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Protein

Cytochrome c oxidase subunit 2

Gene

Mtco2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled electron transport Source: GO_Central
  • lactation Source: RGD
  • positive regulation of ATP biosynthetic process Source: RGD
  • positive regulation of hydrogen peroxide biosynthetic process Source: RGD
  • positive regulation of necrotic cell death Source: RGD
  • response to cold Source: RGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:Mtco2
Synonyms:Coii, COX2, mt-Co2
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi621872 mt-Co2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalSequence analysisAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 227Mitochondrial intermembraneSequence analysisAdd BLAST145

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836771 – 227Cytochrome c oxidase subunit 2Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP00406
PRIDEiP00406

PTM databases

iPTMnetiP00406
SwissPalmiP00406

Expressioni

Gene expression databases

BgeeiENSRNOG00000030371
ExpressionAtlasiP00406 baseline and differential
GenevisibleiP00406 RN

Interactioni

Subunit structurei

Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.By similarity

Protein-protein interaction databases

CORUMiP00406
STRINGi10116.ENSRNOP00000046414

Structurei

3D structure databases

ProteinModelPortaliP00406
SMRiP00406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA
GeneTreeiENSGT00390000017410
HOGENOMiHOG000264988
HOVERGENiHBG012727
InParanoidiP00406
KOiK02261
OMAiWSYEYTD
OrthoDBiEOG091G0IO9

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P00406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYPFQLGLQ DATSPIMEEL TNFHDHTLMI VFLISSLVLY IISLMLTTKL
60 70 80 90 100
THTSTMDAQE VETIWTILPA VILILIALPS LRILYMMDEI NNPVLTVKTM
110 120 130 140 150
GHQWYWSYEY TDYEDLCFDS YMIPTNDLKP GELRLLEVDN RVVLPMELPI
160 170 180 190 200
RMLISSEDVL HSWAVPSLGL KTDAIPGRLN QATVTSNRPG LFYGQCSEIC
210 220
GSNHSFMPIV LEMVPLKYFE NWSASMI
Length:227
Mass (Da):25,928
Last modified:April 1, 2015 - v3
Checksum:i9EA986B08B629664
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17M → I in AAP31514 (PubMed:7981121).Curated1
Sequence conflicti21T → M in AAA67374 (PubMed:6285344).Curated1
Sequence conflicti29M → I in AAP31514 (PubMed:7981121).Curated1
Sequence conflicti45M → I in AAP31514 (PubMed:7981121).Curated1
Sequence conflicti56M → I in AAP31514 (PubMed:7981121).Curated1
Sequence conflicti59Q → H in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti130P → L no nucleotide entry (Ref. 4) Curated1
Sequence conflicti130P → L in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti164A → P no nucleotide entry (Ref. 4) Curated1
Sequence conflicti164A → P in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti165V → I in AAB00992 (PubMed:6091655).Curated1
Sequence conflicti165V → I in CAA32957 (PubMed:2504926).Curated1
Sequence conflicti165V → I in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti179L → P in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti189P → L no nucleotide entry (Ref. 4) Curated1
Sequence conflicti189P → L in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti208P → L no nucleotide entry (Ref. 4) Curated1
Sequence conflicti208P → L in AAA67314 (PubMed:1848093).Curated1
Sequence conflicti218Y → H in AAA67374 (PubMed:6285344).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01434 Genomic DNA Translation: AAA67374.1
M27315 Genomic DNA Translation: AAB00992.1
X14848 Genomic DNA Translation: CAA32957.1
M64496 Genomic DNA Translation: AAA67314.1
AY172581 Genomic DNA Translation: AAN77597.1
S74342 mRNA Translation: AAP31514.1
PIRiA93914 OBRT2
B93914 OBRT2B
RefSeqiAP_004895.1, AC_000022.2
YP_665632.1, NC_001665.2

Genome annotation databases

EnsembliENSRNOT00000043693; ENSRNOP00000046414; ENSRNOG00000030371
GeneIDi26198
KEGGirno:26198

Similar proteinsi

Entry informationi

Entry nameiCOX2_RAT
AccessioniPrimary (citable) accession number: P00406
Secondary accession number(s): Q37738, Q80WI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 2015
Last modified: May 23, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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