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Protein

Cytochrome c oxidase subunit 3

Gene

mt-Co3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102502 mt-Co3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838091 – 261Cytochrome c oxidase subunit 3Add BLAST261

Proteomic databases

PaxDbiP00416
PRIDEiP00416

PTM databases

PhosphoSitePlusiP00416

Expressioni

Gene expression databases

BgeeiENSMUSG00000064358 Expressed in 51 organ(s), highest expression level in heart
ExpressionAtlasiP00416 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi201543, 1 interactor
CORUMiP00416
STRINGi10090.ENSMUSP00000080997

Structurei

3D structure databases

ProteinModelPortaliP00416
SMRiP00416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
GeneTreeiENSGT00390000013064
HOGENOMiHOG000264954
HOVERGENiHBG016686
InParanoidiP00416
KOiK02262
OMAiSIYWWGS
OrthoDBiEOG091G0GH8

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P00416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN
60 70 80 90 100
ILTMYQWWRD VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ISPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGKRNHMN QALLITIMLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,923
Last modified:September 18, 2013 - v2
Checksum:iDAF2EA44599B704E
GO

Sequence cautioni

The sequence CAA24090 differs from that shown. Reason: Erroneous termination at position 262. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248V → I in AAB48650 (PubMed:7332926).Curated1
Sequence conflicti248V → I in CAA24090 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48650.1
V00711 Genomic DNA Translation: CAA24090.1 Sequence problems.
AY172335 Genomic DNA Translation: AAN85128.1
PIRiA00484 OTMS3
RefSeqiNP_904334.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358
GeneIDi17710
KEGGimmu:17710

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48650.1
V00711 Genomic DNA Translation: CAA24090.1 Sequence problems.
AY172335 Genomic DNA Translation: AAN85128.1
PIRiA00484 OTMS3
RefSeqiNP_904334.1, NC_005089.1

3D structure databases

ProteinModelPortaliP00416
SMRiP00416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201543, 1 interactor
CORUMiP00416
STRINGi10090.ENSMUSP00000080997

PTM databases

PhosphoSitePlusiP00416

Proteomic databases

PaxDbiP00416
PRIDEiP00416

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358
GeneIDi17710
KEGGimmu:17710

Organism-specific databases

CTDi4514
MGIiMGI:102502 mt-Co3

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
GeneTreeiENSGT00390000013064
HOGENOMiHOG000264954
HOVERGENiHBG016686
InParanoidiP00416
KOiK02262
OMAiSIYWWGS
OrthoDBiEOG091G0GH8

Miscellaneous databases

PROiPR:P00416
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064358 Expressed in 51 organ(s), highest expression level in heart
ExpressionAtlasiP00416 baseline and differential

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_MOUSE
AccessioniPrimary (citable) accession number: P00416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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