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Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunits I, II and III form the functional core of the enzyme complex.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
  • respiratory chain complex IV assembly Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198938.2

Human Gene Nomenclature Database

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HGNCi
HGNC:7422 MT-CO3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
516050 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P00414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leber hereditary optic neuropathy (LHON)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00216778G → S in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs267606611Ensembl.1
Natural variantiVAR_002168200A → T in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs200613617Ensembl.1
Mitochondrial complex IV deficiency (MT-C4D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
See also OMIM:220110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03305794 – 98Missing in MT-C4D; with RM-MT. 1 Publication5
Recurrent myoglobinuria mitochondrial (RM-MT)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionRecurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine.
See also OMIM:550500

Keywords - Diseasei

Disease mutation, Leber hereditary optic neuropathy, Primary mitochondrial disease

Organism-specific databases

DisGeNET

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DisGeNETi
4514

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MT-CO3

MalaCards human disease database

More...
MalaCardsi
MT-CO3
MIMi220110 phenotype
535000 phenotype
550500 phenotype

Open Targets

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OpenTargetsi
ENSG00000198938

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99845 Genetic recurrent myoglobinuria
254905 Isolated cytochrome C oxidase deficiency
104 Leber hereditary optic neuropathy
550 MELAS

Chemistry databases

Drug and drug target database

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DrugBanki
DB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6648058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001837931 – 261Cytochrome c oxidase subunit 3Add BLAST261

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P00414

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P00414

PeptideAtlas

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PeptideAtlasi
P00414

PRoteomics IDEntifications database

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PRIDEi
P00414

ProteomicsDB human proteome resource

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ProteomicsDBi
51248

Consortium for Top Down Proteomics

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TopDownProteomicsi
P00414

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P00414

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P00414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198938 Expressed in 89 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P00414 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P00414 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA042788

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SNCAP378403EBI-3932264,EBI-985879

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110617, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P00414

Protein interaction database and analysis system

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IntActi
P00414, 9 interactors

Molecular INTeraction database

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MINTi
P00414

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P00414

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P00414

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4664 Eukaryota
COG1845 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013064

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000264954

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG016686

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P00414

KEGG Orthology (KO)

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KOi
K02262

Identification of Orthologs from Complete Genome Data

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OMAi
SIYWWGS

Database of Orthologous Groups

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OrthoDBi
EOG091G0GH8

Database for complete collections of gene phylogenies

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PhylomeDBi
P00414

TreeFam database of animal gene trees

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TreeFami
TF343435

Family and domain databases

Conserved Domains Database

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CDDi
cd01665 Cyt_c_Oxidase_III, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.80, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx

