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Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Protein family/group databases

TCDBi3.D.4.7.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15Mitochondrial matrixAdd BLAST15
Transmembranei16 – 34Helical; Name=IAdd BLAST19
Topological domaini35 – 40Mitochondrial intermembrane6
Transmembranei41 – 66Helical; Name=IIAdd BLAST26
Topological domaini67 – 72Mitochondrial matrix6
Transmembranei73 – 105Helical; Name=IIIAdd BLAST33
Topological domaini106 – 128Mitochondrial intermembraneAdd BLAST23
Transmembranei129 – 152Helical; Name=IVAdd BLAST24
Topological domaini153 – 155Mitochondrial matrix3
Transmembranei156 – 183Helical; Name=VAdd BLAST28
Topological domaini184 – 190Mitochondrial intermembrane7
Transmembranei191 – 223Helical; Name=VIAdd BLAST33
Topological domaini224 – 232Mitochondrial matrix9
Transmembranei233 – 256Helical; Name=VIIAdd BLAST24
Topological domaini257 – 261Mitochondrial intermembrane5

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837461 – 261Cytochrome c oxidase subunit 3Add BLAST261

Proteomic databases

PaxDbiP00415

Interactioni

Protein-protein interaction databases

CORUMiP00415
DIPiDIP-60938N
IntActiP00415, 1 interactor
STRINGi9913.ENSBTAP00000053157

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP00415
SMRiP00415
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00415

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
HOVERGENiHBG016686
InParanoidiP00415

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P00415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN
60 70 80 90 100
MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA
110 120 130 140 150
FYHSSLAPTP ELGGCWPPTG IHPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGDRKHML QALFITITLG VYFTLLQASE YYEAPFTISD GVYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,933
Last modified:February 12, 2003 - v2
Checksum:iA521E76A9089B3FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238A → G in CAA24003 (PubMed:7120390).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA Translation: CAA24003.1 Sequence problems.
AF490528 Genomic DNA Translation: AAM08332.1 Sequence problems.
AF490529 Genomic DNA Translation: AAM08345.1 Sequence problems.
AF493541 Genomic DNA Translation: AAM12795.1 Sequence problems.
AF493542 Genomic DNA Translation: AAM12808.1 Sequence problems.
AF492351 Genomic DNA Translation: AAQ06599.1
PIRiA00483 OTBO3

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA Translation: CAA24003.1 Sequence problems.
AF490528 Genomic DNA Translation: AAM08332.1 Sequence problems.
AF490529 Genomic DNA Translation: AAM08345.1 Sequence problems.
AF493541 Genomic DNA Translation: AAM12795.1 Sequence problems.
AF493542 Genomic DNA Translation: AAM12808.1 Sequence problems.
AF492351 Genomic DNA Translation: AAQ06599.1
PIRiA00483 OTBO3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
3X2QX-ray2.00C/P1-261[»]
5B1AX-ray1.50C/P1-261[»]
5B1BX-ray1.60C/P1-261[»]
5B3SX-ray1.68C/P1-261[»]
5IY5X-ray2.00C/P3-261[»]
5LUFelectron microscopy9.10z1-261[»]
5W97X-ray2.30C/c1-261[»]
5WAUX-ray1.95C/c1-261[»]
5X19X-ray2.20C/P1-261[»]
5X1BX-ray2.40C/P1-261[»]
5X1FX-ray2.20C/P1-261[»]
5XDQX-ray1.77C/P1-261[»]
5XDXX-ray1.99C/P2-261[»]
5XTHelectron microscopy3.90z1-261[»]
5XTIelectron microscopy17.40Bz/z1-261[»]
5Z84X-ray1.85C/P1-261[»]
5Z85X-ray1.85C/P1-261[»]
5Z86X-ray1.85C/P1-261[»]
5ZCOX-ray1.90C/P1-261[»]
5ZCPX-ray1.65C/P1-261[»]
5ZCQX-ray1.65C/P1-261[»]
ProteinModelPortaliP00415
SMRiP00415
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP00415
DIPiDIP-60938N
IntActiP00415, 1 interactor
STRINGi9913.ENSBTAP00000053157

Protein family/group databases

TCDBi3.D.4.7.1 the proton-translocating cytochrome oxidase (cox) superfamily

Proteomic databases

PaxDbiP00415

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
HOVERGENiHBG016686
InParanoidiP00415

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP00415

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_BOVIN
AccessioniPrimary (citable) accession number: P00415
Secondary accession number(s): Q576A5, Q8SE13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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