1
PIRiA30618 OLBO4
RefSeqiNP_001001439.1, NM_001001439.3
XP_005218495.1, XM_005218438.1
UniGeneiBt.107085
Bt.16025

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80D/Q23-169[»]
1OCOX-ray2.80D/Q23-169[»]
1OCRX-ray2.35D/Q23-169[»]
1OCZX-ray2.90D/Q23-169[»]
1V54X-ray1.80D/Q23-169[»]
1V55X-ray1.90D/Q23-169[»]
2DYRX-ray1.80D/Q23-169[»]
2DYSX-ray2.20D/Q23-169[»]
2EIJX-ray1.90D/Q23-169[»]
2EIKX-ray2.10D/Q23-169[»]
2EILX-ray2.10D/Q23-169[»]
2EIMX-ray2.60D/Q23-169[»]
2EINX-ray2.70D/Q23-169[»]
2OCCX-ray2.30D/Q23-169[»]
2Y69X-ray1.95D/Q1-169[»]
2YBBelectron microscopy19.00O23-169[»]
2ZXWX-ray2.50D/Q23-169[»]
3ABKX-ray2.00D/Q23-169[»]
3ABLX-ray2.10D/Q23-169[»]
3ABMX-ray1.95D/Q23-169[»]
3AG1X-ray2.20D/Q23-169[»]
3AG2X-ray1.80D/Q23-169[»]
3AG3X-ray1.80D/Q23-169[»]
3AG4X-ray2.05D/Q23-169[»]
3ASNX-ray3.00D/Q23-169[»]
3ASOX-ray2.30D/Q23-169[»]
3WG7X-ray1.90D/Q23-169[»]
3X2QX-ray2.00D/Q23-169[»]
5B1AX-ray1.50D/Q23-169[»]
5B1BX-ray1.60D/Q23-169[»]
5B3SX-ray1.68D/Q23-169[»]
5GPNelectron microscopy5.40123-169[»]
5IY5X-ray2.00D/Q26-169[»]
5LUFelectron microscopy9.10123-169[»]
5W97X-ray2.30D/d23-169[»]
5WAUX-ray1.95D/d23-169[»]
5X19X-ray2.20D/Q23-169[»]
5X1BX-ray2.40D/Q23-169[»]
5X1FX-ray2.20D/Q23-169[»]
5XDQX-ray1.77D/Q23-169[»]
5XDXX-ray1.99D/Q23-169[»]
5XTHelectron microscopy3.90026-169[»]
5XTIelectron microscopy17.400/B026-169[»]
5Z84X-ray1.85D/Q23-169[»]
5Z85X-ray1.85D/Q23-169[»]
5Z86X-ray1.85D/Q23-169[»]
5ZCOX-ray1.90D/Q23-169[»]
5ZCPX-ray1.65D/Q23-169[»]
5ZCQX-ray1.65D/Q23-169[»]
ProteinModelPortaliP00423
SMRiP00423
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP00423
DIPiDIP-38979N
IntActiP00423, 3 interactors
STRINGi9913.ENSBTAP00000049613

PTM databases

iPTMnetiP00423

Proteomic databases

PaxDbiP00423
PeptideAtlasiP00423
PRIDEiP00423

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079
GeneIDi281090
KEGGibta:281090

Organism-specific databases

CTDi1327
VGNCiVGNC:27634 COX4I1

Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOVERGENiHBG051087
InParanoidiP00423
KOiK02263
OMAiEKHYVYG
OrthoDBiEOG091G0XDH
TreeFamiTF105061

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP00423

Gene expression databases

BgeeiENSBTAG00000016079 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX41_BOVIN
AccessioniPrimary (citable) accession number: P00423
Secondary accession number(s): Q3SZS0, Q5E991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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