The PANTHER Classification System

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PANTHERi
PTHR11403 PTHR11403, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00510 COX3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81452 SSF81452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50253 COX3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P00414-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTN
60 70 80 90 100
TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA
110 120 130 140 150
FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMENNRNQMI QALLITILLG LYFTLLQASE YFESPFTISD GIYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,951
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA04385EF748B7C14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118P → R in CAA24032 (PubMed:7219534).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0085733H → R1 Publication1
Natural variantiVAR_00857435F → S1 Publication1
Natural variantiVAR_00216778G → S in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs267606611Ensembl.1
Natural variantiVAR_00857591V → I1 PublicationCorresponds to variant dbSNP:rs2853825Ensembl.1
Natural variantiVAR_03305794 – 98Missing in MT-C4D; with RM-MT. 1 Publication5
Natural variantiVAR_008576177Q → R1 Publication1
Natural variantiVAR_002168200A → T in LHON; possible rare primary mutation. 1 PublicationCorresponds to variant dbSNP:rs200613617Ensembl.1
Natural variantiVAR_002169251F → L Found in two patients with a diagnosis of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome; unknown pathological significance. 2 Publications1
Natural variantiVAR_008577254V → I1 PublicationCorresponds to variant dbSNP:rs200809063Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58949.2
V00662 Genomic DNA Translation: CAA24032.1
DQ654394 Genomic DNA Translation: ABG27956.1
DQ654395 Genomic DNA Translation: ABG27958.1
DQ654396 Genomic DNA Translation: ABG27960.1
DQ654397 Genomic DNA Translation: ABG27962.1
DQ654398 Genomic DNA Translation: ABG27964.1
DQ654399 Genomic DNA Translation: ABG27966.1
DQ654400 Genomic DNA Translation: ABG27968.1
DQ654401 Genomic DNA Translation: ABG27970.1
DQ654402 Genomic DNA Translation: ABG27972.1
DQ654403 Genomic DNA Translation: ABG27974.1
DQ654404 Genomic DNA Translation: ABG27976.1
DQ654405 Genomic DNA Translation: ABG27978.1
DQ654406 Genomic DNA Translation: ABG27980.1
DQ654407 Genomic DNA Translation: ABG27982.1
DQ654408 Genomic DNA Translation: ABG27984.1
DQ654409 Genomic DNA Translation: ABG27986.1
DQ654410 Genomic DNA Translation: ABG27988.1
DQ654411 Genomic DNA Translation: ABG27990.1
DQ654412 Genomic DNA Translation: ABG27992.1
DQ654413 Genomic DNA Translation: ABG27994.1
DQ654414 Genomic DNA Translation: ABG27996.1
DQ654415 Genomic DNA Translation: ABG27998.1
DQ654416 Genomic DNA Translation: ABG28000.1
DQ654417 Genomic DNA Translation: ABG28002.1
DQ654418 Genomic DNA Translation: ABG28004.1
DQ654419 Genomic DNA Translation: ABG28006.1
DQ654420 Genomic DNA Translation: ABG28008.1
DQ654421 Genomic DNA Translation: ABG28010.1
DQ654422 Genomic DNA Translation: ABG28012.1
DQ654423 Genomic DNA Translation: ABG28014.1
DQ654424 Genomic DNA Translation: ABG28016.1
DQ654425 Genomic DNA Translation: ABG28018.1
DQ654426 Genomic DNA Translation: ABG28020.1
DQ654427 Genomic DNA Translation: ABG28022.1
DQ654428 Genomic DNA Translation: ABG28024.1
DQ654429 Genomic DNA Translation: ABG28026.1
DQ654430 Genomic DNA Translation: ABG28028.1
DQ654431 Genomic DNA Translation: ABG28030.1
DQ654432 Genomic DNA Translation: ABG28032.1
DQ654433 Genomic DNA Translation: ABG28034.1
DQ654434 Genomic DNA Translation: ABG28036.1
DQ654435 Genomic DNA Translation: ABG28038.1
DQ654436 Genomic DNA Translation: ABG28040.1
DQ654437 Genomic DNA Translation: ABG28042.1
DQ654438 Genomic DNA Translation: ABG28044.1
DQ654439 Genomic DNA Translation: ABG28046.1
DQ654440 Genomic DNA Translation: ABG28048.1
DQ654441 Genomic DNA Translation: ABG28050.1
DQ654442 Genomic DNA Translation: ABG28052.1
DQ654443 Genomic DNA Translation: ABG28054.1
AF004341 Genomic DNA Translation: AAB63452.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A00482 OTHU3

NCBI Reference Sequences

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RefSeqi
YP_003024032.1, NC_012920.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000362079; ENSP00000354982; ENSG00000198938

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4514

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58949.2
V00662 Genomic DNA Translation: CAA24032.1
DQ654394 Genomic DNA Translation: ABG27956.1
DQ654395 Genomic DNA Translation: ABG27958.1
DQ654396 Genomic DNA Translation: ABG27960.1
DQ654397 Genomic DNA Translation: ABG27962.1
DQ654398 Genomic DNA Translation: ABG27964.1
DQ654399 Genomic DNA Translation: ABG27966.1
DQ654400 Genomic DNA Translation: ABG27968.1
DQ654401 Genomic DNA Translation: ABG27970.1
DQ654402 Genomic DNA Translation: ABG27972.1
DQ654403 Genomic DNA Translation: ABG27974.1
DQ654404 Genomic DNA Translation: ABG27976.1
DQ654405 Genomic DNA Translation: ABG27978.1
DQ654406 Genomic DNA Translation: ABG27980.1
DQ654407 Genomic DNA Translation: ABG27982.1
DQ654408 Genomic DNA Translation: ABG27984.1
DQ654409 Genomic DNA Translation: ABG27986.1
DQ654410 Genomic DNA Translation: ABG27988.1
DQ654411 Genomic DNA Translation: ABG27990.1
DQ654412 Genomic DNA Translation: ABG27992.1
DQ654413 Genomic DNA Translation: ABG27994.1
DQ654414 Genomic DNA Translation: ABG27996.1
DQ654415 Genomic DNA Translation: ABG27998.1
DQ654416 Genomic DNA Translation: ABG28000.1
DQ654417 Genomic DNA Translation: ABG28002.1
DQ654418 Genomic DNA Translation: ABG28004.1
DQ654419 Genomic DNA Translation: ABG28006.1
DQ654420 Genomic DNA Translation: ABG28008.1
DQ654421 Genomic DNA Translation: ABG28010.1
DQ654422 Genomic DNA Translation: ABG28012.1
DQ654423 Genomic DNA Translation: ABG28014.1
DQ654424 Genomic DNA Translation: ABG28016.1
DQ654425 Genomic DNA Translation: ABG28018.1
DQ654426 Genomic DNA Translation: ABG28020.1
DQ654427 Genomic DNA Translation: ABG28022.1
DQ654428 Genomic DNA Translation: ABG28024.1
DQ654429 Genomic DNA Translation: ABG28026.1
DQ654430 Genomic DNA Translation: ABG28028.1
DQ654431 Genomic DNA Translation: ABG28030.1
DQ654432 Genomic DNA Translation: ABG28032.1
DQ654433 Genomic DNA Translation: ABG28034.1
DQ654434 Genomic DNA Translation: ABG28036.1
DQ654435 Genomic DNA Translation: ABG28038.1
DQ654436 Genomic DNA Translation: ABG28040.1
DQ654437 Genomic DNA Translation: ABG28042.1
DQ654438 Genomic DNA Translation: ABG28044.1
DQ654439 Genomic DNA Translation: ABG28046.1
DQ654440 Genomic DNA Translation: ABG28048.1
DQ654441 Genomic DNA Translation: ABG28050.1
DQ654442 Genomic DNA Translation: ABG28052.1
DQ654443 Genomic DNA Translation: ABG28054.1
AF004341 Genomic DNA Translation: AAB63452.1
PIRiA00482 OTHU3
RefSeqiYP_003024032.1, NC_012920.1

3D structure databases

ProteinModelPortaliP00414
SMRiP00414
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110617, 8 interactors
CORUMiP00414
IntActiP00414, 9 interactors
MINTiP00414
STRINGi9606.ENSP00000354982

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

PTM databases

iPTMnetiP00414
PhosphoSitePlusiP00414

Polymorphism and mutation databases

DMDMi6648058

Proteomic databases

EPDiP00414
PaxDbiP00414
PeptideAtlasiP00414
PRIDEiP00414
ProteomicsDBi51248
TopDownProteomicsiP00414

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362079; ENSP00000354982; ENSG00000198938
GeneIDi4514
KEGGihsa:4514

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4514
DisGeNETi4514
EuPathDBiHostDB:ENSG00000198938.2

GeneCards: human genes, protein and diseases

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GeneCardsi
MT-CO3
GeneReviewsiMT-CO3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0060139
HGNCiHGNC:7422 MT-CO3
HPAiHPA042788
MalaCardsiMT-CO3
MIMi220110 phenotype
516050 gene
535000 phenotype
550500 phenotype
neXtProtiNX_P00414
OpenTargetsiENSG00000198938
Orphaneti99845 Genetic recurrent myoglobinuria
254905 Isolated cytochrome C oxidase deficiency
104 Leber hereditary optic neuropathy
550 MELAS

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
GeneTreeiENSGT00390000013064
HOGENOMiHOG000264954
HOVERGENiHBG016686
InParanoidiP00414
KOiK02262
OMAiSIYWWGS
OrthoDBiEOG091G0GH8
PhylomeDBiP00414
TreeFamiTF343435

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COX3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MT-CO3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4514

Protein Ontology

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PROi
PR:P00414

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198938 Expressed in 89 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiP00414 baseline and differential
GenevisibleiP00414 HS

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00414
Secondary accession number(s): Q14Y83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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